-
2
-
-
0030961006
-
Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions
-
Salceda S., Caro J. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. J Biol Chem. 272:1997;22642-22647.
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
3
-
-
0032493368
-
Regulation of hypoxia-inducible factor 1α is mediated by an oxygen-dependent domain via the ubiquitin-proteasome pathway
-
Huang L.E., Gu J., Schau M., Bunn H.F. Regulation of hypoxia-inducible factor 1α is mediated by an oxygen-dependent domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA. 95:1998;7987-7992.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
4
-
-
0032189844
-
Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1α
-
Wiesener M.S., Turley H., Allen W.E., William C., Eckardt K.U., Talks K.L., Wood S.M., Gatter K.C., Harris A.L., Pugh C.W., et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1α Blood. 92:1998;2260-2268.
-
(1998)
Blood
, vol.92
, pp. 2260-2268
-
-
Wiesener, M.S.1
Turley, H.2
Allen, W.E.3
William, C.4
Eckardt, K.U.5
Talks, K.L.6
Wood, S.M.7
Gatter, K.C.8
Harris, A.L.9
Pugh, C.W.10
-
5
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 399:1999;271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
6
-
-
0034682783
-
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
See annotation [9••]
-
Cockman M.E., Masson N., Mole D.R., Jaakkola P., Chang G.W., Clifford S.C., Maher E.R., Pugh C.W., Ratcliffe P.J., Maxwell P.H. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem. 275:2000;25733-25741. See annotation [9••].
-
(2000)
J Biol Chem
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
Masson, N.2
Mole, D.R.3
Jaakkola, P.4
Chang, G.W.5
Clifford, S.C.6
Maher, E.R.7
Pugh, C.W.8
Ratcliffe, P.J.9
Maxwell, P.H.10
-
7
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
See annotation [9••]
-
Ohh M., Park C.W., Ivan M., Hoffman M.A., Kim T.Y., Huang L.E., Pavletich N., Chau V., Kaelin W.G. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol. 2:2000;423-427. See annotation [9••].
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
Huang, L.E.6
Pavletich, N.7
Chau, V.8
Kaelin, W.G.9
-
8
-
-
0034641615
-
Activation of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein
-
See annotation [9••]
-
Kamura T., Sato S., Iwai K., Czyzyk-Krzeska M., Conaway R.C., Conaway J.W. Activation of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein. Proc Natl Acad Sci USA. 97:2000;10430-10435. See annotation [9••].
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10430-10435
-
-
Kamura, T.1
Sato, S.2
Iwai, K.3
Czyzyk-Krzeska, M.4
Conaway, R.C.5
Conaway, J.W.6
-
9
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
-
This paper and [6••,7••,8••] confirm and extend the role of pVHL in HIF regulation, as recognised in [5]. They demonstrate that the pVHL β domain binds the oxygen dependent degradation domain of HIF-α subunits and that the pVHL-elonginBC-Cul2 complex ubiquitylates HIF-α
-
Tanimoto K., Makino Y., Pereira T., Poellinger L. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J. 19:2000;4298-4309. This paper and [6••,7••,8••] confirm and extend the role of pVHL in HIF regulation, as recognised in [5]. They demonstrate that the pVHL β domain binds the oxygen dependent degradation domain of HIF-α subunits and that the pVHL-elonginBC-Cul2 complex ubiquitylates HIF-α.
-
(2000)
EMBO J
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
Makino, Y.2
Pereira, T.3
Poellinger, L.4
-
10
-
-
0029803552
-
An essential role for p300/CBP in the cellular response to hypoxia
-
Arany Z., Huang L.E., Eckner R., Bhattacharya S., Jiang C., Goldberg M.A., Bunn H.F., Livingston D.M. An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA. 93:1996;12969-12973.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12969-12973
-
-
Arany, Z.1
Huang, L.E.2
Eckner, R.3
Bhattacharya, S.4
Jiang, C.5
Goldberg, M.A.6
Bunn, H.F.7
Livingston, D.M.8
-
11
-
-
0034006016
-
HIF: Mediator of physiological and pathophysiological responses to hypoxia
-
Semenza G.L. HIF: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol. 88:2000;1474-1480.
-
(2000)
J Appl Physiol
, vol.88
, pp. 1474-1480
-
-
Semenza, G.L.1
-
12
-
-
0034107952
-
Mammalian oxygen sensing, signalling and gene regulation
-
Wenger R.H. Mammalian oxygen sensing, signalling and gene regulation. J Exp Biol. 203:2000;1253-1263.
-
(2000)
J Exp Biol
, vol.203
, pp. 1253-1263
-
-
Wenger, R.H.1
-
13
-
-
0034671307
-
Hypoxia inducible regulation of tumor associated carbonic anhydrases
-
This paper demonstrates that carbonic anhydrases (CA) 9 and 12, which were shown previously to be upregulated in cells lacking pVHL [56], are strongly induced by hypoxia. A HIF response element is defined in the CA9 promoter, and CAIX is shown to be a reliable marker of HIF activation in human tumours
-
Wykoff C.C., Beasley N.J.P., Watson P.H., Turner K.J., Pastorek J., Sibtain A., Wilson G.D., Turley H., Maxwell P.H., Pugh C.W., et al. Hypoxia inducible regulation of tumor associated carbonic anhydrases. Cancer Res. 60:2000;7075-7083. This paper demonstrates that carbonic anhydrases (CA) 9 and 12, which were shown previously to be upregulated in cells lacking pVHL [56], are strongly induced by hypoxia. A HIF response element is defined in the CA9 promoter, and CAIX is shown to be a reliable marker of HIF activation in human tumours.
-
(2000)
Cancer Res
, vol.60
, pp. 7075-7083
-
-
Wykoff, C.C.1
Beasley, N.J.P.2
Watson, P.H.3
Turner, K.J.4
Pastorek, J.5
Sibtain, A.6
Wilson, G.D.7
Turley, H.8
Maxwell, P.H.9
Pugh, C.W.10
-
14
-
-
0034649507
-
Identification of novel hypoxia-dependent and independent target genes of the von Hippel-Lindau (VHL) tumor suppressor by mRNA differential expression profiling
-
This study uses a glass-chip based array of 9182 genes to analyse effects of pVHL re-expression in a renal carcinoma line. Differentially expressed genes are identified, and tested in various VHL-competent cells for regulation by hypoxia. The study defined a set of VHL-regulated genes and showed that a high proportion were regulated by oxygen in VHL-competent cells. Although many have functions relevant to tumour biology, surprisingly a number of the genes whose expression is increased by VHL loss might be predicted to be either growth inhibitory or pro-apoptotic
-
Wykoff C., Pugh C., Maxwell P., Harris A., Ratcliffe P. Identification of novel hypoxia-dependent and independent target genes of the von Hippel-Lindau (VHL) tumor suppressor by mRNA differential expression profiling. Oncogene. 19:2000;6297-6305. This study uses a glass-chip based array of 9182 genes to analyse effects of pVHL re-expression in a renal carcinoma line. Differentially expressed genes are identified, and tested in various VHL-competent cells for regulation by hypoxia. The study defined a set of VHL-regulated genes and showed that a high proportion were regulated by oxygen in VHL-competent cells. Although many have functions relevant to tumour biology, surprisingly a number of the genes whose expression is increased by VHL loss might be predicted to be either growth inhibitory or pro-apoptotic.
-
(2000)
Oncogene
, vol.19
, pp. 6297-6305
-
-
Wykoff, C.1
Pugh, C.2
Maxwell, P.3
Harris, A.4
Ratcliffe, P.5
-
15
-
-
0034640269
-
Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells
-
See annotation [17•]
-
Takahashi Y., Takahashi S., Shiga Y., Yoshimi T., Miura T. Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells. J Biol Chem. 275:2000;14139-14146. See annotation [17•].
-
(2000)
J Biol Chem
, vol.275
, pp. 14139-14146
-
-
Takahashi, Y.1
Takahashi, S.2
Shiga, Y.3
Yoshimi, T.4
Miura, T.5
-
16
-
-
0034100836
-
Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)
-
See annotation [17•]
-
Caniggia I., Mostachfi H., Winter J., Gassmann M., Lye S.J., Kuliszewski M., Post M. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). JClin Invest. 105:2000;577-587. See annotation [17•].
-
(2000)
JClin Invest
, vol.105
, pp. 577-587
-
-
Caniggia, I.1
Mostachfi, H.2
Winter, J.3
Gassmann, M.4
Lye, S.J.5
Kuliszewski, M.6
Post, M.7
-
17
-
-
0034647742
-
Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency
-
Studies [13•,14•,15•,16•,17•] establish a role for HIF in regulating expression of genes with a range of functions extending beyond those previously recognised
-
Mukhopadhyay C.K., Mazumder B., Fox P.L. Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J Biol Chem. 275:2000;21048-21054. Studies [13•,14•,15•,16•,17•] establish a role for HIF in regulating expression of genes with a range of functions extending beyond those previously recognised.
-
(2000)
J Biol Chem
, vol.275
, pp. 21048-21054
-
-
Mukhopadhyay, C.K.1
Mazumder, B.2
Fox, P.L.3
-
18
-
-
0030045543
-
Isoenzyme specific regulation of genes involved in energy metabolism by hypoxia, cobalt and desferrioxamine: Similarities with the regulation of erythropoietin
-
Ebert B.L., Gleadle J.M., O'Rourke J.F., Bartlett S.M., Poulton J., Ratcliffe P.J. Isoenzyme specific regulation of genes involved in energy metabolism by hypoxia, cobalt and desferrioxamine: similarities with the regulation of erythropoietin. Biochem J. 313:1995;809-814.
-
(1995)
Biochem J
, vol.313
, pp. 809-814
-
-
Ebert, B.L.1
Gleadle, J.M.2
O'Rourke, J.F.3
Bartlett, S.M.4
Poulton, J.5
Ratcliffe, P.J.6
-
19
-
-
0026485002
-
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
-
Shweiki D., Itin A., Soffer D., Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 359:1992;843-845.
-
(1992)
Nature
, vol.359
, pp. 843-845
-
-
Shweiki, D.1
Itin, A.2
Soffer, D.3
Keshet, E.4
-
20
-
-
0030968939
-
Targeting gene expression to hypoxic tumour cells
-
Dachs G.U., Patterson A.V., Firth J.D., Ratcliffe P.J., Townsend K.M.S., Stratford I.J., Harris A.L. Targeting gene expression to hypoxic tumour cells. Nat Med. 3:1997;515-520.
-
(1997)
Nat Med
, vol.3
, pp. 515-520
-
-
Dachs, G.U.1
Patterson, A.V.2
Firth, J.D.3
Ratcliffe, P.J.4
Townsend, K.M.S.5
Stratford, I.J.6
Harris, A.L.7
-
21
-
-
0030816109
-
Hypoxia inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
Maxwell P.H., Dachs G.U., Gleadle J.M., Nicholls L.G., Harris A.L., Stratford I.J., Hankinson O., Pugh C.W., Ratcliffe P.J. Hypoxia inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA. 94:1997;8104-8109.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
Dachs, G.U.2
Gleadle, J.M.3
Nicholls, L.G.4
Harris, A.L.5
Stratford, I.J.6
Hankinson, O.7
Pugh, C.W.8
Ratcliffe, P.J.9
-
22
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet P., Dor Y., Herbert J.M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394:1998;485-490.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
-
23
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
-
Zhong H., De Marzo A.M., Laughner E., Lim M., Hilton D.A., Zagzag D., Buechler P., Isaacs W.B., Semenza G.L., Simons J.W. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res. 59:1999;5830-5835.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
-
24
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
-
This paper describes immunolocalisation of HIF-1α and HIF-2α in human tissue specimens. Together with [23], it establishes that HIF activation is a common feature of malignant tumours
-
Talks K., Turley H., Gatter K.C., Maxwell P.H., Pugh C.W., Ratcliffe P.J., Harris A.L. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol. 157:2000;411-421. This paper describes immunolocalisation of HIF-1α and HIF-2α in human tissue specimens. Together with [23], it establishes that HIF activation is a common feature of malignant tumours.
-
(2000)
Am J Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.1
Turley, H.2
Gatter, K.C.3
Maxwell, P.H.4
Pugh, C.W.5
Ratcliffe, P.J.6
Harris, A.L.7
-
25
-
-
0034213146
-
Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression
-
This study shows that HIF-1α is more highly expressed in higher-grade brain tumours. HIF-1α expression is noted to be homogeneous in haemangioblastoma, consistent with stabilisation via loss of pVHL
-
Zagzag D., Zhong H., Scalzitti J.M., Laughner E., Simons J.W., Semenza G.L. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 88:2000;2606-2618. This study shows that HIF-1α is more highly expressed in higher-grade brain tumours. HIF-1α expression is noted to be homogeneous in haemangioblastoma, consistent with stabilisation via loss of pVHL.
-
(2000)
Cancer
, vol.88
, pp. 2606-2618
-
-
Zagzag, D.1
Zhong, H.2
Scalzitti, J.M.3
Laughner, E.4
Simons, J.W.5
Semenza, G.L.6
-
26
-
-
0034676331
-
Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
-
HIF subunits are shown to be present by immunohistochemistry and were homogeneously distributed in renal carcinoma and haemangioblastoma, consistent with activation through loss of pVHL function
-
Krieg M., Haas R., Brauch H., Acker T., Flamme I., Plate K.H. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene. 19:2000;5435-5443. HIF subunits are shown to be present by immunohistochemistry and were homogeneously distributed in renal carcinoma and haemangioblastoma, consistent with activation through loss of pVHL function.
-
(2000)
Oncogene
, vol.19
, pp. 5435-5443
-
-
Krieg, M.1
Haas, R.2
Brauch, H.3
Acker, T.4
Flamme, I.5
Plate, K.H.6
-
27
-
-
0034282518
-
Overexpression of hypoxia-inducible factor lα is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
-
HIF1 immunolabelling is performed on specimens from 91 tumours of stage pT1b. Strong expression correlated with shorter survival and disease-free survival
-
Birner P., Schindl M., Obermair A., Plank C., Breitenecker G., Oberhuber G. Overexpression of hypoxia-inducible factor lα is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 60:2000;4693-4696. HIF1 immunolabelling is performed on specimens from 91 tumours of stage pT1b. Strong expression correlated with shorter survival and disease-free survival.
-
(2000)
Cancer Res
, vol.60
, pp. 4693-4696
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
Plank, C.4
Breitenecker, G.5
Oberhuber, G.6
-
28
-
-
0342433777
-
Hypoxia-inducible factor (HIF) and its relationship to apoptosis and proliferation in lung cancer
-
HIF1 immunolabelling is performed on 96 non small cell lung cancers. Expression of HIF-1α was associated with longer median survival time
-
Volm M., Koomagi R. Hypoxia-inducible factor (HIF) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res. 20:2000;1527-1533. HIF1 immunolabelling is performed on 96 non small cell lung cancers. Expression of HIF-1α was associated with longer median survival time.
-
(2000)
Anticancer Res
, vol.20
, pp. 1527-1533
-
-
Volm, M.1
Koomagi, R.2
-
29
-
-
0034021690
-
Hypoxia, clonal selection, and the role of HIF in tumor progression
-
Semenza G.L. Hypoxia, clonal selection, and the role of HIF in tumor progression. Crit Rev Biochem Mol Biol. 35:2000;71-103.
-
(2000)
Crit Rev Biochem Mol Biol
, vol.35
, pp. 71-103
-
-
Semenza, G.L.1
-
30
-
-
0035253381
-
The von Hippel-Lindau tumor suppressor protein
-
Ivan M., Kaelin W.G. The von Hippel-Lindau tumor suppressor protein. Curr Opin Genet Dev. 11:2001;27-34.
-
(2001)
Curr Opin Genet Dev
, vol.11
, pp. 27-34
-
-
Ivan, M.1
Kaelin, W.G.2
-
31
-
-
0034050050
-
Loss of PTEN facilitates HIF-mediated gene expression
-
This study connects PTEN tumour suppressor function with regulation of HIF. Re-expression of PTEN in PTEN-defective glioblastoma cells is shown to downregulate the phosphatidylinositol-3-kinase/Akt pathway and reduce the HIF transcriptional response that is induced by either IGF-1 or hypoxia
-
Zundel W., Schindler C., Haas-Kogan D., Koong A., Kaper F., Chen E., Gottschalk A.R., Ryan H.E., Johnson R.S., Jefferson A.B., et al. Loss of PTEN facilitates HIF-mediated gene expression. Genes Dev. 14:2000;391-396. This study connects PTEN tumour suppressor function with regulation of HIF. Re-expression of PTEN in PTEN-defective glioblastoma cells is shown to downregulate the phosphatidylinositol-3-kinase/Akt pathway and reduce the HIF transcriptional response that is induced by either IGF-1 or hypoxia.
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
Gottschalk, A.R.7
Ryan, H.E.8
Johnson, R.S.9
Jefferson, A.B.10
-
32
-
-
0034654174
-
Modulation of hypoxia-inducible factor lα expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
The epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway was implicated in HIF activation in prostate cancer cell lines using pharmacological inhibitors, expression of dominant negative AKT and PI3K, and expression of wild-type PTEN
-
Zhong H., Chiles K., Feldser D., Laughner E., Hanrahan C., Georgescu M.M., Simons J.W., Semenza G.L. Modulation of hypoxia-inducible factor lα expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 60:2000;1541-1545. The epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway was implicated in HIF activation in prostate cancer cell lines using pharmacological inhibitors, expression of dominant negative AKT and PI3K, and expression of wild-type PTEN.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
Simons, J.W.7
Semenza, G.L.8
-
33
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1α
-
An W.G., Kanekal M., Simon M.C., Maltepe E., Blagosklonny M.V., Neckers L.M. Stabilization of wild-type p53 by hypoxia-inducible factor 1α Nature. 392:1998;405-408.
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
Kanekal, M.2
Simon, M.C.3
Maltepe, E.4
Blagosklonny, M.V.5
Neckers, L.M.6
-
34
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
-
Using cells that are isogenic except for p53 status, p53 is shown to reduce HIF activation. p53 is found to co-immunoprecipitate with HIF-1α, and evidence was presented that Mdm-2 could promote destruction of HIF-1α in the presence of p53
-
Ravi R., Mookerjee B., Bhujwalla Z.M., Sutter C.H., Artemov D., Zeng Q., Dillehay L.E., Madan A., Semenza G.L., Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α Genes Dev. 14:2000;34-44. Using cells that are isogenic except for p53 status, p53 is shown to reduce HIF activation. p53 is found to co-immunoprecipitate with HIF-1α, and evidence was presented that Mdm-2 could promote destruction of HIF-1α in the presence of p53.
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
35
-
-
0030869787
-
Induction of a vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
-
Mazure N.M., Chen E.Y., Laderoute K.R., Giaccia A.J. Induction of a vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood. 90:1997;3322-3331.
-
(1997)
Blood
, vol.90
, pp. 3322-3331
-
-
Mazure, N.M.1
Chen, E.Y.2
Laderoute, K.R.3
Giaccia, A.J.4
-
36
-
-
0035937715
-
Regulation of glut1 mRNA by HIF: Interation between H-ras and hypoxia
-
Chen C., Pore N., Behrooz A., Ismail-Beigi F., Maity A. Regulation of glut1 mRNA by HIF: interation between H-ras and hypoxia. J Biol Chem. 276:2000;9519-9525.
-
(2000)
J Biol Chem
, vol.276
, pp. 9519-9525
-
-
Chen, C.1
Pore, N.2
Behrooz, A.3
Ismail-Beigi, F.4
Maity, A.5
-
37
-
-
0030659531
-
V-SRC induces expression of hypoxia-inducible factor 1 (HIF) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF in tumor progression
-
Jiang B.H., Agani F., Passaniti A., Semenza G.L. V-SRC induces expression of hypoxia-inducible factor 1 (HIF) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF in tumor progression. Cancer Res. 57:1997;5328-5335.
-
(1997)
Cancer Res
, vol.57
, pp. 5328-5335
-
-
Jiang, B.H.1
Agani, F.2
Passaniti, A.3
Semenza, G.L.4
-
38
-
-
0030921103
-
C-Myc transactivation of LDH-A: Implications for tumor metabolism and growth
-
Shim H., Dolde C., Lewis B.C., Wu C.S., Dang G., Jungmann R.A., Dalla-Favera R., Dang C.V. C-Myc transactivation of LDH-A: Implications for tumor metabolism and growth. Proc Natl Acad Sci USA. 94:1997;6658-6663.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 6658-6663
-
-
Shim, H.1
Dolde, C.2
Lewis, B.C.3
Wu, C.S.4
Dang, G.5
Jungmann, R.A.6
Dalla-Favera, R.7
Dang, C.V.8
-
39
-
-
0032169214
-
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT
-
Zelzer E., Levy Y., Kahana C., Shilo B.Z., Rubinstein M., Cohen B. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT. EMBO J. 17:1998;5085-5094.
-
(1998)
EMBO J
, vol.17
, pp. 5085-5094
-
-
Zelzer, E.1
Levy, Y.2
Kahana, C.3
Shilo, B.Z.4
Rubinstein, M.5
Cohen, B.6
-
40
-
-
0033566693
-
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
-
Feldser D., Agani F., Iyer N.V., Pak B., Ferreira G., Semenza G.L. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res. 59:1999;3915-3918.
-
(1999)
Cancer Res
, vol.59
, pp. 3915-3918
-
-
Feldser, D.1
Agani, F.2
Iyer, N.V.3
Pak, B.4
Ferreira, G.5
Semenza, G.L.6
-
41
-
-
0034282388
-
Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1α) in vascular smooth muscle cells
-
This study shows substantial increase in HIF-1α protein in vascular smooth muscle cells in response to various stimuli other than hypoxia. This establishes that stimuli promoting growth can activate HIF in non-transformed cells
-
Richard D.E., Berra E., Pouysségur J. Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1α) in vascular smooth muscle cells. J Biol Chem. 275:2000;26765-26771. This study shows substantial increase in HIF-1α protein in vascular smooth muscle cells in response to various stimuli other than hypoxia. This establishes that stimuli promoting growth can activate HIF in non-transformed cells.
-
(2000)
J Biol Chem
, vol.275
, pp. 26765-26771
-
-
Richard, D.E.1
Berra, E.2
Pouysségur, J.3
-
43
-
-
0032725554
-
P42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF
-
Richard D.E., Berra E., Gothie E., Roux D., Pouysségur J. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF. J Biol Chem. 274:1999;32631-32637.
-
(1999)
J Biol Chem
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothie, E.3
Roux, D.4
Pouysségur, J.5
-
44
-
-
0034282553
-
The Kaposi's Sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α
-
This study shows that expression of the Kaposi's Sarcoma-associated herpes virus G protein-coupled receptor viral gene increased the activity of the HIF pathway. This suggests that the neovascularisation seen in Kaposi's sarcoma could be caused by HIF activation by the viral protein
-
Sodhi A., Montaner S., Patel V., Zohar M., Bais C., Mesri E.A., Gutkind J.S. The Kaposi's Sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1α Cancer Res. 60:2000;4873-4880. This study shows that expression of the Kaposi's Sarcoma-associated herpes virus G protein-coupled receptor viral gene increased the activity of the HIF pathway. This suggests that the neovascularisation seen in Kaposi's sarcoma could be caused by HIF activation by the viral protein.
-
(2000)
Cancer Res
, vol.60
, pp. 4873-4880
-
-
Sodhi, A.1
Montaner, S.2
Patel, V.3
Zohar, M.4
Bais, C.5
Mesri, E.A.6
Gutkind, J.S.7
-
45
-
-
0034326273
-
Coordinate up-regulation of hypoxia inducible factor (HIF)-1α and HIF target genes during multi-stage epidermal carcinogenesis and wound healing
-
This study shows that HIF target gene expression and HIF-1α mRNA progressively increased in a transgenic mouse model of multi-step carcinogenesis. Furthermore, similar changes were found in proliferating keratinocytes in healing wounds. The latter finding links proliferation with HIF activation in a non-malignant setting
-
Elson D.A., Ryan H.E., Snow J.W., Johnson R., Arbeit J.M. Coordinate up-regulation of hypoxia inducible factor (HIF)-1α and HIF target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res. 60:2000;6189-6195. This study shows that HIF target gene expression and HIF-1α mRNA progressively increased in a transgenic mouse model of multi-step carcinogenesis. Furthermore, similar changes were found in proliferating keratinocytes in healing wounds. The latter finding links proliferation with HIF activation in a non-malignant setting.
-
(2000)
Cancer Res
, vol.60
, pp. 6189-6195
-
-
Elson, D.A.1
Ryan, H.E.2
Snow, J.W.3
Johnson, R.4
Arbeit, J.M.5
-
46
-
-
0032403263
-
Increased expression of hypoxia inducible factor-1α in rat and human prostate cancer
-
Zhong H., Agani E., Baccala A.A., Laughner E., Rioseco-Camacho N., Isaacs W.B., Simons J.W., Semenza G.L. Increased expression of hypoxia inducible factor-1α in rat and human prostate cancer. Cancer Res. 58:1998;5280-5284.
-
(1998)
Cancer Res
, vol.58
, pp. 5280-5284
-
-
Zhong, H.1
Agani, E.2
Baccala, A.A.3
Laughner, E.4
Rioseco-Camacho, N.5
Isaacs, W.B.6
Simons, J.W.7
Semenza, G.L.8
-
47
-
-
0034667433
-
Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer
-
Salnikow K., Costa M., Figg W.D., Blagosklonny M.V. Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer. Cancer Res. 60:2000;5630-5634.
-
(2000)
Cancer Res
, vol.60
, pp. 5630-5634
-
-
Salnikow, K.1
Costa, M.2
Figg, W.D.3
Blagosklonny, M.V.4
-
48
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science. 123:1956;309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
49
-
-
0030945198
-
Aerobic glycolysis by proliferating cells: Aprotective strategy against reactive oxygen species
-
Brand K.A., Hermfisse U. Aerobic glycolysis by proliferating cells: aprotective strategy against reactive oxygen species. FASEB J. 11:1997;388-395.
-
(1997)
FASEB J
, vol.11
, pp. 388-395
-
-
Brand, K.A.1
Hermfisse, U.2
-
50
-
-
0034652779
-
Candidate genes for the hypoxic tumor phenotype
-
CDNA array membranes of 588 genes relevant to tumor biology are used to compare normoxic and hypoxic (<0.05% oxygen) expression in a squamous carcinoma-derived cell line. Expression of several genes was found to be induced by hypoxia, including plasminogen activator inhibitor-1 (PAI-1). Furthermore, the level of PAI-1 protein in serum samples from patients with squamous cell carcinoma correlated with the extent of hypoxia in their tumours
-
Koong A.C., Denko N.C., Hudson K.M., Schindler C., Swiersz L., Koch C., Evans S., Ibrahim H., Le Q.T., Terris D.J., et al. Candidate genes for the hypoxic tumor phenotype. Cancer Res. 60:2000;883-887. CDNA array membranes of 588 genes relevant to tumor biology are used to compare normoxic and hypoxic (<0.05% oxygen) expression in a squamous carcinoma-derived cell line. Expression of several genes was found to be induced by hypoxia, including plasminogen activator inhibitor-1 (PAI-1). Furthermore, the level of PAI-1 protein in serum samples from patients with squamous cell carcinoma correlated with the extent of hypoxia in their tumours.
-
(2000)
Cancer Res
, vol.60
, pp. 883-887
-
-
Koong, A.C.1
Denko, N.C.2
Hudson, K.M.3
Schindler, C.4
Swiersz, L.5
Koch, C.6
Evans, S.7
Ibrahim, H.8
Le, Q.T.9
Terris, D.J.10
-
51
-
-
0033970086
-
Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment
-
A subtractive hybridisation and amplification method termed representational difference analysis is used to identify hypoxia-induced (<0.05% oxygen) cDNAs in cultured cervical epithelial cells. In addition to several genes with known functions, two differentially expressed genes encoding short peptides of as yet unknown function were identified
-
Denko N., Schindler C., Koong A., Laderoute K., Green C., Giaccia A. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clin Cancer Res. 6:2000;480-487. A subtractive hybridisation and amplification method termed representational difference analysis is used to identify hypoxia-induced (<0.05% oxygen) cDNAs in cultured cervical epithelial cells. In addition to several genes with known functions, two differentially expressed genes encoding short peptides of as yet unknown function were identified.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 480-487
-
-
Denko, N.1
Schindler, C.2
Koong, A.3
Laderoute, K.4
Green, C.5
Giaccia, A.6
-
52
-
-
0034255036
-
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
-
Expression of Nip3 protein, a pro-apoptotic member of the Bcl-2 family, was shown to be strongly induced by hypoxia, and a HIF response element was identified in the promoter region
-
Bruick R.K. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci USA. 97:2000;9082-9087. Expression of Nip3 protein, a pro-apoptotic member of the Bcl-2 family, was shown to be strongly induced by hypoxia, and a HIF response element was identified in the promoter region.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9082-9087
-
-
Bruick, R.K.1
-
53
-
-
0032100732
-
HIF-1α is required for solid tumor formation and embryonic vascularization
-
Ryan H.E., Lo J., Johnson R.S. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J. 17:1998;3005-3015.
-
(1998)
EMBO J
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
54
-
-
0034529914
-
Suppression of tumor growth through disruption of hypoxia-inducible transcription
-
A polypeptide derived from the carboxy-terminal transactivation domain of HIF-1α is shown to block the interaction between HIF-1α and p300, and when expressed in tumorigenic cell lines to significantly retard tumour growth
-
Kung A.L., Wang S., Klco J.M., Kaelin W.G., Livingston D.M. Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med. 6:2000;1335-1340. A polypeptide derived from the carboxy-terminal transactivation domain of HIF-1α is shown to block the interaction between HIF-1α and p300, and when expressed in tumorigenic cell lines to significantly retard tumour growth.
-
(2000)
Nat Med
, vol.6
, pp. 1335-1340
-
-
Kung, A.L.1
Wang, S.2
Klco, J.M.3
Kaelin, W.G.4
Livingston, D.M.5
-
55
-
-
0033870727
-
Hypoxia-inducible factor-lα is a positive factor in solid tumor growth
-
Ryan H.E., Poloni M., McNulty W., Elson D., Gassmann M., Arbeit J.M., Johnson R.S. Hypoxia-inducible factor-lα is a positive factor in solid tumor growth. Cancer Res. 60:2000;4010-4015.
-
(2000)
Cancer Res
, vol.60
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
Elson, D.4
Gassmann, M.5
Arbeit, J.M.6
Johnson, R.S.7
-
56
-
-
0032514685
-
Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
-
Ivanov S.V., Kuzmin I., Wei M.-H., Pack S., Geil L., Johnson B.E., Stanbridge E.J., Lerman M.I. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc Natl Acad Sci USA. 95:1998;12596-12601.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 12596-12601
-
-
Ivanov, S.V.1
Kuzmin, I.2
Wei, M.-H.3
Pack, S.4
Geil, L.5
Johnson, B.E.6
Stanbridge, E.J.7
Lerman, M.I.8
|