Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 26, 1998, Pages 15356-15361

  Suzuki, Nobutaka ^a   Urano, Jun ^a   Tamanoi, Fuyuhiko ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B 1088; BMS 191563; CASPASE 3; CYTOCHROME C; DIMETHYL SULFOXIDE; DNA FRAGMENT; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE INHIBITOR; SCH 44362; SCH 56582; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; GENE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOCHONDRION; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; RAT;

ALKYL AND ARYL TRANSFERASES; ANDROSTADIENES; ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CASPASES; CELL LINE, TRANSFORMED; CYTOCHROME C GROUP; CYTOSOL; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; FEMALE; FLAVONOIDS; GENES, RAS; HUMANS; INDOLES; KIDNEY; MITOCHONDRIA; OLIGOPEPTIDES; RATS; TUMOR CELLS, CULTURED;

EID: 0032417689     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.26.15356     Document Type: Article

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