Cobalt inhibits the interaction between hypoxia-inducible factor-α and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-α

Journal of Biological Chemistry

Volumn 278, Issue 18, 2003, Pages 15911-15916

  Yuan, Yong ^b   Hilliard, George ^b   Ferguson, Tsuneo ^b   Millhorn, David E ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CHEMICAL BONDS; COBALT; DEGRADATION; ENZYME KINETICS; GENES; HYDROXYLATION;

HYPOXIA-INDUCIBLE FACTORS (HIF);

PROTEINS;

AMINO ACID; COBALT; GENE PRODUCT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; OXYGEN; PROLINE; PROTEASOME; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DEFEROXAMINE; DRUG DERIVATIVE; GLYCINE; HYPOXIA INDUCIBLE FACTOR 2, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR 2, ALPHA SUBUNIT; LIGASE; PC 12; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL STRAIN; HYDROXYLATION; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ANIMAL; CHEMISTRY; CHO CELL; HAMSTER; METABOLISM; MOLECULAR GENETICS; RAT;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CHO CELLS; COBALT; CRICETINAE; DEFEROXAMINE; GLYCINE; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIGASES; MOLECULAR SEQUENCE DATA; RATS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0037844847     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300463200     Document Type: Article

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