High Affinity for Farnesyltransferase and Alternative Prenylation Contribute Individually to K-Ras4B Resistance to Farnesyltransferase Inhibitors

Journal of Biological Chemistry

Volumn 278, Issue 43, 2003, Pages 41718-41727

  Fiordalisi, James J ^a,c   Johnson II, Ronald L ^a   Weinbaum, Carolyn A ^b   Sakabe, Kaoru ^a   Chen, Zhui ^b   Casey, Patrick J ^b   Cox, Adrienne D ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; TUMORS;

CELL GROWTH;

ENZYMES;

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; CHIMERIC PROTEIN; GERANYLTRANSFERASE; K RAS4B PROTEIN; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CELL TRANSFORMATION; COLONY FORMATION; DNA MICROARRAY; DRUG RESISTANCE; ENZYME ACTIVATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRENYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF;

3T3 CELLS; ALKYL AND ARYL TRANSFERASES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELL DIVISION; DNA-BINDING PROTEINS; DRUG RESISTANCE; ENZYME INHIBITORS; ETS-DOMAIN PROTEIN ELK-1; FARNESYLTRANSTRANSFERASE; GENE EXPRESSION PROFILING; HUMANS; MICE; MUTATION; PROTEIN ISOPRENYLATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS P21(RAS); RAS PROTEINS; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA; CERVUS ELAPHUS;

EID: 0142211304     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305733200     Document Type: Article

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