Sequence determinants in hypoxia-inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3

Journal of Biological Chemistry

Volumn 277, Issue 42, 2002, Pages 39792-39800

  Huang, Jianhe ^a   Zhao, Quan ^a   Mooney, Sharon M ^a   Lee, Frank S ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; DEGRADATION; ENZYMES; HYDROXYLATION; TUMORS;

SEQUENCE DETERMINANTS;

BIOCHEMISTRY;

HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOPROTEIN; LIGASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE; PROLYL HYDROXYLASE D1; PROLYL HYDROXYLASE D2; PROLYL HYDROXYLASE D3; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBUNIT; GENE MUTATION; HYDROXYLATION; HYPOXIA; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN MODIFICATION; PROTEIN MOTIF;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; COS CELLS; DNA-BINDING PROTEINS; GENES, DOMINANT; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PLASMIDS; PROCOLLAGEN-PROLINE DIOXYGENASE; PROLINE; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0037131159     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206955200     Document Type: Article

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