Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells

Journal of Biological Chemistry

Volumn 273, Issue 17, 1998, Pages 10618-10623

  Lee, Su Jae ^a   Ha, Mahn Joon ^a   Lee, Jeen ^a   Nguyen, PhuongMai ^a   Choi, Yung Hyun ^a   Pirnia, Farzaneh ^a   Kang, Won Ki ^a   Wang, Xiao Fan ^b   Kim, Seong Jin ^a   Trepel, Jane B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PROTEIN P21; PROTEIN P53;

ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE; CELL DEATH; ENZYME INHIBITION; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROSTATE CARCINOMA; TRANSCRIPTION REGULATION;

APOPTOSIS; BASE SEQUENCE; CARRIER PROTEINS; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MALE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROSTATIC NEOPLASMS; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032562711     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.17.10618     Document Type: Article

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