-
1
-
-
0037016769
-
Jab1 interacts directly with HIF-1α and regulates its stability
-
Bae, M.-Y., Ahn, M.-Y., Jeong, J.-W., Bae, M.-H., Lee, Y. M., Bae, S.-Y., Park, J.-W., Kim, K.-R. and Kim, K.-W. (2002). Jab1 interacts directly with HIF-1α and regulates its stability. J. Biol. Chem. 277, 9-12.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 9-12
-
-
Bae, M.-Y.1
Ahn, M.-Y.2
Jeong, J.-W.3
Bae, M.-H.4
Lee, Y.M.5
Bae, S.-Y.6
Park, J.-W.7
Kim, K.-R.8
Kim, K.-W.9
-
2
-
-
2642601107
-
Software and database for the analysis of mutations in the VHL gene
-
Beroud, C., Joly, D., Gallou, C., Staroz, F., Orfanelli, M. T. and Junien, C. (1998). Software and database for the analysis of mutations in the VHL gene. Nucleic Acids Res 26, 256-258.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 256-258
-
-
Beroud, C.1
Joly, D.2
Gallou, C.3
Staroz, F.4
Orfanelli, M.T.5
Junien, C.6
-
3
-
-
0035936886
-
HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation
-
Berra, E., Richard, D. E., Gothie, E. and Pouyssegur, J. (2001). HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation. FEBS Lett. 491, 85-90.
-
(2001)
FEBS Lett.
, vol.491
, pp. 85-90
-
-
Berra, E.1
Richard, D.E.2
Gothie, E.3
Pouyssegur, J.4
-
4
-
-
0032900610
-
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
-
Bhattacharya, S., Michels, C. L., Leung, M.-K., Arany, Z. P., Kung, A. L. and Livingston, D. M. (1999). Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 13, 64-75.
-
(1999)
Genes Dev.
, vol.13
, pp. 64-75
-
-
Bhattacharya, S.1
Michels, C.L.2
Leung, M.-K.3
Arany, Z.P.4
Kung, A.L.5
Livingston, D.M.6
-
5
-
-
0035500503
-
Hypoxia, the tumour's gateway to progression along the angiogenic pathway
-
Brahimi-Horn, C., Berra, E. and Pouyssegur, J. (2001). Hypoxia, the tumour's gateway to progression along the angiogenic pathway. Trends Cell Biol. 11, S32-S36.
-
(2001)
Trends Cell Biol.
, vol.11
-
-
Brahimi-Horn, C.1
Berra, E.2
Pouyssegur, J.3
-
6
-
-
0035834409
-
A conserved family of prolyl-4-Hydroxylases that modify HIF
-
Bruick, R. K. and McKnight, S. L. (2001). A conserved family of prolyl-4-Hydroxylases that modify HIF. Science 294, 1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
7
-
-
0029842459
-
Oxygen sensing and molecular adaptation to hypoxia
-
Bunn, H. F. and Poyton, R. O. (1996). Oxygen sensing and molecular adaptation to hypoxia. Physiological Rev. 76, 839-885.
-
(1996)
Physiological Rev.
, vol.76
, pp. 839-885
-
-
Bunn, H.F.1
Poyton, R.O.2
-
8
-
-
0037131271
-
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1α
-
Chan, D. A., Sutphin, P. D., Denko, N. C. and Giaccia, A. J. (2002). Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1α. J. Biol. Chem. 277, 40112-40117.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 40112-40117
-
-
Chan, D.A.1
Sutphin, P.D.2
Denko, N.C.3
Giaccia, A.J.4
-
9
-
-
0037432686
-
Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells
-
Cioffi, C. L., Qin Liu, X., Kosinski, P. A., Garay, M. and Bowen, B. R. (2003) Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. Biochem. Biophys. Res. Commun. 303, 947-953.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.303
, pp. 947-953
-
-
Cioffi, C.L.1
Qin Liu, X.2
Kosinski, P.A.3
Garay, M.4
Bowen, B.R.5
-
10
-
-
0034682783
-
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
Cockman, M. E., Masson, N., Mole, D. R., Jaakkola, P., Chang, G. W., Clifford, S. C., Maher, E. R., Pugh, C. W., Ratcliffe, P. J. and Maxwell, P. H. (2000). Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 275, 25733-25741.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
Masson, N.2
Mole, D.R.3
Jaakkola, P.4
Chang, G.W.5
Clifford, S.C.6
Maher, E.R.7
Pugh, C.W.8
Ratcliffe, P.J.9
Maxwell, P.H.10
-
11
-
-
0033584965
-
EPAS1 trans-activation during hypoxia requires p42/p44 MAPK
-
Conrad, P. W., Freeman, T. L., Beitner-Johnson, D. and Millhorn, D. E. (1999). EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J. Biol. Chem. 274, 33709-33713.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33709-33713
-
-
Conrad, P.W.1
Freeman, T.L.2
Beitner-Johnson, D.3
Millhorn, D.E.4
-
12
-
-
0037117486
-
Structural basis for hif-1α/CBP recognition in the cellular hypoxic response
-
Dames, S. A., Martinez-Yamout, M., Guzman, R. N. D., Dyson, H. J. and Wright, P. E. (2002). Structural basis for hif-1α/CBP recognition in the cellular hypoxic response. Proc. Natl. Acad. Sci. USA 99, 5271-5276.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 5271-5276
-
-
Dames, S.A.1
Martinez-Yamout, M.2
Guzman, R.N.D.3
Dyson, H.J.4
Wright, P.E.5
-
13
-
-
0037180452
-
Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway
-
Dann, C. E. I., Bruick, R. K. and Deisenhofer, J. (2002). Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway. Proc. Natl. Acad. Sci. USA 99, 15351-15356.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 15351-15356
-
-
Dann, C.E.I.1
Bruick, R.K.2
Deisenhofer, J.3
-
14
-
-
0033568576
-
Regulation of the Erythropoietin Gene
-
Ebert, B. L. and Bunn, H. F. (1999). Regulation of the Erythropoietin Gene. Blood 94, 1864-1877.
-
(1999)
Blood
, vol.94
, pp. 1864-1877
-
-
Ebert, B.L.1
Bunn, H.F.2
-
15
-
-
0037449811
-
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIE-1α
-
Elkins, J. M., Hewitson, K. S., McNeill, L. A., Seibel, J. F., Schlemminger, I., Pugh, C. W., Ratcliffe, P. J. and Schofield, C. J. (2003). Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIE-1α. J. Biol. Chem. 278, 1802-1806.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 1802-1806
-
-
Elkins, J.M.1
Hewitson, K.S.2
McNeill, L.A.3
Seibel, J.F.4
Schlemminger, I.5
Pugh, C.W.6
Ratcliffe, P.J.7
Schofield, C.J.8
-
16
-
-
0035476509
-
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α
-
Elson, D. A., Thurston, G., Huang, L. E., Ginzinger, D. G., McDonald, D. M., Johnson, R. S. and Arbeit, J. M. (2001). Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α. Genes Dev. 15, 2520-2532.
-
(2001)
Genes Dev.
, vol.15
, pp. 2520-2532
-
-
Elson, D.A.1
Thurston, G.2
Huang, L.E.3
Ginzinger, D.G.4
McDonald, D.M.5
Johnson, R.S.6
Arbeit, J.M.7
-
17
-
-
0033118983
-
Molecular mechanisms of transcription activation by HLF and HIF1 alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
-
Ema, M., Hirota, K., Mimura, J., Abe, H., Yodoi, J., Sogawa, K., Poellinger, L. and Fujii-Kuriyama, Y. (1999). Molecular mechanisms of transcription activation by HLF and HIF1 alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J. 18, 1905-1914.
-
(1999)
EMBO J.
, vol.18
, pp. 1905-1914
-
-
Ema, M.1
Hirota, K.2
Mimura, J.3
Abe, H.4
Yodoi, J.5
Sogawa, K.6
Poellinger, L.7
Fujii-Kuriyama, Y.8
-
18
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologues define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A. et al. (2001). C. elegans EGL-9 and mammalian homologues define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.R.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
-
19
-
-
0037015677
-
Falkor, a novel cell growth regulator isolated by a functional genetic screen
-
Erez, N., Milyavsky, M., Goldfinger, N., Peles, E., Gudkov, A. V. and Rotter, V. (2002). Falkor, a novel cell growth regulator isolated by a functional genetic screen. Oncogene 21, 6713-6721.
-
(2002)
Oncogene
, vol.21
, pp. 6713-6721
-
-
Erez, N.1
Milyavsky, M.2
Goldfinger, N.3
Peles, E.4
Gudkov, A.V.5
Rotter, V.6
-
20
-
-
0037117479
-
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
-
Freedman, S. J., Sun, Z.-Y. J., Poy, F., Kung, A. L., Livingston, D. M., Wagner, G. and Eck, M. J. (2002). Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α. Proc. Natl. Acad. Sci. USA 99, 5367-5372.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 5367-5372
-
-
Freedman, S.J.1
Sun, Z.-Y.J.2
Poy, F.3
Kung, A.L.4
Livingston, D.M.5
Wagner, G.6
Eck, M.J.7
-
21
-
-
0029785838
-
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene
-
Gnarra, J. R., Zhou, S., Merrill, M. J., Wagner, J. R., Krumm, A., Papavassiliou, E., Oldfield, E. H., Klausner, R. D. and Linehan, W. M. (1996). Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc. Natl. Acad. Sci. USA 93, 10589-10594.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10589-10594
-
-
Gnarra, J.R.1
Zhou, S.2
Merrill, M.J.3
Wagner, J.R.4
Krumm, A.5
Papavassiliou, E.6
Oldfield, E.H.7
Klausner, R.D.8
Linehan, W.M.9
-
22
-
-
0343777395
-
Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions
-
1493
-
Gorlach, A., Camenisch, G., Kvietikova, I., Vogt, L., Wenger, R. H. and Gassmann, M. (2000). Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions. Biochim. Biophys. Acta 1493, 125-134.
-
(2000)
Biochim. Biophys. Acta
, pp. 125-134
-
-
Gorlach, A.1
Camenisch, G.2
Kvietikova, I.3
Vogt, L.4
Wenger, R.H.5
Gassmann, M.6
-
23
-
-
0037189565
-
The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine
-
Gradin, K., Takasaki, C., Fujii-Kuriyama, Y. and Sogawa, K. (2002). The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine. J. Biol. Chem. 277, 23508-23514.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 23508-23514
-
-
Gradin, K.1
Takasaki, C.2
Fujii-Kuriyama, Y.3
Sogawa, K.4
-
24
-
-
0036314978
-
Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein
-
Groulx, I. and Lee, S. (2002). Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol. Cell. Biol. 22, 5319-5336.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5319-5336
-
-
Groulx, I.1
Lee, S.2
-
25
-
-
0034116376
-
The PAS superfamily: Sensors of environmental and developmental signals
-
Gu, Y.-Z., Hogenesch, J. B. and Bradfield, C. A. (2000). The PAS superfamily: sensors of environmental and developmental signals. Annu. Rev. Pharm. Toxicol. 40, 519-561.
-
(2000)
Annu. Rev. Pharm. Toxicol.
, vol.40
, pp. 519-561
-
-
Gu, Y.-Z.1
Hogenesch, J.B.2
Bradfield, C.A.3
-
26
-
-
18544386401
-
Hypoxia inducible factor (HIF) asparagine hydroxylase is identical to Factor Inhibiting HIF (FIH) and is related to the cupin structural family
-
Hewitson, K. S., McNeill, L. A., Riordan, M. V., Tian, Y.-M., Bullock, A. N., Welford, R. W., Elkins, J. M., Oldham, N. J., Bhattacharya, S., Gleadle, J. M. et al. (2002). Hypoxia inducible factor (HIF) asparagine hydroxylase is identical to Factor Inhibiting HIF (FIH) and is related to the cupin structural family. J. Biol. Chem. 277, 26351-26355.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.-M.4
Bullock, A.N.5
Welford, R.W.6
Elkins, J.M.7
Oldham, N.J.8
Bhattacharya, S.9
Gleadle, J.M.10
-
27
-
-
0035651033
-
Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1α activation cascade: Implications for HIF-1α gene therapy
-
Hofer, T., Desbaillets, I., Hopfl, G., Gassmann, M. and Wenger, R. H. (2001). Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1α activation cascade: implications for HIF-1α gene therapy. FASEB J. 15, 2715-2717.
-
(2001)
FASEB J.
, vol.15
, pp. 2715-2717
-
-
Hofer, T.1
Desbaillets, I.2
Hopfl, G.3
Gassmann, M.4
Wenger, R.H.5
-
28
-
-
18444368709
-
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
-
Hon, W. C., Wilson, M. I., Harlos, K., Claridge, T. D., Schofield, C. J., Pugh, C. W., Maxwell, P. H., Ratcliffe, P. J., Stuart, D. I. and Jones, E. Y. (2002). Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL. Nature 417, 975-978.
-
(2002)
Nature
, vol.417
, pp. 975-978
-
-
Hon, W.C.1
Wilson, M.I.2
Harlos, K.3
Claridge, T.D.4
Schofield, C.J.5
Pugh, C.W.6
Maxwell, P.H.7
Ratcliffe, P.J.8
Stuart, D.I.9
Jones, E.Y.10
-
29
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily on redox-sensitive stabilization of its α subunit
-
Huang, L. E., Arany, Z., Livingston, D. M. and Bunn, H. F. (1996). Activation of hypoxia-inducible transcription factor depends primarily on redox-sensitive stabilization of its α subunit. J. Biol. Chem. 271, 32253-32259.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32253-32259
-
-
Huang, L.E.1
Arany, Z.2
Livingston, D.M.3
Bunn, H.F.4
-
30
-
-
0032493368
-
Regulation of hypoxia-inducible factor 1α is mediated by an oxygen-dependent domain via the ubiquitin-proteasome pathway
-
Huang, L. E., Gu, J., Schau, M. and Bunn, H. F. (1998). Regulation of hypoxia-inducible factor 1α is mediated by an oxygen-dependent domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 95, 7987-7992.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
31
-
-
0037131159
-
Sequence determinants in hypoxia inducible factor-1a for hydroxylation by the prolyl hydroxylases PHD1, PHD2 and PHD3
-
Huang, J., Zhao, Q., Mooney, S. M. and Lee, F. S. (2002). Sequence determinants in hypoxia inducible factor-1a for hydroxylation by the prolyl hydroxylases PHD1, PHD2 and PHD3. J. Biol. Chem. 277, 39792-39800.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39792-39800
-
-
Huang, J.1
Zhao, Q.2
Mooney, S.M.3
Lee, F.S.4
-
32
-
-
0029785321
-
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
-
Iliopoulos, O., Levy, A. P., Jiang, C., Kaelin, W. G., Jr and Goldberg, M. A. (1996). Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc. Natl. Acad. Sci. USA 93, 10595-10599.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10595-10599
-
-
Iliopoulos, O.1
Levy, A.P.2
Jiang, C.3
Kaelin W.G., Jr.4
Goldberg, M.A.5
-
33
-
-
0035917313
-
2 sensing
-
2 sensing. Science 292, 464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin, W.G.J.10
-
34
-
-
0037108807
-
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
-
Ivan, M., Haberberger, T., Gervasi, D. C., Michelson, K. S., Gunzler, V., Kondo, K., Yang, H., Sorokina, I., Conaway, R. C., Conaway, J. W. et al. (2002). Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc. Natl. Acad. Sci. USA 99, 13459-13464.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 13459-13464
-
-
Ivan, M.1
Haberberger, T.2
Gervasi, D.C.3
Michelson, K.S.4
Gunzler, V.5
Kondo, K.6
Yang, H.7
Sorokina, I.8
Conaway, R.C.9
Conaway, J.W.10
-
35
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292, 468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.-M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
von Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
-
36
-
-
18744375998
-
Regulation and destabilization of HIF-1α by ARD1-mediated acetylation
-
Jeong, J.-W., Bae, M.-K., Ahn, M.-Y., Kim, S.-H., Sohn, T.-K., Bae, M.-H., Yoo, M.-A., Song, E. J., Lee, K.-J. and Kim, K.-W. (2002). Regulation and destabilization of HIF-1α by ARD1-mediated acetylation. Cell 111, 709-720.
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.-W.1
Bae, M.-K.2
Ahn, M.-Y.3
Kim, S.-H.4
Sohn, T.-K.5
Bae, M.-H.6
Yoo, M.-A.7
Song, E.J.8
Lee, K.-J.9
Kim, K.-W.10
-
37
-
-
0035347260
-
Induction of HIF-1alpha in response to hypoxia is instantaneous
-
Jewell, U. R., Kvietikova, I., Scheid, A., Bauer, C., Wenger, R. H. and Gassmann, M. (2001). Induction of HIF-1alpha in response to hypoxia is instantaneous. FASEB J. 15, 1312-1314.
-
(2001)
FASEB J.
, vol.15
, pp. 1312-1314
-
-
Jewell, U.R.1
Kvietikova, I.2
Scheid, A.3
Bauer, C.4
Wenger, R.H.5
Gassmann, M.6
-
39
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxia-inducible factor 1α. Modulation of transcriptional activity by oxygen tension
-
Jiang, B.-H., Zheng, J. Z., Leung, S. W., Roe, R. and Semenza, G. L. (1997). Transactivation and inhibitory domains of hypoxia-inducible factor 1α. Modulation of transcriptional activity by oxygen tension. J. Biol. Chem. 272, 19253-19260.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19253-19260
-
-
Jiang, B.-H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
40
-
-
0036718539
-
Molecular Basis of the VHL Hereditary Cancer Syndrome
-
Kaelin, W. G. (2002). Molecular Basis of the VHL Hereditary Cancer Syndrome. Nature Rev. Cancer 2, 673-682.
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 673-682
-
-
Kaelin, W.G.1
-
41
-
-
0032538797
-
Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1α
-
Kallio, P. J., Okamoto, K., O'Brien, S., Carrero, P., Makino, Y., Tanaka, H. and Poellinger, L. (1998). Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1α. EMBO J. 17, 6573-6586.
-
(1998)
EMBO J.
, vol.17
, pp. 6573-6586
-
-
Kallio, P.J.1
Okamoto, K.2
O'Brien, S.3
Carrero, P.4
Makino, Y.5
Tanaka, H.6
Poellinger, L.7
-
42
-
-
0033525830
-
Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway
-
Kallio, P. J., Wilson, W. J., O'Brien, S., Makino, Y. and Poellinger, L. (1999). Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway. J. Biol. Chem. 274, 6519-6525.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 6519-6525
-
-
Kallio, P.J.1
Wilson, W.J.2
O'Brien, S.3
Makino, Y.4
Poellinger, L.5
-
44
-
-
0035048449
-
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
-
Kim, M. S., Kwon, H. J., Lee, Y. M., Baek, J. H., Jang, J.-E., Lee, S.-W., Moon, E.-J., Kim, H.-S., Lee, S.-K., Chung, H. Y. et al. (2001). Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat. Med. 7, 437-443.
-
(2001)
Nat. Med.
, vol.7
, pp. 437-443
-
-
Kim, M.S.1
Kwon, H.J.2
Lee, Y.M.3
Baek, J.H.4
Jang, J.-E.5
Lee, S.-W.6
Moon, E.-J.7
Kim, H.-S.8
Lee, S.-K.9
Chung, H.Y.10
-
45
-
-
0031893340
-
Prolyl 4-hydroxylases and their protein disulfide isomerase subunit
-
Kivirikko, K. I. and Myllyharju, J. (1998). Prolyl 4-hydroxylases and their protein disulfide isomerase subunit. Matrix Biol. 16, 357-368.
-
(1998)
Matrix Biol.
, vol.16
, pp. 357-368
-
-
Kivirikko, K.I.1
Myllyharju, J.2
-
46
-
-
0041455270
-
Effect of ascorbate on the activity of hypoxia inducible factor (HIF) in cancer cells
-
Knowles, H. J., Raval, R. R., Harris, A. L. and Ratcliffe, P. J. (2003). Effect of ascorbate on the activity of hypoxia inducible factor (HIF) in cancer cells. Cancer Res. 270, 1900-1915.
-
(2003)
Cancer Res.
, vol.270
, pp. 1900-1915
-
-
Knowles, H.J.1
Raval, R.R.2
Harris, A.L.3
Ratcliffe, P.J.4
-
47
-
-
0036528246
-
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
-
Kondo, K., Kico, J., Nakamura, E., Lechpammer, M. and Kaelin, W. G. J. (2002). Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1, 237-246.
-
(2002)
Cancer Cell
, vol.1
, pp. 237-246
-
-
Kondo, K.1
Kico, J.2
Nakamura, E.3
Lechpammer, M.4
Kaelin, W.G.J.5
-
48
-
-
0344838401
-
von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
-
Kuznetsova, A. V., Meller, J., Schnell, P. O., Nash, J. A., Ignacak, M. L., Sanchez, Y., Conaway, J. W., Conaway, R. C. and Czyzyk-Krzeska, M. F. (2003). von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Proc. Natl. Acad. Sci. USA 100, 2706-2711.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 2706-2711
-
-
Kuznetsova, A.V.1
Meller, J.2
Schnell, P.O.3
Nash, J.A.4
Ignacak, M.L.5
Sanchez, Y.6
Conaway, J.W.7
Conaway, R.C.8
Czyzyk-Krzeska, M.F.9
-
49
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L. and Bruick, R. K. (2002a). FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16, 1466-1471.
-
(2002)
Genes Dev.
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
50
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
-
Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J. and Whitelaw, M. L. (2002b). Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch. Science 295, 858-861.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
51
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner, E., Taghavi, P., Chiles, K., Mahon, P. C. and Semenza, G. L. (2001). HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol. Cell. Biol. 21, 3995-4004.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
52
-
-
0036786483
-
Control of the hypoxic reponse in Drosophila melanogaster by the basic helix-loop-helix PAS protein Similar
-
Lavista-Llanos, S., Centanin, L., Irisarri, M., Russo, D. M., Gleadle, J. M., Bocca, S. N., Muzzopappa, M., Ratcliffe, P. J. and Wappner, P. (2002). Control of the hypoxic reponse in Drosophila melanogaster by the basic helix-loop-helix PAS protein Similar. Mol. Cell. Biol. 22, 6842-6853.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 6842-6853
-
-
Lavista-Llanos, S.1
Centanin, L.2
Irisarri, M.3
Russo, D.M.4
Gleadle, J.M.5
Bocca, S.N.6
Muzzopappa, M.7
Ratcliffe, P.J.8
Wappner, P.9
-
53
-
-
0036433394
-
Mammalian EGLN genes have distinct patterns of mRNA expression and regulation
-
Lieb, M. E., Menzies, K., Moschella, M. C., Ni, R. and Taubman, M. B. (2002). Mammalian EGLN genes have distinct patterns of mRNA expression and regulation. Biochem. Cell Biol. 80, 421-426.
-
(2002)
Biochem. Cell Biol.
, vol.80
, pp. 421-426
-
-
Lieb, M.E.1
Menzies, K.2
Moschella, M.C.3
Ni, R.4
Taubman, M.B.5
-
54
-
-
0035895928
-
SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons
-
Lipscomb, E. A., Sarmiere, P. D. and Freeman, R. S. (2001). SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons. J. Biol. Chem. 276, 5085-5092.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5085-5092
-
-
Lipscomb, E.A.1
Sarmiere, P.D.2
Freeman, R.S.3
-
55
-
-
0035932375
-
A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1α, 2α and 3α)
-
Luo, J. C. and Shibuya, M. (2001). A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1α, 2α and 3α). Oncogene 20, 1435-1444.
-
(2001)
Oncogene
, vol.20
, pp. 1435-1444
-
-
Luo, J.C.1
Shibuya, M.2
-
56
-
-
0030447756
-
Induction of cell growth regulatory genes by p53
-
Madden, S. L., Galella, E. A., Riley, D., Bertelsen, A. H. and Beaudry, G. A. (1996). Induction of cell growth regulatory genes by p53. Cancer Res. 56, 5384-5390.
-
(1996)
Cancer Res.
, vol.56
, pp. 5384-5390
-
-
Madden, S.L.1
Galella, E.A.2
Riley, D.3
Bertelsen, A.H.4
Beaudry, G.A.5
-
57
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon, P. C., Hirota, K. and Semenza, G. L. (2001). FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15, 2675-2686.
-
(2001)
Genes Dev.
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
58
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino, Y., Cao, R., Svensson, K., Bertilsson, G., Asman, M., Tanaka, H., Cao, Y., Berkenstam, A. and Poellinger, L. (2001). Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 414, 550-554.
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
Bertilsson, G.4
Asman, M.5
Tanaka, H.6
Cao, Y.7
Berkenstam, A.8
Poellinger, L.9
-
59
-
-
0037031808
-
IPAS is an hypoxia-inducible splicing variant of the HIF-3a locus
-
Makino, Y., Kanopka, A., Wilson, W. J., Tanaka, H. and Poellinger, L. (2002). IPAS is an hypoxia-inducible splicing variant of the HIF-3a locus. J. Biol. Chem. 277, 32405-32408.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32405-32408
-
-
Makino, Y.1
Kanopka, A.2
Wilson, W.J.3
Tanaka, H.4
Poellinger, L.5
-
60
-
-
0036527785
-
The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma
-
Maranchie, J. K., Vasselli, J. R., Riss, J., Bonifacino, J. S., Linehan, W. M. and Klausner, R. D. (2002). The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 1, 247-255.
-
(2002)
Cancer Cell
, vol.1
, pp. 247-255
-
-
Maranchie, J.K.1
Vasselli, J.R.2
Riss, J.3
Bonifacino, J.S.4
Linehan, W.M.5
Klausner, R.D.6
-
61
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
-
Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W. and Ratcliffe, P. J. (2001). Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J. 20, 5197-5206.
-
(2001)
EMBO J.
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
62
-
-
0027461553
-
Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: Evidence for a widespread oxygen sensing mechanism
-
Maxwell, P. H., Pugh, C. W. and Ratcliffe, P. J. (1993). Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: evidence for a widespread oxygen sensing mechanism. Proc. Natl. Acad. Sci. USA 90, 2423-2427.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 2423-2427
-
-
Maxwell, P.H.1
Pugh, C.W.2
Ratcliffe, P.J.3
-
63
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R. and Ratcliffe, P. J. (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.-W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
64
-
-
0035370253
-
Activation of the HIF pathway in cancer
-
Maxwell, P. H., Pugh, C. W. and Ratcliffe, P. J. (2001). Activation of the HIF pathway in cancer. Curr. Opin. Genet. Dev. 11, 293-299.
-
(2001)
Curr. Opin. Genet. Dev.
, vol.11
, pp. 293-299
-
-
Maxwell, P.H.1
Pugh, C.W.2
Ratcliffe, P.J.3
-
65
-
-
0037837724
-
Multiple splice variants of the human HIF-3α locus are targets of the VHL E3 ubiquitin ligase complex
-
Maynard, M. A., Qi, H., Chung, J., Lee, E. H. L., Kondo, Y., Hara, S., Conaway, R. C., Conaway, J. W. and Ohh, M. (2003). Multiple splice variants of the human HIF-3α locus are targets of the VHL E3 ubiquitin ligase complex. J. Biol. Chem. 278, 11032-11040.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11032-11040
-
-
Maynard, M.A.1
Qi, H.2
Chung, J.3
Lee, E.H.L.4
Kondo, Y.5
Hara, S.6
Conaway, R.C.7
Conaway, J.W.8
Ohh, M.9
-
66
-
-
0036846033
-
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803
-
McNeill, L. A., Hewitson, K. S., Claridge, T. D., Seibel, J. F., Horsfall, L. E. and Schofield, C. J. (2002). Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803. J. Biochem. 367, 571-575.
-
(2002)
J. Biochem.
, vol.367
, pp. 571-575
-
-
McNeill, L.A.1
Hewitson, K.S.2
Claridge, T.D.3
Seibel, J.F.4
Horsfall, L.E.5
Schofield, C.J.6
-
67
-
-
0037386143
-
Intracellular localisation of human HIF-1 alpha hydroxylases: Implications for oxygen sensing
-
Metzen, E., Berchner-Pfannschmidt, U., Stengel, P., Marxsen, J. H., Stolze, I., Klinger, M., Huang, W. Q., Wotzlaw, C., Hellwig-Burgel, T., Jelkmann, W., Acker, H. and Fandrey, J. (2003). Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. J. Cell Sci. 116, 1319-1326.
-
(2003)
J. Cell Sci.
, vol.116
, pp. 1319-1326
-
-
Metzen, E.1
Berchner-Pfannschmidt, U.2
Stengel, P.3
Marxsen, J.H.4
Stolze, I.5
Klinger, M.6
Huang, W.Q.7
Wotzlaw, C.8
Hellwig-Burgel, T.9
Jelkmann, W.10
Acker, H.11
Fandrey, J.12
-
68
-
-
0037035851
-
Structure of an HIF-1α-pVHL complex: Hydroxyproline recognition in signaling
-
Min, J.-H., Yang, H., Ivan, M., Gertler, F., Kaelin, W. G. J. and Pavletich, N. P. (2002). Structure of an HIF-1α-pVHL complex: hydroxyproline recognition in signaling. Science 296, 1886-1889.
-
(2002)
Science
, vol.296
, pp. 1886-1889
-
-
Min, J.-H.1
Yang, H.2
Ivan, M.3
Gertler, F.4
Kaelin, W.G.J.5
Pavletich, N.P.6
-
69
-
-
0033593219
-
Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia inducible factor-1α
-
O'Rourke, J. F., Tian, Y.-M., Ratcliffe, P. J. and Pugh, C. W. (1999). Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia inducible factor-1α. J. Biol. Chem. 274, 2060-2071.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 2060-2071
-
-
O'Rourke, J.F.1
Tian, Y.-M.2
Ratcliffe, P.J.3
Pugh, C.W.4
-
70
-
-
0036391915
-
Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors
-
Oehme, F., Ellinghaus, P., Kolkhof, P., Smith, T. J., Ramakrishnan, S., Hutter, J., Schramm, M. and Flamme, I. (2002). Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors. Biochem. Biophys. Res. Commun. 296, 343-349.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.296
, pp. 343-349
-
-
Oehme, F.1
Ellinghaus, P.2
Kolkhof, P.3
Smith, T.J.4
Ramakrishnan, S.5
Hutter, J.6
Schramm, M.7
Flamme, I.8
-
71
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T. Y., Huang, L. E., Pavletich, N., Chau, V. and Kaelin, W. G. (2000). Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell. Biol. 2, 423-427.
-
(2000)
Nat. Cell. Biol.
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
Huang, L.E.6
Pavletich, N.7
Chau, V.8
Kaelin, W.G.9
-
72
-
-
0033854668
-
The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism
-
Prescott, A. G. and Lloyd, M. D. (2000). The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism. Natural Product Reports 17, 367-383.
-
(2000)
Natural Product Reports
, vol.17
, pp. 367-383
-
-
Prescott, A.G.1
Lloyd, M.D.2
-
73
-
-
0030937718
-
Activation of hypoxia inducible factor-1; definition of regulatory domains within the α subunit
-
Pugh, C. W., O'Rourke, J. F., Nagao, M., Gleadle, J. M. and Ratcliffe, P. J. (1997). Activation of hypoxia inducible factor-1; definition of regulatory domains within the α subunit. J. Biol. Chem. 272, 11205-11214.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11205-11214
-
-
Pugh, C.W.1
O'Rourke, J.F.2
Nagao, M.3
Gleadle, J.M.4
Ratcliffe, P.J.5
-
74
-
-
0032725554
-
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
-
Richard, D. E., Berra, E., Gothie, E., Roux, D. and Pouysségur, J. (1999). p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J. Biol. Chem. 274, 32631-32637.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothie, E.3
Roux, D.4
Pouysségur, J.5
-
75
-
-
0036232662
-
Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP
-
Sang, N., Fang, J., Srinivas, V., Leshchinsky, I. and Caro, J. (2002). Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP. Mol. Cell. Biol. 22, 2984-2992.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2984-2992
-
-
Sang, N.1
Fang, J.2
Srinivas, V.3
Leshchinsky, I.4
Caro, J.5
-
76
-
-
0032760945
-
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
-
Schofield, C. J. and Zhang, Z. (1999). Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes. Curr. Opin. Struct. Biol. 9, 722-731.
-
(1999)
Curr. Opin. Struct. Biol.
, vol.9
, pp. 722-731
-
-
Schofield, C.J.1
Zhang, Z.2
-
77
-
-
0033529656
-
Perspectives on oxygen sensing
-
Semenza, G. L. (1999). Perspectives on oxygen sensing. Cell 98, 281-284.
-
(1999)
Cell
, vol.98
, pp. 281-284
-
-
Semenza, G.L.1
-
78
-
-
0034663989
-
HIF-1 and human disease: One highly involved factor
-
Semenza, G. L. (2000a). HIF-1 and human disease: one highly involved factor. Genes Dev. 14, 1983-1991.
-
(2000)
Genes Dev.
, vol.14
, pp. 1983-1991
-
-
Semenza, G.L.1
-
79
-
-
0034006016
-
HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
-
Semenza, G. L. (2000b). HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol. 88, 1474-1480.
-
(2000)
J. Appl. Physiol.
, vol.88
, pp. 1474-1480
-
-
Semenza, G.L.1
-
80
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza, G. L. and Wang, G. L. (1992). A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12, 5447-5454.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
81
-
-
0037165244
-
Novel estrogen and tamoxifen induced genes identified by SAGE (serial analysis of gene expression)
-
Seth, P., Krop, I., Porter, D. and Polyak, K. (2002). Novel estrogen and tamoxifen induced genes identified by SAGE (serial analysis of gene expression). Oncogene 21, 836-843.
-
(2002)
Oncogene
, vol.21
, pp. 836-843
-
-
Seth, P.1
Krop, I.2
Porter, D.3
Polyak, K.4
-
82
-
-
0034712939
-
Hypoxia-inducible factor 1a protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
-
Sutter, C. H., Laughner, E. and Semenza, G. L. (2000). Hypoxia-inducible factor 1a protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc. Natl. Acad. Sci. USA 97, 4748-4753.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 4748-4753
-
-
Sutter, C.H.1
Laughner, E.2
Semenza, G.L.3
-
83
-
-
0035812318
-
Characterization and comparative analysis of the EGLN gene family
-
Taylor, M. S. (2001). Characterization and comparative analysis of the EGLN gene family. Gene 275, 125-132.
-
(2001)
Gene
, vol.275
, pp. 125-132
-
-
Taylor, M.S.1
-
84
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
-
Treins, C., Giorgetti-Peraldi, S., Murdaca, J., Semenza, G. L. and Van Obberghen, E. (2002). Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J. Biol. Chem. 277, 27975-27981.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
Van Obberghen, E.5
-
85
-
-
0032552110
-
Structure of a cephalosporin synthase
-
Valegard, K., van Scheltinga, A. C. T., Lloyd, M. D., Hara, T., Ramaswamy, S., Perrakis, A., Thompson, A., Lee, H. J., Baldwin, J. E., Schofield, C. J. et al. (1998). Structure of a cephalosporin synthase. Nature 394, 805-809.
-
(1998)
Nature
, vol.394
, pp. 805-809
-
-
Valegard, K.1
van Scheltinga, A.C.T.2
Lloyd, M.D.3
Hara, T.4
Ramaswamy, S.5
Perrakis, A.6
Thompson, A.7
Lee, H.J.8
Baldwin, J.E.9
Schofield, C.J.10
-
86
-
-
0034739533
-
Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor
-
Vincent, K. A., Shyu, K. G., Luo, Y., Magner, M., Tio, R. A., Jiang, C., Goldberg, M. A., Akita, G. Y., Gregory, R. J. and Isner, J. M. (2000). Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor. Circulation 102, 2255-2261.
-
(2000)
Circulation
, vol.102
, pp. 2255-2261
-
-
Vincent, K.A.1
Shyu, K.G.2
Luo, Y.3
Magner, M.4
Tio, R.A.5
Jiang, C.6
Goldberg, M.A.7
Akita, G.Y.8
Gregory, R.J.9
Isner, J.M.10
-
87
-
-
0027136260
-
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
-
Wang, G. L. and Semenza, G. L. (1993). Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82, 3610-3615.
-
(1993)
Blood
, vol.82
, pp. 3610-3615
-
-
Wang, G.L.1
Semenza, G.L.2
-
89
-
-
0028298483
-
Identification of a novel growth factor-responsive gene in vascular smooth muscle cells
-
Wax, S. D., Rosenfield, C. L. and Taubman, M. B. (1994). Identification of a novel growth factor-responsive gene in vascular smooth muscle cells. J. Biol. Chem. 269, 13041-13047.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 13041-13047
-
-
Wax, S.D.1
Rosenfield, C.L.2
Taubman, M.B.3
-
90
-
-
0034107952
-
Mammalian oxygen sensing, signalling and gene regulation
-
Wenger, R. H. (2000). Mammalian oxygen sensing, signalling and gene regulation. J. Exp. Biol. 20, 1253-1263.
-
(2000)
J. Exp. Biol.
, vol.20
, pp. 1253-1263
-
-
Wenger, R.H.1
-
91
-
-
0036320934
-
2-regulated gene expression
-
2-regulated gene expression. FASEB J. 16, 1151-1162.
-
(2002)
FASEB J.
, vol.16
, pp. 1151-1162
-
-
Wenger, R.H.1
-
92
-
-
0036667348
-
Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis
-
William, C., Masson, N., Tian, Y. M., Mahmood, S. A., Wilson, M. I., Bicknell, R., Eckardt, K. U., Maxwell, P. H., Ratcliffe, P. J. and Pugh, C. W. (2002). Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis. Proc. Natl. Acad. Sci. USA 99, 10423-10428.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10423-10428
-
-
William, C.1
Masson, N.2
Tian, Y.M.3
Mahmood, S.A.4
Wilson, M.I.5
Bicknell, R.6
Eckardt, K.U.7
Maxwell, P.H.8
Ratcliffe, P.J.9
Pugh, C.W.10
-
93
-
-
0035859692
-
HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu, F., White, S. B., Zhao, Q. and Lee, F. S. (2001). HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. USA 98, 9630-9635.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.B.2
Zhao, Q.3
Lee, F.S.4
-
94
-
-
0037844847
-
Cobalt inhibits the interaction between hypoxia inducible factor-α and von Hippel-Lindau protein by direct binding to hypoxia inducible factor-α
-
Yuan, Y., Hilliard, G., Ferguson, T. and Millhorn, D. E. (2003). Cobalt inhibits the interaction between hypoxia inducible factor-α and von Hippel-Lindau protein by direct binding to hypoxia inducible factor-α. J. Biol. Chem. 278, 15911-15916.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 15911-15916
-
-
Yuan, Y.1
Hilliard, G.2
Ferguson, T.3
Millhorn, D.E.4
-
95
-
-
0033981009
-
Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase
-
Zhang, Z. H., Ren, J. S., Stammers, D. K., Baldwin, J. E., Harlos, K. and Schofield, C. J. (2000). Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase. Nat. Struct. Biol. 7, 127-133.
-
(2000)
Nat. Struct. Biol.
, vol.7
, pp. 127-133
-
-
Zhang, Z.H.1
Ren, J.S.2
Stammers, D.K.3
Baldwin, J.E.4
Harlos, K.5
Schofield, C.J.6
-
96
-
-
0032583527
-
Substrate binding to the alpha-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: Coupling mechanism of oxidative decarboxylation and hydroxylation
-
Zhou, J., Gunsior, M., Bachmann, B. O., Townsend, C. A. and Solomon, E. I. (1998). Substrate binding to the alpha-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: coupling mechanism of oxidative decarboxylation and hydroxylation. J. Am. Chem. Soc. 120, 13539-13540.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 13539-13540
-
-
Zhou, J.1
Gunsior, M.2
Bachmann, B.O.3
Townsend, C.A.4
Solomon, E.I.5
-
97
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F., Chen, E., Gottschalk, A. R., Ryan, H. E., Johnson, R. S., Jefferson, A. B. et al. (2000). Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 14, 391-396.
-
(2000)
Genes Dev.
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
Gottschalk, A.R.7
Ryan, H.E.8
Johnson, R.S.9
Jefferson, A.B.10
|