Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in node mouse xenografts

Oncogene

Volumn 16, Issue 11, 1998, Pages 1467-1473

  Sun, Jiazhi ^a   Qian, Yimin ^b   Hamilton, Andrew D ^b   Sebti, Saïd M ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Farnesyltransferase; Geranylgeranyltransferase; Prenylation and antitumor efficacy; Ras

Indexed keywords

FARNESYL TRANS TRANSFERASE; GERANYLGERANYLTRANSFERASE 1; GERANYLGERANYLTRANSFERASE INHIBITOR; GERANYLTRANSFERASE; GGTI 297; MITOGEN ACTIVATED PROTEIN KINASE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; ONCOPROTEIN; PRENYLAMINE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; INTRAPERITONEAL DRUG ADMINISTRATION; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE N RAS; ONCOGENE RAS; PRENYLATION; PRIORITY JOURNAL; PROTEIN PROCESSING; TUMOR GROWTH; XENOGRAFT;

ANIMALIA; MUS MUSCULUS;

EID: 0032546264     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1201656     Document Type: Article

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