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Volumn 102, Issue 4, 2003, Pages 1490-1498

Involvement of nitric oxide in farnesyltransferase inhibitor-mediated apoptosis in chronic myeloid leukemia cells

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CD34 ANTIGEN; FAS LIGAND; FAS RECEPTOR; LONAFARNIB; MESSENGER RNA; NITRIC OXIDE; PROTEIN; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RECEPTOR; UNCLASSIFIED DRUG;

EID: 0042237727     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-01-0178     Document Type: Article
Times cited : (30)

References (66)
  • 1
    • 0002457485 scopus 로고
    • Ras proto-oncogene activation in human malignancy
    • Garrett CT, Sell S, eds. Totowa, NJ: Humana Press
    • Clark GJ, Der CJ. Ras proto-oncogene activation in human malignancy. In: Garrett CT, Sell S, eds. Cellular Cancer Markers. Totowa, NJ: Humana Press; 1995:17-52.
    • (1995) Cellular Cancer Markers , pp. 17-52
    • Clark, G.J.1    Der, C.J.2
  • 2
    • 0032704708 scopus 로고    scopus 로고
    • Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
    • Rowinsky EK, Windle JJ, Von Hoff DD. Ras protein farnesyltransferase: a strategic target for anticancer therapeutic development. J Clin Oncol. 1999;17:3631-3652.
    • (1999) J Clin Oncol , vol.17 , pp. 3631-3652
    • Rowinsky, E.K.1    Windle, J.J.2    Von Hoff, D.D.3
  • 3
    • 0033620684 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors: Targeting the molecular basis of cancer
    • Oliff A. Farnesyltransferase inhibitors: targeting the molecular basis of cancer. Biochim Biophys Acta. 1999;1423:19-30.
    • (1999) Biochim Biophys Acta , vol.1423 , pp. 19-30
    • Oliff, A.1
  • 4
    • 0035908493 scopus 로고    scopus 로고
    • Blocking oncogenic Ras signaling for cancer therapy
    • Adjei AA. Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst. 2001;93: 1062-1074.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1062-1074
    • Adjei, A.A.1
  • 5
    • 0032937404 scopus 로고    scopus 로고
    • Modulation of the immune response and tumor growth by activated Ras
    • Weijzen S, Velders MP, Kast WM. Modulation of the immune response and tumor growth by activated Ras. Leukemia. 1999;13:502-513.
    • (1999) Leukemia , vol.13 , pp. 502-513
    • Weijzen, S.1    Velders, M.P.2    Kast, W.M.3
  • 6
    • 0029329510 scopus 로고
    • The Ras signaling pathway and the molecular basis of myeloid leukemogenesis
    • Shannon K. The Ras signaling pathway and the molecular basis of myeloid leukemogenesis. Curr Opin Hematol. 1995;2:305-308.
    • (1995) Curr Opin Hematol , vol.2 , pp. 305-308
    • Shannon, K.1
  • 7
    • 0031937682 scopus 로고    scopus 로고
    • The molecular pathophysiology of myeloid leukaemias: Ras revisited
    • Byrne JL, Marshall CJ. The molecular pathophysiology of myeloid leukaemias: Ras revisited. Br J Haematol. 1998;100:256-264.
    • (1998) Br J Haematol , vol.100 , pp. 256-264
    • Byrne, J.L.1    Marshall, C.J.2
  • 8
    • 0034284027 scopus 로고    scopus 로고
    • Targeting the Ras signaling pathway: A rational, mechanism-based treatment for hematologic malignancies?
    • Reuter CW, Morgan MA, Bergmann L. Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies? Blood. 2000;96:1655-1669.
    • (2000) Blood , vol.96 , pp. 1655-1669
    • Reuter, C.W.1    Morgan, M.A.2    Bergmann, L.3
  • 9
    • 0030036452 scopus 로고    scopus 로고
    • Ras and myelodysplasia: Lessons from the last decade
    • Parker J, Mufti GJ. Ras and myelodysplasia: lessons from the last decade. Semin Hematol. 1996; 33:206-224.
    • (1996) Semin Hematol , vol.33 , pp. 206-224
    • Parker, J.1    Mufti, G.J.2
  • 11
    • 0034104590 scopus 로고    scopus 로고
    • The Ras branch of small GTPases: Ras family members don't fall far from the tree
    • Reuther CW, Der CJ. The Ras branch of small GTPases: Ras family members don't fall far from the tree. Curr Opin Cell Biol. 2000;12:157-165.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 157-165
    • Reuther, C.W.1    Der, C.J.2
  • 12
    • 0030992130 scopus 로고    scopus 로고
    • Protein prenylation, et cetera: Signal transduction in two dimensions
    • Gelb MH. Protein prenylation, et cetera: signal transduction in two dimensions. Science. 1997; 275:1750-1751.
    • (1997) Science , vol.275 , pp. 1750-1751
    • Gelb, M.H.1
  • 13
    • 0029966304 scopus 로고    scopus 로고
    • Protein prenyltransferases
    • Casey PJ, Seabra MC. Protein prenyltransferases. J Biol Chem. 1996;271:5289-5292.
    • (1996) J Biol Chem , vol.271 , pp. 5289-5292
    • Casey, P.J.1    Seabra, M.C.2
  • 14
    • 0034722890 scopus 로고    scopus 로고
    • Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-tobedside translational studies
    • Sebti SM, Hamilton AD. Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-tobedside translational studies. Oncogene. 2000; 19:6584-6593.
    • (2000) Oncogene , vol.19 , pp. 6584-6593
    • Sebti, S.M.1    Hamilton, A.D.2
  • 15
    • 0037122699 scopus 로고    scopus 로고
    • Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors
    • Houssin R, Pommery J, Salaun MC, et al. Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors. J Med Chem. 2002;45:533-536.
    • (2002) J Med Chem , vol.45 , pp. 533-536
    • Houssin, R.1    Pommery, J.2    Salaun, M.C.3
  • 16
    • 0035383789 scopus 로고    scopus 로고
    • Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase I clinical-laboratory correlative trial
    • Karp JE, Lancet JE, Kaufmann SH, et al. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase I clinical-laboratory correlative trial. Blood. 2001;97:3361-3369.
    • (2001) Blood , vol.97 , pp. 3361-3369
    • Karp, J.E.1    Lancet, J.E.2    Kaufmann, S.H.3
  • 17
    • 0034846550 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors as targeted therapies for hematological malignancies
    • Karp JE. Farnesyltransferase inhibitors as targeted therapies for hematological malignancies. Semin Hematol. 2001;38(suppl 7):16-23.
    • (2001) Semin Hematol , vol.38 , Issue.SUPPL. 7 , pp. 16-23
    • Karp, J.E.1
  • 18
    • 79960971531 scopus 로고    scopus 로고
    • Phase I study of a farnesyl transferase inhibitor (FTI), BMS-214662, in patients with refractory or relapsed acute leukemias
    • Cortes J, Kurzrock R, O'Brien SM. Phase I study of a farnesyl transferase inhibitor (FTI), BMS-214662, in patients with refractory or relapsed acute leukemias [abstract]. Blood. 2001: 98;594a.
    • (2001) Blood , vol.98
    • Cortes, J.1    Kurzrock, R.2    O'Brien, S.M.3
  • 19
    • 0035282901 scopus 로고    scopus 로고
    • Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia
    • Peters DG, Hoover RR, Gerlach MJ, et al. Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia. Blood. 2001;97:1404-1412.
    • (2001) Blood , vol.97 , pp. 1404-1412
    • Peters, D.G.1    Hoover, R.R.2    Gerlach, M.J.3
  • 20
    • 0035869396 scopus 로고    scopus 로고
    • Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling
    • Morgan MA, Dolp O, Reuter CWM. Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling. Blood. 2001;97:1823-1834.
    • (2001) Blood , vol.97 , pp. 1823-1834
    • Morgan, M.A.1    Dolp, O.2    Reuter, C.W.M.3
  • 21
    • 0036655766 scopus 로고    scopus 로고
    • Myelodysplastic syndrome overview
    • Kurzrock R. Myelodysplastic syndrome overview. Semin Hematol. 2002;39(suppl 2):18-25.
    • (2002) Semin Hematol , vol.39 , Issue.SUPPL. 2 , pp. 18-25
    • Kurzrock, R.1
  • 22
    • 0032541625 scopus 로고    scopus 로고
    • Non-ras targets for farnesyltransferase inhibitors: Focus on Rho
    • Lebowitz PF, Prendergast GC. Non-ras targets for farnesyltransferase inhibitors: focus on Rho. Oncogene. 1998;17:1439-1447.
    • (1998) Oncogene , vol.17 , pp. 1439-1447
    • Lebowitz, P.F.1    Prendergast, G.C.2
  • 23
    • 0032981812 scopus 로고    scopus 로고
    • Targeting farnesyltransferase: Is Ras relevant?
    • Prendergast GC, Du W.Targeting farnesyltransferase: is Ras relevant? Drug Resist Updat. 1999; 2:81-84.
    • (1999) Drug Resist Updat , vol.2 , pp. 81-84
    • Prendergast, G.C.1    Du, W.2
  • 24
    • 0033016719 scopus 로고    scopus 로고
    • Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB
    • Du W, Lebowitz PF, Prendergast GC. Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Mol Cell Biol. 1999;19:1831-1840.
    • (1999) Mol Cell Biol , vol.19 , pp. 1831-1840
    • Du, W.1    Lebowitz, P.F.2    Prendergast, G.C.3
  • 25
    • 0034050541 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors: Antineoplastic mechanism and clinical prospects
    • Prendergast GC. Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects. Curr Opin Cell Biol. 2000;12:166-173.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 166-173
    • Prendergast, G.C.1
  • 26
    • 0033231190 scopus 로고    scopus 로고
    • Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors
    • Du W, Prendergast GC. Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors. Cancer Res. 1999;59:5492-5496.
    • (1999) Cancer Res , vol.59 , pp. 5492-5496
    • Du, W.1    Prendergast, G.C.2
  • 28
    • 0030749458 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors and cancer treatment: Targeting simply Ras?
    • Cox AD, Der CJ. Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras? Biochim Biophys Acta. 1997;1333:51-71.
    • (1997) Biochim Biophys Acta , vol.1333 , pp. 51-71
    • Cox, A.D.1    Der, C.J.2
  • 29
    • 0037081268 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors reverse Ras-mediated inhibition of Fas gene expression
    • Zhang B, Prendergast GC, Fenton RG, Farnesyltransferase inhibitors reverse Ras-mediated inhibition of Fas gene expression. Cancer Res. 2002; 62:452-458.
    • (2002) Cancer Res , vol.62 , pp. 452-458
    • Zhang, B.1    Prendergast, G.C.2    Fenton, R.G.3
  • 30
    • 0033860183 scopus 로고    scopus 로고
    • RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors
    • Liu AX, Du W, Liu JP, Jessell TM, Prendergast GC. RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors. Mol Cell Biol. 2000;20:6105-6113.
    • (2000) Mol Cell Biol , vol.20 , pp. 6105-6113
    • Liu, A.X.1    Du, W.2    Liu, J.P.3    Jessell, T.M.4    Prendergast, G.C.5
  • 31
    • 0035932960 scopus 로고    scopus 로고
    • RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage
    • Liu AX, Cerniglia GJ, Bernhard EJ, Prendergast GC. RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage. Proc Natl Acad Sci U S A. 2001;98:6192-6197.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6192-6197
    • Liu, A.X.1    Cerniglia, G.J.2    Bernhard, E.J.3    Prendergast, G.C.4
  • 32
    • 0028950123 scopus 로고
    • Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene
    • Sawyers CL, McLaughlin J, Witte ON. Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. J Exp Med. 1995;181:307-313.
    • (1995) J Exp Med , vol.181 , pp. 307-313
    • Sawyers, C.L.1    McLaughlin, J.2    Witte, O.N.3
  • 34
    • 0033603435 scopus 로고    scopus 로고
    • Signaling pathways activated by oncogenic forms of Abl tyrosine kinase
    • Zou X, Calame K. Signaling pathways activated by oncogenic forms of Abl tyrosine kinase. J Biol Chem. 1999;274:18141-18144.
    • (1999) J Biol Chem , vol.274 , pp. 18141-18144
    • Zou, X.1    Calame, K.2
  • 35
    • 0032578384 scopus 로고    scopus 로고
    • BCR/ ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac
    • Skorski T, Wlodarski P, Daheron L, et al. BCR/ ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac. Proc Natl Acad Sci U S A. 1998;95:11858-11862.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11858-11862
    • Skorski, T.1    Wlodarski, P.2    Daheron, L.3
  • 36
    • 0033564140 scopus 로고    scopus 로고
    • Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt
    • Majewski M, Nieborowska-Skorska M, Salomoni P, et al. Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt. Cancer Res. 1999;59:2815-2819.
    • (1999) Cancer Res , vol.59 , pp. 2815-2819
    • Majewski, M.1    Nieborowska-Skorska, M.2    Salomoni, P.3
  • 37
    • 0030826412 scopus 로고    scopus 로고
    • A cytoplasmic inhibitor of the JNK signal transduction pathway
    • Dickens M, Rogers JS, Cavanagh J, et al. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science. 1997;277:693-697.
    • (1997) Science , vol.277 , pp. 693-697
    • Dickens, M.1    Rogers, J.S.2    Cavanagh, J.3
  • 38
    • 0033557972 scopus 로고    scopus 로고
    • GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway
    • Shi CS,Tuscano JM, Witte ON, Kehrl JH. GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway. Blood. 1999;93: 1338-1345.
    • (1999) Blood , vol.93 , pp. 1338-1345
    • Shi, C.S.1    Tuscano, J.M.2    Witte, O.N.3    Kehrl, J.H.4
  • 39
    • 0035817343 scopus 로고    scopus 로고
    • p62(dok),a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl)
    • Di Cristofano A, Niki M, Zhao M, et al. p62(dok),a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). J Exp Med. 2001;194: 275-284.
    • (2001) J Exp Med , vol.194 , pp. 275-284
    • Di Cristofano, A.1    Niki, M.2    Zhao, M.3
  • 40
    • 18544372618 scopus 로고    scopus 로고
    • Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells
    • Sonoyama J, Matsumura I, Ezoe S, et al. Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells. J Biol Chem. 2002;277:8076-8082.
    • (2002) J Biol Chem , vol.277 , pp. 8076-8082
    • Sonoyama, J.1    Matsumura, I.2    Ezoe, S.3
  • 41
    • 0035855648 scopus 로고    scopus 로고
    • Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells
    • Hoover RR, Gerlach MJ, Koh EY, Daley GQ. Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells. Oncogene. 2001;20:5826-5835.
    • (2001) Oncogene , vol.20 , pp. 5826-5835
    • Hoover, R.R.1    Gerlach, M.J.2    Koh, E.Y.3    Daley, G.Q.4
  • 42
    • 0029081523 scopus 로고
    • Nitric oxide suppression of human hematopoiesis in vitro: Contribution to inhibitory action of interferongamma and tumor necrosis factor-alpha
    • Maciejewski JP, Selleri C, Sato T, et al. Nitric oxide suppression of human hematopoiesis in vitro: contribution to inhibitory action of interferongamma and tumor necrosis factor-alpha. J Clin Invest. 1995;96:1085-1092.
    • (1995) J Clin Invest , vol.96 , pp. 1085-1092
    • Maciejewski, J.P.1    Selleri, C.2    Sato, T.3
  • 43
    • 0032417689 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells
    • Suzuki N, Urano J, Tamanoi F. Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells. Proc Natl Acad Sci U S A. 1998;95:15356-15361.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15356-15361
    • Suzuki, N.1    Urano, J.2    Tamanoi, F.3
  • 44
    • 0036244305 scopus 로고    scopus 로고
    • Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis
    • Boyd CS, Cadenas E. Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis. Biol Chem. 2002;383:411-423.
    • (2002) Biol Chem , vol.383 , pp. 411-423
    • Boyd, C.S.1    Cadenas, E.2
  • 45
    • 0037372488 scopus 로고    scopus 로고
    • Efficacy of the farnesyltransferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies
    • Cortes J, Albitar M, Thomas D, et al. Efficacy of the farnesyltransferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies. Blood. 2003,101:1692-1697.
    • (2003) Blood , vol.101 , pp. 1692-1697
    • Cortes, J.1    Albitar, M.2    Thomas, D.3
  • 46
    • 0036655765 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: Current therapies and the potential role of farnesyltransferase inhibitors
    • Keating A. Chronic myeloid leukemia: current therapies and the potential role of farnesyltransferase inhibitors. Semin Hematol. 2002;39(suppl 2):11-17.
    • (2002) Semin Hematol , vol.39 , Issue.SUPPL. 2 , pp. 11-17
    • Keating, A.1
  • 47
    • 0038428763 scopus 로고    scopus 로고
    • Pilot study of SCH66336 (Lonafarnib), a farnesyltransferase inhibitor (FTI), in patients with chronic myeloid leukemia (CML), in chronic or accelerated phase resistant or refractory to imatinib
    • Cortes JE, Daley G, Talpaz M, et al. Pilot study of SCH66336 (Lonafarnib), a farnesyltransferase inhibitor (FTI), in patients with chronic myeloid leukemia (CML), in chronic or accelerated phase resistant or refractory to imatinib [abstract]. Blood. 2002;100:164a.
    • (2002) Blood , vol.100
    • Cortes, J.E.1    Daley, G.2    Talpaz, M.3
  • 48
    • 0034651043 scopus 로고    scopus 로고
    • Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyl-transferase inhibitors
    • Emanuel PD, Snyder RC, Wiley T, Gopurala B, Castleberry RP, Inhibition of juvenile myelomonocytic leukemia cell growth in vitro by farnesyl-transferase inhibitors. Blood. 2000;95:639-645.
    • (2000) Blood , vol.95 , pp. 639-645
    • Emanuel, P.D.1    Snyder, R.C.2    Wiley, T.3    Gopurala, B.4    Castleberry, R.P.5
  • 49
    • 0037049768 scopus 로고    scopus 로고
    • BCR/ABL regulates response to DNA damage: The role inresistance to genotoxic treatment and in genomic instability
    • Skorski T. BCR/ABL regulates response to DNA damage: the role inresistance to genotoxic treatment and in genomic instability. Oncogene. 2002; 21:8591-8604.
    • (2002) Oncogene , vol.21 , pp. 8591-8604
    • Skorski, T.1
  • 50
    • 0032147137 scopus 로고    scopus 로고
    • Fas-mediated modulation o Bcr/Abl in chronic myelogenous leukemia results in differential effects on apoptosis
    • Selleri C, Maciejewski JP, Pane F, et al. Fas-mediated modulation o Bcr/Abl in chronic myelogenous leukemia results in differential effects on apoptosis. Blood. 1998;92:981-989.
    • (1998) Blood , vol.92 , pp. 981-989
    • Selleri, C.1    Maciejewski, J.P.2    Pane, F.3
  • 51
    • 0030969311 scopus 로고    scopus 로고
    • Involvement of Fas-mediated apoptosis in the inhibitory effects of interferon-alpha in chronic myelogenous leukemia
    • Selleri C, Sato T, Del Vecchio L, et al. Involvement of Fas-mediated apoptosis in the inhibitory effects of interferon-alpha in chronic myelogenous leukemia. Blood. 1997;89:957-964.
    • (1997) Blood , vol.89 , pp. 957-964
    • Selleri, C.1    Sato, T.2    Del Vecchio, L.3
  • 52
    • 0033214185 scopus 로고    scopus 로고
    • BCR/ABL mRNA and the P210(BCR/ABL) protein are downmodulated by interferon-alpha in chronic myeloid leukemia patients
    • Pane F, Mostarda I, Selleri C, et al. BCR/ABL mRNA and the P210(BCR/ABL) protein are downmodulated by interferon-alpha in chronic myeloid leukemia patients. Blood. 1999;94:2200-2207.
    • (1999) Blood , vol.94 , pp. 2200-2207
    • Pane, F.1    Mostarda, I.2    Selleri, C.3
  • 53
    • 0034640254 scopus 로고    scopus 로고
    • The prodomain of caspase-1 enhances Fas-mediated apoptosis through facilitation of caspase-8 activation
    • Tatsuta T, Shiraishi A, Mountz JD. The prodomain of caspase-1 enhances Fas-mediated apoptosis through facilitation of caspase-8 activation. J Biol Chem. 2000;275:14248-14254.
    • (2000) J Biol Chem , vol.275 , pp. 14248-14254
    • Tatsuta, T.1    Shiraishi, A.2    Mountz, J.D.3
  • 54
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 55
    • 0037164865 scopus 로고    scopus 로고
    • Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli
    • Arnoult D, Parone P, Martinou JC, Antonsson B, Estaquier J, Ameisen JC. Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J Cell Biol. 2002;159:923-929.
    • (2002) J Cell Biol , vol.159 , pp. 923-929
    • Arnoult, D.1    Parone, P.2    Martinou, J.C.3    Antonsson, B.4    Estaquier, J.5    Ameisen, J.C.6
  • 56
    • 0032032270 scopus 로고    scopus 로고
    • Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
    • Amarante-Mendes GP, Naekyung Kim C, Liu L, et al. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3. Blood. 1998;91:1700-1705.
    • (1998) Blood , vol.91 , pp. 1700-1705
    • Amarante-Mendes, G.P.1    Naekyung Kim, C.2    Liu, L.3
  • 57
    • 0036487232 scopus 로고    scopus 로고
    • Bcl-2 family of proteins: Life-or-death switch in mitochondria
    • Tsujimoto Y. Bcl-2 family of proteins: life-or-death switch in mitochondria. Biosci Rep. 2002; 22:47-58.
    • (2002) Biosci Rep , vol.22 , pp. 47-58
    • Tsujimoto, Y.1
  • 58
    • 0029015690 scopus 로고
    • Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2
    • Sanchez-Garcia I, Grutz G. Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2. Proc Natl Acad Sci U S A. 1995;92:5287-5291.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5287-5291
    • Sanchez-Garcia, I.1    Grutz, G.2
  • 59
    • 0036064594 scopus 로고    scopus 로고
    • Manumycin inhibits farnesyltransferase and induces apoptosis of drug-resistant interleukin 6-producing myeloma cells
    • Frassanito MA, Cusmai A, Piccoli C, Dammacco F. Manumycin inhibits farnesyltransferase and induces apoptosis of drug-resistant interleukin 6-producing myeloma cells. Br J Haematol. 2002; 118:157-165.
    • (2002) Br J Haematol , vol.118 , pp. 157-165
    • Frassanito, M.A.1    Cusmai, A.2    Piccoli, C.3    Dammacco, F.4
  • 60
    • 0033828545 scopus 로고    scopus 로고
    • Mechanisms involved in the pro- and anti-apoptotic role of NO in human leukemia
    • Kolb JP. Mechanisms involved in the pro- and anti-apoptotic role of NO in human leukemia. Leukemia. 2000;14:1685-1694.
    • (2000) Leukemia , vol.14 , pp. 1685-1694
    • Kolb, J.P.1
  • 61
    • 85014196381 scopus 로고    scopus 로고
    • Nitric oxide induces the apoptosis of human BCR-ABL-positive myeloid leukemia cells: Evidence for the chelation of intracellular iron
    • - Ferry-Dumazet H, Mamani-Matsuda M, Dupouy M, et al. Nitric oxide induces the apoptosis of human BCR-ABL-positive myeloid leukemia cells: evidence for the chelation of intracellular iron. Leukemia. 2002;16:708-715.
    • (2002) Leukemia , vol.16 , pp. 708-715
    • Ferry-Dumazet, H.1    Mamani-Matsuda, M.2    Dupouy, M.3
  • 62
    • 0035071832 scopus 로고    scopus 로고
    • Nitric oxide and cell survival: Megakaryocytes say "NO"
    • Selleri C, Maciejewski JP. Nitric oxide and cell survival: megakaryocytes say "NO." J Lab Clin Med. 2001;137:225-230.
    • (2001) J Lab Clin Med , vol.137 , pp. 225-230
    • Selleri, C.1    Maciejewski, J.P.2
  • 63
    • 0035874941 scopus 로고    scopus 로고
    • Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: Implications in breast cancer
    • Pervin S, Singh R, Gau CL, Edamatsu H, Tamanoi F, Chaudhuri G. Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: implications in breast cancer. Cancer Res. 2001;61:4701-4706.
    • (2001) Cancer Res , vol.61 , pp. 4701-4706
    • Pervin, S.1    Singh, R.2    Gau, C.L.3    Edamatsu, H.4    Tamanoi, F.5    Chaudhuri, G.6
  • 64
    • 0034777538 scopus 로고    scopus 로고
    • Protein farnesylation in mammalian cells: Effects of farnesyltransferase inhibitors on cancer cells
    • Tamanoi F, Gau CL, Jiang C, Edamatsu H, Kato-Stankiewicz J. Protein farnesylation in mammalian cells: effects of farnesyltransferase inhibitors on cancer cells. Cell Mol Life Sci. 2001;58:1636-1649.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 1636-1649
    • Tamanoi, F.1    Gau, C.L.2    Jiang, C.3    Edamatsu, H.4    Kato-Stankiewicz, J.5
  • 65
    • 0034674417 scopus 로고    scopus 로고
    • Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice
    • Chen Z, Sun J, Pradines A, Favre G, Adnane J, Sebti SM. Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice. J Biol Chem. 2000;275:17974-17978.
    • (2000) J Biol Chem , vol.275 , pp. 17974-17978
    • Chen, Z.1    Sun, J.2    Pradines, A.3    Favre, G.4    Adnane, J.5    Sebti, S.M.6
  • 66
    • 0036683409 scopus 로고    scopus 로고
    • Overcoming STI571 resistance with the farnesyltransferase inhibitor SCH66336
    • Hoover RR, Mahon FX, Melo JV, Daley GQ Overcoming STI571 resistance with the farnesyltransferase inhibitor SCH66336. Blood. 2002; 100:1068-1071.
    • (2002) Blood , vol.100 , pp. 1068-1071
    • Hoover, R.R.1    Mahon, F.X.2    Melo, J.V.3    Daley, G.Q.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.