Mammalian oxygen sensing, signalling and gene regulation

Journal of Experimental Biology

Volumn 203, Issue 8, 2000, Pages 1253-1263

  Wenger, Roland H ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Dioxin receptor; Erythropoietin; Haem protein; Hypoxia inducible factor; PAS domain; Protein stability

Indexed keywords

DNA BINDING PROTEIN; HEME; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NUCLEAR PROTEIN; OXYGEN; TRANSCRIPTION FACTOR;

ANIMAL; ANOXIA; CELL HYPOXIA; DIMERIZATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANOXIA; CELL HYPOXIA; DIMERIZATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HEME; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NUCLEAR PROTEINS; OXYGEN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0034107952     PISSN: 00220949     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (127)

1. Acker, H. (1994). Mechanisms and meaning of cellular oxygen sensing in the organism. Respir. Physiol. 95, 1-10.
2. 2 sensor in the rat carotid body. FEBS Lett. 256, 75-78.
3. Agani, F. and Semenza, G. L. (1998). Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity. Mol. Pharmac. 54, 749-754.
4. Arany, Z., Huang, L. E., Eckner, R., Bhattacharya, S., Jiang, C., Goldberg, M. A., Bunn, H. F. and Livingston, D. M. (1996). An essential role for p300/CBP in the cellular response to hypoxia. Proc. Natl. Acad. Sci. USA 93, 12969-12973.
5. phox subunit of NADPH oxidase. Proc. Natl. Acad. Sci. USA 96, 7944-7949.
6. Bhattacharya, S., Michels, C. L., Leung, M. K., Arany, Z. P., Kung, A. L. and Livingston, D. M. (1999). Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 13, 64-75.
7. 2 sensor. J. Biol. Chem. 273, 3320-3326.
8. Bunn, H. F. and Poyton, R. O. (1996). Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76, 839-885.
9. Canbolat, O., Fandrey, J. and Jelkmann, W. (1998). Effects of modulators of the production and degradation of hydrogen peroxide on erythropoietin synthesis. Respir. Physiol. 114, 175-183.
10. Carrero, P., Okamoto, K., Coumailleau, P., O'Brien, S., Tanaka, H. and Poellinger, L. (2000). Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1α. Mol. Cell. Biol. 20, 402-415.
11. Chandel, N. S., Budinger, G. R., Choe, S. H. and Schumacker, P. T. (1997). Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes. J. Biol. Chem. 272, 18808-18816.
12. Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C. and Schumacker, P. T. (1998). Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc. Natl. Acad. Sci. USA 95, 11715-11720.
13. Chilov, D., Camenisch, G., Kvietikova, I., Ziegler, U., Gassmann, M. and Wenger, R. H. (1999). Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1α. J. Cell Sci. 112, 1203-1212.
14. Conrad, P. W., Freeman, T. L., Beitner-Johnson, D. and Millhorn, D. E. (1999). EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J. Biol. Chem. 274, 33709-33713.
15. 2 sensor protein in the rat carotid body. Biochem. J. 272, 743-747.
16. Damert, A., Ikeda, E. and Risau, W. (1997). Activator-protein-1 binding potentiates the hypoxia-inducible factor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells. Biochem. J. 327, 419-423.
17. Duranteau, J., Chandel, N. S., Kulisz, A., Shao, Z. and Schumacker, P. T. (1998). Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes. J. Biol. Chem. 273, 11619-11624.
18. Ebert, B. L. and Bunn, H. F. (1998). Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor and p300/CREB binding protein. Mol. Cell. Biol. 18, 4089-4096.
19. Ebert, B. L., Firth, J. D. and Ratcliffe, P. J. (1995). Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct cis-acting sequences. J. Biol. Chem. 270, 29083-29089.
20. 1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle. Proc. Natl. Acad. Sci. USA 94, 9487-9492.
21. Ehleben, W., Porwol, T., Fandrey, J. and Acker, H. (1998). The influence of phenobarbital on cytochromes and reactive oxygen species in erythropoietin producing HepG2 cells. FEBS Lett. 440, 343-347.
22. Ema, M., Hirota, K., Mimura, J., Abe, H., Yodoi, J., Sogawa, K., Poellinger, L. and Fujii-Kuriyama, Y. (1999). Molecular mechanisms of transcription activation by HLF and HIF1-α in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J. 18, 1905-1914.
23. Ema, M., Taya, S., Yokotani, N., Sogawa, K., Matsuda, Y. and Fujii-Kuriyama, Y. (1997), A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl. Acad. Sci. USA 94, 4273-4278.
24. Estes, S. D., Stoler, D. L. and Anderson, G. R. (1995). Anoxic induction of a sarcoma virus-related VL30 retrotransposon is mediated by a cis-acting element which binds hypoxia-inducible factor 1 and an anoxia-inducible factor. J. Virol. 69, 6335-6341.
25. Fandrey, J., Frede, S., Ehleben, W., Porwol, T., Acker, H. and Jelkmann, W. (1997). Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species. Kidney Int. 51, 492-496.
26. Fandrey, J., Frede, S. and Jelkmann, W. (1994). Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem. J. 303, 507-510.
27. Fandrey, J., Seydel, F. P., Siegers, C. P. and Jelkmann, W. (1990). Role of cytochrome P450 in the control of the production of erythropoietin. Life Sci. 47, 127-134.
28. Feldser, D., Agani, F., Iyer, N. V., Pak, B., Ferreira, G. and Semenza, G. L. (1999). Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2. Cancer Res. 59, 3915-3918.
29. Firth, J. D., Ebert, B. L., Pugh, C. W. and Ratcliffe, P. J. (1994). Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3′ enhancer. Proc. Natl. Acad. Sci. USA 91, 6496-6500.
30. Firth, J. D., Ebert, B. L. and Ratcliffe, P. J. (1995). Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cyclic AMP response elements. J. Biol. Chem. 270, 21021-21027.
31. Flamme, I., Frohlich, T., von Reutern, M., Kappel, A., Damert, A. and Risau, W. (1997). HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels. Mech. Dev. 63, 51-60.
32. Forsythe, J. A., Jiang, B. H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D. and Semenza, G. L. (1996). Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16, 4604-4613.
33. Galson, D. L., Tsuchiya, T., Tendler, D. S., Huang, L. E., Ren, Y., Ogura, T. and Bunn, H. F. (1995). The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol. Cell. Biol. 15, 2135-2144.
34. Gassmann, M., Kvietikova, I., Rolfs, A. and Wenger, R. H. (1997). Oxygen- and dioxin-regulated gene expression in mouse hepatoma cells. Kidney Int. 51, 567-574.
35. Gerber, H. P., Condorelli, F., Park, J. and Ferrara, N. (1997). Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Fit-1, but not Flk-1/KDR, is up-regulated by hypoxia. J. Biol. Chem. 272, 23659-23667.
36. Gleadle, J. M., Ebert, B. L. and Ratcliffe, P. J. (1995) Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing. Eur. J. Biochem. 234, 92-99.
37. Goldberg, M. A., Dunning, S. P. and Bunn, H. F. (1988). Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242, 1412-1415.
38. Goldwasser, E., Alibali, P. and Gardner, A. (1995). Differential inhibition by iodonium compounds of induced erythropoietin expression. J. Biol. Chem. 270, 2628-2629.
39. Gong, W., Hao, B., Mansy, S. S., Gonzalez, G., Gilles-Gonzalez, M. A. and Chan, M. K. (1998). Structure of a biological oxygen sensor: a new mechanism for heme-driven signal transduction. Proc. Natl. Acad. Sci. USA 95, 15177-15182.
40. Görlach, A., Fandrey, J., Holtermann, G. and Acker, H. (1994). Effects of cobalt on haem proteins of erythropoietin-producing HepG2 cells in multicellular spheroid culture. FEBS Lett. 348, 216-218.
41. Görlach, A., Holtermann, G., Jelkmann, W., Hancock, J. T., Jones, S. A., Jones, O. T. and Acker, H. (1993). Photometric characteristics of haem proteins in erythropoietin-producing hepatoma cells (HepG2). Biochem. J. 290, 771-776.
42. Gradin, K., McGuire, J., Wenger, R. H., Kvietikova, I., Whitelaw, M. L., Toftgård, R., Tora, L., Gassmann, M. and Poellinger, L. (1996). Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol. Cell. Biol. 16, 5221-5231.
43. Graven, K. K., Yu, Q., Pan, D., Roncarati, J. S. and Farber, H. W. (1999). Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene. Biochim. Biophys. Acta 1447, 208-218.
44. Gu, Y. Z., Moran, S. M., Hogenesch, J. B., Wartman, L. and Bradfield, C. A. (1998). Molecular characterization and chromosomal localization of a third α-class hypoxia inducible factor subunit, HIF3α. Gene Expr. 7, 205-213.
45. Harder, D. R., Narayanan, J., Birks, E. K., Liard, J. F., Imig, J. D., Lombard, J. H., Lange, A. R. and Roman, R. J. (1996). Identification of a putative microvascular oxygen sensor. Circ. Res. 79, 54-61.
46. Hellwig-Burgel, T., Rutkowski, K., Metzen, E., Fandrey, J. and Jelkmann, W. (1999). Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1. Blood 94, 1561-1567.
47. Ho, V. T. and Bunn, H. F. (1996). Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein. Biochem. Biophys. Res. Commun. 223, 175-180.
48. Hoffman, E. C., Reyes, H., Chu, F. F., Sander, F., Conley, L. H., Brooks, B. A. and Hankinson, O. (1991). Cloning of a factor required for activity of the Ah (dioxin) receptor. Science 252, 954-958.
49. Hogenesch, J. B., Chan, W. K., Jackiw, V. H., Brown, R. C., Gu, Y. Z., Pray-Grant, M., Perdew, G. H. and Bradfield, C. A. (1997). Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. Biol. Chem. 272, 8581-8593.
50. Hogenesch, J. B., Gu, Y. Z., Jain, S. J. and Bradfield, C. A. (1998). The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc. Natl. Acad. Sci. USA 95, 5474-5479.
51. Hohler, B., Lange, B., Holzapfel, B., Goldenberg, A., Hanze, J., Sell, A., Testan, H., Moller, W. and Kummer, W. (1999) Hypoxic upregulation of tyrosine hydroxylase gene expression is paralleled, but not induced, by increased generation of reactive oxygen species in PC12 cells. FEBS Lett. 457, 53-56.
52. Hu, B., Wright, E., Campbell, L. and Blanchard, K. L. (1997) In vivo analysis of DNA-protein interactions on the human erythropoietin enhancer. Mol. Cell. Biol. 17, 851-856.
53. Hu, J., Discher, D. J., Bishopric, N. H. and Webster, K. A. (1998). Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem. Biophys. Res. Commun. 245, 894-899.
54. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 95, 7987-7992.
55. Huang, L. E., Arany, Z., Livingston, D. M. and Bunn, H. F. (1996). Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its a subunit. J. Biol. Chem. 271, 32253-32259.
56. Iwai, K., Drake, S. K., Wehr, N. B., Weissman, A. M., LaVaute, T., Minato, N., Klausner, R. D., Levine, R. L. and Rouault, T. A. (1998). Iron-dependent oxidation, ubiquitination and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins. Proc. Natl. Acad. Sci. USA 95, 4924-4928.
57. 2 homeostasis by hypoxia-inducible factor 1α. Genes Dev. 12, 149-162.
58. 2 tension. Am. J. Physiol. 271, C1172-C1180.
59. Jiang, B. H., Zheng, J. Z., Leung, S. W., Roe, R. and Semenza, G. L. (1997). Transactivation and inhibitory domains of hypoxia-inducible factor 1α. Modulation of transcriptional activity by oxygen tension. J. Biol. Chem. 272, 19253-19260.
60. Kallio, P. J., Okamoto, K., O'Brien, S., Carrero, P., Makino, Y., Tanaka, H. and Poellinger, L. (1998). Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1α. EMBO J. 17, 6573-6586.
61. Kallio, P. J., Pongratz, I., Gradin, K., McGuire, J. and Poellinger, L. (1997). Activation of hypoxia-inducible factor 1α: posttranscriptional regulation and conformational change by recruitment of the Amt transcription factor. Proc. Nail. Acad. Sci. USA 94, 5667-5672.
62. Kallio, P. J., Wilson, W. J. S. O. B., Makino, Y. and Poellinger, L. (1999). Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway. J. Biol. Chem. 274, 6519-6525.
63. 2. FEBS Lett. 388, 228-232.
64. 2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene and the insulin-dependent activation of the glucokinase gene in rat hepatocytes. Biochem. J. 335, 425-432.
65. 2. Biochem. J. 321, 17-20.
66. Kietzmann, T., Roth, U. and Jungermann, K. (1999). Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood 94, 4177-4185.
67. Kotch, L. E., Iyer, N. V., Laughner, E. and Semenza, G. L. (1999). Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev. Biol. 209, 254-267.
68. 2 sensors in hypoxic regulation of tyrosine hydroxylase gene expression. Am. J. Physiol. 274, C167-C174.
69. Kummer, W. and Acker, H. (1995). Immunohistochemical demonstration of four subunits of neutrophil NAD(P)H oxidase in type I cells of carotid body. J. Appl. Physiol. 78, 1904-1909.
70. Kvietikova, I., Wenger, R. H., Marti, H. H. and Gassmann, M. (1995). The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site. Nucleic Acids Res. 23, 4542-4550.
71. Kvietikova, I., Wenger, R. H., Marti, H. H. and Gassmann, M. (1997). The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive. Kidney Int. 51, 564-566.
72. 2 sensor. Brain Res. 684, 194-200.
73. Lahiri, S., Ehleben, W. and Acker, H. (1999). Chemoreceptor discharges and cytochrome redox changes of the rat carotid body: role of heme ligands. Proc. Natl. Acad. Sci. USA 96, 9427-9432.
74. Lee, P. J., Jiang, B. H., Chin, B. Y., Iyer, N. V., Alam, J., Semenza, G. L. and Choi, A. M. (1997). Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J. Biol. Chem. 272, 5375-5381.
75. Levy, A. P., Levy, N. S., Wegner, S. and Goldberg, M. A. (1995). Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J. Biol. Chem. 270, 13333-13340.
76. Li, H., Ko, H. P. and Whitlock, J. P. (1996) Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of ARNT and HIF1α. J. Biol. Chem. 271, 21262-21267.
77. Liu, Y., Cox, S. R., Morita, T. and Kourembanas, S. (1995). Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′enhancer. Circ. Res. 77, 638-643.
78. Lok, C. N. and Ponka, P. (1999). Identification of a hypoxia response element in the transferrin receptor gene. J. Biol. Chem. 274, 24147-24152.
79. Maxwell, P. H., Wiesener, M. S., Chang, G. W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R. and Ratcliffe, P. J. (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-275.
80. Melillo, G., Musso, T., Sica, A., Taylor, L. S., Cox, G. W. and Varesio, L. (1995). A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. Exp. Med. 182, 1683-1693.
81. Nguyen, S. V. and Claycomb, W. C. (1999). Hypoxia regulates the expression of the adrenomedullin and HIF-1 genes in cultured HL-1 cardiomyocytes. Biochem. Biophys. Res. Commun. 265, 382-386.
82. Okino, S. T., Chichester, C. H. and Whitlock, J. P., Jr (1998). Hypoxia-inducible mammalian gene expression analyzed in vivo at a TATA-driven promoter and at an initiator-driven promoter. J. Biol. Chem. 273, 23837-23843.
83. O'Rourke, J. F., Tian, Y. M., Ratcliffe, P. J. and Pugh, C. W. (1999). Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1α. J. Biol. Chem. 274, 2060-2071.
84. Palmer, L. A., Semenza, G. L., Stoler, M. H. and Johns, R. A. (1998). Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am. J. Physiol. 274, L212-L219.
85. Porwol, T., Ehleben, W., Zierold, K., Fandrey, J. and Acker, H. (1998). The influence of nickel and cobalt on putative members of the oxygen-sensing pathway of erythropoietin-producing HepG2 cells. Eur. J. Biochem. 256, 16-23.
86. Pugh, C. W., O'Rourke, J. F., Nagao, M., Gleadle, J. M. and Ratcliffe, P. J. (1997). Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit. J. Biol. Chem. 272, 11205-11214.
87. Qi, Y., Jamindar, T. M. and Dawson, G. (1995). Hypoxia alters iron homeostasis and induces ferritin synthesis in oligodendrocytes. J. Neurochem. 64, 2458-2464.
88. Richard, D. E., Berra, E., Gothic, E., Roux, D. and Pouyssegur, J. (1999). p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J. Biol. Chem. 274, 32631-32637.
89. Rolfs, A., Kvietikova, I., Gassmann, M. and Wenger, R. H. (1997). Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J. Biol. Chem. 272, 20055-20062.
90. Ryan, H. E., Lo, J. and Johnson, R. S. (1998). HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J. 17, 3005-3015.
91. Salceda, S., Beck, I. and Caro, J. (1996) Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia. Arch. Biochem. Biophys. 334, 389-394.
92. Salceda, S., Beck, I., Srinivas, V. and Caro, J. (1997). Complex role of protein phosphorylation in gene activation by hypoxia. Kidney Int. 51, 556-559.
93. Salceda, S. and Caro, J. (1997). Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J. Biol. Chem. 272, 22642-22647.
94. Schmaltz, C., Hardenbergh, P. H., Wells, A. and Fisher, D. E. (1998). Regulation of proliferation-survival decisions during tumor cell hypoxia. Mol. Cell. Biol. 18, 2845-2854.
95. 2 homeostasis. Curr. Opin. Genet. Dev. 8, 588-594.
96. Semenza, G. L., Jiang, B. H., Leung, S. W., Passantino, R., Concordet, J. P., Maire, P. and Giallongo, A. (1996). Hypoxia response elements in the aldolase A, enolase I and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 271, 32529-32537.
97. Semenza, G. L., Roth, P. H., Fang, H. M. and Wang, G. L. (1994). Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269, 23757-23763.
98. Srinivas, V., Zhang, L. P., Zhu, X. H. and Caro, J. (1999a). Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor α (HIF-α) proteins. Biochem. Biophys. Res. Commun. 260, 557-561.
99. Srinivas, V., Zhu, X., Salceda, S., Nakamura, R. and Caro, J. (1999b). Hypoxia-inducible factor 1α (HIF-1α) is a non-heme iron protein. Implications for oxygen sensing [retraction of V. Srinivas, X. Zhu, S. Salceda, R. Nakamura and J. Caro (1998). J. Biol. Chem. 273, 18019-18022]. J. Biol. Chem. 274, 1180.
100. Suzuki, Y. J., Forman, H. J. and Sevanian, A. (1997). Oxidants as stimulators of signal transduction. Free Radical Biol. Med. 22, 269-285.
101. Tacchini, L., Blanchi, L., Bernelli-Zazzera, A. and Cairo, G. (1999). Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation. J. Biol. Chem. 274, 24142-24146.
102. Tan, C. C. and Ratcliffe, P. J. (1991). Effect of inhibitors of oxidative phosphorylation on erythropoietin mRNA in isolated perfused rat kidneys. Am. J. Physiol. 261, F982-F987.
103. Taylor, B. L. and Zhulin, I. B. (1999). PAS domains: internal sensors of oxygen, redox potential and light. Microbiol. Mol. Biol. Rev. 63, 479-506.
104. Taylor, C. T., Lisco, S. J., Awtrey, C. S. and Colgan, S. P. (1998). Hypoxia inhibits cyclic nucleotide-stimulated epithelial ion transport: role for nucleotide cyclases as oxygen sensors. J. Pharmac. Exp. Ther. 284, 568-575.
105. Tazuke, S. I., Mazure, N. M., Sugawara, J., Carland, G., Faessen, G. H., Suen, L. F., Irwin, J. C., Powell, D. R., Giaccia, A. J. and Giudice, L. C. (1998). Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1)gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc. Natl. Acad. Sci. USA 95, 10188-10193.
106. Tian, H., Hammer, R. E., Matsumoto, A. M., Russell, D. W. and McKnight, S. L. (1998). The hypoxia-responsive transcription factor EPAS1 is essential for cutecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 12, 3320-3324.
107. Tian, H., McKnight, S. L. and Russell, D. W. (1997). Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11, 72-82.
108. Vanden Hoek, T. L., Becker, L. B., Shao, Z., Li, C. and Schumacker, P. T. (1998). Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J. Biol. Chem. 273, 18092-18098.
109. + channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines. Proc. Natl. Acad. Sci. USA 93, 13182-13187.
110. 2 tension. Proc. Natl. Acad. Sci. USA 92, 5510-5514.
111. Wang, G. L., Jiang, B. H. and Semenza, G. L. (1995b). Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem. Biophys. Res. Commun. 216, 669-675.
112. Wang, G. L. and Semenza, G. L. (1993a). Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 268, 21513-21518.
113. Wang, G. L. and Semenza, G. L. (1993b). Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood 82, 3610-3615.
114. Wenger, R. H. and Gassmann, M. (1997). Oxygen(es) and the hypoxia-inducible factor-1. Biol. Chem. 378, 609-616.
115. Wenger, R. H., Kvietikova, I., Rolfs, A., Camenisch, G. and Gassmann, M. (1998a). Oxygen-regulated erythropoietin gene expression is dependent on a CpG methylation-free hypoxia-inducible factor-1 DNA-binding site. Eur. J. Biochem. 253, 771-777.
116. Wenger, R. H., Marti, H. H., Bauer, C. and Gassmann, M. (1998b). Optimal erythropoietin expression in human hepatoma cell lines requires activation of multiple signalling pathways. Int. J. Mol. Med. 2, 317-324.
117. Wenger, R. H., Marti, H. H., Schuerer-Maly, C. C., Kvietikova, I., Bauer, C., Gassmann, M. and Maly, F. E. (1996). Hypoxic induction of gene expression in chronic granulomatous disease-derived B-cell lines: oxygen sensing is independent of the cytochrome b558-containing nicotinamide adenine dinucleotide phosphate oxidase. Blood 87, 756-761.
118. Wenger, R. H., Rolfs, A., Kvietikova, I., Spielmann, P., Zimmermann, D. R. and Gassmann, M. (1997) The mouse gene for hypoxia-inducible factor-1α. Genomic organization, expression and characterization of an alternative first exon and 5′ flanking sequence. Eur. J. Biochem. 246, 155-165.
119. Wenger, R. H., Rolfs, A., Spielmann, P., Zimmermann, D. R. and Gassmann, M. (1998c). Mouse hypoxia-inducible factor-1α is encoded by two different mRNA isoforms - expression from a tissue-specific and a housekeeping-type promoter. Blood 91, 3471-3480.
120. Wiesener, M. S., Turley, H., Allen, W. E., Willam, C., Eckardt, K. U., Talks, K. L., Wood, S. M., Gatter, K. C., Harris, A. L., Pugh, C. W., Ratcliffe, P. J. and Maxwell, P. H. (1998). Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1α. Blood 92, 2260-2268.
121. Wilson, D. F., Mokashi, A., Chugh, D., Vinogradov, S., Osanai, S. and Lahiri, S. (1994). The primary oxygen sensor of the cat carotid body is cytochrome a3 of the mitochondrial respiratory chain. FEBS Lett. 351, 370-374.
122. Wood, S. M., Gleadle, J. M., Pugh, C. W., Hankinson, O. and Ratcliffe, P. J. (1996). The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J. Biol. Chem. 271, 15117-15123.
123. Wood, S. M., Wiesener, M. S., Yeates, K. M., Okada, N., Pugh, C. W., Maxwell, P. H. and Ratcliffe, P. J. (1998). Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 α-subunit (HIF-1α). Characterization of HIF-1α-dependent and -independent hypoxia-inducible gene expression. J. Biol. Chem. 273, 8360-8368.
124. 2-sensing protein (NADPH oxidase) in chemoreceptor cells. Microsc. Res. Tech. 37, 101-106.
125. Youngson, C., Nurse, C., Yeger, H. and Cutz, E. (1993). Oxygen sensing in airway chemoreceptors. Nature 365, 153-155.
126. Yu, A. Y., Shimoda, L. A., Iyer, N. V., Huso, D. L., Sun, X., McWilliams, R., Beaty, T., Sham, J. S., Wiener, C. M., Sylvester, J. T. and Semenza, G. L. (1999). Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. J. Clin. Invest. 103, 691-696.
127. Zelzer, E., Levy, Y., Kahana, C., Shilo, B. Z., Rubinstein, M. and Cohen, B. (1998). Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT. EMBO J. 17, 5085-5094.