Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

Leukemia

Volumn 15, Issue 9, 2001, Pages 1398-1407

  Xia, Z ^a   Tan, M M ^a   Wei Lynn Wong, W ^a,b   Dimitroulakos, J ^a   Minden, M D ^a   Penn, L Z ^a,b  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

AML; Apoptosis; Geranylgeranylation; HMG CoA reductase; Lovastatin; Mevalonate

Indexed keywords

6 N (3,3 DIMETHYLALLYL)ADENINE; ADENINE DERIVATIVE; CHOLESTEROL; DESMOSTEROL; DOLICHOL; DOLICHOL PHOSPHATE; FARNESYL DIPHOSPHATE; FTT 277; GERANYLGERANYL PYROPHOSPHATE; GGTI 298; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LANOSTEROL; MEVINOLIN; MEVINOLINIC ACID; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN GERANYLGERANYLTRANSFERASE INHIBITOR; SQUALENE; TERPENOID; TRANSFERASE INHIBITOR; UBIQUINONE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; HYPOTHESIS; LEUKEMIA CELL; PRENYLATION; PRIORITY JOURNAL;

EID: 0034857309     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402196     Document Type: Article

References (46)

1. Regulation of the mevalonate pathway
2. Bile acid biosynthesis
3. Sterols and isoprenoids: Signaling molecules derived from the cholesterol biosynthetic pathway
4. Relationships among dolichyl phosphate, glycoprotein synthesis, and cell culture growth
5. Biosynthesis of ubiquinone
6. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol
7. Branch-point reactions in the biosynthesis of cholesterol, dolichol, ubiquinone and prenylated proteins
8. Signaling molecules derived from the cholesterol biosynthetic pathway
9. Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach
10. Lovastatin-induced apoptosis of human medulloblastoma cell lines in vitro
11. Lovastatin induces apoptosis in malignant mesothelioma cells
12. HMG-CoA reductase mediates the biological effects of retinoic acid on human neuroblastoma cells: Lovastatin specifically targets P-glycoprotein-expressing cells
13. Differential sensitivity of various pediatric cancers and squamous cell carcinomas to lovastatin-induced apoptosis: Therapeutic implications
14. Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin
15. Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia
16. Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity
17. The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism
18. HMG-CoA reductase inhibitors induce apoptosis in mouse proximal tubular cells in primary culture
19. Cholesterol biosynthesis and metabolism
20. Features of apoptotic cells measured by flow cytometry
21. Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure
22. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
23. Biology of the Rap proteins, members of the ras superfamily of GTP- binding proteins
24. Geranylgeranylation of Rab proteins
25. Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac
26. Mevalonate prevents lovastatin-induced apoptosis in medulloblastoma cell lines
27. Lovastatin-induced proliferation inhibition and apoptosis in C6 glial cells
28. Isoprenoid-mediated inhibition of mevalonate synthesis: Potential application to cancer
29. Induction of apoptosis in p53-null HL-60 cells by inhibition of lanosterol 14-alpha demethylase
30. Inhibition of cholesterol biosynthesis by squalene epoxidase inhibitor avoids apoptotic cell death in L6 myoblasts
31. Cholesterol, but not its esters, triggers programmed cell death in human erythroleukemia K562 cells
32. Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death
33. Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism
34. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
35. Protein prenylation: Molecular mechanisms and functional consequences
36. Lovastatin-induced apoptosis in prostate stromal cells
37. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells
38. Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling
39. Dual role of Ras and Rho proteins: At the cutting edge of life and death
40. ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells
41. Identification of a putative target for Rho as the serine-threonine kinase protein kinase N
42. Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins
43. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
44. Farnesyltransferase inhibitors: Antineoplastic mechanism and clinical prospects
45. Specific labeling of isoprenylated proteins: Application to study inhibitors of the post-translational farnesylation and geranylgeranylation
46. Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB