-
1
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos J.L. ras oncogenes in human cancer: a review. Cancer Res. 49:1989;4682-4689.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
3
-
-
0028137615
-
Activators and effectors of ras p21 proteins
-
McCormack F. Activators and effectors of ras p21 proteins. Curr Opin Genet Dev. 4:1994;71-76.
-
(1994)
Curr Opin Genet Dev
, vol.4
, pp. 71-76
-
-
McCormack, F.1
-
4
-
-
0028272507
-
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
-
Leevers S.J., Paterson H.F., Marshall C.J. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature. 369:1994;411-414.
-
(1994)
Nature
, vol.369
, pp. 411-414
-
-
Leevers, S.J.1
Paterson, H.F.2
Marshall, C.J.3
-
5
-
-
0030581475
-
Cell signalling. Raf gets it together
-
Marshall C.J. Cell signalling. Raf gets it together. Nature. 383:1996;127-128.
-
(1996)
Nature
, vol.383
, pp. 127-128
-
-
Marshall, C.J.1
-
6
-
-
0027215820
-
A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
-
Lange-Carter C.A., Pleiman C.M., Gardner A.M., et al. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science. 260:1993;315-319.
-
(1993)
Science
, vol.260
, pp. 315-319
-
-
Lange-Carter, C.A.1
Pleiman, C.M.2
Gardner, A.M.3
-
7
-
-
0026778133
-
The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibres in response to growth factors
-
Ridley A.J., Hall A. The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibres in response to growth factors. Cell. 70:1992;389-399.
-
(1992)
Cell
, vol.70
, pp. 389-399
-
-
Ridley, A.J.1
Hall, A.2
-
8
-
-
0028500187
-
The activation of phosphatidylinositol 3-kinase by Ras
-
Kodaki T., Woscholski R., Hallberg B., et al. The activation of phosphatidylinositol 3-kinase by Ras. Curr Biol. 4:1994;798-806.
-
(1994)
Curr Biol
, vol.4
, pp. 798-806
-
-
Kodaki, T.1
Woscholski, R.2
Hallberg, B.3
-
9
-
-
0030904561
-
The PI3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
-
Kennedy S.G., Wagner A.J., Conzen S.D., et al. The PI3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11:1997;701-713.
-
(1997)
Genes Dev
, vol.11
, pp. 701-713
-
-
Kennedy, S.G.1
Wagner, A.J.2
Conzen, S.D.3
-
10
-
-
0029762606
-
Ras biology in atomic detail
-
McCormick F. Ras biology in atomic detail. Nat Struct Biol. 3:1996;653-655.
-
(1996)
Nat Struct Biol
, vol.3
, pp. 653-655
-
-
McCormick, F.1
-
11
-
-
0020132123
-
Isolation of transforming sequence from a human bladder cancer cell line
-
Shih C., Weinberg R.A. Isolation of transforming sequence from a human bladder cancer cell line. Cell. 29:1982;161-169.
-
(1982)
Cell
, vol.29
, pp. 161-169
-
-
Shih, C.1
Weinberg, R.A.2
-
13
-
-
0027451706
-
The extracellular matrix as a cell survival pathway
-
Meredith J.E., Fazeli B., Schwartz M.A. The extracellular matrix as a cell survival pathway. Mol Biol Cell. 4:1993;953-961.
-
(1993)
Mol Biol Cell
, vol.4
, pp. 953-961
-
-
Meredith, J.E.1
Fazeli, B.2
Schwartz, M.A.3
-
14
-
-
0028057613
-
Disruption of epithelial cell-matrix interactions induces apoptosis
-
Frisch S.M., Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol. 124:1994;619-626.
-
(1994)
J Cell Biol
, vol.124
, pp. 619-626
-
-
Frisch, S.M.1
Francis, H.2
-
15
-
-
0029562231
-
Massive programmed cell death in intestinal cells induced by three-dimensional growth conditions: Suppression by mutant c-Ha-ras oncogene expression
-
Rak J., Mitsuhashi Y., Erdos V., et al. Massive programmed cell death in intestinal cells induced by three-dimensional growth conditions: suppression by mutant c-Ha-ras oncogene expression. J Cell Biol. 131:1995;1587-1598.
-
(1995)
J Cell Biol
, vol.131
, pp. 1587-1598
-
-
Rak, J.1
Mitsuhashi, Y.2
Erdos, V.3
-
16
-
-
0028822834
-
Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
-
Rak J., Mitsuhashi Y., Bayko L., et al. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res. 55:1995;4575-4580.
-
(1995)
Cancer Res
, vol.55
, pp. 4575-4580
-
-
Rak, J.1
Mitsuhashi, Y.2
Bayko, L.3
-
17
-
-
0002457485
-
Ras proto-oncogene activation in human malignancy
-
C.T. Markers, T. Garret, & S. Sell. Totowa, NJ: Humana Press
-
Clark G.J., Der C.J. ras proto-oncogene activation in human malignancy. Markers C.T., Garret T., Sell S. Cellular cancer. 1995;17-52 Humana Press, Totowa, NJ.
-
(1995)
Cellular Cancer
, pp. 17-52
-
-
Clark, G.J.1
Der, C.J.2
-
18
-
-
0029002907
-
Aberrant function of the Ras signal transduction pathway in human breast cancer
-
Clark G.J., Der C.J. Aberrant function of the Ras signal transduction pathway in human breast cancer. Breast Cancer Res Treat. 35:1995;133-144.
-
(1995)
Breast Cancer Res Treat
, vol.35
, pp. 133-144
-
-
Clark, G.J.1
Der, C.J.2
-
19
-
-
0032900619
-
Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis
-
Norgaard P., Law B., Joseph H., et al. Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis. Clin Cancer Res. 5:1999;35-42.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 35-42
-
-
Norgaard, P.1
Law, B.2
Joseph, H.3
-
20
-
-
0030061450
-
Overexpression of the Ras-related TC21/R-Ras2 protein may contribute to the development of human breast cancers
-
Clark G.J., Kinch M.S., Gilmer T.M., Burridge K., Der C.J. Overexpression of the Ras-related TC21/R-Ras2 protein may contribute to the development of human breast cancers. Oncogene. 12:1996;169-176.
-
(1996)
Oncogene
, vol.12
, pp. 169-176
-
-
Clark, G.J.1
Kinch, M.S.2
Gilmer, T.M.3
Burridge, K.4
Der, C.J.5
-
21
-
-
0031465906
-
Proliferation of human malignant astrocytomas is dependent on Ras activation
-
Guha A., Feldkamp M.M., Lau N., Bos G., Pawson A. Proliferation of human malignant astrocytomas is dependent on Ras activation. Oncogene. 15:1997;2755-2765.
-
(1997)
Oncogene
, vol.15
, pp. 2755-2765
-
-
Guha, A.1
Feldkamp, M.M.2
Lau, N.3
Bos, G.4
Pawson, A.5
-
22
-
-
0026747866
-
Isoprenoid addition to ras protein is the critical modification for its membrane association and transforming activity
-
Kato K., Cox A.D., Hisaka M.M., et al. Isoprenoid addition to ras protein is the critical modification for its membrane association and transforming activity. Proc Natl Acad Sci USA. 89:1992;6403-6407.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 6403-6407
-
-
Kato, K.1
Cox, A.D.2
Hisaka, M.M.3
-
23
-
-
0026353346
-
Sequence dependence of protein isoprenylation
-
Moores S.L., Schaber M.D., Mosser S.D., et al. Sequence dependence of protein isoprenylation. J Biol Chem. 166:1991;14603-14610.
-
(1991)
J Biol Chem
, vol.166
, pp. 14603-14610
-
-
Moores, S.L.1
Schaber, M.D.2
Mosser, S.D.3
-
24
-
-
0012915993
-
Lipid modifications or proteins in the Ras superfamily
-
L. Birnbaumer, & B. Dickey. New York: Springer-Verlag
-
Gibbs J.B. Lipid modifications or proteins in the Ras superfamily. Birnbaumer L., Dickey B. GTPases in biology. 1993;335-344 Springer-Verlag, New York.
-
(1993)
GTPases in Biology
, pp. 335-344
-
-
Gibbs, J.B.1
-
25
-
-
0029966304
-
Protein prenyltransferases
-
Casey P.J., Seabra M.C. Protein prenyltransferases. J Biol Chem. 271:1996;5289-5292.
-
(1996)
J Biol Chem
, vol.271
, pp. 5289-5292
-
-
Casey, P.J.1
Seabra, M.C.2
-
26
-
-
0039329306
-
Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetics in vitro
-
James G.L., Goldstein J.L., Brown M.S. Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetics in vitro. J Biol Chem. 266:1995;14603-14610.
-
(1995)
J Biol Chem
, vol.266
, pp. 14603-14610
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
-
27
-
-
0028920240
-
CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB
-
Armstrong S.A., Hannah V.C., Goldstein J.L., et al. CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB. J Biol Chem. 270:1995;7864-7868.
-
(1995)
J Biol Chem
, vol.270
, pp. 7864-7868
-
-
Armstrong, S.A.1
Hannah, V.C.2
Goldstein, J.L.3
-
28
-
-
0030865773
-
Ras farnesyltransferase: A new therapeutic target
-
Leonard D.M. Ras farnesyltransferase: a new therapeutic target. J Med Chem. 40:1997;2971-2990.
-
(1997)
J Med Chem
, vol.40
, pp. 2971-2990
-
-
Leonard, D.M.1
-
29
-
-
0032704708
-
Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
-
Rowinsky E.K., Windle J.J., VonHoff D.D. Ras protein farnesyltransferase: a strategic target for anticancer therapeutic development. J Clin Oncol. 17:1999;3631-3652.
-
(1999)
J Clin Oncol
, vol.17
, pp. 3631-3652
-
-
Rowinsky, E.K.1
Windle, J.J.2
Vonhoff, D.D.3
-
30
-
-
0025194466
-
Inhibition of purified p21Ras farnesyl:protein transferase by Cys-AAX tetrapeptides
-
Reiss Y., Goldstein J.L., Seabra M.C., et al. Inhibition of purified p21Ras farnesyl:protein transferase by Cys-AAX tetrapeptides. Cell. 62:1990;81-88.
-
(1990)
Cell
, vol.62
, pp. 81-88
-
-
Reiss, Y.1
Goldstein, J.L.2
Seabra, M.C.3
-
31
-
-
0028835253
-
A peptidomimetic inhibitor of farnesyl protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
-
Sepp-Lorenzino L., Ma Z., Rands E., et al. A peptidomimetic inhibitor of farnesyl protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res. 55:1995;5302-5309.
-
(1995)
Cancer Res
, vol.55
, pp. 5302-5309
-
-
Sepp-Lorenzino, L.1
Ma, Z.2
Rands, E.3
-
32
-
-
0029150669
-
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
-
Khol N.E., Omer C.A., Conner M.W., et al. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat Med. 1:1995;792-797.
-
(1995)
Nat Med
, vol.1
, pp. 792-797
-
-
Khol, N.E.1
Omer, C.A.2
Conner, M.W.3
-
33
-
-
0028352281
-
Design and structural requirements of potent peptidomimetics inhibitors of p21ras farnesyltransferase
-
Qian Y., Blaskovich M.A., Saleem M., et al. Design and structural requirements of potent peptidomimetics inhibitors of p21ras farnesyltransferase. J Biol Chem. 269:1994;12410-12413.
-
(1994)
J Biol Chem
, vol.269
, pp. 12410-12413
-
-
Qian, Y.1
Blaskovich, M.A.2
Saleem, M.3
-
34
-
-
0029000897
-
Bisubstrate inhibitors of farnesyltransferase: A novel class of specific inhibitors of ras transformed cells
-
Manne V., Yan N., Carboni J.M., et al. Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells. Oncogene. 10:1995;1763-1779.
-
(1995)
Oncogene
, vol.10
, pp. 1763-1779
-
-
Manne, V.1
Yan, N.2
Carboni, J.M.3
-
35
-
-
0029586503
-
Novel tricyclic inhibitors of farnesyl protein transferase
-
Bishop W.R., Bond R., Petrin J., et al. Novel tricyclic inhibitors of farnesyl protein transferase. J Biol Chem. 270:1995;30611-30618.
-
(1995)
J Biol Chem
, vol.270
, pp. 30611-30618
-
-
Bishop, W.R.1
Bond, R.2
Petrin, J.3
-
36
-
-
14344254868
-
Anti-tumour activity of SCH66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumour xenograft models and wap-ras transgenic mice
-
Liu M., Bryant M.S., Chen J., et al. Anti-tumour activity of SCH66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumour xenograft models and wap-ras transgenic mice. Cancer Res. 58:1998;4947-4956.
-
(1998)
Cancer Res
, vol.58
, pp. 4947-4956
-
-
Liu, M.1
Bryant, M.S.2
Chen, J.3
-
37
-
-
0000179877
-
R115777, a novel imidazole farnesyl protein transferase inhibitor (FTI) with potent oral antitumour activity
-
abstr 2169
-
Skrzat S., Angibaud P., Venet M., et al. R115777, a novel imidazole farnesyl protein transferase inhibitor (FTI) with potent oral antitumour activity. Proc Am Assoc Cancer Res. 39:1998;317. abstr 2169.
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 317
-
-
Skrzat, S.1
Angibaud, P.2
Venet, M.3
-
38
-
-
0000506486
-
Farnesyl transferase inhibitor (FTI): Effect of ras activation
-
abstr 2168
-
Todd A.V., Applegate T.L., Fuery C.J., et al. Farnesyl transferase inhibitor (FTI): effect of ras activation. Proc Am Assoc Cancer Res. 39:1998;317. abstr 2168.
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 317
-
-
Todd, A.V.1
Applegate, T.L.2
Fuery, C.J.3
-
39
-
-
0000179875
-
R115777, a selective farnesyl protein transferase inhibitor (FTI) induces anti-angiogenic, apoptotic and anti-proliferative activity in CAPAN-2 and LoVo tumour xenografts
-
abstr 2170
-
Smets G., Xhonneux B., Cornelissen F., et al. R115777, a selective farnesyl protein transferase inhibitor (FTI) induces anti-angiogenic, apoptotic and anti-proliferative activity in CAPAN-2 and LoVo tumour xenografts. Proc Am Assoc Cancer Res. 39:1998;318. abstr 2170.
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 318
-
-
Smets, G.1
Xhonneux, B.2
Cornelissen, F.3
-
40
-
-
0007372993
-
High affinity for FTPase and alternative prenylation contribute individually to K-Ras resistance to FTIs
-
Fiordalisi J.J., Rushton B.C., Toussaint L.G., Johnson R.L., Cox A.D. High affinity for FTPase and alternative prenylation contribute individually to K-Ras resistance to FTIs. Proc Am Assoc Cancer Res. 40:1999;521.
-
(1999)
Proc Am Assoc Cancer Res
, vol.40
, pp. 521
-
-
Fiordalisi, J.J.1
Rushton, B.C.2
Toussaint, L.G.3
Johnson, R.L.4
Cox, A.D.5
-
41
-
-
0029664317
-
Resistance of K-RasB proteins to farnesyltransferase inhibitors in Rat1 cells
-
James G., Goldstein J.L., Brown M.S. Resistance of K-RasB proteins to farnesyltransferase inhibitors in Rat1 cells. Proc Natl Acad Sci USA. 93:1996;4454-4458.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 4454-4458
-
-
James, G.1
Goldstein, J.L.2
Brown, M.S.3
-
42
-
-
0028318136
-
Farnesylytransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of actin cytoskeleton
-
Prendergast G.C., Davide J.P., deSolms S.J., et al. Farnesylytransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of actin cytoskeleton. Mol Cell Biol. 14:1994;4193-4202.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 4193-4202
-
-
Prendergast, G.C.1
Davide, J.P.2
Desolms, S.J.3
-
43
-
-
0028973293
-
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras/Raf complexes
-
Lerner E.C., Qian Y., Blaskovich M.A., et al. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras/Raf complexes. J Biol Chem. 270:1995;26802-26806.
-
(1995)
J Biol Chem
, vol.270
, pp. 26802-26806
-
-
Lerner, E.C.1
Qian, Y.2
Blaskovich, M.A.3
-
44
-
-
0030749458
-
Farnesyltransferase inhibitors and cancer treatment: Targeting simply ras?
-
Cox A.D., Der C.J. Farnesyltransferase inhibitors and cancer treatment: targeting simply ras? Biochim Biophys Acta. 1333:1997;F51-71.
-
(1997)
Biochim Biophys Acta
, vol.1333
, pp. 51-71
-
-
Cox, A.D.1
Der, C.J.2
-
45
-
-
0031004491
-
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells
-
Miquel K., Pradines A., Sun J., et al. GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells. Cancer Res. 57:1997;1846-1850.
-
(1997)
Cancer Res
, vol.57
, pp. 1846-1850
-
-
Miquel, K.1
Pradines, A.2
Sun, J.3
-
46
-
-
0032493641
-
A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild-type tumor cells
-
Sepp-Lorenzino L., Rosen N. A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild-type tumor cells. J Biol Chem. 273:1998;20243-20251.
-
(1998)
J Biol Chem
, vol.273
, pp. 20243-20251
-
-
Sepp-Lorenzino, L.1
Rosen, N.2
-
47
-
-
0033016719
-
Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB
-
Du W., Lebowitz P.F., Prendergast G.C. Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Mol Cell Biol. 19:1999;1831-1840.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1831-1840
-
-
Du, W.1
Lebowitz, P.F.2
Prendergast, G.C.3
-
48
-
-
0031050738
-
Farnesylytransferase inhibitors induce apoptosis of ras-transformed cells denied substratum attachment
-
Lebowitz P.F., Sakamuro D., Prendergast G.C. Farnesylytransferase inhibitors induce apoptosis of ras-transformed cells denied substratum attachment. Cancer Res. 57:1997;708-713.
-
(1997)
Cancer Res
, vol.57
, pp. 708-713
-
-
Lebowitz, P.F.1
Sakamuro, D.2
Prendergast, G.C.3
-
49
-
-
0032417689
-
Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells
-
Suzuki N., Urano J., Tamanoi F. Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells. Proc Natl Acad Sci USA. 95:1998;15356-15361.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15356-15361
-
-
Suzuki, N.1
Urano, J.2
Tamanoi, F.3
-
50
-
-
0033539952
-
Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects
-
Feldkamp M.M., Lau N., Guha A. Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects. Oncogene. 18:1999;7514-7526.
-
(1999)
Oncogene
, vol.18
, pp. 7514-7526
-
-
Feldkamp, M.M.1
Lau, N.2
Guha, A.3
-
51
-
-
0033198386
-
Activation of the PI3'K-AKT pathway masks the pro-apoptotic effects of farnesyltransferase inhibitors
-
Du W., Liu A., Prendergast G.C. Activation of the PI3'K-AKT pathway masks the pro-apoptotic effects of farnesyltransferase inhibitors. Cancer Res. 59:1999;4208-4212.
-
(1999)
Cancer Res
, vol.59
, pp. 4208-4212
-
-
Du, W.1
Liu, A.2
Prendergast, G.C.3
-
52
-
-
0032539559
-
Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones
-
Moasser M.M., Sepp-Lorenzino L., Khol N.E., et al. Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones. Proc Natl Acad Sci USA. 95:1998;1369-1374.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1369-1374
-
-
Moasser, M.M.1
Sepp-Lorenzino, L.2
Khol, N.E.3
-
53
-
-
0000546214
-
Combined cell cycle and cytotoxic effects of paclitaxel and R115777, a specific inhibitor of p21 ras function and protein farnesylation in human prostate and breast carcinoma cell lines
-
abstr
-
Ranganathan S., McCauley R.A., Hudes G.R. Combined cell cycle and cytotoxic effects of paclitaxel and R115777, a specific inhibitor of p21 ras function and protein farnesylation in human prostate and breast carcinoma cell lines. Proc Am Assoc Cancer Res. 40:1999;A3448. abstr.
-
(1999)
Proc Am Assoc Cancer Res
, vol.40
, pp. 3448
-
-
Ranganathan, S.1
McCauley, R.A.2
Hudes, G.R.3
-
54
-
-
0000546213
-
Interaction of the farnesyl protein transferase inhibitor R115777 with cytotoxic chemotherapeutics in vitro and in vivo
-
abstr
-
Skrazt S.G., Bowden C.R., End D.W. Interaction of the farnesyl protein transferase inhibitor R115777 with cytotoxic chemotherapeutics in vitro and in vivo. Proc Am Assoc Cancer Res. 40:1999;A3447. abstr.
-
(1999)
Proc Am Assoc Cancer Res
, vol.40
, pp. 3447
-
-
Skrazt, S.G.1
Bowden, C.R.2
End, D.W.3
-
55
-
-
0000229537
-
Enhanced efficacy of the farnesyl protein transferase inhibitor SCH66336 in combination with paclitaxel
-
abstr
-
Shi B., Gurnani M., Yaremko B., et al. Enhanced efficacy of the farnesyl protein transferase inhibitor SCH66336 in combination with paclitaxel. Proc Am Assoc Cancer Res. 40:1999;A3457. abstr.
-
(1999)
Proc Am Assoc Cancer Res
, vol.40
, pp. 3457
-
-
Shi, B.1
Gurnani, M.2
Yaremko, B.3
-
56
-
-
0039921552
-
The farnesyl transferase inhibitor SCH66336 induces cell cycle changes in sensitive human tumor cell lines and prevents the farnesylation of the centromere associated proteins CENP-E and CENP-F
-
abstr
-
Ashar H.R., James L., Gray K., et al. The farnesyl transferase inhibitor SCH66336 induces cell cycle changes in sensitive human tumor cell lines and prevents the farnesylation of the centromere associated proteins CENP-E and CENP-F. Proc Am Assoc Cancer Res. 41:2000;A1398. abstr.
-
(2000)
Proc Am Assoc Cancer Res
, vol.41
, pp. 1398
-
-
Ashar, H.R.1
James, L.2
Gray, K.3
-
57
-
-
0000097049
-
The farnesyl protein transferase (FTPase) inhibitor L-788,123 in patients with solid cancers
-
abstr
-
Britten C.D., Rowinsky E., Yao S.-L., et al. The farnesyl protein transferase (FTPase) inhibitor L-788,123 in patients with solid cancers. Proc Am Soc Clin Oncol. 18:1999;A597. abstr.
-
(1999)
Proc Am Soc Clin Oncol
, vol.18
, pp. 597
-
-
Britten, C.D.1
Rowinsky, E.2
Yao, S.-L.3
-
58
-
-
0000322353
-
Phase I trial of the farnesyl protein transferase (FPTase) inhibitor L-778,123 on a 14 or 28-day dosing schedule
-
abstr
-
Rubin E., Abbruzzese L.J., Morrison B.W., et al. Phase I trial of the farnesyl protein transferase (FPTase) inhibitor L-778,123 on a 14 or 28-day dosing schedule. Proc Am Soc Clin Oncol. 19:2000;A689. abstr.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
, pp. 689
-
-
Rubin, E.1
Abbruzzese, L.J.2
Morrison, B.W.3
-
59
-
-
0000441628
-
Phase I clinical trial of the farnesyltransferase inhibitor BMS-214662 in patients with advanced solid tumors
-
abstr
-
Ryan D.P., Eder J.P., Supko J.G., et al. Phase I clinical trial of the farnesyltransferase inhibitor BMS-214662 in patients with advanced solid tumors. Proc Am Soc Clin Oncol. 19:2000;A720. abstr.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
, pp. 720
-
-
Ryan, D.P.1
Eder, J.P.2
Supko, J.G.3
-
60
-
-
0008144459
-
Pharmacokinetics and pharmacodynamics of the farnesyltransferase inhibitor BMS-214662 in patients with advanced solid tumors
-
abstr
-
Sonnichsen D., Damle B., Manning J., et al. Pharmacokinetics and pharmacodynamics of the farnesyltransferase inhibitor BMS-214662 in patients with advanced solid tumors. Proc Am Soc Clin Oncol. 19:2000;A691. abstr.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
, pp. 691
-
-
Sonnichsen, D.1
Damle, B.2
Manning, J.3
-
61
-
-
0034071688
-
A phase I trial of the farnesyl transferase inhibitor SCH66336: Evidence for biological and clinical activity
-
Adjei A.A., Erlichman C., Davis J.D., et al. A phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity. Cancer Res. 60:2000;1871-1877.
-
(2000)
Cancer Res
, vol.60
, pp. 1871-1877
-
-
Adjei, A.A.1
Erlichman, C.2
Davis, J.D.3
-
62
-
-
0000494252
-
Phase I and pharmacokinetic study of SCH66336, a novel FPTI using a 2-week on, 2-week off schedule
-
abstr
-
Hurwitz H.I., Colvin O.M., Petros W.P., et al. Phase I and pharmacokinetic study of SCH66336, a novel FPTI using a 2-week on, 2-week off schedule. Proc Am Soc Clin Oncol. 18:1999;A599. abstr.
-
(1999)
Proc Am Soc Clin Oncol
, vol.18
, pp. 599
-
-
Hurwitz, H.I.1
Colvin, O.M.2
Petros, W.P.3
-
63
-
-
0000375697
-
Phase I and pharmacologic study of continuous daily oral SCH66336, a novel farnesyl transferase inhibitor in patients with solid tumors
-
abstr
-
Eskens F., Awada A., Verweij J., et al. Phase I and pharmacologic study of continuous daily oral SCH66336, a novel farnesyl transferase inhibitor in patients with solid tumors. Proc Am Soc Clin Oncol. 18:1999;A600. abstr.
-
(1999)
Proc Am Soc Clin Oncol
, vol.18
, pp. 600
-
-
Eskens, F.1
Awada, A.2
Verweij, J.3
-
64
-
-
18544412314
-
Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer
-
Zujewski J., Horak I.D., Bol C.J., et al. Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer. J Clin Oncol. 18:2000;927-935.
-
(2000)
J Clin Oncol
, vol.18
, pp. 927-935
-
-
Zujewski, J.1
Horak, I.D.2
Bol, C.J.3
-
65
-
-
0000535592
-
Phase I clinical and pharmacokinetic trial of the farnesylytransferase inhibitor R115777 on a 21-day dosing schedule
-
abstr
-
Hudes G.R., Schol J., Baab J., et al. Phase I clinical and pharmacokinetic trial of the farnesylytransferase inhibitor R115777 on a 21-day dosing schedule. Proc Am Soc Clin Oncol. 18:1999;A601. abstr.
-
(1999)
Proc Am Soc Clin Oncol
, vol.18
, pp. 601
-
-
Hudes, G.R.1
Schol, J.2
Baab, J.3
-
66
-
-
0000165190
-
Phase I and pharmacokinetic study with the novel farnesyltransferase inhibitor R115777
-
abstr
-
Schellens J.H., deKlerk G., Swart M., et al. Phase I and pharmacokinetic study with the novel farnesyltransferase inhibitor R115777. Proc Am Soc Clin Oncol. 19:2000;A715. abstr.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
, pp. 715
-
-
Schellens, J.H.1
Deklerk, G.2
Swart, M.3
-
67
-
-
0001133883
-
A phase I and PK study of farnesyl transferase inhibitor L-788,123 adminstered as a seven day continuous infusion in combination with paclitaxel
-
abstr
-
Sharma S., Britten C., Spriggs D., et al. A phase I and PK study of farnesyl transferase inhibitor L-788,123 adminstered as a seven day continuous infusion in combination with paclitaxel. Proc Am Soc Clin Oncol. 19:2000;A719. abstr.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
, pp. 719
-
-
Sharma, S.1
Britten, C.2
Spriggs, D.3
-
68
-
-
0003054845
-
Phase I study of farnesyltransferase inhibitor SCH66336 with paclitaxel in solid tumours: Dose-finding, pharmacokinetics, efficacy/safety
-
abstr
-
Khuri F.R., Glisson B.S., Meyers M.L., et al. Phase I study of farnesyltransferase inhibitor SCH66336 with paclitaxel in solid tumours: dose-finding, pharmacokinetics, efficacy/safety. Proc Am Soc Clin Oncol. 19:2000;A799. abstr.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
, pp. 799
-
-
Khuri, F.R.1
Glisson, B.S.2
Meyers, M.L.3
-
69
-
-
0001133884
-
A phase I pharmacokinetic study of the farnesyltransferase inhibitor R115777 in combination with gemcitabine
-
Patnik A., Eckhardht S., Itzbicka E., et al. A phase I pharmacokinetic study of the farnesyltransferase inhibitor R115777 in combination with gemcitabine. Proc Am Soc Clin Oncol. 19:2000;A5A.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
-
-
Patnik, A.1
Eckhardht, S.2
Itzbicka, E.3
-
70
-
-
0000144681
-
Phase I pharmacokinetic trial of the farnesyl transferase inhibitor SCH66336 plus gemcitabine in advanced cancers
-
abstr
-
Hurwitz H.I., Amado R., Prager D., et al. Phase I pharmacokinetic trial of the farnesyl transferase inhibitor SCH66336 plus gemcitabine in advanced cancers. Proc Am Soc Clin Oncol. 19:2000;A717. abstr.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
, pp. 717
-
-
Hurwitz, H.I.1
Amado, R.2
Prager, D.3
-
71
-
-
0003221837
-
Phase I combination trial of the farnesyltransferase inhibitor R115777 with a 5FU/LV regimen in advanced colorectal or pancreatic cancer
-
abstr
-
Peeters M., VanCustem E., Marse H., et al. Phase I combination trial of the farnesyltransferase inhibitor R115777 with a 5FU/LV regimen in advanced colorectal or pancreatic cancer. Proc Am Soc Clin Oncol. 18:1999;A859. abstr.
-
(1999)
Proc Am Soc Clin Oncol
, vol.18
, pp. 859
-
-
Peeters, M.1
Vancustem, E.2
Marse, H.3
-
72
-
-
0029921232
-
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras transformed rat embryo fibroblasts
-
Bernhard E.J., Kao G., Cox A.D., et al. The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras transformed rat embryo fibroblasts. Cancer Res. 56:1996;1727-1730.
-
(1996)
Cancer Res
, vol.56
, pp. 1727-1730
-
-
Bernhard, E.J.1
Kao, G.2
Cox, A.D.3
-
73
-
-
0032522849
-
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes
-
Bernhard E.J., McKenna W.G., Hamilton A.D., et al. Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes. Cancer Res. 58:1998;1754-1761.
-
(1998)
Cancer Res
, vol.58
, pp. 1754-1761
-
-
Bernhard, E.J.1
McKenna, W.G.2
Hamilton, A.D.3
-
75
-
-
0000322356
-
Phase I trial of farnesyl protein transferase inhibitor L-778,123 in combination with radiotherapy
-
abstr
-
Hahn S.M., Kiel K., Morrison B.W., et al. Phase I trial of farnesyl protein transferase inhibitor L-778,123 in combination with radiotherapy. Proc Am Soc Clin Oncol. 19:2000;A906. abstr.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
, pp. 906
-
-
Hahn, S.M.1
Kiel, K.2
Morrison, B.W.3
-
76
-
-
0003017679
-
Use of farnesyl transferase inhibitor R115777 in relapsed and refractory acute leukemias: Preliminary results of a phase I trial
-
abstr
-
Lancet J., Rosenblatt J.L., Liesveld J.L., et al. Use of farnesyl transferase inhibitor R115777 in relapsed and refractory acute leukemias: preliminary results of a phase I trial. Proc Am Soc Clin Oncol. 19:2000;A5B. abstr.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
-
-
Lancet, J.1
Rosenblatt, J.L.2
Liesveld, J.L.3
-
77
-
-
0000968068
-
A phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced breast cancer
-
abstr
-
Johnston S.R.D., Ellis P.A., Houston S., et al. A phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced breast cancer. Proc Am Soc Clin Oncol. 19:2000;A318. abstr.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
, pp. 318
-
-
Johnston, S.R.D.1
Ellis, P.A.2
Houston, S.3
-
78
-
-
0034084316
-
Comparison of potential markers of farnesyltransferase inhibition
-
Adeji A.A., Davis J.N., Erlichman C., Svingen P.A., Kaufmann S.H. Comparison of potential markers of farnesyltransferase inhibition. Clin Cancer Res. 6:2000;2318-2325.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2318-2325
-
-
Adeji, A.A.1
Davis, J.N.2
Erlichman, C.3
Svingen, P.A.4
Kaufmann, S.H.5
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