Hypoxia: The tumor's gateway to progression along the angiogenic pathway

Trends in Cell Biology

Volumn 11, Issue 11, 2001, Pages

  Brahimi Horn, Christiane ^a   Berra, Edurne ^a   Pouysségur, Jacques ^a  

^a CENTRE ANTOINE LACASSAGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; HYPOXIA INDUCIBLE FACTOR 1; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN SUBUNIT;

ANGIOGENESIS; CANCER CHEMOTHERAPY; CYTOKINE RELEASE; GENE THERAPY; GENETIC TRANSCRIPTION; HYPOXIA; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; TUMOR; TUMOR GROWTH; VASCULARIZATION;

ANIMALS; CELL HYPOXIA; GENE THERAPY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MIXED FUNCTION OXYGENASES; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; OXYGENASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0035500503     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(01)02126-2     Document Type: Review

References (42)

1. HIF-1 and human disease: One highly involved factor
2. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
3. Activation of the HIF pathway in cancer
4. Angiogenesis in cancer and other diseases
5. The von Hippel-Lindau tumor suppressor protein
6. Defective placental vasculogenesis causes embryonic lethality in VHL-defective mice
7. Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila
8. MAP kinases and hypoxia in the control of VEGF expression
9. Signaling angiogenesis via p42/p44 MAP kinase and hypoxia
10. HIF-1: Régulateur central de l'hypoxie
11. Angiogenesis: How a tumor adapts to hypoxia
12. HIF-1 and mechanisms of hypoxia sensing
13. Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1α
14. Molecular mechanisms of transcription activation by HLF and HIF1α in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
15. Transactivation and inhibitory domains of hypoxia-inducible factor 1α. Modulation of transcriptional activity by oxygen tension
16. Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia-inducible factor-1α
17. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit
18. Functional analysis of an oxygen-regulated transcriptional enhancer lying 3′ to the mouse erythropoietin gene
19. Hypoxia-inducible nuclear factors bind to an enhancer element located 3′ to the human erythropoietin gene
20. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
21. 2-driven proteasomal degradation irrespective of its subcellular localization: Nucleus or cytoplasm
22. 2-dependent degradation domain via the ubiquitin-proteasome pathway
23. Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor α (HIF-α) proteins
24. Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
25. Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
26. The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
27. Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein
28. Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein
29. Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway
30. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
31. 2 sensing
32. 2-regulated prolyl hydroxylation
33. Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
34. Prolyl 4-hydroxylases and their protein disulfide isomerase subunit
35. HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation
36. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT
37. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells
38. Expression of hypoxia-inducible factor 1: Mechanisms and consequences
39. Exploiting the hypoxic cancer cell: Mechanism and therapeutic strategies
40. Development of a hypoxia-responsive vector for tumor-specific gene therapy
41. Suppression of tumor growth through disruption of hypoxia-inducible transcription
42. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration