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0029898894
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Protein prenylation: Molecular mechanisms and functional consequences
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Reviews the early work on the discovery and properties of protein prenyltransferases, CaaX endoproteolysis, and methyl esterification
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Zhang F.L., Casey P.J. Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65:1996;241-269. Reviews the early work on the discovery and properties of protein prenyltransferases, CaaX endoproteolysis, and methyl esterification.
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Zhang, F.L.1
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Protein isoprenylation and methylation at carboxyl-terminal cysteine residues
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Traces the early work on the discovery of peptide and protein prenylation
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Cox, A.D.1
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High-quality protein knowledge resource: SWISS-PROT and TrEMBL brief
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this is the source for the sequence and postulated functions of the various proteins depicted in Table 1
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Bioinformatics
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O'Donovan, C.1
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Farnesyltransferase inhibitors
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third ed. F. Tamanoi, Sigman D.S. San Diego: Academic Press
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The Enzymes
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Gibbs, J.B.1
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Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies
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Sebti, S.M.1
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Farnesyl transferase inhibitors: A major breakthrough in anticancer therapy?
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Caponigro, F.1
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A phase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer
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Hahn S.M., Bernhard E.J., Regine W., Mohiuddin M., Haller D.G., Stevenson J.P., Smith D., Pramanik B., Tepper J., DeLaney T.F., Kiel K.E., Morrison B., Deutsch P., Muschel R.J., McKenna W.G. A phase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer. Clin. Cancer Res. 8:2002;1065-1072.
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Hahn, S.M.1
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Stevenson, J.P.6
Smith, D.7
Pramanik, B.8
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DeLaney, T.F.10
Kiel, K.E.11
Morrison, B.12
Deutsch, P.13
Muschel, R.J.14
McKenna, W.G.15
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Clinical development of farnesyltransferase inhibitors in leukemias and myelodysplastic syndrome
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Farnesyltransferase inhibitors in breast cancer therapy
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Dy G.K., Adjei A.A. Farnesyltransferase inhibitors in breast cancer therapy. Cancer Invest. 20(Suppl. 2):2002;30-37.
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Dy, G.K.1
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77956703004
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Biochemistry of Rab geranylgeranyltransferase
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3rd ed. F. Tamanoi, Sigman D.S. San Diego: Academic Press. Reviews the mechanistic and X-ray crystallographic studies of GGTase-II
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Seabra M.G. Biochemistry of Rab geranylgeranyltransferase. 3rd ed. Tamanoi F., Sigman D.S. The Enzymes. vol. XXI:2001;131-154 Academic Press, San Diego. Reviews the mechanistic and X-ray crystallographic studies of GGTase-II.
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The Enzymes
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Seabra, M.G.1
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14
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77956681958
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Protein geranylgeranyltransferase type I
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3rd ed. F. Tamanoi, Sigman D.S. San Diego: Academic Press
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Yokayama K., Gelb M.H. Protein geranylgeranyltransferase type I. 3rd ed. Tamanoi F., Sigman D.S. The Enzymes. vol. XXI:2001;105-130 Academic Press, San Diego.
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Yokayama, K.1
Gelb, M.H.2
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0028920240
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CAAX geranylgeranyltransferase transfers farnesyl as efficiently as geranylgeranyl to RhoB
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Mechanism of catalysis by protein farnesyltransferase
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3rd ed. F. Tamanoi, Sigman D.S. San Diego: Academic Press
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Spence R.A., Casey P.J. Mechanism of catalysis by protein farnesyltransferase. 3rd ed. Tamanoi F., Sigman D.S. The Enzymes. vol. XXI:2001;1-18 Academic Press, San Diego.
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Spence, R.A.1
Casey, P.J.2
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77956690026
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Structure of protein farnesyltransferase
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3rd ed. F. Tamanoi, Sigman D.S. San Diego: Academic Press. (Reviews the X-ray crystallographic studies of FTase)
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Terry K.L., Long S.B., Beese L.S. Structure of protein farnesyltransferase. 3rd ed. Tamanoi F., Sigman D.S. The Enzymes. vol. XXI:2001;19-46 Academic Press, San Diego. (Reviews the X-ray crystallographic studies of FTase).
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The Enzymes
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Terry, K.L.1
Long, S.B.2
Beese, L.S.3
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67349170052
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Mutational analysis of protein farnesyltransferase
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3rd ed. F. Tamanoi, Sigman D.S. San Diego: Academic Press
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Urano J., Yang W., Tamanoi F. Mutational analysis of protein farnesyltransferase. 3rd ed. Tamanoi F., Sigman D.S. The Enzymes. vol. XXI:2001;47-80 Academic Press, San Diego.
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Urano, J.1
Yang, W.2
Tamanoi, F.3
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19
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0032480805
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H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate
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Hightower K.E., Huang C., Casey P.J., Fierke C.A. H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate. Biochemistry. 37:1998;15555-15562.
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Fierke, C.A.4
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0031017064
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Evidence for a catalytic role of zinc in protein farnesyltranferase
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Role of metals in the reaction catalyzed by protein farnesyltransferase
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Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I
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0029007293
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A mechanism for posttranslational modifications of proteins by yeast protein farnesyltransferase
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Dolence J.M., Poulter C.D. A mechanism for posttranslational modifications of proteins by yeast protein farnesyltransferase. Proc. Natl. Acad. Sci. USA. 92:1995;5008-5011.
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Dolence, J.M.1
Poulter, C.D.2
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0034646238
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Huang C., Hightower K.E., Fierke C.A. Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state. Biochemistry. 39:2000;2593-2602.
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Huang, C.1
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Fierke, C.A.3
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0029007105
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Protein farnesyltransferases: Kinetics of farnesyl pyrophosphate binding and product release
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Furfine E.S., Leban J.J., Landavazo A., Moomaw J.F., Casey P.J. Protein farnesyltransferases: kinetics of farnesyl pyrophosphate binding and product release. Biochemistry. 34:1995;6857-6862.
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Furfine, E.S.1
Leban, J.J.2
Landavazo, A.3
Moomaw, J.F.4
Casey, P.J.5
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Substrate binding is required for release of product from mammalian protein farnesyltransferase
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Tschantz W.R., Furfine E.S., Casey P.J. Substrate binding is required for release of product from mammalian protein farnesyltransferase. J. Biol. Chem. 272:1997;9989-9993.
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Tschantz, W.R.1
Furfine, E.S.2
Casey, P.J.3
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Reaction path of protein farnesyltransferase at atomic resolution
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Formulation of the reaction pathway for FTase and its relationship to the enzymology of GGTase-II
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Long S.B., Casey P.J., Beese L.S. Reaction path of protein farnesyltransferase at atomic resolution. Nature. 419:2002;645-650. Formulation of the reaction pathway for FTase and its relationship to the enzymology of GGTase-II.
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Long, S.B.1
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Rate-determining processes and the number of simultaneously active sties of D-glyceraldehyde 3-phosphate dehydrogenase
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Trentham, D.R.1
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Role of the carboxyterminal residue in peptide binding to protein farnesyltransferase and protein geranylgeranyltransferase
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Roskoski R., Jr.1
Ritchie, P.A.2
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0035822631
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Time-dependent inhibition of protein farnesyltransferase by a benzodiazepine peptide mimetic
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Roskoski R., Jr.1
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