-
1
-
-
0026316096
-
Growth factors and cancer
-
Aaronson SA 1991 Growth factors and cancer. Science 254 1146-1153.
-
(1991)
Science
, vol.254
, pp. 1146-1153
-
-
Aaronson, S.A.1
-
2
-
-
0001391575
-
Phase II study of anti-epidermal growth factor receptor (EGFR) antibody cetuximab (IMC-C225) in combination with gemcitabine in patients with advanced pancreatic cancer
-
Abbruzzese J, Rosenberg A, Xiong Q, LoBuglio A, Schmidt W, Wolff R, Needle M & Waksal H 2001 Phase II study of anti-epidermal growth factor receptor (EGFR) antibody cetuximab (IMC-C225) in combination with gemcitabine in patients with advanced pancreatic cancer. Proceedings of the American Society for Clinical Oncology 20 130.
-
(2001)
Proceedings of the American Society for Clinical Oncology
, vol.20
, pp. 130
-
-
Abbruzzese, J.1
Rosenberg, A.2
Xiong, Q.3
LoBuglio, A.4
Schmidt, W.5
Wolff, R.6
Needle, M.7
Waksal, H.8
-
3
-
-
0035418622
-
Activated extracellular signal-regulated kinases: Association with epidermal growth factor receptor/transforming growth factor α expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments
-
Albanell J, Cordony-Servat J, Rojo F, Del Campo JM, Sauleda S, Anido J, Raspall G, Giralt J, Roselló J, Nicholson RI, Mendelsohn J & Baselga J 2001 Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor α expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments. Cancer Research 61 6500-6510.
-
(2001)
Cancer Research
, vol.61
, pp. 6500-6510
-
-
Albanell, J.1
Cordony-Servat, J.2
Rojo, F.3
Del Campo, J.M.4
Sauleda, S.5
Anido, J.6
Raspall, G.7
Giralt, J.8
Roselló, J.9
Nicholson, R.I.10
Mendelsohn, J.11
Baselga, J.12
-
4
-
-
0036139727
-
Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition
-
Albanell J, Rojo F, Averbuch S, Feyereislova A, Mascaro JM, Herbst R, LoRusso P, Rischin D, Sauleda S, Gee J, Nicholson RI & Baselga J 2002 Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition. Journal of Clinical Oncology 20 110-124.
-
(2002)
Journal of Clinical Oncology
, vol.20
, pp. 110-124
-
-
Albanell, J.1
Rojo, F.2
Averbuch, S.3
Feyereislova, A.4
Mascaro, J.M.5
Herbst, R.6
LoRusso, P.7
Rischin, D.8
Sauleda, S.9
Gee, J.10
Nicholson, R.I.11
Baselga, J.12
-
5
-
-
0029053716
-
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas
-
Alimandi M, Romano A, Curia MC, Muraro R, Fedi P, Aaronson SA, Di Fiore PP & Kraus MH 1995 Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. Oncogene 10 1813-1821.
-
(1995)
Oncogene
, vol.10
, pp. 1813-1821
-
-
Alimandi, M.1
Romano, A.2
Curia, M.C.3
Muraro, R.4
Fedi, P.5
Aaronson, S.A.6
Di Fiore, P.P.7
Kraus, M.H.8
-
6
-
-
0035892346
-
ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression
-
Anderson NG, Ahmad T, Chan K, Dobson R & Bundred NJ 2001 ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression. International Journal of Cancer 94 774-782.
-
(2001)
International Journal of Cancer
, vol.94
, pp. 774-782
-
-
Anderson, N.G.1
Ahmad, T.2
Chan, K.3
Dobson, R.4
Bundred, N.J.5
-
7
-
-
0001011182
-
ZD1839 (Iressa), a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2 overexpressing breast cancer cells
-
Anido J, Albanell J, Rojo F, Arribas J, Averbuch S & Baselga J 2002 ZD1839 (Iressa), a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2 overexpressing breast cancer cells. Proceedings of the American Association of Cancer Research 43 783.
-
(2002)
Proceedings of the American Association of Cancer Research
, vol.43
, pp. 783
-
-
Anido, J.1
Albanell, J.2
Rojo, F.3
Arribas, J.4
Averbuch, S.5
Baselga, J.6
-
9
-
-
0030801361
-
Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site
-
Arteaga CL, Ramsey TT, Shawver LK & Guyer CA 1997 Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site. Journal of Biological Chemistry 272 23247-23254.
-
(1997)
Journal of Biological Chemistry
, vol.272
, pp. 23247-23254
-
-
Arteaga, C.L.1
Ramsey, T.T.2
Shawver, L.K.3
Guyer, C.A.4
-
10
-
-
0013159054
-
Development and characterization of a rhuMAb HER2 antibody ADCC assay for clinical evaluation of cytotoxic potency
-
Baly DL, Wirth CM, Allison DA, Gilkerson E, Hotaling TE & Fox JA 1997 Development and characterization of a rhuMAb HER2 antibody ADCC assay for clinical evaluation of cytotoxic potency. Proceedings of the American Association of Cancer Research 38 27.
-
(1997)
Proceedings of the American Association of Cancer Research
, vol.38
, pp. 27
-
-
Baly, D.L.1
Wirth, C.M.2
Allison, D.A.3
Gilkerson, E.4
Hotaling, T.E.5
Fox, J.A.6
-
11
-
-
0035939330
-
Studies leading to the identification of ZD1839 (IRESSA): An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer
-
Barker AJ, Gibson KH, Grundy W, Godfrey AA, Barlow JJ, Healy MP, Woodburn JR, Aston SE, Curry BJ, Scarlett L, Henthom L & Richards L 2001 Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. Bioorganic and Medicinal Chemistry Letters 11 1911-1914.
-
(2001)
Bioorganic and Medicinal Chemistry Letters
, vol.11
, pp. 1911-1914
-
-
Barker, A.J.1
Gibson, K.H.2
Grundy, W.3
Godfrey, A.A.4
Barlow, J.J.5
Healy, M.P.6
Woodburn, J.R.7
Aston, S.E.8
Curry, B.J.9
Scarlett, L.10
Henthom, L.11
Richards, L.12
-
12
-
-
0027290650
-
Anti-tumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies
-
Baselga J, Norton L, Masui H, Pandiella A, Coplan K, Miller WH & Mendelsohn J 1993 Anti-tumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. Journal of the National Cancer Institute 85 1327-1333.
-
(1993)
Journal of the National Cancer Institute
, vol.85
, pp. 1327-1333
-
-
Baselga, J.1
Norton, L.2
Masui, H.3
Pandiella, A.4
Coplan, K.5
Miller, W.H.6
Mendelsohn, J.7
-
13
-
-
0029991439
-
Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer
-
Baselga J, Tripathy D, Mendelsohn J, Baughman S, Benz CC, Dantis L, Sklarin NT, Seidman AD, Hudis CA, Moore J, Rosen PP, Twaddell T, Henderson IC & Norton L 1996 Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. Journal of Clinical Oncology 14 737-744.
-
(1996)
Journal of Clinical Oncology
, vol.14
, pp. 737-744
-
-
Baselga, J.1
Tripathy, D.2
Mendelsohn, J.3
Baughman, S.4
Benz, C.C.5
Dantis, L.6
Sklarin, N.T.7
Seidman, A.D.8
Hudis, C.A.9
Moore, J.10
Rosen, P.P.11
Twaddell, T.12
Henderson, I.C.13
Norton, L.14
-
14
-
-
0032127350
-
Recombinant humanized anti-HER2 antibody (Herceptin) enhances the anti-tumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
-
Baselga J, Norton L, Albanell J, Kim YM & Mendelsohn J 1998 Recombinant humanized anti-HER2 antibody (Herceptin) enhances the anti-tumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Cancer Research 58 2825-2831.
-
(1998)
Cancer Research
, vol.58
, pp. 2825-2831
-
-
Baselga, J.1
Norton, L.2
Albanell, J.3
Kim, Y.M.4
Mendelsohn, J.5
-
15
-
-
0000240853
-
Continuous administration of ZD1839 (Iressa), a novel epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in patients with five selected tumor types: Evidence of activity and good tolerability
-
Baselga J, Herbst R, LoRusso P, Rischin D, Ranson M, Plummer R, Raymond E, Maddox AM, Kaye SB, Kieback DG, Harris A & Ochs J 2000a Continuous administration of ZD1839 (Iressa), a novel epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in patients with five selected tumor types: evidence of activity and good tolerability. Proceedings of the American Society for Clinical Oncology 19 177.
-
(2000)
Proceedings of the American Society for Clinical Oncology
, vol.19
, pp. 177
-
-
Baselga, J.1
Herbst, R.2
LoRusso, P.3
Rischin, D.4
Ranson, M.5
Plummer, R.6
Raymond, E.7
Maddox, A.M.8
Kaye, S.B.9
Kieback, D.G.10
Harris, A.11
Ochs, J.12
-
16
-
-
19244366949
-
Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
-
Baselga J, Pfister D, Cooper MR, Cohen R, Burtness B, Bos M, D'Andrea G, Seidman A, Norton L, Gunnett K, Falcey J, Anderson V, Waksal H & Mendelsohn J 2000b Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. Journal of Clinical Oncology 18 904-914.
-
(2000)
Journal of Clinical Oncology
, vol.18
, pp. 904-914
-
-
Baselga, J.1
Pfister, D.2
Cooper, M.R.3
Cohen, R.4
Burtness, B.5
Bos, M.6
D'Andrea, G.7
Seidman, A.8
Norton, L.9
Gunnett, K.10
Falcey, J.11
Anderson, V.12
Waksal, H.13
Mendelsohn, J.14
-
17
-
-
0029912203
-
All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired
-
Baulida J, Kraus MH, Alimandi M, Di Fiore PP & Carpenter G 1996 All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. Journal of Biological Chemistry 271 5251-5257.
-
(1996)
Journal of Biological Chemistry
, vol.271
, pp. 5251-5257
-
-
Baulida, J.1
Kraus, M.H.2
Alimandi, M.3
Di Fiore, P.P.4
Carpenter, G.5
-
18
-
-
0034782219
-
Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma
-
Bei R, Pompa G, Vitolo D, Moriconi E, Ciocci L, Quaranta M, Frati L, Kraus MH & Muraro R 2001 Co-localization of multiple ErbB receptors in stratified epithelium of oral squamous cell carcinoma. Journal of Pathology 195 343-348.
-
(2001)
Journal of Pathology
, vol.195
, pp. 343-348
-
-
Bei, R.1
Pompa, G.2
Vitolo, D.3
Moriconi, E.4
Ciocci, L.5
Quaranta, M.6
Frati, L.7
Kraus, M.H.8
Muraro, R.9
-
19
-
-
0033748391
-
Antitumor activity of combined treatment of human cancer cells with ionizing radiations and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide
-
Bianco C, Bianco R, Tortora G, Damiano V, Guerrieri P, Montemaggi P, Mendelsohn J, De Placido S, Bianco AR & Ciardiello F 2000 Antitumor activity of combined treatment of human cancer cells with ionizing radiations and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide. Clinical Cancer Research 6 4343-4350.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 4343-4350
-
-
Bianco, C.1
Bianco, R.2
Tortora, G.3
Damiano, V.4
Guerrieri, P.5
Montemaggi, P.6
Mendelsohn, J.7
De Placido, S.8
Bianco, A.R.9
Ciardiello, F.10
-
20
-
-
0003000030
-
Continued response following treatment with IMC-C225, an EGFR MoAb, combined with RT in advanced head and neck malignancies
-
Bonner JA, Ezekiel MP, Robert F, Meredith RF, Spencer SA & Waksal HW 2000 Continued response following treatment with IMC-C225, an EGFR MoAb, combined with RT in advanced head and neck malignancies. Proceedings of the American Society for Clinical Oncology 19 4.
-
(2000)
Proceedings of the American Society for Clinical Oncology
, vol.19
, pp. 4
-
-
Bonner, J.A.1
Ezekiel, M.P.2
Robert, F.3
Meredith, R.F.4
Spencer, S.A.5
Waksal, H.W.6
-
21
-
-
0035817742
-
Mammary glands reconstituted with Neu/ErbB-2 transformed HC-11 cells provide a novel orthotopic tumor model for testing anti-cancer agents
-
Brandt R, Wong AML & Hynes NE 2001 Mammary glands reconstituted with Neu/ErbB-2 transformed HC-11 cells provide a novel orthotopic tumor model for testing anti-cancer agents. Oncogene 20 5459-5465.
-
(2001)
Oncogene
, vol.20
, pp. 5459-5465
-
-
Brandt, R.1
Wong, A.M.L.2
Hynes, N.E.3
-
22
-
-
18844473781
-
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanism
-
Bruns CJ, Harbison MT, Davis DW, Portera CA, Tsan R, McConkey DJ, Abbruzzese J, Evans DB, Hicklin DJ & Radinsky R 2000a Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanism. Clinical Cancer Research 6 1936-1948.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 1936-1948
-
-
Bruns, C.J.1
Harbison, M.T.2
Davis, D.W.3
Portera, C.A.4
Tsan, R.5
McConkey, D.J.6
Abbruzzese, J.7
Evans, D.B.8
Hicklin, D.J.9
Radinsky, R.10
-
23
-
-
0034212763
-
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
-
Bruns CJ, Solorzano CC, Harbison MT, Ozawa S, Tsan R, Fan D, Abbruzzese J, Traxler P, Buchdunger E, Rdinsky R & Fidler IJ 2000b Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Research 60 2926-2935.
-
(2000)
Cancer Research
, vol.60
, pp. 2926-2935
-
-
Bruns, C.J.1
Solorzano, C.C.2
Harbison, M.T.3
Ozawa, S.4
Tsan, R.5
Fan, D.6
Abbruzzese, J.7
Traxler, P.8
Buchdunger, E.9
Rdinsky, R.10
Fidler, I.J.11
-
24
-
-
0035873822
-
Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer
-
Burstein HJ, Kuter I, Campos SM, Gelman RS, Tribou L, Parker LM, Manola J, Younger J, Matulonis U, Bunnell CA, Partridge AH, Richardson PG, Clarke K, Shulamn LN & Winer EP 2001 Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. Journal of Clinical Oncology 19 2722-2730.
-
(2001)
Journal of Clinical Oncology
, vol.19
, pp. 2722-2730
-
-
Burstein, H.J.1
Kuter, I.2
Campos, S.M.3
Gelman, R.S.4
Tribou, L.5
Parker, L.M.6
Manola, J.7
Younger, J.8
Matulonis, U.9
Bunnell, C.A.10
Partridge, A.H.11
Richardson, P.G.12
Clarke, K.13
Shulamn, L.N.14
Winer, E.P.15
-
26
-
-
0000827015
-
Blockage of the EGF-receptor by ZD1839 resulted in growth inhibition of human breast cancer cell lines with up-regulation of the activated EGFR and/or HER2
-
Campiglio M, Normanno N, Olgiati C, Locatelli A, Fumagalli M, Viganò L, Gianni L & Menard S 2002 Blockage of the EGF-receptor by ZD1839 resulted in growth inhibition of human breast cancer cell lines with up-regulation of the activated EGFR and/or HER2. Proceedings of the American Association of Cancer Research 43 603.
-
(2002)
Proceedings of the American Association of Cancer Research
, vol.43
, pp. 603
-
-
Campiglio, M.1
Normanno, N.2
Olgiati, C.3
Locatelli, A.4
Fumagalli, M.5
Viganò, L.6
Gianni, L.7
Menard, S.8
-
28
-
-
0026610881
-
HER2 antibody for human cancer therapy
-
HER2 antibody for human cancer therapy. PNAS 89 4285-4289.
-
(1992)
PNAS
, vol.89
, pp. 4285-4289
-
-
Carter, P.1
Presta, L.2
Gorman, C.M.3
Ridgway, J.B.B.4
Henner, D.5
Wong, W.-L.T.6
Rowland, A.M.7
Kotts, C.8
Carver, M.E.9
Shepard, H.M.10
-
29
-
-
0033994814
-
EGF-related antisense oligonucleotides inhibit the proliferation of human ovarian carcinoma cells
-
Casamassimi A, De Luca A, Agrawal S, Stromberg K, Salomon DS & Normanno N 2000 EGF-related antisense oligonucleotides inhibit the proliferation of human ovarian carcinoma cells. Annals of Oncology 11 319-325.
-
(2000)
Annals of Oncology
, vol.11
, pp. 319-325
-
-
Casamassimi, A.1
De Luca, A.2
Agrawal, S.3
Stromberg, K.4
Salomon, D.S.5
Normanno, N.6
-
31
-
-
0034782994
-
Expression profile of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder
-
Chow NH, Chan SH, Tzai TS, Ho CL & Liu HS 2001 Expression profile of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder. Clinical Cancer Research 7 1957-1962.
-
(2001)
Clinical Cancer Research
, vol.7
, pp. 1957-1962
-
-
Chow, N.H.1
Chan, S.H.2
Tzai, T.S.3
Ho, C.L.4
Liu, H.S.5
-
32
-
-
0025052403
-
Epidermal growth factor regultes the in vitro sensitivity of human ovarian carcinoma cells to cisplatin
-
Christen RD, Hom DK, MacLeod CL, Hafstrom L & Howell SB 1990 Epidermal growth factor regultes the in vitro sensitivity of human ovarian carcinoma cells to cisplatin. Journal of Clinical Investigation 86 1632-1640.
-
(1990)
Journal of Clinical Investigation
, vol.86
, pp. 1632-1640
-
-
Christen, R.D.1
Hom, D.K.2
MacLeod, C.L.3
Hafstrom, L.4
Howell, S.B.5
-
33
-
-
16144362509
-
Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A
-
Ciardiello F, Damiano V, Bianco R, Bianco C, Fontanini G, De Laurentiis M, De Placido S, Mendelsohn J, Bianco AR & Tortora G 1996 Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A. Journal of the National Cancer Institute 88 1770-1776.
-
(1996)
Journal of the National Cancer Institute
, vol.88
, pp. 1770-1776
-
-
Ciardiello, F.1
Damiano, V.2
Bianco, R.3
Bianco, C.4
Fontanini, G.5
De Laurentiis, M.6
De Placido, S.7
Mendelsohn, J.8
Bianco, A.R.9
Tortora, G.10
-
34
-
-
0032904485
-
Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225
-
Ciardiello F, Bianco R, Damiano V, De Lorenzo S, Pepe S, De Placido S, Fan Z, Mendelsohn J, Bianco AR & Tortora G 1999 Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. Clinical Cancer Research 5 909-916.
-
(1999)
Clinical Cancer Research
, vol.5
, pp. 909-916
-
-
Ciardiello, F.1
Bianco, R.2
Damiano, V.3
De Lorenzo, S.4
Pepe, S.5
De Placido, S.6
Fan, Z.7
Mendelsohn, J.8
Bianco, A.R.9
Tortora, G.10
-
35
-
-
0034068319
-
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
-
Ciardiello F, Caputo R, Bianco R, Damiano V, Pomatico G, De Placido S, Bianco AR & Tortora G 2000 Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clinical Cancer Research 6 2053-2063.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 2053-2063
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
Damiano, V.4
Pomatico, G.5
De Placido, S.6
Bianco, A.R.7
Tortora, G.8
-
36
-
-
0034896362
-
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
-
Ciardiello F, Caputo R, Bianco R, Damiano V, Fontanini G, Cuccato S, De Placido S, Bianco AR & Tortora G 2001 Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clinical Cancer Research 7 1459-1465.
-
(2001)
Clinical Cancer Research
, vol.7
, pp. 1459-1465
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
Damiano, V.4
Fontanini, G.5
Cuccato, S.6
De Placido, S.7
Bianco, A.R.8
Tortora, G.9
-
37
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
Cobleigh MA, Vogel CL, Tripathy D, Robert JN, Scholl S, Fehrenbacher L, Wolter JM, Paton V, Shak S, Lieberman G & Slamon DJ 1999 Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. Journal of Clinical Oncology 17 2639-2648.
-
(1999)
Journal of Clinical Oncology
, vol.17
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
Robert, J.N.4
Scholl, S.5
Fehrenbacher, L.6
Wolter, J.M.7
Paton, V.8
Shak, S.9
Lieberman, G.10
Slamon, D.J.11
-
38
-
-
0029804204
-
The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells
-
Cohen BD, Kiener PA, Green JM, Foy L, Fell HP & Zhang K 1996 The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells. Journal of Biological Chemistry 271 30897-30903.
-
(1996)
Journal of Biological Chemistry
, vol.271
, pp. 30897-30903
-
-
Cohen, B.D.1
Kiener, P.A.2
Green, J.M.3
Foy, L.4
Fell, H.P.5
Zhang, K.6
-
39
-
-
0001303067
-
Phase II study of ZD1839 (Iressa) in recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN)
-
Cohen EE, Rosen F, Dekker A, Bajda C, Stenson K, Shulman KL, Lamont E, Kozloff M & Vokes EE 2002 Phase II study of ZD1839 (Iressa) in recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Proceedings of the American Society for Clinical Oncology 21 225.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 225
-
-
Cohen, E.E.1
Rosen, F.2
Dekker, A.3
Bajda, C.4
Stenson, K.5
Shulman, K.L.6
Lamont, E.7
Kozloff, M.8
Vokes, E.E.9
-
40
-
-
0036099675
-
ErbB2 is essential in the prevention of dilated cardiomyopathy
-
Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J, Chien KR & Lee K-F 2002 ErbB2 is essential in the prevention of dilated cardiomyopathy. Nature Medicine 8 459-465.
-
(2002)
Nature Medicine
, vol.8
, pp. 459-465
-
-
Crone, S.A.1
Zhao, Y.Y.2
Fan, L.3
Gu, Y.4
Minamisawa, S.5
Liu, Y.6
Peterson, K.L.7
Chen, J.8
Kahn, R.9
Condorelli, G.10
Ross, J.11
Chien, K.R.12
Lee, K.-F.13
-
41
-
-
0032500675
-
Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2
-
Crovello CS, Lai C, Cantley LC & Carraway KL 1998 Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2. Journal of Biological Chemistry 273 26954-26961.
-
(1998)
Journal of Biological Chemistry
, vol.273
, pp. 26954-26961
-
-
Crovello, C.S.1
Lai, C.2
Cantley, L.C.3
Carraway, K.L.4
-
42
-
-
0036834993
-
Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas
-
D'Antonio A, Losito S, Pignata S, Grassi M, Perrone F, De Luca A, Tambaro R, Bianco C, Gullick WJ, Johnson GR, Iaffaioli VR, Salomon DS & Normanno N 2002 Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. International Journal of Oncology 21 941-948.
-
(2002)
International Journal of Oncology
, vol.21
, pp. 941-948
-
-
D'Antonio, A.1
Losito, S.2
Pignata, S.3
Grassi, M.4
Perrone, F.5
De Luca, A.6
Tambaro, R.7
Bianco, C.8
Gullick, W.J.9
Johnson, G.R.10
Iaffaioli, V.R.11
Salomon, D.S.12
Normanno, N.13
-
43
-
-
0030866189
-
Anti-sense oligonucleotides directed against EGF-related growth factors enhance anti-proliferative effect of conventional anti-tumor drugs in human colon-cancer cells
-
De Luca A, Selvam MP, Sandomenico C, Pepe S, Bianco AR, Ciardiello F, Salomon DS & Normanno N 1997 Anti-sense oligonucleotides directed against EGF-related growth factors enhance anti-proliferative effect of conventional anti-tumor drugs in human colon-cancer cells. International Journal of Cancer 73 277-282.
-
(1997)
International Journal of Cancer
, vol.73
, pp. 277-282
-
-
De Luca, A.1
Selvam, M.P.2
Sandomenico, C.3
Pepe, S.4
Bianco, A.R.5
Ciardiello, F.6
Salomon, D.S.7
Normanno, N.8
-
44
-
-
0033521850
-
EGF-related peptides are involved in the proliferation and survival of MDA-MB-468 human breast carcinoma cells
-
De Luca A, Casamassimi A, Selvam MP, Losito S, Ciardiello F, Agrawal S, Salomon DS & Normanno N 1999 EGF-related peptides are involved in the proliferation and survival of MDA-MB-468 human breast carcinoma cells. International Journal of Cancer 80 589-594.
-
(1999)
International Journal of Cancer
, vol.80
, pp. 589-594
-
-
De Luca, A.1
Casamassimi, A.2
Selvam, M.P.3
Losito, S.4
Ciardiello, F.5
Agrawal, S.6
Salomon, D.S.7
Normanno, N.8
-
45
-
-
0034735754
-
Simultaneous blockade of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts
-
De Luca A, Arra C, D'Antonio A, Casamassimi A, Losito S, Ferraro P, Ciardiello F, Salomon DS & Normanno N 2000 Simultaneous blockade of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts. Oncogene 19 5863-5871.
-
(2000)
Oncogene
, vol.19
, pp. 5863-5871
-
-
De Luca, A.1
Arra, C.2
D'Antonio, A.3
Casamassimi, A.4
Losito, S.5
Ferraro, P.6
Ciardiello, F.7
Salomon, D.S.8
Normanno, N.9
-
46
-
-
0026520472
-
The physiology of transforming growth factor-alpha
-
Derynck R 1992 The physiology of transforming growth factor-alpha. Cancer Research 58 27-52.
-
(1992)
Cancer Research
, vol.58
, pp. 27-52
-
-
Derynck, R.1
-
47
-
-
0027494496
-
Increased epidermal growth factor receptor in an estrogen-responsive, adriamycin-resistant MCF-7 cell line
-
Dickstein B, Valverius EM, Wosikowski K, Saceda M, Pearson JW, Martin MB & Bates SE 1993 Increased epidermal growth factor receptor in an estrogen-responsive, adriamycin-resistant MCF-7 cell line. Journal of Cellular Physiology 157 110-118.
-
(1993)
Journal of Cellular Physiology
, vol.157
, pp. 110-118
-
-
Dickstein, B.1
Valverius, E.M.2
Wosikowski, K.3
Saceda, M.4
Pearson, J.W.5
Martin, M.B.6
Bates, S.E.7
-
48
-
-
0028999833
-
Increased resistance to cytotoxic agents in ZR75B human breast cancer cells transfected with epidermal growth factor receptor
-
Dickstein BM, Wosikowski K & Bates SE 1995 Increased resistance to cytotoxic agents in ZR75B human breast cancer cells transfected with epidermal growth factor receptor. Molecular and Cellular Endocrinology 110 205-211.
-
(1995)
Molecular and Cellular Endocrinology
, vol.110
, pp. 205-211
-
-
Dickstein, B.M.1
Wosikowski, K.2
Bates, S.E.3
-
49
-
-
0031041268
-
Abrogation of cisplatin-induced programmed cell death in human breast cancer cells by epidermal growth factor antisense RNA
-
Dixit M, Yang J-L, Poirier MC, Price JO, Andrews PA & Arteaga CL 1997 Abrogation of cisplatin-induced programmed cell death in human breast cancer cells by epidermal growth factor antisense RNA. Journal of the National Cancer Institute 89 365-373.
-
(1997)
Journal of the National Cancer Institute
, vol.89
, pp. 365-373
-
-
Dixit, M.1
Yang, J.-L.2
Poirier, M.C.3
Price, J.O.4
Andrews, P.A.5
Arteaga, C.L.6
-
50
-
-
0033985682
-
EGF receptor and p21WAF1 expression are reciprocally altered as ME-180 cervical carcinoma cells progress from high to low cisplatin sensitivity
-
Donato NJ, Perez M, Kang H, Siddik ZH, Ling YH & Perez-Soler R 2000 EGF receptor and p21WAF1 expression are reciprocally altered as ME-180 cervical carcinoma cells progress from high to low cisplatin sensitivity. Clinical Cancer Research 6 193-202.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 193-202
-
-
Donato, N.J.1
Perez, M.2
Kang, H.3
Siddik, Z.H.4
Ling, Y.H.5
Perez-Soler, R.6
-
51
-
-
0001303066
-
Phase II trial of ZD1839 (Iressa), an EGF receptor inhibitor, in patients with advanced renal cell carcinoma
-
Drucker BJ, Schwartz L, Marion S & Motzer R 2002 Phase II trial of ZD1839 (Iressa), an EGF receptor inhibitor, in patients with advanced renal cell carcinoma. Proceedings of the American Society for Clinical Oncology 21 181.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 181
-
-
Drucker, B.J.1
Schwartz, L.2
Marion, S.3
Motzer, R.4
-
52
-
-
0030953468
-
Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation
-
Elenius K, Paul S, Allison G, Sun J & Klagsbrun M 1997 Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. EMBO Journal 16 1268-1278.
-
(1997)
EMBO Journal
, vol.16
, pp. 1268-1278
-
-
Elenius, K.1
Paul, S.2
Allison, G.3
Sun, J.4
Klagsbrun, M.5
-
53
-
-
0033594546
-
Characterisation of a naturally occurring ErbB-4 isoform that does not bind or activate phosphatidyl inositol 3-kinase
-
Elenius K, Choi CJ, Paul S, Nishi E & Klagsbrun M 1999 Characterisation of a naturally occurring ErbB-4 isoform that does not bind or activate phosphatidyl inositol 3-kinase. Oncogene 18 2607-2615.
-
(1999)
Oncogene
, vol.18
, pp. 2607-2615
-
-
Elenius, K.1
Choi, C.J.2
Paul, S.3
Nishi, E.4
Klagsbrun, M.5
-
54
-
-
0036534121
-
Phase II studies of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
-
Esteva FJ, Valero V, Booser D, Guerra LT, Murray JL, Pustzai L, Cristofanili M, Arun B, Esmaeli B, Fritsche HA, Sneige N, Smith TL & Hortobagyi GN 2002 Phase II studies of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer. Journal of Clinical Oncology 20 1800-1808.
-
(2002)
Journal of Clinical Oncology
, vol.20
, pp. 1800-1808
-
-
Esteva, F.J.1
Valero, V.2
Booser, D.3
Guerra, L.T.4
Murray, J.L.5
Pustzai, L.6
Cristofanili, M.7
Arun, B.8
Esmaeli, B.9
Fritsche, H.A.10
Sneige, N.11
Smith, T.L.12
Hortobagyi, G.N.13
-
55
-
-
0027428571
-
Anti-tumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminodichloroplatinum on well estabilished A431 cell xenografts
-
Fan Z, Baselga J, Masui H & Mendelsohn J 1993 Anti-tumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminodichloroplatinum on well estabilished A431 cell xenografts. Cancer Research 53 4637-4642.
-
(1993)
Cancer Research
, vol.53
, pp. 4637-4642
-
-
Fan, Z.1
Baselga, J.2
Masui, H.3
Mendelsohn, J.4
-
56
-
-
0028116305
-
Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells
-
Fan Z, Lu Y, Wu X & Mendelsohn J 1994 Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. Journal of Biological Chemistry 269 27595-27602.
-
(1994)
Journal of Biological Chemistry
, vol.269
, pp. 27595-27602
-
-
Fan, Z.1
Lu, Y.2
Wu, X.3
Mendelsohn, J.4
-
57
-
-
0030693984
-
Reciprocal changes in p27(Kip1) and p21(Cip1) in growth inhibition mediated by blockade or overstimulation of epidermal growth factor receptors
-
Fan Z, Shang BY, Lu Y, Chou JL & Mendelsohn J 1997 Reciprocal changes in p27(Kip1) and p21(Cip1) in growth inhibition mediated by blockade or overstimulation of epidermal growth factor receptors. Clinical Cancer Research 3 1943-1948.
-
(1997)
Clinical Cancer Research
, vol.3
, pp. 1943-1948
-
-
Fan, Z.1
Shang, B.Y.2
Lu, Y.3
Chou, J.L.4
Mendelsohn, J.5
-
58
-
-
0002200965
-
Intermittent oral ZD1839 (Iressa), a novel epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), shows evidence of good tolerability and activity: Final results from a phase I study
-
Ferry D, Hammond L, Ranson M, Kris MG, Miller V, Murray P, Tullo A, Feyereislova A, Averbuch S & Rowinsky E 2000 Intermittent oral ZD1839 (Iressa), a novel epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), shows evidence of good tolerability and activity: final results from a phase I study. Proceedings of the American Society for Clinical Oncology 19 3.
-
(2000)
Proceedings of the American Society for Clinical Oncology
, vol.19
, pp. 3
-
-
Ferry, D.1
Hammond, L.2
Ranson, M.3
Kris, M.G.4
Miller, V.5
Murray, P.6
Tullo, A.7
Feyereislova, A.8
Averbuch, S.9
Rowinsky, E.10
-
59
-
-
0001069404
-
Phase II evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced ovarian carcinoma
-
Finkler N, Gordon A, Crozier M, Edwards R, Figueroa J, Garcia A, Hainsworth J, Irwin D, Silberman S, Allen L, Ferrante K, Fisher D & Nadler P 2001 Phase II evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advanced ovarian carcinoma. Proceedings of the American Society for Clinical Oncology 20 208.
-
(2001)
Proceedings of the American Society for Clinical Oncology
, vol.20
, pp. 208
-
-
Finkler, N.1
Gordon, A.2
Crozier, M.3
Edwards, R.4
Figueroa, J.5
Garcia, A.6
Hainsworth, J.7
Irwin, D.8
Silberman, S.9
Allen, L.10
Ferrante, K.11
Fisher, D.12
Nadler, P.13
-
60
-
-
0031907022
-
Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non small-cell lung cancer: Amphiregulin and microvessel count are independent prognostic indicators of survival
-
Fontanini G, De Laurentiis M, Vignati S, Chinè S, Lucchi M, Silvestri V, Mussi A, De Placido S, Tortora G, Bianco AR, Gullick W, Angeletti CA, Bevilacqua G & Ciardiello F 1998 Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. Clinical Cancer Research 4 241-249.
-
(1998)
Clinical Cancer Research
, vol.4
, pp. 241-249
-
-
Fontanini, G.1
De Laurentiis, M.2
Vignati, S.3
Chinè, S.4
Lucchi, M.5
Silvestri, V.6
Mussi, A.7
De Placido, S.8
Tortora, G.9
Bianco, A.R.10
Gullick, W.11
Angeletti, C.A.12
Bevilacqua, G.13
Ciardiello, F.14
-
61
-
-
0028799821
-
Enhanced erbB-3 expression in human pancreatic cancer correlates with tumor progression
-
Friess H, Yamanaka Y, Kobrin MS, Do DA, Buchler MW & Korc M 1995 Enhanced erbB-3 expression in human pancreatic cancer correlates with tumor progression. Clinical Cancer Research 1 1413-1420.
-
(1995)
Clinical Cancer Research
, vol.1
, pp. 1413-1420
-
-
Friess, H.1
Yamanaka, Y.2
Kobrin, M.S.3
Do, D.A.4
Buchler, M.W.5
Korc, M.6
-
62
-
-
0032848367
-
Concomitant analysis of the epidermal growth factor receptor family in esophageal cancer: Overexpression of epidermal growth factor receptor mRNA but not for c-erbB-2 and c-erbB-3
-
Friess H, Fukuda A, Tang WH, Eichenberger A, Furlan N, Zimmermann A, Korc M & Buchler MW 1999 Concomitant analysis of the epidermal growth factor receptor family in esophageal cancer: overexpression of epidermal growth factor receptor mRNA but not for c-erbB-2 and c-erbB-3. World Journal of Surgery 23 1010-1018.
-
(1999)
World Journal of Surgery
, vol.23
, pp. 1010-1018
-
-
Friess, H.1
Fukuda, A.2
Tang, W.H.3
Eichenberger, A.4
Furlan, N.5
Zimmermann, A.6
Korc, M.7
Buchler, M.W.8
-
63
-
-
0034043977
-
Site-directed irreversible inhibitors of the erbB family of receptor tyrosine kinases as novel chemotherapeutic agents for cancer
-
Fry DW 2000 Site-directed irreversible inhibitors of the erbB family of receptor tyrosine kinases as novel chemotherapeutic agents for cancer. Anti-Cancer Drug Design 15 3-16.
-
(2000)
Anti-Cancer Drug Design
, vol.15
, pp. 3-16
-
-
Fry, D.W.1
-
64
-
-
0003336304
-
Final results from a phase II trial of ZD1839 ('Iressa') for patients with advanced non-small-cell lung cancer (IDEAL 1)
-
Fukuoka M, Yano S, Giaccone G, Tamura T, Nakagawa K, Douillard JY, Nishiwaki Y, Vansteenkiste JF, Kudo S, Averbuch S, Macleod A, Feyereislova A & Baselga J 2002 Final results from a phase II trial of ZD1839 ('Iressa') for patients with advanced non-small-cell lung cancer (IDEAL 1). Proceedings of the American Society for Clinical Oncology 21 298.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 298
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.Y.6
Nishiwaki, Y.7
Vansteenkiste, J.F.8
Kudo, S.9
Averbuch, S.10
Macleod, A.11
Feyereislova, A.12
Baselga, J.13
-
65
-
-
0027976892
-
c-erbB-3 and c-erbB-2 protein expression in node-negative breast carcinoma - An immunocytochemical study
-
Gasparini G, Gullick WJ, Maluta S, Dalla Palma P, Caffo O, Leonardi E, Boracchi P, Pozza F, Lemoine NR & Bevilacqua P 1994 c-erbB-3 and c-erbB-2 protein expression in node-negative breast carcinoma - an immunocytochemical study. European Journal of Cancer 30A 16-22.
-
(1994)
European Journal of Cancer
, vol.30 A
, pp. 16-22
-
-
Gasparini, G.1
Gullick, W.J.2
Maluta, S.3
Dalla Palma, P.4
Caffo, O.5
Leonardi, E.6
Boracchi, P.7
Pozza, F.8
Lemoine, N.R.9
Bevilacqua, P.10
-
66
-
-
0030741967
-
Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma
-
Gilbertson RJ, Perry RH, Kelly PJ, Pearson AD & Lunec J 1997 Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma. Cancer Research 57 3272-3280.
-
(1997)
Cancer Research
, vol.57
, pp. 3272-3280
-
-
Gilbertson, R.J.1
Perry, R.H.2
Kelly, P.J.3
Pearson, A.D.4
Lunec, J.5
-
67
-
-
0021254542
-
Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity
-
Gill GN, Kawamoto T, Cochet C, Le A, Sato JD, Masui H, MacLeod C & Mendelsohn J 1984 Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. Journal of Biological Chemistry 259 7755-7760.
-
(1984)
Journal of Biological Chemistry
, vol.259
, pp. 7755-7760
-
-
Gill, G.N.1
Kawamoto, T.2
Cochet, C.3
Le, A.4
Sato, J.D.5
Masui, H.6
MacLeod, C.7
Mendelsohn, J.8
-
68
-
-
0035266135
-
Expression of erbB-4/HER-4 growth factor receptor isoforms in ovarian cancer
-
Gilmour LM, Macleod KG, McCaig A, Gullick WJ, Smyth JF & Langdon SP 2001 Expression of erbB-4/HER-4 growth factor receptor isoforms in ovarian cancer. Cancer Research 61 2169-2176.
-
(2001)
Cancer Research
, vol.61
, pp. 2169-2176
-
-
Gilmour, L.M.1
Macleod, K.G.2
McCaig, A.3
Gullick, W.J.4
Smyth, J.F.5
Langdon, S.P.6
-
69
-
-
0028819660
-
Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
-
Goldstein NI, Prewett M, Zuklys K, Rockwell P & Mendelsohn J 1995 Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clinical Cancer Research 1 1311-1318.
-
(1995)
Clinical Cancer Research
, vol.1
, pp. 1311-1318
-
-
Goldstein, N.I.1
Prewett, M.2
Zuklys, K.3
Rockwell, P.4
Mendelsohn, J.5
-
70
-
-
0000363735
-
ZD1839 ('Iressa') in combination with gemcitabine and cisplatin in chemonaive patients with advanced solid tumors: Final results of a phase I trial
-
Gonzalez-Larriba JL, Giaccone G, van Osterom AT, Alfonso R, Smit EF, Martens M, Peters GJ, van der Vijgh WJF, Smith R, Fandi A & Averbuch S 2002 ZD1839 ('Iressa') in combination with gemcitabine and cisplatin in chemonaive patients with advanced solid tumors: final results of a phase I trial. Proceedings of the American Society for Clinical Oncology 21 95.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 95
-
-
Gonzalez-Larriba, J.L.1
Giaccone, G.2
Van Osterom, A.T.3
Alfonso, R.4
Smit, E.F.5
Martens, M.6
Peters, G.J.7
Van der Vijgh, W.J.F.8
Smith, R.9
Fandi, A.10
Averbuch, S.11
-
71
-
-
0000834718
-
NCIC CTG IND. 122: A two part phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) ZD1839
-
Goss G, Hirte H, Batist G, Stewart D, Miller W, Lorimer I, Abugaber A, Matthews S & Seymour L 2000 NCIC CTG IND. 122: a two part phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) ZD1839. Proceedings of the American Society for Clinical Oncology 19 225.
-
(2000)
Proceedings of the American Society for Clinical Oncology
, vol.19
, pp. 225
-
-
Goss, G.1
Hirte, H.2
Batist, G.3
Stewart, D.4
Miller, W.5
Lorimer, I.6
Abugaber, A.7
Matthews, S.8
Seymour, L.9
-
72
-
-
0032942803
-
ErbB-4 mRNA expression is decreased in non-metastatic pancreatic cancer
-
Graber HU, Friess H, Kaufmann B, Willi D, Zimmermann A, Korc M & Buchler MW 1999 ErbB-4 mRNA expression is decreased in non-metastatic pancreatic cancer. International Journal of Cancer 84 24-27.
-
(1999)
International Journal of Cancer
, vol.84
, pp. 24-27
-
-
Graber, H.U.1
Friess, H.2
Kaufmann, B.3
Willi, D.4
Zimmermann, A.5
Korc, M.6
Buchler, M.W.7
-
73
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all erbB receptors, is a mediator of lateral signaling
-
Graus-Porta D, Beerli RR, Daly JM & Hynes NE 1997 ErbB-2, the preferred heterodimerization partner of all erbB receptors, is a mediator of lateral signaling. EMBO Journal 16 1647-1655.
-
(1997)
EMBO Journal
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
Daly, J.M.3
Hynes, N.E.4
-
74
-
-
0034959016
-
The Type 1 growth factor receptors and their ligands considered as a complex system
-
Gullick WJ 2001 The Type 1 growth factor receptors and their ligands considered as a complex system. Endocrine-Related Cancer 8 75-82.
-
(2001)
Endocrine-Related Cancer
, vol.8
, pp. 75-82
-
-
Gullick, W.J.1
-
75
-
-
0028168569
-
Insect cell-expressed p180erbB-3 possesses an impaired tyrosine kinase activity
-
Guy PM, Platkp JV, Cantley LC, Cerione RA & Carraway KL 1994 Insect cell-expressed p180erbB-3 possesses an impaired tyrosine kinase activity. PNAS 91 8132-8136.
-
(1994)
PNAS
, vol.91
, pp. 8132-8136
-
-
Guy, P.M.1
Platkp, J.V.2
Cantley, L.C.3
Cerione, R.A.4
Carraway, K.L.5
-
76
-
-
0033614356
-
Neuregulin-4: A novel growth factor that acts through the ErbB-4 receptor tyrosine kinase
-
Harari D, Tzahar E, Romano J, Shelly M, Pierce JH, Andrews GC & Yarden Y 1999 Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. Oncogene 18 2681-2689.
-
(1999)
Oncogene
, vol.18
, pp. 2681-2689
-
-
Harari, D.1
Tzahar, E.2
Romano, J.3
Shelly, M.4
Pierce, J.H.5
Andrews, G.C.6
Yarden, Y.7
-
77
-
-
0030060259
-
Relationship between c-erbB-2 oncoprotein, epidermal growth factor receptor, and estrogen receptor expression in patients with ductal breast carcinoma. Association with tumor phenotypes
-
Harlozinska A, Bar JK, Wenderski R & Bebenek M 1996 Relationship between c-erbB-2 oncoprotein, epidermal growth factor receptor, and estrogen receptor expression in patients with ductal breast carcinoma. Association with tumor phenotypes. In Vivo 10 217-222.
-
(1996)
In Vivo
, vol.10
, pp. 217-222
-
-
Harlozinska, A.1
Bar, J.K.2
Wenderski, R.3
Bebenek, M.4
-
78
-
-
0024822342
-
Epidermal growth factor receptors in breast cancer: Association with early relapse and death, poor response to hormones and interactions with neu
-
Harris AL, Nicholson S, Sainsbury JRC, Famdon J & Wright C 1989 Epidermal growth factor receptors in breast cancer: association with early relapse and death, poor response to hormones and interactions with neu. Journal of Steroid Biochemistry 34 123-131.
-
(1989)
Journal of Steroid Biochemistry
, vol.34
, pp. 123-131
-
-
Harris, A.L.1
Nicholson, S.2
Sainsbury, J.R.C.3
Famdon, J.4
Wright, C.5
-
79
-
-
0035398631
-
Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
-
Hidalgo M, Siu LL, Nemunaitis J, Rizzo J, Hammond LA, Takimoto C, Eckhardt SG, Tolcher A, Britten CD, Denis L, Ferrante K, Von Hoff DD, Silberman S & Rowinski EK 2001 Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. Journal of Clinical Oncology 19 3267-3279.
-
(2001)
Journal of Clinical Oncology
, vol.19
, pp. 3267-3279
-
-
Hidalgo, M.1
Siu, L.L.2
Nemunaitis, J.3
Rizzo, J.4
Hammond, L.A.5
Takimoto, C.6
Eckhardt, S.G.7
Tolcher, A.8
Britten, C.D.9
Denis, L.10
Ferrante, K.11
Von Hoff, D.D.12
Silberman, S.13
Rowinski, E.K.14
-
80
-
-
0003282151
-
Phase I trial of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor (EGFR), in patients with advanced solid tumors
-
Hidalgo M, Erlichman C, Rowinski EK, Koepp-Norris J, Jensen K, Boni J, Korth-Bradley J, Quinn S & Zacharchuk C 2002 Phase I trial of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor (EGFR), in patients with advanced solid tumors. Proceedings of the American Society for Clinical Oncology 21 17.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 17
-
-
Hidalgo, M.1
Erlichman, C.2
Rowinski, E.K.3
Koepp-Norris, J.4
Jensen, K.5
Boni, J.6
Korth-Bradley, J.7
Quinn, S.8
Zacharchuk, C.9
-
81
-
-
0036570203
-
ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
-
Hirata A, Ogawa S, Kometani T, Kuwano T, Naito S, Kuwano M & Ono M 2002 ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Research 62 2554-2560.
-
(2002)
Cancer Research
, vol.62
, pp. 2554-2560
-
-
Hirata, A.1
Ogawa, S.2
Kometani, T.3
Kuwano, T.4
Naito, S.5
Kuwano, M.6
Ono, M.7
-
82
-
-
0000229081
-
Efficacy and safety of the anti-epidermal growth factor receptor antibody (EGFR) IMC-C225 in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin containing chemotherapy
-
Hong WK, Arquette M, Nabell L, Needle M, Waksal HW & Herbst RS 2001 Efficacy and safety of the anti-epidermal growth factor receptor antibody (EGFR) IMC-C225 in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin containing chemotherapy. Proceedings of the American Society for Clinical Oncology 20 224.
-
(2001)
Proceedings of the American Society for Clinical Oncology
, vol.20
, pp. 224
-
-
Hong, W.K.1
Arquette, M.2
Nabell, L.3
Needle, M.4
Waksal, H.W.5
Herbst, R.S.6
-
83
-
-
0034084314
-
Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
-
Huang SM & Harari PM 2000 Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clinical Cancer Research 6 2166-2174.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 2166-2174
-
-
Huang, S.M.1
Harari, P.M.2
-
84
-
-
0033561522
-
Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinoma of the head and neck
-
Huang SM, Bock JM & Harari PM 1999 Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinoma of the head and neck. Cancer Research 59 1935-1940.
-
(1999)
Cancer Research
, vol.59
, pp. 1935-1940
-
-
Huang, S.M.1
Bock, J.M.2
Harari, P.M.3
-
85
-
-
0024478054
-
p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor
-
Hudziak RM, Lewis GD, Winget M, Fendly BM, Shepard HM & Ullrich A 1989 p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. Molecular and Cellular Biology 9 1165-1172.
-
(1989)
Molecular and Cellular Biology
, vol.9
, pp. 1165-1172
-
-
Hudziak, R.M.1
Lewis, G.D.2
Winget, M.3
Fendly, B.M.4
Shepard, H.M.5
Ullrich, A.6
-
86
-
-
0034489116
-
Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma
-
Inoue K, Slaton JW, Perrotte P, Davis DW, Bruns CJ, Hicklin DJ, McConkey DJ, Sweeney P, Radinsky R & Dinney CP 2000 Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma. Clinical Cancer Research 6 4874-4884.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 4874-4884
-
-
Inoue, K.1
Slaton, J.W.2
Perrotte, P.3
Davis, D.W.4
Bruns, C.J.5
Hicklin, D.J.6
McConkey, D.J.7
Sweeney, P.8
Radinsky, R.9
Dinney, C.P.10
-
87
-
-
0035906821
-
Expression and clinical significance of erbB receptor family in hepatocellular carcinoma
-
Ito Y, Takeda T, Sakon M, Tsujimoto M, Higashiyama S, Noda K, Miyoshi E, Monden M & Matsuura N 2001 Expression and clinical significance of erbB receptor family in hepatocellular carcinoma. British Journal of Cancer 84 1377-1383.
-
(2001)
British Journal of Cancer
, vol.84
, pp. 1377-1383
-
-
Ito, Y.1
Takeda, T.2
Sakon, M.3
Tsujimoto, M.4
Higashiyama, S.5
Noda, K.6
Miyoshi, E.7
Monden, M.8
Matsuura, N.9
-
88
-
-
0013113593
-
Zd1839 ('Iressa') shows antitumor activity in patients with recurrent non-small-cell lung cancer treated on a compassionate use protocol
-
Jarine PA, Ostler PA, Lucca J, Fidias P, Skarin AT, Lynch TJ & Johnson BE 2002 Zd1839 ('Iressa') shows antitumor activity in patients with recurrent non-small-cell lung cancer treated on a compassionate use protocol. Proceedings of the American Society for Clinical Oncology 21 319.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 319
-
-
Jarine, P.A.1
Ostler, P.A.2
Lucca, J.3
Fidias, P.4
Skarin, A.T.5
Lynch, T.J.6
Johnson, B.E.7
-
89
-
-
0010233988
-
Growth stimulation of A431 cells by EGF: Identification of high affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody
-
Kawamoto T, Sato JD, Le A, Polikoff J, Sato GH & Mendelsohn J 1983 Growth stimulation of A431 cells by EGF: identification of high affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. PNAS 80 1337-1341.
-
(1983)
PNAS
, vol.80
, pp. 1337-1341
-
-
Kawamoto, T.1
Sato, J.D.2
Le, A.3
Polikoff, J.4
Sato, G.H.5
Mendelsohn, J.6
-
90
-
-
0034693635
-
K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21 (WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma
-
Kawesha A, Ghaneh P, Andren-Sandberg A, Ograed D, Skar R, Dawiskiba S, Evans JD, Campbell F, Lemoine N & Neoptolemos JP 2000 K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21 (WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma. International Journal of Cancer 89 469-474.
-
(2000)
International Journal of Cancer
, vol.89
, pp. 469-474
-
-
Kawesha, A.1
Ghaneh, P.2
Andren-Sandberg, A.3
Ograed, D.4
Skar, R.5
Dawiskiba, S.6
Evans, J.D.7
Campbell, F.8
Lemoine, N.9
Neoptolemos, J.P.10
-
91
-
-
0030959114
-
A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors
-
Klapper LN, Vaisman N, Hurwitz E, Pinkas-Kramarski R, Yarden Y & Sela M 1997 A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors. Oncogene 14 2099-2109.
-
(1997)
Oncogene
, vol.14
, pp. 2099-2109
-
-
Klapper, L.N.1
Vaisman, N.2
Hurwitz, E.3
Pinkas-Kramarski, R.4
Yarden, Y.5
Sela, M.6
-
93
-
-
0001303063
-
A phase II trial of ZD1839 ('Iressa') in advanced non-small-cell lung cancer (NSCLC) patients who had failed platinum and docetaxel based regimens (IDEAL 2)
-
Kris MG, Natale RB, Herbst RS, Lynch TJJ, Prager D, Belani CP, Schiller JH, Kelly K, Spiridonidis C, Albain KS, Brahmenr JR, Sandler A, Crawford J, Lutzker SG, Lilenbaum R, Helms L, Wolf M, Averbuch S, Ochs J & Kay A 2002 A phase II trial of ZD1839 ('Iressa') in advanced non-small-cell lung cancer (NSCLC) patients who had failed platinum and docetaxel based regimens (IDEAL 2). Proceedings of the American Society for Clinical Oncology 21 292.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 292
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch, T.J.J.4
Prager, D.5
Belani, C.P.6
Schiller, J.H.7
Kelly, K.8
Spiridonidis, C.9
Albain, K.S.10
Brahmenr, J.R.11
Sandler, A.12
Crawford, J.13
Lutzker, S.G.14
Lilenbaum, R.15
Helms, L.16
Wolf, M.17
Averbuch, S.18
Ochs, J.19
Kay, A.20
more..
-
94
-
-
0029101188
-
Enhancement of drug sensitivity of human malignancies by epidermal growth factor
-
Kroning R, Jones JA, Hom DK, Chuang CC, Sanga R, Los G, Howell SB & Christen RD 1995 Enhancement of drug sensitivity of human malignancies by epidermal growth factor. British Journal of Cancer 72 615-620.
-
(1995)
British Journal of Cancer
, vol.72
, pp. 615-620
-
-
Kroning, R.1
Jones, J.A.2
Hom, D.K.3
Chuang, C.C.4
Sanga, R.5
Los, G.6
Howell, S.B.7
Christen, R.D.8
-
95
-
-
0025968042
-
Regulation of phosphorylation of the c-erbB-2/HER2 gene product by a monoclonal antibody and serum growth factor(s) in human mammary carcinoma cells
-
Kumar R, Shepard HM & Mendelsohn J 1991 Regulation of phosphorylation of the c-erbB-2/HER2 gene product by a monoclonal antibody and serum growth factor(s) in human mammary carcinoma cells. Molecular and Cellular Biology 11 979-986.
-
(1991)
Molecular and Cellular Biology
, vol.11
, pp. 979-986
-
-
Kumar, R.1
Shepard, H.M.2
Mendelsohn, J.3
-
98
-
-
0002618270
-
Pilot trial of ZD1839 ('Iressa'), an oral inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, in combination with carboplatin and paclitaxel in previously untreated advanced non-small-cell lung cancer (NSCLC)
-
Laurie SA, Miller VA, Johnson D, Ng KK, Heelan RT, Pizzo BA, Perez WJ, Kris MG, Ochs J & Averbuch S 2000 Pilot trial of ZD1839 ('Iressa'), an oral inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, in combination with carboplatin and paclitaxel in previously untreated advanced non-small-cell lung cancer (NSCLC). Lung Cancer 29 (Suppl 1) 71.
-
(2000)
Lung Cancer
, vol.29
, Issue.SUPPL. 1
, pp. 71
-
-
Laurie, S.A.1
Miller, V.A.2
Johnson, D.3
Ng, K.K.4
Heelan, R.T.5
Pizzo, B.A.6
Perez, W.J.7
Kris, M.G.8
Ochs, J.9
Averbuch, S.10
-
99
-
-
0027076771
-
Expression of the ERBB3 product in breast cancer
-
Lemoine NR, Barnes DM, Hollywood DP, Hughes CM, Smith P, Dublin E, Prigent SA, Gullick WJ & Hurst HC 1992 Expression of the ERBB3 product in breast cancer. British Journal of Cancer 66 1116-1121.
-
(1992)
British Journal of Cancer
, vol.66
, pp. 1116-1121
-
-
Lemoine, N.R.1
Barnes, D.M.2
Hollywood, D.P.3
Hughes, C.M.4
Smith, P.5
Dublin, E.6
Prigent, S.A.7
Gullick, W.J.8
Hurst, H.C.9
-
100
-
-
0032526729
-
Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers
-
Lenferink AEG, Pinkas-Kramarski R, Van de Poll ML, van Vugt MJH, Klapper LN, Tzahar E, Waterman H, Sela M, Van Zoelen EJ & Yarden Y 1998 Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO Journal 17 3385-3397.
-
(1998)
EMBO Journal
, vol.17
, pp. 3385-3397
-
-
Lenferink, A.E.G.1
Pinkas-Kramarski, R.2
Van de Poll, M.L.3
Van Vugt, M.J.H.4
Klapper, L.N.5
Tzahar, E.6
Waterman, H.7
Sela, M.8
Van Zoelen, E.J.9
Yarden, Y.10
-
102
-
-
0013154078
-
Expanded access single institution clinical program experience with ZD1839 (Iressa) for patients with advanced non-small-cell lung cancer (NSCLC)
-
Liem AK, Cheng H, Quan E, Ucar K, Al-Jazayrly G, Barton C, Cloo L & Tchekmedyian S 2002 Expanded access single institution clinical program experience with ZD1839 (Iressa) for patients with advanced non-small-cell lung cancer (NSCLC). Proceedings of the American Society for Clinical Oncology 21 222b.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
-
-
Liem, A.K.1
Cheng, H.2
Quan, E.3
Ucar, K.4
Al-Jazayrly, G.5
Barton, C.6
Cloo, L.7
Tchekmedyian, S.8
-
103
-
-
0037017877
-
Sequence-dependent effects of ZD1839 ('Iressa') in combination with cytotoxic treatment in human head and neck cancer
-
Magne N, Fischel JL, Dubreuil A, Formento P, Marcie S, Lagrange JL & Milano G 2002a Sequence-dependent effects of ZD1839 ('Iressa') in combination with cytotoxic treatment in human head and neck cancer. British Journal of Cancer 86 819-827.
-
(2002)
British Journal of Cancer
, vol.86
, pp. 819-827
-
-
Magne, N.1
Fischel, J.L.2
Dubreuil, A.3
Formento, P.4
Marcie, S.5
Lagrange, J.L.6
Milano, G.7
-
104
-
-
0037029703
-
Influence of epidermal growth factor receptor (EGFR), p53 and intrinsic MAP kinase pathway status of tumor cells on the antiproliferative effect of ZD1839 ('Iressa')
-
Magne N, Fischel JL, Dubreuil A, Formento P, Poupon MF, Laurent-Puig P & Milano G 2002b Influence of epidermal growth factor receptor (EGFR), p53 and intrinsic MAP kinase pathway status of tumor cells on the antiproliferative effect of ZD1839 ('Iressa'). British Journal of Cancer 86 1518-1523.
-
(2002)
British Journal of Cancer
, vol.86
, pp. 1518-1523
-
-
Magne, N.1
Fischel, J.L.2
Dubreuil, A.3
Formento, P.4
Poupon, M.F.5
Laurent-Puig, P.6
Milano, G.7
-
105
-
-
0035004747
-
Targeting cycloxygenase-2 and HER-2/neu pathways inhibits colorectal carcinoma growth
-
Mann M, Sheng H, Shao J, Williams CS, Pisacane PI, Sliwkowski MX & DuBois RN 2001 Targeting cycloxygenase-2 and HER-2/neu pathways inhibits colorectal carcinoma growth. Gastroenterology 120 1713-1719.
-
(2001)
Gastroenterology
, vol.120
, pp. 1713-1719
-
-
Mann, M.1
Sheng, H.2
Shao, J.3
Williams, C.S.4
Pisacane, P.I.5
Sliwkowski, M.X.6
DuBois, R.N.7
-
106
-
-
0028969683
-
Type 1 growth factor receptors: An overview of recent developments
-
Mason S & Gullick WJ 1995 Type 1 growth factor receptors: an overview of recent developments. The Breast 4 11-18.
-
(1995)
The Breast
, vol.4
, pp. 11-18
-
-
Mason, S.1
Gullick, W.J.2
-
108
-
-
0031928378
-
Increased expression of erbB-3 in colorectal cancer is associated with concomitant increase in the level of erbB-2
-
Maurer CA, Friess H, Kretshmann B, Zimmermann A, Stauffer A, Bauer HU, Korc M & Buchler MW 1998 Increased expression of erbB-3 in colorectal cancer is associated with concomitant increase in the level of erbB-2. Human Pathology 29 771-777.
-
(1998)
Human Pathology
, vol.29
, pp. 771-777
-
-
Maurer, C.A.1
Friess, H.2
Kretshmann, B.3
Zimmermann, A.4
Stauffer, A.5
Bauer, H.U.6
Korc, M.7
Buchler, M.W.8
-
109
-
-
0033966576
-
In vivo enhancement of tumor radio-response by C225 antiepidermal growth factor receptor antibody
-
Milas L, Mason K, Hunter N, Petersen S, Yamakawa M, Ang K, Mendelsohn J & Fan Z 2000 In vivo enhancement of tumor radio-response by C225 antiepidermal growth factor receptor antibody. Clinical Cancer Research 6 701-708.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 701-708
-
-
Milas, L.1
Mason, K.2
Hunter, N.3
Petersen, S.4
Yamakawa, M.5
Ang, K.6
Mendelsohn, J.7
Fan, Z.8
-
110
-
-
0001159137
-
A pilot trial demonstrates the safety of ZD1839 (Iressa), an oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in combination with carboplatin (C) and paclitaxel (P) in previously untreated advanced non-small lung cancer (NSLC)
-
Miller VA, Johnson D, Heelan RT, Pizzo BA, Perez WJ, Bass A, Kris MG, Ochs J & Averbuch S 2001 A pilot trial demonstrates the safety of ZD1839 (Iressa), an oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in combination with carboplatin (C) and paclitaxel (P) in previously untreated advanced non-small lung cancer (NSLC). Proceedings of the American Society for Clinical Oncology 20 326.
-
(2001)
Proceedings of the American Society for Clinical Oncology
, vol.20
, pp. 326
-
-
Miller, V.A.1
Johnson, D.2
Heelan, R.T.3
Pizzo, B.A.4
Perez, W.J.5
Bass, A.6
Kris, M.G.7
Ochs, J.8
Averbuch, S.9
-
111
-
-
0035476803
-
The tyrosine kinase inhibitor ZD1839 ('Iressa') inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells
-
Moasser MM, Basso A, Averbuch SD & Rosen N 2001 The tyrosine kinase inhibitor ZD1839 ('Iressa') inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Research 61 7184-7188.
-
(2001)
Cancer Research
, vol.61
, pp. 7184-7188
-
-
Moasser, M.M.1
Basso, A.2
Averbuch, S.D.3
Rosen, N.4
-
112
-
-
0035874981
-
Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells
-
Molina MA, Codony-Servat J, Albanell J, Rojo F, Arribas J & Baselga J 2001 Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Research 61 4744-4749.
-
(2001)
Cancer Research
, vol.61
, pp. 4744-4749
-
-
Molina, M.A.1
Codony-Servat, J.2
Albanell, J.3
Rojo, F.4
Arribas, J.5
Baselga, J.6
-
113
-
-
0034625346
-
Expression of oncogenic epidermal growth factor family kinases induces paclitaxel resistance and alters beta-tubulin isotype expression
-
Montgomery RB, Guzman J, O'Rourke DM & Stahl WL 2000 Expression of oncogenic epidermal growth factor family kinases induces paclitaxel resistance and alters beta-tubulin isotype expression. Journal of Biological Chemistry 275 17358-17363.
-
(2000)
Journal of Biological Chemistry
, vol.275
, pp. 17358-17363
-
-
Montgomery, R.B.1
Guzman, J.2
O'Rourke, D.M.3
Stahl, W.L.4
-
114
-
-
0034722893
-
From oncogene to drug: Development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents
-
Morin MJ 2000 From oncogene to drug: development of small molecule tyrosine kinase inhibitors as anti-tumor and anti-angiogenic agents. Oncogene 19 6574-6583.
-
(2000)
Oncogene
, vol.19
, pp. 6574-6583
-
-
Morin, M.J.1
-
115
-
-
0036606779
-
The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor related peptides
-
Motoyama A, Hynes NE & Lane HA 2002 The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor related peptides. Cancer Research 62 3151-3158.
-
(2002)
Cancer Research
, vol.62
, pp. 3151-3158
-
-
Motoyama, A.1
Hynes, N.E.2
Lane, H.A.3
-
116
-
-
0035893560
-
Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo
-
Moulder SL, Yakes FM, Muthuswamy SK, Bianco R, Simpson JF & Arteaga CL 2001 Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Research 61 8887-8895.
-
(2001)
Cancer Research
, vol.61
, pp. 8887-8895
-
-
Moulder, S.L.1
Yakes, F.M.2
Muthuswamy, S.K.3
Bianco, R.4
Simpson, J.F.5
Arteaga, C.L.6
-
117
-
-
0030774045
-
Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase
-
Moyer JD, Barbacci EG, Iwata KK, Arnold L, Boman B, Cunningham A, DiOrio C, Doty J, Morin MJ, Moyer MP, Neveu M, Pollack VA, Pustilnik LR, Reynolds MM, Sloan D, Theleman A & Miller P 1997 Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Research 57 4838-4848.
-
(1997)
Cancer Research
, vol.57
, pp. 4838-4848
-
-
Moyer, J.D.1
Barbacci, E.G.2
Iwata, K.K.3
Arnold, L.4
Boman, B.5
Cunningham, A.6
DiOrio, C.7
Doty, J.8
Morin, M.J.9
Moyer, M.P.10
Neveu, M.11
Pollack, V.A.12
Pustilnik, L.R.13
Reynolds, M.M.14
Sloan, D.15
Theleman, A.16
Miller, P.17
-
118
-
-
0032860819
-
Controlled dimerization of ErbB receptors provids evidence for differential signaling by homo- and heterodimers
-
Muthuswamy SK, Gilman M & Brugge JS 1999 Controlled dimerization of ErbB receptors provids evidence for differential signaling by homo- and heterodimers. Molecular and Cellular Biology 19 6845-6857.
-
(1999)
Molecular and Cellular Biology
, vol.19
, pp. 6845-6857
-
-
Muthuswamy, S.K.1
Gilman, M.2
Brugge, J.S.3
-
121
-
-
0000004189
-
A phase I intermittent dose escalation trial of ZD1839 (Iressa) in
-
Nakagawa K, Yamamoto N, Kudoh S, Negoro S, Takeda K, Tamura T & Fukuoka M 2000 A phase I intermittent dose escalation trial of ZD1839 (Iressa) in Japanese patients with solid malignant tumours. Proceedings of the American Society for Clinical Oncology 19 183.
-
(2000)
Proceedings of the American Society for Clinical Oncology
, vol.19
, pp. 183
-
-
Nakagawa, K.1
Yamamoto, N.2
Kudoh, S.3
Negoro, S.4
Takeda, K.5
Tamura, T.6
Fukuoka, M.7
-
122
-
-
0029032371
-
Expression of messenger RNA for amphiregulin, heregulin and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas
-
Normanno N, Kim N, Wen D, Smith K, Harris AL, Plowman GD, Colletta G, Ciardiello F & Salomon DS 1995 Expression of messenger RNA for amphiregulin, heregulin and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas. Breast Cancer Research and Treatment 35 293-297.
-
(1995)
Breast Cancer Research and Treatment
, vol.35
, pp. 293-297
-
-
Normanno, N.1
Kim, N.2
Wen, D.3
Smith, K.4
Harris, A.L.5
Plowman, G.D.6
Colletta, G.7
Ciardiello, F.8
Salomon, D.S.9
-
123
-
-
9044251968
-
Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides
-
Normanno N, Bianco C, Damiano V, de Angelis E, Selvam MP, Grassi M, Magliulo G, Tortora G, Bianco AR, Mendelsohn J, Salomon DS & Ciardiello F 1996 Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides. Clinical Cancer Research 2 601-609.
-
(1996)
Clinical Cancer Research
, vol.2
, pp. 601-609
-
-
Normanno, N.1
Bianco, C.2
Damiano, V.3
De Angelis, E.4
Selvam, M.P.5
Grassi, M.6
Magliulo, G.7
Tortora, G.8
Bianco, A.R.9
Mendelsohn, J.10
Salomon, D.S.11
Ciardiello, F.12
-
125
-
-
0036225446
-
Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth
-
Normanno N, Campiglio M, De Luca A, Somenzi G, Maiello M, Ciardiello F, Gianni L, Salomon DS & Menard S 2002 Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth. Annals of Oncology 13 65-72.
-
(2002)
Annals of Oncology
, vol.13
, pp. 65-72
-
-
Normanno, N.1
Campiglio, M.2
De Luca, A.3
Somenzi, G.4
Maiello, M.5
Ciardiello, F.6
Gianni, L.7
Salomon, D.S.8
Menard, S.9
-
126
-
-
0031840484
-
ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner
-
Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B & Hynes NE 1998 ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner. Molecular and Cellular Biology 18 5042-5051.
-
(1998)
Molecular and Cellular Biology
, vol.18
, pp. 5042-5051
-
-
Olayioye, M.A.1
Graus-Porta, D.2
Beerli, R.R.3
Rohrer, J.4
Gay, B.5
Hynes, N.E.6
-
127
-
-
0033546315
-
ErbB receptor-induced activation of Stat transcription factors is mediated by Src tyrosine kinases
-
Olayioye MA, Beuvink I, Korsch K, Daly JM & Hynes NE 1999 ErbB receptor-induced activation of Stat transcription factors is mediated by Src tyrosine kinases. Journal of Biological Chemistry 274 17209-17218.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 17209-17218
-
-
Olayioye, M.A.1
Beuvink, I.2
Korsch, K.3
Daly, J.M.4
Hynes, N.E.5
-
128
-
-
0034600849
-
The ErbB signalling network: Receptor dimerisation in development and cancer
-
Olayioye MA, Neve RM, Lane HA & Hynes NE 2000 The ErbB signalling network: receptor dimerisation in development and cancer. EMBO Journal 19 3159-3167.
-
(2000)
EMBO Journal
, vol.19
, pp. 3159-3167
-
-
Olayioye, M.A.1
Neve, R.M.2
Lane, H.A.3
Hynes, N.E.4
-
129
-
-
0034697631
-
Effects of c-erbB-2 overexpression on the drug sensitivities of normal human mammary epithelial cells
-
Orr MS, O'Connor PM & Kohn KW 2000 Effects of c-erbB-2 overexpression on the drug sensitivities of normal human mammary epithelial cells. Journal of the National Cancer Institute 92 987-994.
-
(2000)
Journal of the National Cancer Institute
, vol.92
, pp. 987-994
-
-
Orr, M.S.1
O'Connor, P.M.2
Kohn, K.W.3
-
130
-
-
0027049721
-
Prognostic significance of co-expression of c-erbB-2 oncoprotein and epidermal growth factor receptor in breast cancer patients
-
Osaki A, Toi M, Yamada H, Kawami H, Kuroi K & Toge T 1992 Prognostic significance of co-expression of c-erbB-2 oncoprotein and epidermal growth factor receptor in breast cancer patients. American Journal of Surgery 164 323-326.
-
(1992)
American Journal of Surgery
, vol.164
, pp. 323-326
-
-
Osaki, A.1
Toi, M.2
Yamada, H.3
Kawami, H.4
Kuroi, K.5
Toge, T.6
-
131
-
-
8944263473
-
Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and cripto in human normal and malignant breast tissue
-
Panico L, D'Antonio A, Salvatore G, Mezza E, Tortora G, De Laurentiis M, De Placido S, Giordano T, Merino M, Salomon DS, Gullick WJ, Pettinato G, Schnitt SJ, Bianco AR & Ciardiello F 1996 Differential immunohistochemical detection of transforming growth factor alpha, amphiregulin and cripto in human normal and malignant breast tissue. International Journal of Cancer 65 51-56.
-
(1996)
International Journal of Cancer
, vol.65
, pp. 51-56
-
-
Panico, L.1
D'Antonio, A.2
Salvatore, G.3
Mezza, E.4
Tortora, G.5
De Laurentiis, M.6
De Placido, S.7
Giordano, T.8
Merino, M.9
Salomon, D.S.10
Gullick, W.J.11
Pettinato, G.12
Schnitt, S.J.13
Bianco, A.R.14
Ciardiello, F.15
-
132
-
-
0000799257
-
Antibody dependent cell-mediated cytotoxicity in breast cancer patients in Phase HI clinical trials of a humanized anti-HER2 antibody
-
Pegram MD, Baly D, Wirth C, Gilkerson E, Slamon DJ, Sliwkowski MX, Bauer K & Fox JA 1997a Antibody dependent cell-mediated cytotoxicity in breast cancer patients in Phase HI clinical trials of a humanized anti-HER2 antibody. Proceedings of the American Association of Cancer Research 38 602.
-
(1997)
Proceedings of the American Association of Cancer Research
, vol.38
, pp. 602
-
-
Pegram, M.D.1
Baly, D.2
Wirth, C.3
Gilkerson, E.4
Slamon, D.J.5
Sliwkowski, M.X.6
Bauer, K.7
Fox, J.A.8
-
133
-
-
0030870295
-
The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells
-
Pegram MD, Finn RS, Arzoo K, Beryt M, Pietras RJ & Slamon DJ 1997b The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells. Oncogene 15 537-547.
-
(1997)
Oncogene
, vol.15
, pp. 537-547
-
-
Pegram, M.D.1
Finn, R.S.2
Arzoo, K.3
Beryt, M.4
Pietras, R.J.5
Slamon, D.J.6
-
134
-
-
0031903646
-
Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
-
Pegram MD, Lipton A, Hayes DF, Weber BL, Baselga J, Tripathy D, Baly D, Baughman SA, Twaddell T, Glaspy JA & Slamon DJ 1998 Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. Journal of Clinical Oncology 16 2659-2671.
-
(1998)
Journal of Clinical Oncology
, vol.16
, pp. 2659-2671
-
-
Pegram, M.D.1
Lipton, A.2
Hayes, D.F.3
Weber, B.L.4
Baselga, J.5
Tripathy, D.6
Baly, D.7
Baughman, S.A.8
Twaddell, T.9
Glaspy, J.A.10
Slamon, D.J.11
-
135
-
-
0033118889
-
Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers
-
Pegram M, Hsu S, Lewis G, Pietras R, Beryt M, Sliwkowski M, Coombs D, Baly D, Kabbinavar F & Slamon D 1999 Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers. Oncogene 18 2241-2251.
-
(1999)
Oncogene
, vol.18
, pp. 2241-2251
-
-
Pegram, M.1
Hsu, S.2
Lewis, G.3
Pietras, R.4
Beryt, M.5
Sliwkowski, M.6
Coombs, D.7
Baly, D.8
Kabbinavar, F.9
Slamon, D.10
-
136
-
-
0027720285
-
Neu and its ligands: From an oncogene to neural factors
-
Peles E & Yarden Y 1993 Neu and its ligands: from an oncogene to neural factors. Bioessays 15 815-824.
-
(1993)
Bioessays
, vol.15
, pp. 815-824
-
-
Peles, E.1
Yarden, Y.2
-
137
-
-
0000329007
-
A phase H trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients with advanced, EGFR-expressing non-small-cell lung cancer (NSCLC)
-
Perez-Soler R, Chachoua A, Huberman M, Karp D, Rigas J, Hammond L, Rowinsky E, Preston G, Ferrante K, Allen L, Nadler P & Bonomi P 2001 A phase H trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients with advanced, EGFR-expressing non-small-cell lung cancer (NSCLC). Proceedings of the American Society for Clinical Oncology 20 310.
-
(2001)
Proceedings of the American Society for Clinical Oncology
, vol.20
, pp. 310
-
-
Perez-Soler, R.1
Chachoua, A.2
Huberman, M.3
Karp, D.4
Rigas, J.5
Hammond, L.6
Rowinsky, E.7
Preston, G.8
Ferrante, K.9
Allen, L.10
Nadler, P.11
Bonomi, P.12
-
138
-
-
0032972944
-
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
-
Perrotte P, Matsumoto T, Inoue K, Kuniyasu H, Eve BY, Hicklin DJ, Radinsky R & Dinney CP 1999 Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clinical Cancer Research 5 257-265.
-
(1999)
Clinical Cancer Research
, vol.5
, pp. 257-265
-
-
Perrotte, P.1
Matsumoto, T.2
Inoue, K.3
Kuniyasu, H.4
Eve, B.Y.5
Hicklin, D.J.6
Radinsky, R.7
Dinney, C.P.8
-
139
-
-
0001223491
-
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
-
Petit AM, Rak J, Hung MC, Rockwell P, Goldstein N, Fendly B & Kerbel RS 1997 Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. American Journal of Pathology 151 1523-1530.
-
(1997)
American Journal of Pathology
, vol.151
, pp. 1523-1530
-
-
Petit, A.M.1
Rak, J.2
Hung, M.C.3
Rockwell, P.4
Goldstein, N.5
Fendly, B.6
Kerbel, R.S.7
-
140
-
-
0028200221
-
Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells
-
Pietras RJ, Fendly BM, Chazin VR, Pegram MD, Howell SB & Slamon DJ 1994 Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells. Oncogene 9 1829-1838.
-
(1994)
Oncogene
, vol.9
, pp. 1829-1838
-
-
Pietras, R.J.1
Fendly, B.M.2
Chazin, V.R.3
Pegram, M.D.4
Howell, S.B.5
Slamon, D.J.6
-
141
-
-
0032578797
-
Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs
-
Pietras RJ, Pegram MD, Finn RS, Maneval D & Slamon DJ 1998 Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs. Oncogene 17 2235-2249.
-
(1998)
Oncogene
, vol.17
, pp. 2235-2249
-
-
Pietras, R.J.1
Pegram, M.D.2
Finn, R.S.3
Maneval, D.4
Slamon, D.J.5
-
142
-
-
0028031085
-
Brain neurons and glial cells express neu differentiation factor/heregulin: A survival factor for astrocytes
-
Pinkas-Kramarski R, Eilam R, Spiegler O, Lavi S, Liu N, Chang D, Wen D, Schwartz M & Yarden Y 1994 Brain neurons and glial cells express neu differentiation factor/heregulin: a survival factor for astrocytes. PNAS 91 9387-9391.
-
(1994)
PNAS
, vol.91
, pp. 9387-9391
-
-
Pinkas-Kramarski, R.1
Eilam, R.2
Spiegler, O.3
Lavi, S.4
Liu, N.5
Chang, D.6
Wen, D.7
Schwartz, M.8
Yarden, Y.9
-
143
-
-
0029783549
-
Neu differentiation factor/neuregulin isoforms activate distance receptor combinations
-
Pinkas-Kramarski R, Shelly M, Glathe S, Ratzkin BJ & Yarden Y 1996 Neu differentiation factor/neuregulin isoforms activate distance receptor combinations. Journal of Biological Chemistry 271 19029-19032.
-
(1996)
Journal of Biological Chemistry
, vol.271
, pp. 19029-19032
-
-
Pinkas-Kramarski, R.1
Shelly, M.2
Glathe, S.3
Ratzkin, B.J.4
Yarden, Y.5
-
144
-
-
0032695910
-
Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and anti-tumor effects in athymic mice
-
Pollack VA, Savage DM, Baker DA, Tsaparikos KE, Sloan DE, Moyer JD, Barbacci EG, Pustilnik LR, Smolarek TA, Davis JA, Vaidya MP, Arnold LD, Doty JL, Iwata KH & Morin MJ 1999 Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and anti-tumor effects in athymic mice. Journal of Pharmacology and Experimental Therapeutics 291 739-748.
-
(1999)
Journal of Pharmacology and Experimental Therapeutics
, vol.291
, pp. 739-748
-
-
Pollack, V.A.1
Savage, D.M.2
Baker, D.A.3
Tsaparikos, K.E.4
Sloan, D.E.5
Moyer, J.D.6
Barbacci, E.G.7
Pustilnik, L.R.8
Smolarek, T.A.9
Davis, J.A.10
Vaidya, M.P.11
Arnold, L.D.12
Doty, J.L.13
Iwata, K.H.14
Morin, M.J.15
-
145
-
-
0026454327
-
Production and characterization of a polyclonal antibody to the c-erbB-3 protein: Examination of c-erbB-3 protein expression in adenocarcinomas
-
Poller DN, Spendlove I, Baker C, Church R, Ellis IO, Plowman GD & Mayer RJ 1992 Production and characterization of a polyclonal antibody to the c-erbB-3 protein: examination of c-erbB-3 protein expression in adenocarcinomas. Journal of Pathology 168 275-280.
-
(1992)
Journal of Pathology
, vol.168
, pp. 275-280
-
-
Poller, D.N.1
Spendlove, I.2
Baker, C.3
Church, R.4
Ellis, I.O.5
Plowman, G.D.6
Mayer, R.J.7
-
146
-
-
0343819997
-
Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERBB2, ERBB3) in colorectal adenocarcinomas and adenomas
-
Porebska I, Harlozinska A & Bojarowski T 2000 Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERBB2, ERBB3) in colorectal adenocarcinomas and adenomas. Tumour Biology 21 105-115.
-
(2000)
Tumour Biology
, vol.21
, pp. 105-115
-
-
Porebska, I.1
Harlozinska, A.2
Bojarowski, T.3
-
147
-
-
0034992521
-
The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification
-
Prenzel N, Fischer OM, Streit S, Hart S & Ullrich A 2001 The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocrine-Related Cancer 8 11-31.
-
(2001)
Endocrine-Related Cancer
, vol.8
, pp. 11-31
-
-
Prenzel, N.1
Fischer, O.M.2
Streit, S.3
Hart, S.4
Ullrich, A.5
-
148
-
-
0028216712
-
Identification of c-erbB-3 binding sites for phosphatidylinosiol 3′-kinase and SHC using an EGF receptor/c-erbB-3 chimera
-
Prigent SA & Gullick WJ 1994 Identification of c-erbB-3 binding sites for phosphatidylinosiol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera. EMBO Journal 13 2831-2841.
-
(1994)
EMBO Journal
, vol.13
, pp. 2831-2841
-
-
Prigent, S.A.1
Gullick, W.J.2
-
149
-
-
0028344577
-
Expression of transforming growth factor alpha, amphiregulin, and cripto-1 in human breast carcinomas
-
Qi C-F, Liscia DS, Normanno N, Merlo G, Johnson GR, Gullick WJ, Ciardiello F, Brandt R, Kim N, Kenney N & Salomon DS 1994 Expression of transforming growth factor alpha, amphiregulin, and cripto-1 in human breast carcinomas. British Journal of Cancer 69 903-910.
-
(1994)
British Journal of Cancer
, vol.69
, pp. 903-910
-
-
Qi, C.-F.1
Liscia, D.S.2
Normanno, N.3
Merlo, G.4
Johnson, G.R.5
Gullick, W.J.6
Ciardiello, F.7
Brandt, R.8
Kim, N.9
Kenney, N.10
Salomon, D.S.11
-
150
-
-
0029818168
-
Expression of the type 1 tyrosine kinase growth factor receptors EGF receptor, c-erbB-2 and c-erbB-3 in bladder cancer
-
Rajkumar T, Stamp GW, Pandha HS, Waxman J & Gullick WJ 1996 Expression of the type 1 tyrosine kinase growth factor receptors EGF receptor, c-erbB-2 and c-erbB-3 in bladder cancer. Journal of Pathology 179 381-385.
-
(1996)
Journal of Pathology
, vol.179
, pp. 381-385
-
-
Rajkumar, T.1
Stamp, G.W.2
Pandha, H.S.3
Waxman, J.4
Gullick, W.J.5
-
151
-
-
0003282145
-
Phase I trial of erlotinib (OSI-774) in combination with gemcitabine (G) and cisplatin (P) in patients with advanced solid tumors
-
Ratain MJ, George CM, Janisch L, Kindler HL, Ryan C, Wood DL, Nadlr PI & Vokes EE 2002 Phase I trial of erlotinib (OSI-774) in combination with gemcitabine (G) and cisplatin (P) in patients with advanced solid tumors. Proceedings of the American Society for Clinical Oncology 21 76b.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
-
-
Ratain, M.J.1
George, C.M.2
Janisch, L.3
Kindler, H.L.4
Ryan, C.5
Wood, D.L.6
Nadlr, P.I.7
Vokes, E.E.8
-
152
-
-
0030027165
-
Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta
-
Riese DJ, Bermingham Y, van Raaij M, Buckley SD, Plowman GD & Stem DF 1996 Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta. Oncogene 12 345-353.
-
(1996)
Oncogene
, vol.12
, pp. 345-353
-
-
Riese, D.J.1
Bermingham, Y.2
Van Raaij, M.3
Buckley, S.D.4
Plowman, G.D.5
Stem, D.F.6
-
153
-
-
0003282147
-
A phase 1 clinical and pharmacokinetic study of oral CI-1033, a pan-ErbB tyrosine kinase inhibitor, in patients with advanced solid tumors
-
Rinehart JJ, Wilding G, Willson J, Krishnamurthi S, Natale RB, Mani S, Burnett D, Olson S, Bycott P, Owens-Grillo JK, Hes M & Lenehan P 2002 A phase 1 clinical and pharmacokinetic study of oral CI-1033, a pan-ErbB tyrosine kinase inhibitor, in patients with advanced solid tumors. Proceedings of the American Society for Clinical Oncology 21 11.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 11
-
-
Rinehart, J.J.1
Wilding, G.2
Willson, J.3
Krishnamurthi, S.4
Natale, R.B.5
Mani, S.6
Burnett, D.7
Olson, S.8
Bycott, P.9
Owens-Grillo, J.K.10
Hes, M.11
Lenehan, P.12
-
154
-
-
0003243810
-
ZD1839 ('Iressa') as a single agent for the treatment of metastatic non-small-cell lung cancer
-
Ruckdeschel JC, Simon G, Antonia S, Haura E, Williams C, Wagner H, Lima CR, Ettienne K, Vaughn J & Bepler G 2002 ZD1839 ('Iressa') as a single agent for the treatment of metastatic non-small-cell lung cancer. Proceedings of the American Society for Clinical Oncology 21 318.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 318
-
-
Ruckdeschel, J.C.1
Simon, G.2
Antonia, S.3
Haura, E.4
Williams, C.5
Wagner, H.6
Lima, C.R.7
Ettienne, K.8
Vaughn, J.9
Bepler, G.10
-
155
-
-
0035476866
-
The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer
-
Rusnak DW, Affleck K, Cockerill SG, Stubberfield G, Harris R, Page M, Smith KJ, Guntrip SB, Carter MC, Shaw RJ, Jowett A, Stables J, Topley P, Wood ER, Brignola PS, Kadwell SH, Reep BR, Mullin RJ, Alligood KJ, Keith BR, Crosby RM, Murray DM, Knight WB, Gilmer TM & Lackey K 2001 The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer. Cancer Research 61 7196-7203.
-
(2001)
Cancer Research
, vol.61
, pp. 7196-7203
-
-
Rusnak, D.W.1
Affleck, K.2
Cockerill, S.G.3
Stubberfield, G.4
Harris, R.5
Page, M.6
Smith, K.J.7
Guntrip, S.B.8
Carter, M.C.9
Shaw, R.J.10
Jowett, A.11
Stables, J.12
Topley, P.13
Wood, E.R.14
Brignola, P.S.15
Kadwell, S.H.16
Reep, B.R.17
Mullin, R.J.18
Alligood, K.J.19
Keith, B.R.20
Crosby, R.M.21
Murray, D.M.22
Knight, W.B.23
Gilmer, T.M.24
Lackey, K.25
more..
-
156
-
-
0026725097
-
Differential immunohistochemical localization of amphiregulin and cripto in human normal colon and colorectal tumors
-
Saeki T, Chen-Feng Q, Johnson GR, Gullick W, Tahara E, Normanno N, Ciardiello F, Kenney N, Stromberg K & Salomon DS 1992 Differential immunohistochemical localization of amphiregulin and cripto in human normal colon and colorectal tumors. Cancer Research 52 3467-3473.
-
(1992)
Cancer Research
, vol.52
, pp. 3467-3473
-
-
Saeki, T.1
Chen-Feng, Q.2
Johnson, G.R.3
Gullick, W.4
Tahara, E.5
Normanno, N.6
Ciardiello, F.7
Kenney, N.8
Stromberg, K.9
Salomon, D.S.10
-
157
-
-
0027978099
-
Immunohistochemical detection of cripto-1, amphiregulin and transforming growth factor alpha in human gastric carcinomas and intestinal metaplasias
-
Saeki T, Salomon DS, Normanno N, Johnson GR, Gullick WJ, Mandai K, Moriwaki S, Tahashima S, Kuniyasu M, Tahara E, Kawami H, Nishiyama M & Toge T 1994 Immunohistochemical detection of cripto-1, amphiregulin and transforming growth factor alpha in human gastric carcinomas and intestinal metaplasias. International Journal of Oncology 5 215-223.
-
(1994)
International Journal of Oncology
, vol.5
, pp. 215-223
-
-
Saeki, T.1
Salomon, D.S.2
Normanno, N.3
Johnson, G.R.4
Gullick, W.J.5
Mandai, K.6
Moriwaki, S.7
Tahashima, S.8
Kuniyasu, M.9
Tahara, E.10
Kawami, H.11
Nishiyama, M.12
Toge, T.13
-
159
-
-
17744371840
-
The EGF-CFC family: Novel epidermal growth factor related proteins in development and cancer
-
Salomon DS, Bianco C, Ebert AD, Kahn NI, DeSantis M, Normanno N, Wechselberger C, Seno M, Williams K, Sanicola M, Foley S, Gullick WJ & Persico MG 2000 The EGF-CFC family: novel epidermal growth factor related proteins in development and cancer. Endocrine-Related Cancer 7 199-226.
-
(2000)
Endocrine-Related Cancer
, vol.7
, pp. 199-226
-
-
Salomon, D.S.1
Bianco, C.2
Ebert, A.D.3
Kahn, N.I.4
DeSantis, M.5
Normanno, N.6
Wechselberger, C.7
Seno, M.8
Williams, K.9
Sanicola, M.10
Foley, S.11
Gullick, W.J.12
Persico, M.G.13
-
160
-
-
0002823211
-
Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11 refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
-
Saltz L, Rubin M, Hochster H, Tchekmeydian NS, Waksal H, Needle M & LoBuglio A 2001 Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11 refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proceedings of the American Society for Clinical Oncology 20 3.
-
(2001)
Proceedings of the American Society for Clinical Oncology
, vol.20
, pp. 3
-
-
Saltz, L.1
Rubin, M.2
Hochster, H.3
Tchekmeydian, N.S.4
Waksal, H.5
Needle, M.6
LoBuglio, A.7
-
161
-
-
0001407135
-
Single agent IMC-C225 (Erbitux) has activity in CPT-11 refractory colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR)
-
Saltz L, Meropol NJ, Loehrer PJ, Waksal H, Needle M & Mayer RJ 2002 Single agent IMC-C225 (Erbitux) has activity in CPT-11 refractory colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR). Proceedings of the American Society for Clinical Oncology 21 127.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 127
-
-
Saltz, L.1
Meropol, N.J.2
Loehrer, P.J.3
Waksal, H.4
Needle, M.5
Mayer, R.J.6
-
162
-
-
0028176034
-
Ligand and p185c-neu density govern receptor interactions and tyrosine kinase activation
-
Samanta A, LaVea CM, Dougall WC, Qian X & Green MI 1994 Ligand and p185c-neu density govern receptor interactions and tyrosine kinase activation. PNAS 91 1711-1715.
-
(1994)
PNAS
, vol.91
, pp. 1711-1715
-
-
Samanta, A.1
LaVea, C.M.2
Dougall, W.C.3
Qian, X.4
Green, M.I.5
-
163
-
-
0027165407
-
Expression of the c-erbB-3 gene product in gastric cancer
-
Sanidas EE, Felipe MI, Linehan J, Lemoine NR, Gullick WJ, Rajkumar T & Levison DA 1993 Expression of the c-erbB-3 gene product in gastric cancer. International Journal of Cancer 54 935-940.
-
(1993)
International Journal of Cancer
, vol.54
, pp. 935-940
-
-
Sanidas, E.E.1
Felipe, M.I.2
Linehan, J.3
Lemoine, N.R.4
Gullick, W.J.5
Rajkumar, T.6
Levison, D.A.7
-
164
-
-
0026174552
-
Characterization of an anti-p185HER2 monoclonal antibody that stimulates receptor function and inhibits tumor cell growth
-
Sarup JC, Johnson RM, King KL, Fendly BM, Lipari MT, Napier MA, Ullrich A & Shepard HM 1991 Characterization of an anti-p185HER2 monoclonal antibody that stimulates receptor function and inhibits tumor cell growth. Growth Regulation 1 72-82.
-
(1991)
Growth Regulation
, vol.1
, pp. 72-82
-
-
Sarup, J.C.1
Johnson, R.M.2
King, K.L.3
Fendly, B.M.4
Lipari, M.T.5
Napier, M.A.6
Ullrich, A.7
Shepard, H.M.8
-
165
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J 2000 Cell signaling by receptor tyrosine kinases. Cell 103 211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
166
-
-
0000568621
-
Phase 2 clinical trial evaluating the safety and effectiveness of ABX-EGF in renal cell cancer (RCC)
-
Schwartz G, Dutche JP, Vogelzang NJ, Gollob J, Thompson J, Bukowski RM, Figlin RA, Lohner M, Roskos L, Hwang CC, Foon K, Schwab G & Rowinski EK 2002 Phase 2 clinical trial evaluating the safety and effectiveness of ABX-EGF in renal cell cancer (RCC). Proceedings of the American Society for Clinical Oncology 21 24.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 24
-
-
Schwartz, G.1
Dutche, J.P.2
Vogelzang, N.J.3
Gollob, J.4
Thompson, J.5
Bukowski, R.M.6
Figlin, R.A.7
Lohner, M.8
Roskos, L.9
Hwang, C.C.10
Foon, K.11
Schwab, G.12
Rowinski, E.K.13
-
167
-
-
0026360077
-
HER2 signal transduction in breast tumor cells
-
HER2 signal transduction in breast tumor cells. Journal of Biological Chemistry 266 14300-14305.
-
(1991)
Journal of Biological Chemistry
, vol.266
, pp. 14300-14305
-
-
Scott, G.K.1
Dodson, P.A.2
Montgomery, P.A.3
Johnson, R.M.4
Sarup, J.C.5
Wong, W.L.6
Ullrich, A.7
Shepard, H.M.8
Benz, C.C.9
-
168
-
-
0035873815
-
Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification
-
Seidman AD, Fornier MN, Esteva FJ, Tan L, Kaptain S, Bach A, Panageas KS, Arroyo C, Valero V, Currie V, Gilewski T, Theodolou M, Moynahan ME, Moasser M, Sklarin N, Dickler M, D'Andrea G, Cristofanili M, Rivera E, Hortobagyi GN, Norton L & Hudis CA 2001 Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification. Journal of Clinical Oncology 19 2587-2595.
-
(2001)
Journal of Clinical Oncology
, vol.19
, pp. 2587-2595
-
-
Seidman, A.D.1
Fornier, M.N.2
Esteva, F.J.3
Tan, L.4
Kaptain, S.5
Bach, A.6
Panageas, K.S.7
Arroyo, C.8
Valero, V.9
Currie, V.10
Gilewski, T.11
Theodolou, M.12
Moynahan, M.E.13
Moasser, M.14
Sklarin, N.15
Dickler, M.16
D'Andrea, G.17
Cristofanili, M.18
Rivera, E.19
Hortobagyi, G.N.20
Norton, L.21
Hudis, C.A.22
more..
-
169
-
-
0003264493
-
Phase II evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advance squamous cell carcinoma of the head and neck
-
Senzer NN, Soulieres D, Siu L, Agarwala S, Vokes E, Hidalgo M, Silberman S, Allen L, Ferrante K, Fisher D, Marsolais C & Nadler P 2001 Phase II evaluation of OSI-774, a potent oral antagonist of the EGFR-TK in patients with advance squamous cell carcinoma of the head and neck. Proceedings of the American Society for Clinical Oncology 20 2.
-
(2001)
Proceedings of the American Society for Clinical Oncology
, vol.20
, pp. 2
-
-
Senzer, N.N.1
Soulieres, D.2
Siu, L.3
Agarwala, S.4
Vokes, E.5
Hidalgo, M.6
Silberman, S.7
Allen, L.8
Ferrante, K.9
Fisher, D.10
Marsolais, C.11
Nadler, P.12
-
170
-
-
0032562561
-
Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes
-
Shelly M, Pinkas-Kramarski R, Guarino BC, Waterman H, Wang LM, Lyass L, Alimandi M, Kuo A, Bacus SS, Pierce JH, Andrews GC & Yarden Y 1998 Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes. Journal of Biological Chemistry 273 10496-10505.
-
(1998)
Journal of Biological Chemistry
, vol.273
, pp. 10496-10505
-
-
Shelly, M.1
Pinkas-Kramarski, R.2
Guarino, B.C.3
Waterman, H.4
Wang, L.M.5
Lyass, L.6
Alimandi, M.7
Kuo, A.8
Bacus, S.S.9
Pierce, J.H.10
Andrews, G.C.11
Yarden, Y.12
-
171
-
-
0034895886
-
Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer
-
Shin DM, Donato NJ, Perez-Soler R, Shin HJC, Wu JY, Zhang P, Lawhorn K, Khuri FR, Glisson BS, Myers J, Clayman G, Pfister D, Falcey J, Waksal H, Mendelsohn J & Hong WK 2001 Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer. Clinical Cancer Research 7 1204-1213.
-
(2001)
Clinical Cancer Research
, vol.7
, pp. 1204-1213
-
-
Shin, D.M.1
Donato, N.J.2
Perez-Soler, R.3
Shin, H.J.C.4
Wu, J.Y.5
Zhang, P.6
Lawhorn, K.7
Khuri, F.R.8
Glisson, B.S.9
Myers, J.10
Clayman, G.11
Pfister, D.12
Falcey, J.13
Waksal, H.14
Mendelsohn, J.15
Hong, W.K.16
-
172
-
-
0036799377
-
PKB/Akt mediates cell-cycle progression by phosphorylation of p27kip1 at threonine 157 and modulation of its cellular localization
-
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J & Arteaga CL 2002 PKB/Akt mediates cell-cycle progression by phosphorylation of p27kip1 at threonine 157 and modulation of its cellular localization. Nature Medicine 8 1145-1152.
-
(2002)
Nature Medicine
, vol.8
, pp. 1145-1152
-
-
Shin, I.1
Yakes, F.M.2
Rojo, F.3
Shin, N.Y.4
Bakin, A.V.5
Baselga, J.6
Arteaga, C.L.7
-
173
-
-
0024593476
-
Structure and function of human amphiregulin: A member of the epidermal growth factor family
-
Shoyab M, Plowman GD, McDonald VL, Bradley JG & Todaro GJ 1989 Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science 243 1074-1076.
-
(1989)
Science
, vol.243
, pp. 1074-1076
-
-
Shoyab, M.1
Plowman, G.D.2
McDonald, V.L.3
Bradley, J.G.4
Todaro, G.J.5
-
174
-
-
0029002850
-
c-erbB growth-factor-receptor proteins in ovarian tumours
-
Simpson BJ, Phillips HA, Lessels AM, Langdon SP & Miller WR 1995a c-erbB growth-factor-receptor proteins in ovarian tumours. International Journal of Cancer 64 202-206.
-
(1995)
International Journal of Cancer
, vol.64
, pp. 202-206
-
-
Simpson, B.J.1
Phillips, H.A.2
Lessels, A.M.3
Langdon, S.P.4
Miller, W.R.5
-
175
-
-
0028937536
-
c-erbB-3 protein expression in ovarian tumours
-
Simpson BJ, Weatherill J, Miller EP, Lessels AM, Langdon SP & Miller WR 1995b c-erbB-3 protein expression in ovarian tumours. British Journal of Cancer 71 758-762.
-
(1995)
British Journal of Cancer
, vol.71
, pp. 758-762
-
-
Simpson, B.J.1
Weatherill, J.2
Miller, E.P.3
Lessels, A.M.4
Langdon, S.P.5
Miller, W.R.6
-
176
-
-
0034489914
-
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa) an inhibitor of EGFR tyrosine kinase
-
Sirotnak FM, Zakowsky MF, Miller VA, Scher HI & Kris MG 2000 Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa) an inhibitor of EGFR tyrosine kinase. Clinical Cancer Research 6 4885-4892.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 4885-4892
-
-
Sirotnak, F.M.1
Zakowsky, M.F.2
Miller, V.A.3
Scher, H.I.4
Kris, M.G.5
-
177
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, Fleming T, Eiermann W, Wolter J, Pegram M, Baselga J & Norton L 2001 Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. New England Journal of Medicine 344 783-792.
-
(2001)
New England Journal of Medicine
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.11
Norton, L.12
-
178
-
-
0031865433
-
Expression of epidermal growth factor receptor family proteins (EGFR, c-erbB-2 and c-erbB-3) in gastric cancer and chronic gastritis
-
Slesak B, Harlozinska A, Porebska I, Bojarowski T, Lapinska J, Rzeszutko M & Wojnar A 1998 Expression of epidermal growth factor receptor family proteins (EGFR, c-erbB-2 and c-erbB-3) in gastric cancer and chronic gastritis. Anticancer Research 18 2727-2732.
-
(1998)
Anticancer Research
, vol.18
, pp. 2727-2732
-
-
Slesak, B.1
Harlozinska, A.2
Porebska, I.3
Bojarowski, T.4
Lapinska, J.5
Rzeszutko, M.6
Wojnar, A.7
-
180
-
-
0032851961
-
Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin)
-
Sliwkowski MX, Lofgren JA, Lewis GD, Hotaling TE, Fendly BM & Fox JA 1999 Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin). Seminars in Oncology 26 60-70.
-
(1999)
Seminars in Oncology
, vol.26
, pp. 60-70
-
-
Sliwkowski, M.X.1
Lofgren, J.A.2
Lewis, G.D.3
Hotaling, T.E.4
Fendly, B.M.5
Fox, J.A.6
-
181
-
-
1642416401
-
ZD1839 (Iressa) in progressive pretreated non-small-cell lung cancer (NSCLC): Results from compassionate use in patients at the Istituto Clinico Humanitas, Rozzano, Milano
-
Soto Parra HJ, Cavina R, Campagnoli E, Zucali P, Ginnani V, Latteri F, Ferrari B, Pedicini V, Roncalli M & Santoro A 2002 ZD1839 (Iressa) in progressive pretreated non-small-cell lung cancer (NSCLC): results from compassionate use in patients at the Istituto Clinico Humanitas, Rozzano, Milano. Proceedings of the American Society for Clinical Oncology 21 210b.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
-
-
Soto Parra, H.J.1
Cavina, R.2
Campagnoli, E.3
Zucali, P.4
Ginnani, V.5
Latteri, F.6
Ferrari, B.7
Pedicini, V.8
Roncalli, M.9
Santoro, A.10
-
183
-
-
0034654554
-
Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers
-
Srinivasan R, Gillett GE, Barnes DM & Gullick WJ 2000 Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. Cancer Research 60 1483-1487.
-
(2000)
Cancer Research
, vol.60
, pp. 1483-1487
-
-
Srinivasan, R.1
Gillett, G.E.2
Barnes, D.M.3
Gullick, W.J.4
-
184
-
-
0036145181
-
EGFR family expression in breast carcinomas, c-erbB-2 and c-erbB-4 have different effects on survival
-
Suo Z, Risberg B, Kalsson MG, Willman K, Tierens A, Skovlund E & Nesland JM 2002 EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 have different effects on survival. Journal of Pathology 196 17-25.
-
(2002)
Journal of Pathology
, vol.196
, pp. 17-25
-
-
Suo, Z.1
Risberg, B.2
Kalsson, M.G.3
Willman, K.4
Tierens, A.5
Skovlund, E.6
Nesland, J.M.7
-
185
-
-
0036473508
-
Targeting the EGF receptor in ovarian cancer with the tyrosine kinase inhibitor ZD1839 ('Iressa')
-
Swell JM, Macleod KG, Ritchie A, Smyth JF & Langdon SP 2002 Targeting the EGF receptor in ovarian cancer with the tyrosine kinase inhibitor ZD1839 ('Iressa'). British Journal of Cancer 86 456-462.
-
(2002)
British Journal of Cancer
, vol.86
, pp. 456-462
-
-
Swell, J.M.1
Macleod, K.G.2
Ritchie, A.3
Smyth, J.F.4
Langdon, S.P.5
-
186
-
-
0033827119
-
Combination chemoprevention of intestinal neoplasia
-
Torrance CJ, Jackson PE, Montgomery E, Kinzler KW, Vogelstein B, Wissner A, Nunes M, Frost P & Discafani CM 2000 Combination chemoprevention of intestinal neoplasia. Nature Medicine 6 1024-1028.
-
(2000)
Nature Medicine
, vol.6
, pp. 1024-1028
-
-
Torrance, C.J.1
Jackson, P.E.2
Montgomery, E.3
Kinzler, K.W.4
Vogelstein, B.5
Wissner, A.6
Nunes, M.7
Frost, P.8
Discafani, C.M.9
-
187
-
-
0345012210
-
Herceptin in combination with cisplatin and gemcitabine in patients with HER2 overexpressing, untreated, advanced, non-small-cell lung cancer (NSCLC): Final report of a phase II trial
-
Tran HT, Herbst RS, Glisson BS, Pister KM, Khuri FR, Oh YW, Ordonez NG, Lee P, El-Naggar AK, Hong WK & Zinner RG 2002 Herceptin in combination with cisplatin and gemcitabine in patients with HER2 overexpressing, untreated, advanced, non-small-cell lung cancer (NSCLC): final report of a phase II trial. Proceedings of the American Society for Clinical Oncology 21 307.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 307
-
-
Tran, H.T.1
Herbst, R.S.2
Glisson, B.S.3
Pister, K.M.4
Khuri, F.R.5
Oh, Y.W.6
Ordonez, N.G.7
Lee, P.8
El-Naggar, A.K.9
Hong, W.K.10
Zinner, R.G.11
-
188
-
-
0029665946
-
C-erbB-3 in human breast carcinoma expression and relation to prognosis and established prognostic indicators
-
Travis A, Pinder SE, Robertson JF, Bell JA, Wencyk P, Gullick WJ, Nicholson RI, Poller DN, Blamey RW, Elston CW & Ellis IO 1996 C-erbB-3 in human breast carcinoma. expression and relation to prognosis and established prognostic indicators. British Journal of Cancer 74 229-233.
-
(1996)
British Journal of Cancer
, vol.74
, pp. 229-233
-
-
Travis, A.1
Pinder, S.E.2
Robertson, J.F.3
Bell, J.A.4
Wencyk, P.5
Gullick, W.J.6
Nicholson, R.I.7
Poller, D.N.8
Blamey, R.W.9
Elston, C.W.10
Ellis, I.O.11
-
189
-
-
0034788453
-
Tyrosine kinase inhibitors: From rational design to clinical trials
-
Traxler P, Bold G, Buchdunger E, Caravatti G, Furet P, Manley P, O'Reilly T, Wood J & Zimmermann J 2001 Tyrosine kinase inhibitors: from rational design to clinical trials. Medicinal Research Reviews 21 499-512.
-
(2001)
Medicinal Research Reviews
, vol.21
, pp. 499-512
-
-
Traxler, P.1
Bold, G.2
Buchdunger, E.3
Caravatti, G.4
Furet, P.5
Manley, P.6
O'Reilly, T.7
Wood, J.8
Zimmermann, J.9
-
190
-
-
0029814271
-
A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
-
Tzahar E, Waterman H, Chen X, Levkowitz G, Karunagaran D, Lavi S, Ratzkin BJ & Yarden Y 1996 A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Molecular and Cellular Biology 16 5276-5287.
-
(1996)
Molecular and Cellular Biology
, vol.16
, pp. 5276-5287
-
-
Tzahar, E.1
Waterman, H.2
Chen, X.3
Levkowitz, G.4
Karunagaran, D.5
Lavi, S.6
Ratzkin, B.J.7
Yarden, Y.8
-
192
-
-
18644370396
-
Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
-
Kip1 by PKB/Akt-mediated phosphorylation in breast cancer. Nature Medicine 8 1136-1144.
-
(2002)
Nature Medicine
, vol.8
, pp. 1136-1144
-
-
Viglietto, G.1
Motti, M.L.2
Bruni, P.3
Melillo, R.M.4
D'Alessio, A.5
Califano, D.6
Vinci, F.7
Chiappetta, G.8
Tsichlis, P.9
Bellacosa, A.10
Fusco, A.11
Santoro, M.12
-
193
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, Gutheil JC, Harris LN, Fehrenbacher L, Slamon DJ, Murphy M, Novotny WF, Burchmore M, Shak S, Stewart SJ & Press M 2002 Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. Journal of Clinical Oncology 20 719-726.
-
(2002)
Journal of Clinical Oncology
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
Gutheil, J.C.4
Harris, L.N.5
Fehrenbacher, L.6
Slamon, D.J.7
Murphy, M.8
Novotny, W.F.9
Burchmore, M.10
Shak, S.11
Stewart, S.J.12
Press, M.13
-
194
-
-
0031417680
-
Altered gene expression in drug-resistant human breast cancer cells
-
Wosikowski K, Schuurhuis D, Kops GJ, Saceda M & Bates SE 1997 Altered gene expression in drug-resistant human breast cancer cells. Clinical Cancer Research 3 2405-2414.
-
(1997)
Clinical Cancer Research
, vol.3
, pp. 2405-2414
-
-
Wosikowski, K.1
Schuurhuis, D.2
Kops, G.J.3
Saceda, M.4
Bates, S.E.5
-
195
-
-
0028969852
-
Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin
-
Wu X, Fan Z, Masui H, Rosen N & Mendelsohn J 1995 Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. Journal of Clinical Investigation 95 1897-1905.
-
(1995)
Journal of Clinical Investigation
, vol.95
, pp. 1897-1905
-
-
Wu, X.1
Fan, Z.2
Masui, H.3
Rosen, N.4
Mendelsohn, J.5
-
197
-
-
0033372557
-
Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members
-
Xia W, Lau YK, Zhang HZ, Xiao FY, Johnston DA, Liu AR, Li L, Katz RL & Hung MC 1999 Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clinical Cancer Research 5 4164-4174.
-
(1999)
Clinical Cancer Research
, vol.5
, pp. 4164-4174
-
-
Xia, W.1
Lau, Y.K.2
Zhang, H.Z.3
Xiao, F.Y.4
Johnston, D.A.5
Liu, A.R.6
Li, L.7
Katz, R.L.8
Hung, M.C.9
-
198
-
-
0037099532
-
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
-
Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S & Arteaga CL 2002 Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt is required for antibody-mediated effects on p27, cyclin D1, and antitumor action. Cancer Research 62 4132-4141.
-
(2002)
Cancer Research
, vol.62
, pp. 4132-4141
-
-
Yakes, F.M.1
Chinratanalab, W.2
Ritter, C.A.3
King, W.4
Seelig, S.5
Arteaga, C.L.6
-
199
-
-
0033590602
-
Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225
-
Ye D, Mendelsohn J & Fan Z 1999 Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225. Oncogene 18 731-738.
-
(1999)
Oncogene
, vol.18
, pp. 731-738
-
-
Ye, D.1
Mendelsohn, J.2
Fan, Z.3
-
200
-
-
0032542281
-
Dual effects of erbB-2 depletion on the regulation of DNA repair and cell cycle mechanisms in non-small cell lung cancer cells
-
You XL, Zeng-Rong N, Al Moustafa AE & Alaoui-Jamali MA 1998 Dual effects of erbB-2 depletion on the regulation of DNA repair and cell cycle mechanisms in non-small cell lung cancer cells. Oncogene 17 3177-3186.
-
(1998)
Oncogene
, vol.17
, pp. 3177-3186
-
-
You, X.L.1
Zeng-Rong, N.2
Al Moustafa, A.E.3
Alaoui-Jamali, M.A.4
-
201
-
-
0032214980
-
Overexpression of ErbB-2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase
-
Yu D, Jing T, Liu B, Yao J, Tan M, McDonnell TJ & Hung MC 1998a Overexpression of ErbB-2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. Molecular Cell 2 581-591.
-
(1998)
Molecular Cell
, vol.2
, pp. 581-591
-
-
Yu, D.1
Jing, T.2
Liu, B.3
Yao, J.4
Tan, M.5
McDonnell, T.J.6
Hung, M.C.7
-
202
-
-
0032559889
-
Overexpression of both p185c-erbB2 and pl70mdr-1 renders breast cancer cells highly resistant to taxol
-
Yu D, Liu B, Jing T, Sun D, Price JE, Singletary SE, Ibrahim N, Hortobagyi GN & Hung MC 1998b Overexpression of both p185c-erbB2 and pl70mdr-1 renders breast cancer cells highly resistant to taxol. Oncogene 16 2087-2094.
-
(1998)
Oncogene
, vol.16
, pp. 2087-2094
-
-
Yu, D.1
Liu, B.2
Jing, T.3
Sun, D.4
Price, J.E.5
Singletary, S.E.6
Ibrahim, N.7
Hortobagyi, G.N.8
Hung, M.C.9
-
203
-
-
12644279865
-
Neuregulin 3 (NRG3): A novel neural tissue-enriched protein that binds and activated ErbB4
-
Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Bush J & Godowski PJ 1997 Neuregulin 3 (NRG3): a novel neural tissue-enriched protein that binds and activated ErbB4. PNAS 94 9562-9567.
-
(1997)
PNAS
, vol.94
, pp. 9562-9567
-
-
Zhang, D.1
Sliwkowski, M.X.2
Mark, M.3
Frantz, G.4
Akita, R.5
Sun, Y.6
Hillan, K.7
Crowley, C.8
Bush, J.9
Godowski, P.J.10
-
204
-
-
0002839618
-
Biomarker modulation in tumor and skin biopsy samples from patients with solid tumors following treatment with the pan-ErbB tyrosine kinase inhibitor, CI-1033
-
Zinner RG, Donato NJ, Nemunaitis J, Cunningham CC, Shin HJ, Zentgraf RE, Ayers GD, Glisson BS, Khuri FR, Kies MS, Eiseman I, Lenehan PF, Hong WK & Shin DM 2002 Biomarker modulation in tumor and skin biopsy samples from patients with solid tumors following treatment with the pan-ErbB tyrosine kinase inhibitor, CI-1033. Proceedings of the American Society for Clinical Oncology 21 15.
-
(2002)
Proceedings of the American Society for Clinical Oncology
, vol.21
, pp. 15
-
-
Zinner, R.G.1
Donato, N.J.2
Nemunaitis, J.3
Cunningham, C.C.4
Shin, H.J.5
Zentgraf, R.E.6
Ayers, G.D.7
Glisson, B.S.8
Khuri, F.R.9
Kies, M.S.10
Eiseman, I.11
Lenehan, P.F.12
Hong, W.K.13
Shin, D.M.14
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