SM-20 Is a Novel Mitochondrial Protein That Causes Caspase-dependent Cell Death in Nerve Growth Factor-dependent Neurons

Journal of Biological Chemistry

Volumn 276, Issue 7, 2001, Pages 5085-5092

  Lipscomb, Elizabeth A ^a   Sarmiere, Patrick D ^a   Freeman, Robert S ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; CELLS; DYES;

APOPTOSIS; NERVE GROWTH FACTOR (NGF); NEURONS;

PROTEINS;

AMINO ACID; CASPASE; CASPASE 3; CASPASE INHIBITOR; CYTOCHROME C OXIDASE; CYTOCHROME OXIDASE I; DIHYDROFOLATE REDUCTASE FUSION PROTEIN; DYE; MITOCHONDRIAL PROTEIN; NERVE GROWTH FACTOR; NEUROTROPHIN; SM 20 PROTEIN; UNCLASSIFIED DRUG; ASPARTIC ACID; BENZYLOXYCARBONYL ASPARTYL(O METHYL)FLUOROMETHANE; BENZYLOXYCARBONYL-ASPARTYL(O-METHYL)FLUOROMETHANE; CASP3 PROTEIN, MOUSE; CYTOCHROME C; DNA BINDING PROTEIN; DRUG DERIVATIVE; EGLN1 PROTEIN, MOUSE; ENZYME INHIBITOR; IMMEDIATE EARLY PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL MITOCHONDRIAL TARGETING SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; ENZYME ACTIVATION; GENE OVEREXPRESSION; IMMUNOFLUORESCENCE; MITOCHONDRION; MOUSE; NERVE CELL; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; SYMPATHETIC NERVE CELL; UPREGULATION; ANIMAL; CELL CULTURE; CELL LINE; CELL STRAIN 3T3; CYTOLOGY; DRUG ANTAGONISM; GENE DELETION; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; SYMPATHETIC GANGLION;

ANIMALIA;

3T3 CELLS; ANIMALS; APOPTOSIS; ASPARTIC ACID; CASPASE 3; CASPASES; CELL DEATH; CELL LINE; CELLS, CULTURED; CYTOCHROME C GROUP; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GANGLIA, SYMPATHETIC; IMMEDIATE-EARLY PROTEINS; MICE; MITOCHONDRIA; NERVE GROWTH FACTOR; NEURONS; PROTEIN TRANSPORT; SEQUENCE DELETION;

EID: 0035895928     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008407200     Document Type: Article

References (31)

1. Martin, D. P., Schmidt, R. E., DiStefano, P. S., Lowry, O. H., Carter, J. G., and Johnson, E. M. (1988) J. Cell Biol. 106, 829-844
2. Edwards, S. N., Buckmaster, A. E., and Tolkovsky, A. M. (1991) J. Neurochem. 57, 2140-2143
3. Freeman, R. S., Estus, S., and Johnson, E. M. (1994) Neuron 12, 343-355
4. Estus, S., Zaks, W. J., Freeman, R. S., Gruda, M., Bravo, R., and Johnson, E. M. (1994) J. Cell Biol. 127, 1717-1727
5. Ham, J., Babij, C., Whitfield, J., Pfarr, C. M., Lallemand, D., Yaniv, M., and Rubin, L. L. (1995) Neuron 14, 927-939
6. Watson, A., Eilers, A., Lallemand, D., Kyriakis, J., Rubin, L. L., and Ham, J. (1998) J. Neurosci. 18, 751-762
7. Kranenburg, O., van der Eb, A. J., and Zantema, A. (1996) EMBO J. 15, 46-54
8. Park, D. S., Levine, B., Ferrari, G., and Greene, L. A. (1997) J. Neurosci. 17, 8975-8983
9. Park, D. S., Morris, E. J., Padmanabhan, J., Shelanski, M. L., Geller, H. M., and Greene, L. A. (1998) J. Cell Biol. 143, 457-467
10. Lipscomb, E. A., Sarmiere, P. D., Crowder, R. J., and Freeman, R. S. (1999) J. Neurochem. 73, 429-432
11. Martin, D. P., Wallace, T. L., and Johnson, E. M. (1990) J. Neurosci. 10, 184-193
12. Crowder, R. J., and Freeman, R. S. (1998) J. Neurosci. 18, 2933-2943
13. Wax, S. D., Rosenfield, C. L., and Taubman, M. B. (1994) J. Biol. Chem. 269, 13041-13047
14. Moschella, M. C., Menzies, K., Tsao, L., Lieb, M. A., Kohtz, J. D., Kohtz, D. S., and Taubman, M. B. (1999) Gene Expr. 8, 59-66
15. Wax, S. D., Tsao, L., Lieb, M. E., Fallon, J. T., and Taubman, M. B. (1996) Lab. Invest. 74, 797-808
16. Madden, S. L., Galella, E. A., Riley, D., Bertelsen, A. H., and Beaudry, G. A. (1996) Cancer Res. 56, 5384-5390
17. Darby, C., Cosma, C. L., Thomas, J. H., and Manoil, C. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 15202-15207
18. Trent, C., Tsung, N., and Horvitz, R. (1983) Genetics 104, 619-647
19. Green, D. R., and Reed, J. C. (1998) Science 281, 1309-1312
20. Johnson, L. V., Walsh, M. L., and Chen, L. B. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 990-994
21. Krajewski, S., Tanaka, S., Takayama, S., Schibler, M. J., Fenton, W., and Reed, J. C. (1993) Cancer Res. 53, 4701-4714
22. Reed, J. C., Meister, L., Tanaka, S., Cuddy, M., Yum, S., Geyer, C., and Pleasure, D. (1991) Cancer Res. 51, 6529-6538
23. Modica-Napolitano, J. S., Steele, G. D. J., and Chen, L. B. (1989) Cancer Res. 49, 3369-3373
24. Hurt, E. C., and van Loon, A. P. G. M. (1986) Trends Biochem. Sci. 11, 204-207
25. Neupert, W. (1997) Annu. Rev. Biochem. 66, 863-917
26. Deshmukh, M., Vasilakos, J., Deckwerth, T. L., Lampe, P. A., Shivers, B. D., and Johnson, E. M. (1996) J. Cell Biol. 135, 1341-1354
27. Deshmukh, M., and Johnson, E. M. (1998) Neuron 21, 695-705
28. Kluck, R. M., Bossy-Wetzel, E., Green, D. R., and Newmeyer, D. D. (1997) Science 275, 1132-1136
29. Putcha, G. V., Deshmukh, M., and Johnson, E. M. (1999) J. Neurosci. 19, 7476-7485
30. Neame, S. J., Rubin, L. L., and Philpott, K. L. (1998) J. Cell Biol. 142, 1583-1593
31. Dupuy, D., Aubert, I., Dupérat, V. G., Petit, J., Taine, L., Stef, M., Bloch, B., and Arveiler, B. (2000) Genomics 69, 348-354