메뉴 건너뛰기




Volumn 2003, Issue 1, 2003, Pages 48-70

Prodrugs for gene-directed enzyme-prodrug therapy (suicide gene therapy)

Author keywords

[No Author keywords available]

Indexed keywords

2' EXOMETHANOCARBATHYMIDINE; 4 HYDROXYCYCLOPHOSPHAMIDE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; 6 METHYLPURINE DEOXYRIBOSIDE; 6 METHYLTHIOINOSINE; ACICLOVIR; ALKYLATING AGENT; ANTIFUNGAL AGENT; ANTIMETABOLITE; CYCLOPHOSPHAMIDE; CYTOCHROME P450; CYTOSINE DEAMINASE; CYTOTOXIN; ENZYME; FLUCYTOSINE; FLUDARABINE; FLUOROURACIL; GANCICLOVIR; GANCICLOVIR DERIVATIVE; GANCICLOVIR ELAIDIC ACID ESTER; IFOSFAMIDE; NUCLEOSIDE PHOSPHORYLASE; PENCICLOVIR; PRODRUG; RALTITREXED; THYMIDINE KINASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALACICLOVIR; ZIDOVUDINE;

EID: 0038685423     PISSN: 11107243     EISSN: None     Source Type: Journal    
DOI: 10.1155/S1110724303209098     Document Type: Review
Times cited : (107)

References (160)
  • 1
    • 0033831098 scopus 로고    scopus 로고
    • Gene therapy scores against cancer
    • Anderson WF. Gene therapy scores against cancer. Nat Med. 2000;6(8):862-863.
    • (2000) Nat Med , vol.6 , Issue.8 , pp. 862-863
    • Anderson, W.F.1
  • 2
    • 0029884764 scopus 로고    scopus 로고
    • Recent developments in the design of bioreductive drugs
    • Denny WA, Wilson WR, Hay MP. Recent developments in the design of bioreductive drugs. Br J Cancer Suppl. 1996;27:S32-S38.
    • (1996) Br J Cancer Suppl , vol.27
    • Denny, W.A.1    Wilson, W.R.2    Hay, M.P.3
  • 3
    • 0030742974 scopus 로고    scopus 로고
    • The role of the bystander effect in suicide gene therapy
    • Pope IM, Poston GJ, Kinsella AR. The role of the bystander effect in suicide gene therapy. Eur J Cancer. 1997;33(7):1005-1016.
    • (1997) Eur J Cancer , vol.33 , Issue.7 , pp. 1005-1016
    • Pope, I.M.1    Poston, G.J.2    Kinsella, A.R.3
  • 4
    • 0036494169 scopus 로고    scopus 로고
    • Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures
    • Wilson WR, Pullen SM, Hogg A, Helsby NA, Hicks KO, Denny WA. Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures. Cancer Res. 2002;62(5):1425-1432.
    • (2002) Cancer Res , vol.62 , Issue.5 , pp. 1425-1432
    • Wilson, W.R.1    Pullen, S.M.2    Hogg, A.3    Helsby, N.A.4    Hicks, K.O.5    Denny, W.A.6
  • 5
    • 0034502383 scopus 로고    scopus 로고
    • Guanosine analogues as anti-herpesvirus agents
    • De Clercq E. Guanosine analogues as anti-herpesvirus agents. Nucleosides Nucleotides Nucleic Acids. 2000;19(10-12):1531-1541.
    • (2000) Nucleosides Nucleotides Nucleic Acids , vol.19 , Issue.10-12 , pp. 1531-1541
    • De Clercq, E.1
  • 6
    • 0034839485 scopus 로고    scopus 로고
    • Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents
    • De Clercq E, Andrei G, Snoeck R, et al. Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents. Nucleosides Nucleotides Nucleic Acids. 2001;20(4-7):271-285.
    • (2001) Nucleosides Nucleotides Nucleic Acids , vol.20 , Issue.4-7 , pp. 271-285
    • De Clercq, E.1    Andrei, G.2    Snoeck, R.3
  • 7
    • 0033900009 scopus 로고    scopus 로고
    • Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: Role of gap-junctional intercellular communication
    • Mesnil M, Yamasaki H. Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication. Cancer Res. 2000;60(15):3989-3999.
    • (2000) Cancer Res , vol.60 , Issue.15 , pp. 3989-3999
    • Mesnil, M.1    Yamasaki, H.2
  • 8
    • 0034102736 scopus 로고    scopus 로고
    • Enhanced green fluorescent protein fusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome p450 4B1: Applications for prodrug-activating gene therapy
    • Steffens S, Frank S, Fischer U, et al. Enhanced green fluorescent protein fusion proteins of herpes simplex virus type 1 thymidine kinase and cytochrome p450 4B1: applications for prodrug-activating gene therapy. Cancer Gene Ther. 2000;7(5):806-812.
    • (2000) Cancer Gene Ther , vol.7 , Issue.5 , pp. 806-812
    • Steffens, S.1    Frank, S.2    Fischer, U.3
  • 9
    • 0035448565 scopus 로고    scopus 로고
    • Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas
    • Jacobs A, Voges J, Reszka R, et al. Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas. Lancet. 2001;358(9283):727-729.
    • (2001) Lancet , vol.358 , Issue.9283 , pp. 727-729
    • Jacobs, A.1    Voges, J.2    Reszka, R.3
  • 10
    • 0032169967 scopus 로고    scopus 로고
    • Superior cytotoxicity with ganciclovir compared with acyclovir and 1-β-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: A novel paradigm for cell killing
    • Rubsam LZ, Davidson BL, Shewach DS. Superior cytotoxicity with ganciclovir compared with acyclovir and 1-β-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing. Cancer Res. 1998;58(17):3873-3882.
    • (1998) Cancer Res , vol.58 , Issue.17 , pp. 3873-3882
    • Rubsam, L.Z.1    Davidson, B.L.2    Shewach, D.S.3
  • 11
    • 0034060815 scopus 로고    scopus 로고
    • Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: Comparison of ganciclovir, penciclovir and aciclovir
    • Thust R, Tomicic M, Klocking R, Wutzler P, Kaina B. Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: comparison of ganciclovir, penciclovir and aciclovir. Mutagenesis. 2000;15(2):177-184.
    • (2000) Mutagenesis , vol.15 , Issue.2 , pp. 177-184
    • Thust, R.1    Tomicic, M.2    Klocking, R.3    Wutzler, P.4    Kaina, B.5
  • 12
    • 0028864786 scopus 로고
    • The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro
    • Fick J, Barker FG 2nd, Dazin P, Westphale EM, Beyer EC, Israel MA. The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro. Proc Natl Acad Sci USA. 1995;92(24):11071-11075.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.24 , pp. 11071-11075
    • Fick, J.1    Barker F.G. II2    Dazin, P.3    Westphale, E.M.4    Beyer, E.C.5    Israel, M.A.6
  • 13
    • 0030724139 scopus 로고    scopus 로고
    • Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes
    • Denning C, Pitts JD. Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes. Hum Gene Ther. 1997;8(15):1825-1835.
    • (1997) Hum Gene Ther , vol.8 , Issue.15 , pp. 1825-1835
    • Denning, C.1    Pitts, J.D.2
  • 14
    • 0030668915 scopus 로고    scopus 로고
    • A "distant" bystander effect of suicide gene therapy: Regression of nontransduced tumors together with a distant transduced tumor
    • Kianmanesh AR, Perrin H, Panis Y, et al. A "distant" bystander effect of suicide gene therapy: regression of nontransduced tumors together with a distant transduced tumor. Hum Gene Ther. 1997;8(15):1807-1814.
    • (1997) Hum Gene Ther , vol.8 , Issue.15 , pp. 1807-1814
    • Kianmanesh, A.R.1    Perrin, H.2    Panis, Y.3
  • 15
    • 0035038479 scopus 로고    scopus 로고
    • Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques
    • Eaton JD, Perry MJA, Todryk SM, et al. Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques. Gene Ther. 2001;8(7):557-567.
    • (2001) Gene Ther , vol.8 , Issue.7 , pp. 557-567
    • Eaton, J.D.1    Perry, M.J.A.2    Todryk, S.M.3
  • 16
    • 0036211907 scopus 로고    scopus 로고
    • Systemic activation of the immune system during ganciclovir treatment following intratumoral herpes simplex virus type 1 thymidine kinase gene transfer in an adolescent ependymoma patient
    • Kramm CM, Korholz D, Rainov NG, et al. Systemic activation of the immune system during ganciclovir treatment following intratumoral herpes simplex virus type 1 thymidine kinase gene transfer in an adolescent ependymoma patient. Neuropediatrics. 2002;33(1):6-9.
    • (2002) Neuropediatrics , vol.33 , Issue.1 , pp. 6-9
    • Kramm, C.M.1    Korholz, D.2    Rainov, N.G.3
  • 17
    • 0034694011 scopus 로고    scopus 로고
    • A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
    • Rainov NG, Fetell M, Cloughesy T, et al. A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther. 2000;11(17):2389-2401.
    • (2000) Hum Gene Ther , vol.11 , Issue.17 , pp. 2389-2401
    • Rainov, N.G.1    Fetell, M.2    Cloughesy, T.3
  • 18
    • 0034098464 scopus 로고    scopus 로고
    • In vitro evaluation of mutant HSV-1 thymidine kinases for suicide gene therapy
    • Kokoris MS, Sabo P, Black ME. In vitro evaluation of mutant HSV-1 thymidine kinases for suicide gene therapy. Anticancer Res. 2000;20(2A):959-963.
    • (2000) Anticancer Res , vol.20 , Issue.2 A , pp. 959-963
    • Kokoris, M.S.1    Sabo, P.2    Black, M.E.3
  • 19
    • 0035300565 scopus 로고    scopus 로고
    • Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing
    • Black ME, Kokoris MS, Sabo P. Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing. Cancer Res. 2001;61(7):3022-3026.
    • (2001) Cancer Res , vol.61 , Issue.7 , pp. 3022-3026
    • Black, M.E.1    Kokoris, M.S.2    Sabo, P.3
  • 20
    • 0034636067 scopus 로고    scopus 로고
    • Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities
    • Hinds TA, Compadre C, Hurlburt BK, Drake RR. Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities. Biochemistry. 2000;39(14):4105-4111.
    • (2000) Biochemistry , vol.39 , Issue.14 , pp. 4105-4111
    • Hinds, T.A.1    Compadre, C.2    Hurlburt, B.K.3    Drake, R.R.4
  • 21
    • 0032820255 scopus 로고    scopus 로고
    • Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant
    • Kokoris MS, Sabo P, Adman ET, Black ME. Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant. Gene Ther. 1999;6(8):1415-1426.
    • (1999) Gene Ther , vol.6 , Issue.8 , pp. 1415-1426
    • Kokoris, M.S.1    Sabo, P.2    Adman, E.T.3    Black, M.E.4
  • 22
    • 0035266284 scopus 로고    scopus 로고
    • Protease pretreatment increases the efficacy of adenovirus-mediated gene therapy for the treatment of an experimental glioblastoma model
    • Kuriyama N, Kuriyama H, Julin CM, Lamborn KR, Israel MA. Protease pretreatment increases the efficacy of adenovirus-mediated gene therapy for the treatment of an experimental glioblastoma model. Cancer Res. 2001;61(5):1805-1809.
    • (2001) Cancer Res , vol.61 , Issue.5 , pp. 1805-1809
    • Kuriyama, N.1    Kuriyama, H.2    Julin, C.M.3    Lamborn, K.R.4    Israel, M.A.5
  • 23
    • 0034490547 scopus 로고    scopus 로고
    • Combined suicide and granulocytemacrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity
    • Jones RK, Pope IM, Kinsella AR, Watson AJM, Christmas SE. Combined suicide and granulocytemacrophage colony-stimulating factor gene therapy induces complete tumor regression and generates antitumor immunity. Cancer Gene Ther. 2000;7(12):1519-1528.
    • (2000) Cancer Gene Ther , vol.7 , Issue.12 , pp. 1519-1528
    • Jones, R.K.1    Pope, I.M.2    Kinsella, A.R.3    Watson, A.J.M.4    Christmas, S.E.5
  • 25
    • 0030729670 scopus 로고    scopus 로고
    • Retrovirus-mediated herpes simplex virus thymidine kinase gene transduction renders human thyroid carcinoma cell lines sensitive to ganciclovir and radiation in vitro and in vivo
    • Nishihara E, Nagayama Y, Mawatari F, et al. Retrovirus-mediated herpes simplex virus thymidine kinase gene transduction renders human thyroid carcinoma cell lines sensitive to ganciclovir and radiation in vitro and in vivo. Endocrinology. 1997;138(11):4577-4583.
    • (1997) Endocrinology , vol.138 , Issue.11 , pp. 4577-4583
    • Nishihara, E.1    Nagayama, Y.2    Mawatari, F.3
  • 26
    • 0033253012 scopus 로고    scopus 로고
    • Prodrug activation gene therapy and external beam irradiation in the treatment of prostate cancer
    • Atkinson G, Hall SJ. Prodrug activation gene therapy and external beam irradiation in the treatment of prostate cancer. Urology. 1999;54(6):1098-2104.
    • (1999) Urology , vol.54 , Issue.6 , pp. 1098-2104
    • Atkinson, G.1    Hall, S.J.2
  • 27
    • 0030801745 scopus 로고    scopus 로고
    • Retinoids augment the bystander effect in vitro and in vivo in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy
    • Park JY, Elshami AA, Amin K, Rizk N, Kaiser LR, Albelda SM. Retinoids augment the bystander effect in vitro and in vivo in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy. Gene Ther. 1997;4(9):909-917.
    • (1997) Gene Ther , vol.4 , Issue.9 , pp. 909-917
    • Park, J.Y.1    Elshami, A.A.2    Amin, K.3    Rizk, N.4    Kaiser, L.R.5    Albelda, S.M.6
  • 28
    • 0032747138 scopus 로고    scopus 로고
    • Enzyme prodrug gene therapy: Synergistic use of the herpes simplex virus-cellular thymidine kinase/ganciclovir system and thymidylate synthase inhibitors for the treatment of colon cancer
    • Wildner O, Blaese RM, Candotti F. Enzyme prodrug gene therapy: synergistic use of the herpes simplex virus-cellular thymidine kinase/ganciclovir system and thymidylate synthase inhibitors for the treatment of colon cancer. Cancer Res. 1999;59(20):5233-5238.
    • (1999) Cancer Res , vol.59 , Issue.20 , pp. 5233-5238
    • Wildner, O.1    Blaese, R.M.2    Candotti, F.3
  • 29
    • 0033230464 scopus 로고    scopus 로고
    • Synergybetween the herpes simplex virus tk/ganciclovir prodrug suicide system and the topoisomerase I inhibitor topotecan
    • Wildner O, Blaese RM, Morris JC. Synergybetween the herpes simplex virus tk/ganciclovir prodrug suicide system and the topoisomerase I inhibitor topotecan. Hum Gene Ther. 1999;10(16):2679-2687.
    • (1999) Hum Gene Ther , vol.10 , Issue.16 , pp. 2679-2687
    • Wildner, O.1    Blaese, R.M.2    Morris, J.C.3
  • 30
    • 0031907361 scopus 로고    scopus 로고
    • Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells
    • Balzarini J, Degreve B, Andrei G, et al. Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells. Gene Ther. 1998;5(3):419-426.
    • (1998) Gene Ther , vol.5 , Issue.3 , pp. 419-426
    • Balzarini, J.1    Degreve, B.2    Andrei, G.3
  • 31
    • 0034792704 scopus 로고    scopus 로고
    • Ganciclovir and penciclovir, but not acyclovir, induce apoptosis in herpes simplex virus thymidine kinase-transformed baby hamster kidney cells
    • Shaw MM, Gurr WK, Watts PA, Littler E, Field HJ. Ganciclovir and penciclovir, but not acyclovir, induce apoptosis in herpes simplex virus thymidine kinase-transformed baby hamster kidney cells. Antiviral Chem Chemother. 2001;12:175-186
    • (2001) Antiviral Chem Chemother , vol.12 , pp. 175-186
    • Shaw, M.M.1    Gurr, W.K.2    Watts, P.A.3    Littler, E.4    Field, H.J.5
  • 32
    • 0033974798 scopus 로고    scopus 로고
    • Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: Implications for gene therapeutic approaches
    • Thust R, Tomicic M, Klocking R, Voutilainen N, Wutzler P, Kaina B. Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches. Cancer Gene Ther. 2000;7(1):107-117.
    • (2000) Cancer Gene Ther , vol.7 , Issue.1 , pp. 107-117
    • Thust, R.1    Tomicic, M.2    Klocking, R.3    Voutilainen, N.4    Wutzler, P.5    Kaina, B.6
  • 33
    • 14444288754 scopus 로고    scopus 로고
    • Improvement of gene therapy for ovarian cancer by using acyclovir instead of ganciclovir in adenovirus mediated thymidine kinase gene therapy
    • Tong XW, Engehausen DG, Kaufman RH, et al. Improvement of gene therapy for ovarian cancer by using acyclovir instead of ganciclovir in adenovirus mediated thymidine kinase gene therapy. Anticancer Res. 1998;18(2A):713-718.
    • (1998) Anticancer Res , vol.18 , Issue.2 A , pp. 713-718
    • Tong, X.W.1    Engehausen, D.G.2    Kaufman, R.H.3
  • 34
    • 0033935125 scopus 로고    scopus 로고
    • Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant herpes simplex virus-thymidine kinase in combination with acyclovir
    • Valerie K, Brust D, Farnsworth J, et al. Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant herpes simplex virus-thymidine kinase in combination with acyclovir. Cancer Gene Ther. 2000;7(6):879-884.
    • (2000) Cancer Gene Ther , vol.7 , Issue.6 , pp. 879-884
    • Valerie, K.1    Brust, D.2    Farnsworth, J.3
  • 35
    • 0035205990 scopus 로고    scopus 로고
    • Adenovirus-mediated thymidine kinase gene therapy in combination with topotecan for patients with recurrent ovarian cancer: 2.5-Year follow-up
    • Hasenburg A, Tong XW, Fischer DC, et al. Adenovirus-mediated thymidine kinase gene therapy in combination with topotecan for patients with recurrent ovarian cancer: 2.5-year follow-up. Gynecol Oncol. 2001;83(3):549-554.
    • (2001) Gynecol Oncol , vol.83 , Issue.3 , pp. 549-554
    • Hasenburg, A.1    Tong, X.W.2    Fischer, D.C.3
  • 36
    • 0032800784 scopus 로고    scopus 로고
    • Thymidine kinase (TK) gene therapy of solid tumors: Valacyclovir facilitates outpatient treatment
    • Hasenburg A, Tong XW, Rojas-Martinez A, et al. Thymidine kinase (TK) gene therapy of solid tumors: valacyclovir facilitates outpatient treatment. Anticancer Res. 1999;19(3B):2163-2165.
    • (1999) Anticancer Res , vol.19 , Issue.3 B , pp. 2163-2165
    • Hasenburg, A.1    Tong, X.W.2    Rojas-Martinez, A.3
  • 37
    • 0035501397 scopus 로고    scopus 로고
    • Phase I/II trial evaluating combined radiotherapy and in situ gene therapy with or without hormonal therapy in the treatment of prostate cancer - A preliminary report
    • Teh BS, Aguilar-Cordova E, Kernen K, et al. Phase I/II trial evaluating combined radiotherapy and in situ gene therapy with or without hormonal therapy in the treatment of prostate cancer - a preliminary report. Int J Radiat Oncol Biol Phys. 2001;51(3):605-613.
    • (2001) Int J Radiat Oncol Biol Phys , vol.51 , Issue.3 , pp. 605-613
    • Teh, B.S.1    Aguilar-Cordova, E.2    Kernen, K.3
  • 38
    • 0034041950 scopus 로고    scopus 로고
    • Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer
    • Shalev M, Kadmon D, Teh BS, et al. Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer. J Urol. 2000;163(6):1747-1750.
    • (2000) J Urol , vol.163 , Issue.6 , pp. 1747-1750
    • Shalev, M.1    Kadmon, D.2    Teh, B.S.3
  • 39
    • 0031912176 scopus 로고    scopus 로고
    • Efficient syntheses of (E)-5-(2-bromovinyl)-2′-deoxy-4′-thiouridine; a nucleoside analogue with potent biological activity
    • Basnak I, Otter GP, Duncombe RJ, et al. Efficient syntheses of (E)-5-(2-bromovinyl)-2′-deoxy-4′-thiouridine; a nucleoside analogue with potent biological activity. Nucleosides Nucleotides. 1998;17(1-3):29-38.
    • (1998) Nucleosides Nucleotides , vol.17 , Issue.1-3 , pp. 29-38
    • Basnak, I.1    Otter, G.P.2    Duncombe, R.J.3
  • 40
    • 0034922609 scopus 로고    scopus 로고
    • (E)-5-(2-bromovinyl)-2′-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase-expressing cells
    • Hamel W, Zirkel D, Mehdorn HM, Westphal M, Israel MA. (E)-5-(2-bromovinyl)-2′-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase-expressing cells. Cancer Gene Ther. 2001;8(5):388-396.
    • (2001) Cancer Gene Ther , vol.8 , Issue.5 , pp. 388-396
    • Hamel, W.1    Zirkel, D.2    Mehdorn, H.M.3    Westphal, M.4    Israel, M.A.5
  • 41
    • 18544405495 scopus 로고    scopus 로고
    • Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues
    • Degreve B, De Clercq E, Balzarini J. Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues. Gene Ther. 1999;6(2):162-170.
    • (1999) Gene Ther , vol.6 , Issue.2 , pp. 162-170
    • Degreve, B.1    De Clercq, E.2    Balzarini, J.3
  • 42
    • 0035206505 scopus 로고    scopus 로고
    • Human glioma cells expressing herpes simplex virus thymidine kinase gene treated with acyclovir, ganciclovir and bromovinyldeoxyuridine. Evaluation of their activity in vitro and in nude mice
    • Hlubinova K, Hlavaty J, Altaner C. Human glioma cells expressing herpes simplex virus thymidine kinase gene treated with acyclovir, ganciclovir and bromovinyldeoxyuridine. Evaluation of their activity in vitro and in nude mice. Neoplasma. 2001;48(5):398-406.
    • (2001) Neoplasma , vol.48 , Issue.5 , pp. 398-406
    • Hlubinova, K.1    Hlavaty, J.2    Altaner, C.3
  • 43
    • 0033669748 scopus 로고    scopus 로고
    • The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy
    • Grignet-Debrus C, Cool V, Baudson N, Velu T, Calberg-Bacq CM. The role of cellular- and prodrug-associated factors in the bystander effect induced by the Varicella zoster and Herpes simplex viral thymidine kinases in suicide gene therapy. Cancer Gene Ther. 2000;7(11):1456-1468.
    • (2000) Cancer Gene Ther , vol.7 , Issue.11 , pp. 1456-1468
    • Grignet-Debrus, C.1    Cool, V.2    Baudson, N.3    Velu, T.4    Calberg-Bacq, C.M.5
  • 44
    • 0030758623 scopus 로고    scopus 로고
    • Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells
    • Grignet-Debrus C, Calberg-Bacq CM. Potential of Varicella zoster virus thymidine kinase as a suicide gene in breast cancer cells. Gene Ther. 1997;4(6):560-569.
    • (1997) Gene Ther , vol.4 , Issue.6 , pp. 560-569
    • Grignet-Debrus, C.1    Calberg-Bacq, C.M.2
  • 45
    • 0033037012 scopus 로고    scopus 로고
    • Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling
    • Christians FC, Scapozza L, Crameri A, Folkers G, Stemmer WP. Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling. NatBiotechnol. 1999;17(3):259-264.
    • (1999) NatBiotechnol , vol.17 , Issue.3 , pp. 259-264
    • Christians, F.C.1    Scapozza, L.2    Crameri, A.3    Folkers, G.4    Stemmer, W.P.5
  • 46
    • 0029815436 scopus 로고    scopus 로고
    • Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides?
    • Marquez VE, Siddiqui MA, Ezzitouni A, et al. Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides? J Med Chem. 1996;39(19):3739-3747.
    • (1996) J Med Chem , vol.39 , Issue.19 , pp. 3739-3747
    • Marquez, V.E.1    Siddiqui, M.A.2    Ezzitouni, A.3
  • 47
    • 0034622629 scopus 로고    scopus 로고
    • Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine
    • Prota A, Vogt J, Pilger B, et al. Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine. Biochemistry. 2000;39(31):9597-9603.
    • (2000) Biochemistry , vol.39 , Issue.31 , pp. 9597-9603
    • Prota, A.1    Vogt, J.2    Pilger, B.3
  • 48
    • 0036597936 scopus 로고    scopus 로고
    • Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase
    • Noy R, Ben-Zvi Z, Manor E, et al. Antitumor activity and metabolic activation of N-methanocarbathymidine, a novel thymidine analogue with a pseudosugar rigidly fixed in the northern conformation, in murine colon cancer cells expressing herpes simplex thymidine kinase. Mol Cancer Ther. 2002;1:585-593.
    • (2002) Mol Cancer Ther , vol.1 , pp. 585-593
    • Noy, R.1    Ben-Zvi, Z.2    Manor, E.3
  • 49
    • 0036304598 scopus 로고    scopus 로고
    • The structure of Escherichia coli cytosine deaminase
    • Ireton GC, McDermott G, Black ME, Stoddard BL. The structure of Escherichia coli cytosine deaminase. J Mol Biol. 2002;315(4):687-697.
    • (2002) J Mol Biol , vol.315 , Issue.4 , pp. 687-697
    • Ireton, G.C.1    McDermott, G.2    Black, M.E.3    Stoddard, B.L.4
  • 50
    • 0029943796 scopus 로고    scopus 로고
    • Monitoring gene therapy with cytosine deaminase: In vitro studies using tritiated-5-fluorocytosine
    • Haberkorn U, Oberdorfer F, Gebert J, et al. Monitoring gene therapy with cytosine deaminase: in vitro studies using tritiated-5-fluorocytosine. J Nucl Med. 1996;37(1):87-94.
    • (1996) J Nucl Med , vol.37 , Issue.1 , pp. 87-94
    • Haberkorn, U.1    Oberdorfer, F.2    Gebert, J.3
  • 51
    • 0033578358 scopus 로고    scopus 로고
    • Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy
    • Stegman LD, Rehemtulla A, Beattie B, et al. Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc Natl Acad Sci USA. 1999;96(17):9821-9826.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.17 , pp. 9821-9826
    • Stegman, L.D.1    Rehemtulla, A.2    Beattie, B.3
  • 52
    • 0032526178 scopus 로고    scopus 로고
    • Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-flucytosine
    • Lawrence TS, Rehemtulla A, Ng EY, Wilson M, Trosko JE, Stetson PL. Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-flucytosine. Cancer Res. 1998;58(12):2588-2593.
    • (1998) Cancer Res , vol.58 , Issue.12 , pp. 2588-2593
    • Lawrence, T.S.1    Rehemtulla, A.2    Ng, E.Y.3    Wilson, M.4    Trosko, J.E.5    Stetson, P.L.6
  • 53
    • 0029637158 scopus 로고
    • VDEPT: An enzyme/prodrug gene therapy approach for the treatment of metastatic colorectal cancer
    • Huber BE, Richards CA, Austin EA. VDEPT: an enzyme/prodrug gene therapy approach for the treatment of metastatic colorectal cancer. Advanced Drug Delivery Reviews. 1995;17:279-292.
    • (1995) Advanced Drug Delivery Reviews , vol.17 , pp. 279-292
    • Huber, B.E.1    Richards, C.A.2    Austin, E.A.3
  • 54
    • 0037089556 scopus 로고    scopus 로고
    • High and selective expression of yeast cytosine deaminase under a carcinoembryonic antigen promoter-enhancer
    • Nyati MK, Sreekumar A, Li S, et al. High and selective expression of yeast cytosine deaminase under a carcinoembryonic antigen promoter-enhancer. Cancer Res. 2002;62(8):2337-2342.
    • (2002) Cancer Res , vol.62 , Issue.8 , pp. 2337-2342
    • Nyati, M.K.1    Sreekumar, A.2    Li, S.3
  • 55
    • 0031087212 scopus 로고    scopus 로고
    • Enzyme/prodrug gene therapy approach for breast cancer using a recombinant adenovirus expressing Escherichia coli cytosine deaminase
    • Li Z, Shanmugam N, Katayose D, et al. Enzyme/prodrug gene therapy approach for breast cancer using a recombinant adenovirus expressing Escherichia coli cytosine deaminase. Cancer Gene Ther. 1997;4(2):113-117.
    • (1997) Cancer Gene Ther , vol.4 , Issue.2 , pp. 113-117
    • Li, Z.1    Shanmugam, N.2    Katayose, D.3
  • 56
    • 0036468901 scopus 로고    scopus 로고
    • Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas
    • Miller CR, Williams CR, Buchsbaum DJ, Gillespie GY. Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas. Cancer Res. 2002;62(3):773-780.
    • (2002) Cancer Res , vol.62 , Issue.3 , pp. 773-780
    • Miller, C.R.1    Williams, C.R.2    Buchsbaum, D.J.3    Gillespie, G.Y.4
  • 57
    • 0031941292 scopus 로고    scopus 로고
    • Regional "pro-drug" gene therapy: Intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma
    • Topf N, Worgall S, Hackett NR, Crystal RG. Regional "pro-drug" gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma. Gene Ther. 1998;5(4):507-513.
    • (1998) Gene Ther , vol.5 , Issue.4 , pp. 507-513
    • Topf, N.1    Worgall, S.2    Hackett, N.R.3    Crystal, R.G.4
  • 58
    • 0033820505 scopus 로고    scopus 로고
    • Prostate-specific suicide gene therapy using the prostate-specific membrane antigen promoter and enhancer
    • O'Keefe DS, Uchida A, Bacich DJ, et al. Prostate-specific suicide gene therapy using the prostate-specific membrane antigen promoter and enhancer. Prostate. 2000;45(2):149-157.
    • (2000) Prostate , vol.45 , Issue.2 , pp. 149-157
    • O'Keefe, D.S.1    Uchida, A.2    Bacich, D.J.3
  • 59
    • 0033119291 scopus 로고    scopus 로고
    • Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts
    • Kievit E, Bershad E, Ng E, et al. Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts. Cancer Res. 1999;59(7):1417-1421.
    • (1999) Cancer Res , vol.59 , Issue.7 , pp. 1417-1421
    • Kievit, E.1    Bershad, E.2    Ng, E.3
  • 60
    • 0034547928 scopus 로고    scopus 로고
    • Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts
    • Kievit E, Nyati MK, Ng E, et al. Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts. Cancer Res. 2000;60(23):6649-6655.
    • (2000) Cancer Res , vol.60 , Issue.23 , pp. 6649-6655
    • Kievit, E.1    Nyati, M.K.2    Ng, E.3
  • 61
    • 0032717286 scopus 로고    scopus 로고
    • Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma
    • Kuriyama S, Mitoro A, Yamazaki M, et al. Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma. Scand J Gastroenterol. 1999;34(10):1033-1041.
    • (1999) Scand J Gastroenterol , vol.34 , Issue.10 , pp. 1033-1041
    • Kuriyama, S.1    Mitoro, A.2    Yamazaki, M.3
  • 62
    • 0030467588 scopus 로고    scopus 로고
    • Killing Epstein-Barr virus-positive B lymphocytes by gene therapy: Comparing the efficacy of cytosine deaminase and herpes simplex virus thymidine kinase
    • Rogers RP, Ge JQ, Holley-Guthrie E, et al. Killing Epstein-Barr virus-positive B lymphocytes by gene therapy: comparing the efficacy of cytosine deaminase and herpes simplex virus thymidine kinase. Hum Gene Ther. 1999;7(18):2235-2245.
    • (1999) Hum Gene Ther , vol.7 , Issue.18 , pp. 2235-2245
    • Rogers, R.P.1    Ge, J.Q.2    Holley-Guthrie, E.3
  • 63
    • 0032851547 scopus 로고    scopus 로고
    • Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model
    • Shirakawa T, Gardner TA, Ko SC, et al. Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model. J Urol. 1999;162(pt 1):949-954.
    • (1999) J Urol , vol.162 , Issue.PART 1 , pp. 949-954
    • Shirakawa, T.1    Gardner, T.A.2    Ko, S.C.3
  • 64
    • 0028800141 scopus 로고
    • Enzyme/prodrug gene therapy: Comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line
    • Trinh QT, Austin EA, Murray DM, Knick VC, Huber BE. Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line. Cancer Res. 1995;55(21):4808-4812.
    • (1995) Cancer Res , vol.55 , Issue.21 , pp. 4808-4812
    • Trinh, Q.T.1    Austin, E.A.2    Murray, D.M.3    Knick, V.C.4    Huber, B.E.5
  • 65
    • 0033958068 scopus 로고    scopus 로고
    • Experimental gene therapy for brain tumors using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene with 5-fluorocytosine
    • Adachi Y, Tamiya T, Ichikawa T, et al. Experimental gene therapy for brain tumors using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene with 5-fluorocytosine. Hum Gene Ther. 2000;11(1):77-89.
    • (2000) Hum Gene Ther , vol.11 , Issue.1 , pp. 77-89
    • Adachi, Y.1    Tamiya, T.2    Ichikawa, T.3
  • 66
    • 0033914616 scopus 로고    scopus 로고
    • Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of Escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine
    • Koyama F, Sawada H, Hirao T, Fujii H, Hamada H, Nakano H. Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of Escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine. Cancer Gene Ther. 2000;7(7):1015-1022.
    • (2000) Cancer Gene Ther , vol.7 , Issue.7 , pp. 1015-1022
    • Koyama, F.1    Sawada, H.2    Hirao, T.3    Fujii, H.4    Hamada, H.5    Nakano, H.6
  • 67
    • 0031024794 scopus 로고    scopus 로고
    • Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity
    • Rogulski KR, Kim JH, Kim SH, Freytag SO. Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity. Hum Gene Ther. 1997;8(1):73-85.
    • (1997) Hum Gene Ther , vol.8 , Issue.1 , pp. 73-85
    • Rogulski, K.R.1    Kim, J.H.2    Kim, S.H.3    Freytag, S.O.4
  • 68
    • 0032481577 scopus 로고    scopus 로고
    • Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies
    • Aghi M, Kramm CM, Chou TC, Breakefield XO, Chiocca EA. Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. J Natl Cancer Inst. 1998;90(5):370-380.
    • (1998) J Natl Cancer Inst , vol.90 , Issue.5 , pp. 370-380
    • Aghi, M.1    Kramm, C.M.2    Chou, T.C.3    Breakefield, X.O.4    Chiocca, E.A.5
  • 69
    • 0030768615 scopus 로고    scopus 로고
    • Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts
    • Hanna NN, Mauceri HJ, Wayne JD, Hallahan DE, Kufe DW, Weichselbaum RR. Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts. Cancer Res. 1997;57(19):4205-4209.
    • (1997) Cancer Res , vol.57 , Issue.19 , pp. 4205-4209
    • Hanna, N.N.1    Mauceri, H.J.2    Wayne, J.D.3    Hallahan, D.E.4    Kufe, D.W.5    Weichselbaum, R.R.6
  • 70
    • 0030817590 scopus 로고    scopus 로고
    • Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo
    • Pederson LC, Buchsbaum DJ, Vickers SM et al. Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo. Cancer Res. 1997;57(19):4325-4332.
    • (1997) Cancer Res , vol.57 , Issue.19 , pp. 4325-4332
    • Pederson, L.C.1    Buchsbaum, D.J.2    Vickers, S.M.3
  • 71
    • 0031803611 scopus 로고    scopus 로고
    • Selective in vivo radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells transduced with the E. coli cytosine deaminase (CD) gene
    • Gabel M, Kim JH, Kolozsvary A, Khil M, Freytag S. Selective in vivo radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells transduced with the E. coli cytosine deaminase (CD) gene. Int J Radiat Oncol Biol Phys. 1998;41(4):883-887.
    • (1998) Int J Radiat Oncol Biol Phys , vol.41 , Issue.4 , pp. 883-887
    • Gabel, M.1    Kim, J.H.2    Kolozsvary, A.3    Khil, M.4    Freytag, S.5
  • 72
    • 0033022611 scopus 로고    scopus 로고
    • Genetic prodrug activation therapy for breast cancer: A phase I clinical trial of erbB-2-directed suicide gene expression
    • Pandha HS, Martin LA, Rigg A, et al. Genetic prodrug activation therapy for breast cancer: A phase I clinical trial of erbB-2-directed suicide gene expression. J. Clin Oncol. 1999;17(7):2180-2189.
    • (1999) J Clin Oncol , vol.17 , Issue.7 , pp. 2180-2189
    • Pandha, H.S.1    Martin, L.A.2    Rigg, A.3
  • 73
    • 0031572855 scopus 로고    scopus 로고
    • The crystal structure of Escherichia coli purine nucleoside phosphorylase: A comparison with the human enzyme reveals a conserved topology
    • Mao C, Cook WJ, Zhou M, Koszalka GW, Krenitsky TA, Ealick SE. The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology. Structure. 1997;5(10):1373-1383.
    • (1997) Structure , vol.5 , Issue.10 , pp. 1373-1383
    • Mao, C.1    Cook, W.J.2    Zhou, M.3    Koszalka, G.W.4    Krenitsky, T.A.5    Ealick, S.E.6
  • 74
    • 0033759371 scopus 로고    scopus 로고
    • In vivo sensitization of ovarian tumors to chemotherapy by expression of E. coli purine nucleoside phosphorylase in a small fraction of cells
    • Gadi VK, Alexander SD, Kudlow JE, Allan P, Parker WB, Sorscher EJ. In vivo sensitization of ovarian tumors to chemotherapy by expression of E. coli purine nucleoside phosphorylase in a small fraction of cells. Gene Ther. 2000;7(20):1738-1743.
    • (2000) Gene Ther , vol.7 , Issue.20 , pp. 1738-1743
    • Gadi, V.K.1    Alexander, S.D.2    Kudlow, J.E.3    Allan, P.4    Parker, W.B.5    Sorscher, E.J.6
  • 75
    • 0030710957 scopus 로고    scopus 로고
    • Relative efficiency of tumor cell killing in vitro by two enzyme-prodrug systems delivered by identical adenovirus vectors
    • Lockett LJ, Molloy PL, Russell PJ, Both GW. Relative efficiency of tumor cell killing in vitro by two enzyme-prodrug systems delivered by identical adenovirus vectors. Clin Cancer Res. 1997;3(11):2075-2080.
    • (1997) Clin Cancer Res , vol.3 , Issue.11 , pp. 2075-2080
    • Lockett, L.J.1    Molloy, P.L.2    Russell, P.J.3    Both, G.W.4
  • 76
    • 0032551657 scopus 로고    scopus 로고
    • In vivo gene therapy for prostate cancer: Preclinical evaluation of two different enzyme-directed prodrug therapy systems delivered by identical adenovirus vectors
    • Martiniello-Wilks R, Garcia-Aragon J, Daja MM, et al. In vivo gene therapy for prostate cancer: preclinical evaluation of two different enzyme-directed prodrug therapy systems delivered by identical adenovirus vectors. Hum Gene Ther. 1998;9(11):1617-1626.
    • (1998) Hum Gene Ther , vol.9 , Issue.11 , pp. 1617-1626
    • Martiniello-Wilks, R.1    Garcia-Aragon, J.2    Daja, M.M.3
  • 77
    • 0033999780 scopus 로고    scopus 로고
    • Gene therapy of hepatocellular carcinoma in vitro and in vivo in nude mice by adenoviral transfer of the Escherichia coli purine nucleoside phosphorylase gene
    • Mohr L, Shankara S, Yoon SK, et al. Gene therapy of hepatocellular carcinoma in vitro and in vivo in nude mice by adenoviral transfer of the Escherichia coli purine nucleoside phosphorylase gene. Hepatology. 2000;31(3):606-614.
    • (2000) Hepatology , vol.31 , Issue.3 , pp. 606-614
    • Mohr, L.1    Shankara, S.2    Yoon, S.K.3
  • 78
    • 0031580711 scopus 로고    scopus 로고
    • In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase
    • Parker WB, King SA, Allan PW, et al. In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase. Hum Gene Ther. 1997;8(14):1637-1644.
    • (1997) Hum Gene Ther , vol.8 , Issue.14 , pp. 1637-1644
    • Parker, W.B.1    King, S.A.2    Allan, P.W.3
  • 79
    • 0034868947 scopus 로고    scopus 로고
    • Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro
    • Krohne TU, Shankara S, Geissler M, et al. Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro. Hepatology. 2001;34(3):511-518.
    • (2001) Hepatology , vol.34 , Issue.3 , pp. 511-518
    • Krohne, T.U.1    Shankara, S.2    Geissler, M.3
  • 80
    • 0032901285 scopus 로고    scopus 로고
    • Cytochrome P450-based cancer gene therapy: Recent advances and future prospects
    • Waxman DJ, Chen L, Hecht JE, Jounaidi Y. Cytochrome P450-based cancer gene therapy: recent advances and future prospects. Drug Metab Rev. 1999;31(2):503-522.
    • (1999) Drug Metab Rev , vol.31 , Issue.2 , pp. 503-522
    • Waxman, D.J.1    Chen, L.2    Hecht, J.E.3    Jounaidi, Y.4
  • 81
    • 0028936342 scopus 로고
    • Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: Development of a combined chemotherapy/cancer gene therapy strategy
    • Chen L, Waxman DJ. Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy. Cancer Res. 1995;55(3):581-589.
    • (1995) Cancer Res , vol.55 , Issue.3 , pp. 581-589
    • Chen, L.1    Waxman, D.J.2
  • 82
    • 0028832191 scopus 로고
    • Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm
    • Wei MX, Tamiya T, Rhee RJ, Breakefield XO, Chiocca EA. Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm. Clin Cancer Res. 1995;1(10):1171-1177.
    • (1995) Clin Cancer Res , vol.1 , Issue.10 , pp. 1171-1177
    • Wei, M.X.1    Tamiya, T.2    Rhee, R.J.3    Breakefield, X.O.4    Chiocca, E.A.5
  • 83
    • 0029993999 scopus 로고    scopus 로고
    • Gene therapy for malignant gliomas using replication incompetent retroviral and adenoviral vectors encoding the cytochrome P450 2B1 gene together with cyclophosphamide
    • Manome Y, Wen PY, Chen L, et al. Gene therapy for malignant gliomas using replication incompetent retroviral and adenoviral vectors encoding the cytochrome P450 2B1 gene together with cyclophosphamide. Gene Ther. 1996;3(6):513-520.
    • (1996) Gene Ther , vol.3 , Issue.6 , pp. 513-520
    • Manome, Y.1    Wen, P.Y.2    Chen, L.3
  • 84
    • 0030810198 scopus 로고    scopus 로고
    • Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene
    • Chen L, Yu LJ, Waxman DJ. Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene. Cancer Res. 1997;57(21):4830-4837.
    • (1997) Cancer Res , vol.57 , Issue.21 , pp. 4830-4837
    • Chen, L.1    Yu, L.J.2    Waxman, D.J.3
  • 85
    • 0033943812 scopus 로고    scopus 로고
    • Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model
    • Huang Z, Raychowdhury MK, Waxman DJ. Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model. Cancer Gene Ther. 2000;7(7):1034-1042.
    • (2000) Cancer Gene Ther , vol.7 , Issue.7 , pp. 1034-1042
    • Huang, Z.1    Raychowdhury, M.K.2    Waxman, D.J.3
  • 86
    • 0034885956 scopus 로고    scopus 로고
    • Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors
    • Huang Z, Waxman DJ. Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors. Cancer Gene Ther. 2001;8(6):450-458.
    • (2001) Cancer Gene Ther , vol.8 , Issue.6 , pp. 450-458
    • Huang, Z.1    Waxman, D.J.2
  • 87
    • 0033802511 scopus 로고    scopus 로고
    • Cytochrome P-450 2C9 sensitizes human prostate tumor cells to cyclophosphamide via a bystander effect
    • Zhou D, Lu Y, Steiner MS, Dalton JT. Cytochrome P-450 2C9 sensitizes human prostate tumor cells to cyclophosphamide via a bystander effect. Antimicrob Agents Chemother. 2000;44(10):2659-2663.
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.10 , pp. 2659-2663
    • Zhou, D.1    Lu, Y.2    Steiner, M.S.3    Dalton, J.T.4
  • 88
    • 0032190113 scopus 로고    scopus 로고
    • Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy
    • Jounaidi Y, Hecht JE, Waxman DJ. Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy. Cancer Res. 1998;58(19):4391-4401.
    • (1998) Cancer Res , vol.58 , Issue.19 , pp. 4391-4401
    • Jounaidi, Y.1    Hecht, J.E.2    Waxman, D.J.3
  • 89
    • 0034909829 scopus 로고    scopus 로고
    • Direct retroviral delivery of human cytochrome P450 2B6 for genedirected enzyme prodrug therapy of cancer
    • Kan O, Griffiths L, Baban D, et al. Direct retroviral delivery of human cytochrome P450 2B6 for genedirected enzyme prodrug therapy of cancer. Cancer Gene Ther. 2001;8(7):473-482.
    • (2001) Cancer Gene Ther , vol.8 , Issue.7 , pp. 473-482
    • Kan, O.1    Griffiths, L.2    Baban, D.3
  • 90
    • 0035360868 scopus 로고    scopus 로고
    • Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy
    • Jounaidi Y, Waxman DJ. Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy. Cancer Res. 2001;61(11):4437-4444.
    • (2001) Cancer Res , vol.61 , Issue.11 , pp. 4437-4444
    • Jounaidi, Y.1    Waxman, D.J.2
  • 91
    • 0035049257 scopus 로고    scopus 로고
    • Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide
    • Karle P, Renner M, Salmons B, Gunzburg WH. Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide. Cancer Gene Ther. 2001;8(3):220-230.
    • (2001) Cancer Gene Ther , vol.8 , Issue.3 , pp. 220-230
    • Karle, P.1    Renner, M.2    Salmons, B.3    Gunzburg, W.H.4
  • 92
    • 0034115137 scopus 로고    scopus 로고
    • Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine
    • Kammertoens T, Gelbmann W, Karle P, et al. Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine. Cancer Gene Ther. 2000;7(4):629-636.
    • (2000) Cancer Gene Ther , vol.7 , Issue.4 , pp. 629-636
    • Kammertoens, T.1    Gelbmann, W.2    Karle, P.3
  • 93
    • 7344268645 scopus 로고    scopus 로고
    • Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450
    • Lohr M, Muller P, Karle P, et al. Targeted chemotherapy by intratumour injection of encapsulated cells engineered to produce CYP2B1, an ifosfamide activating cytochrome P450. Gene Ther. 1998;5(8):1070-1078.
    • (1998) Gene Ther , vol.5 , Issue.8 , pp. 1070-1078
    • Lohr, M.1    Muller, P.2    Karle, P.3
  • 94
    • 0034660849 scopus 로고    scopus 로고
    • Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy
    • Jounaidi Y, Waxman DJ. Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy. Cancer Res. 2000;60(14):3761-3769.
    • (2000) Cancer Res , vol.60 , Issue.14 , pp. 3761-3769
    • Jounaidi, Y.1    Waxman, D.J.2
  • 95
    • 0034032741 scopus 로고    scopus 로고
    • The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy
    • Thatcher NJ, Edwards RJ, Lemoine NR, Doehmer J, Davies DS. The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy. Cancer Gene Ther. 2000;7(4):521-525.
    • (2000) Cancer Gene Ther , vol.7 , Issue.4 , pp. 521-525
    • Thatcher, N.J.1    Edwards, R.J.2    Lemoine, N.R.3    Doehmer, J.4    Davies, D.S.5
  • 96
    • 0032503657 scopus 로고    scopus 로고
    • New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol
    • Rainov NG, Dobberstein KU, Sena-Esteves M, et al. New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol. Hum Gene Ther. 1998;9(9):1261-1273.
    • (1998) Hum Gene Ther , vol.9 , Issue.9 , pp. 1261-1273
    • Rainov, N.G.1    Dobberstein, K.U.2    Sena-Esteves, M.3
  • 97
    • 0033914287 scopus 로고    scopus 로고
    • Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma
    • Mohr L, Rainov NG, Mohr UG, Wands JR. Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma. Cancer Gene Ther. 2000;7(7):1008-1014.
    • (2000) Cancer Gene Ther , vol.7 , Issue.7 , pp. 1008-1014
    • Mohr, L.1    Rainov, N.G.2    Mohr, U.G.3    Wands, J.R.4
  • 98
    • 85047698115 scopus 로고    scopus 로고
    • Differential cytotoxicity and bystander effect of the rabbit cytochrome P450 4B1 enzyme gene by two different prodrugs: Implications for pharmacogene therapy
    • Frank S, Steffens S, Fischer U, Tlolko A, Rainov NG, Kramm CM. Differential cytotoxicity and bystander effect of the rabbit cytochrome P450 4B1 enzyme gene by two different prodrugs: implications for pharmacogene therapy. Cancer Gene Ther. 2002;9(2):178-188.
    • (2002) Cancer Gene Ther , vol.9 , Issue.2 , pp. 178-188
    • Frank, S.1    Steffens, S.2    Fischer, U.3    Tlolko, A.4    Rainov, N.G.5    Kramm, C.M.6
  • 99
    • 0025189891 scopus 로고
    • Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2
    • Springer CJ, Antoniw P, Bagshawe KD, Searle F, Bisset GM, Jarman M. Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. J Med Chem. 1990;33(2):677-681.
    • (1990) J Med Chem , vol.33 , Issue.2 , pp. 677-681
    • Springer, C.J.1    Antoniw, P.2    Bagshawe, K.D.3    Searle, F.4    Bisset, G.M.5    Jarman, M.6
  • 100
    • 0029815716 scopus 로고    scopus 로고
    • Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination
    • Marais R, Spooner RA, Light Y, Martin J, Springer CJ. Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination. Cancer Res. 1996;56(20):4735-4742.
    • (1996) Cancer Res , vol.56 , Issue.20 , pp. 4735-4742
    • Marais, R.1    Spooner, R.A.2    Light, Y.3    Martin, J.4    Springer, C.J.5
  • 101
    • 0033759444 scopus 로고    scopus 로고
    • In suicide gene therapy, the site of subcellular localization of the activating enzyme is more important than the rate at which it activates prodrug
    • Spooner RA, Martin J, Friedlos F, Marais R, Springer CJ. In suicide gene therapy, the site of subcellular localization of the activating enzyme is more important than the rate at which it activates prodrug. Cancer Gene Ther. 2000;7(10):1348-1356.
    • (2000) Cancer Gene Ther , vol.7 , Issue.10 , pp. 1348-1356
    • Spooner, R.A.1    Martin, J.2    Friedlos, F.3    Marais, R.4    Springer, C.J.5
  • 102
    • 0034688260 scopus 로고    scopus 로고
    • Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect
    • Stribbling SM, Friedlos F, Martin J, et al. Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect. Hum Gene Ther. 2000;11(2):285-292.
    • (2000) Hum Gene Ther , vol.11 , Issue.2 , pp. 285-292
    • Stribbling, S.M.1    Friedlos, F.2    Martin, J.3
  • 104
    • 0032542264 scopus 로고    scopus 로고
    • Self-immolative nitrogen mustard prodrugs for suicide gene therapy
    • Niclescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, et al. Self-immolative nitrogen mustard prodrugs for suicide gene therapy. J Med Chem. 1998;41(26):5297-5309.
    • (1998) J Med Chem , vol.41 , Issue.26 , pp. 5297-5309
    • Niclescu-Duvaz, D.1    Niculescu-Duvaz, I.2    Friedlos, F.3
  • 105
    • 0035875235 scopus 로고    scopus 로고
    • Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material
    • Webley SD, Francis RJ, Pedley RB, et al. Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material. Br J Cancer. 2001;84(12):1671-1676.
    • (2001) Br J Cancer , vol.84 , Issue.12 , pp. 1671-1676
    • Webley, S.D.1    Francis, R.J.2    Pedley, R.B.3
  • 106
    • 0037086075 scopus 로고    scopus 로고
    • Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models
    • Friedlos F, Davies L, Scanlon I, et al. Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models. Cancer Res. 2002;62(6):1724-1729.
    • (2002) Cancer Res , vol.62 , Issue.6 , pp. 1724-1729
    • Friedlos, F.1    Davies, L.2    Scanlon, I.3
  • 107
    • 0033168032 scopus 로고    scopus 로고
    • Self-immolative anthracycline prodrugs for suicide gene therapy
    • Niculescu-Duvaz I, Niculescu-Duvaz D, Friedlos F, et al. Self-immolative anthracycline prodrugs for suicide gene therapy. J Med Chem. 1999;42(13):2485-2489.
    • (1999) J Med Chem , vol.42 , Issue.13 , pp. 2485-2489
    • Niculescu-Duvaz, I.1    Niculescu-Duvaz, D.2    Friedlos, F.3
  • 108
    • 0033585434 scopus 로고    scopus 로고
    • Toward an enzyme/prodrug strategy for cancer gene therapy: Endogenous activation of carboxypeptidase A mutants by the PACE/Furin family of propeptidases
    • Hamstra DA, Rehemtulla A. Toward an enzyme/prodrug strategy for cancer gene therapy: endogenous activation of carboxypeptidase A mutants by the PACE/Furin family of propeptidases. Hum Gene Ther. 1999;10(2):235-248.
    • (1999) Hum Gene Ther , vol.10 , Issue.2 , pp. 235-248
    • Hamstra, D.A.1    Rehemtulla, A.2
  • 109
    • 0033961881 scopus 로고    scopus 로고
    • Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-α-peptide prodrugs
    • Hamstra DA, Page M, Maybaum J, Rehemtulla A. Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-α-peptide prodrugs. Cancer Res. 2000;60(3):657-665.
    • (2000) Cancer Res , vol.60 , Issue.3 , pp. 657-665
    • Hamstra, D.A.1    Page, M.2    Maybaum, J.3    Rehemtulla, A.4
  • 110
    • 0035392963 scopus 로고    scopus 로고
    • Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase
    • Wierdl M, Morton CL, Weeks JK, Danks MK, Harris LC, Potter PM. Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase. Cancer Res. 2001;61(13):5078-5082.
    • (2001) Cancer Res , vol.61 , Issue.13 , pp. 5078-5082
    • Wierdl, M.1    Morton, C.L.2    Weeks, J.K.3    Danks, M.K.4    Harris, L.C.5    Potter, P.M.6
  • 111
    • 0028333762 scopus 로고
    • A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells
    • Ogasawara H, Nishio K, Takeda Y, et al. A novel antitumor antibiotic, KW-2189 is activated by carboxyl esterase and induces DNA strand breaks in human small cell lung cancer cells. Jpn J Cancer Res. 1994;85(4):418-425.
    • (1994) Jpn J Cancer Res , vol.85 , Issue.4 , pp. 418-425
    • Ogasawara, H.1    Nishio, K.2    Takeda, Y.3
  • 112
    • 0032523096 scopus 로고    scopus 로고
    • In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors
    • Kojima A, Hackett NR, Ohwada A, Crystal RG. In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors. J Clin Invest. 1998;101(8):1789-1796.
    • (1998) J Clin Invest , vol.101 , Issue.8 , pp. 1789-1796
    • Kojima, A.1    Hackett, N.R.2    Ohwada, A.3    Crystal, R.G.4
  • 113
    • 0035392940 scopus 로고    scopus 로고
    • A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11
    • Meck MM, Wierdl M, Wagner LM, et al. A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11. Cancer Res. 2001;61(13):5083-5089.
    • (2001) Cancer Res , vol.61 , Issue.13 , pp. 5083-5089
    • Meck, M.M.1    Wierdl, M.2    Wagner, L.M.3
  • 114
    • 0032510381 scopus 로고    scopus 로고
    • Intensely potent doxorubicin analogues: Structure-activity relationship
    • Farquhar D, Cherif A, Bakina E, Nelson JA. Intensely potent doxorubicin analogues: structure-activity relationship. J Med Chem. 1998;41(6):965-972.
    • (1998) J Med Chem , vol.41 , Issue.6 , pp. 965-972
    • Farquhar, D.1    Cherif, A.2    Bakina, E.3    Nelson, J.A.4
  • 116
    • 0029808844 scopus 로고    scopus 로고
    • Gene cloning, purification, and characterization of NfsB, a minor oxygen-insensitive nitroreductase from Escherichia coli, similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri
    • Zenno S, Koike H, Tanokura M, Saigo K. Gene cloning, purification, and characterization of NfsB, a minor oxygen-insensitive nitroreductase from Escherichia coli, similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri. J Biochem (Tokyo). 1996;120(4):736-744.
    • (1996) J Biochem (Tokyo) , vol.120 , Issue.4 , pp. 736-744
    • Zenno, S.1    Koike, H.2    Tanokura, M.3    Saigo, K.4
  • 117
    • 0026745562 scopus 로고
    • The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) -I. Purification and properties of a nitroreductase enzyme from Escherichia coli - A potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT)
    • Anlezark GM, Melton RG, Sherwood RF, Coles B, Friedlos F, Knox RJ. The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) -I. Purification and properties of a nitroreductase enzyme from Escherichia coli - a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT). Biochem Pharmacol. 1992;44(12):2289-2295.
    • (1992) Biochem Pharmacol , vol.44 , Issue.12 , pp. 2289-2295
    • Anlezark, G.M.1    Melton, R.G.2    Sherwood, R.F.3    Coles, B.4    Friedlos, F.5    Knox, R.J.6
  • 118
    • 0034609776 scopus 로고    scopus 로고
    • Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: A prodrug-activating enzyme
    • Parkinson GN, Skelly JV, Neidle S. Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme. J Med Chem. 2000;43(20):3624-3631.
    • (2000) J Med Chem , vol.43 , Issue.20 , pp. 3624-3631
    • Parkinson, G.N.1    Skelly, J.V.2    Neidle, S.3
  • 119
    • 0035946957 scopus 로고    scopus 로고
    • The structure of Escherichia coli nitroreductase complexed with nicotinic acid: Three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution
    • Lovering AL, Hyde EI, Searle PF, White SA. The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution. J Mol Biol. 2001;309(1):203-213.
    • (2001) J Mol Biol , vol.309 , Issue.1 , pp. 203-213
    • Lovering, A.L.1    Hyde, E.I.2    Searle, P.F.3    White, S.A.4
  • 120
    • 0026075733 scopus 로고
    • Bioactivation of CB 1954: Reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species
    • Knox RJ, Friedlos F, Marchbank T, Roberts JJ. Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species. Biochem Pharmacol. 1991;42(9):1691-1697.
    • (1991) Biochem Pharmacol , vol.42 , Issue.9 , pp. 1691-1697
    • Knox, R.J.1    Friedlos, F.2    Marchbank, T.3    Roberts, J.J.4
  • 121
    • 0031974255 scopus 로고    scopus 로고
    • Gene-directed enzyme prodrug therapy: Quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase
    • Friedlos F, Court S, Ford M, Denny WA, Springer C. Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase. Gene Ther. 1998;5(1):105-112.
    • (1998) Gene Ther , vol.5 , Issue.1 , pp. 105-112
    • Friedlos, F.1    Court, S.2    Ford, M.3    Denny, W.A.4    Springer, C.5
  • 122
    • 0030956976 scopus 로고    scopus 로고
    • The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite
    • Bridgewater JA, Knox RJ, Pitts JD, Collins MK, Springer CJ. The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite. Hum Gene Ther. 1997;8(6):709-717.
    • (1997) Hum Gene Ther , vol.8 , Issue.6 , pp. 709-717
    • Bridgewater, J.A.1    Knox, R.J.2    Pitts, J.D.3    Collins, M.K.4    Springer, C.J.5
  • 123
    • 0031694118 scopus 로고    scopus 로고
    • Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954
    • McNeish IA, Green NK, Gilligan MG, et al. Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954. Gene Ther. 1998;5(8):1061-1069.
    • (1998) Gene Ther , vol.5 , Issue.8 , pp. 1061-1069
    • McNeish, I.A.1    Green, N.K.2    Gilligan, M.G.3
  • 124
    • 0031183755 scopus 로고    scopus 로고
    • Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene
    • Green NK, Youngs DJ, Neoptolemos JP, et al. Sensitization of colorectal and pancreatic cancer cell lines to the prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by retroviral transduction and expression of the E. coli nitroreductase gene. Cancer Gene Ther. 1997;4(4):229-238.
    • (1997) Cancer Gene Ther , vol.4 , Issue.4 , pp. 229-238
    • Green, N.K.1    Youngs, D.J.2    Neoptolemos, J.P.3
  • 125
    • 0034109287 scopus 로고    scopus 로고
    • Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954
    • Djeha AH, Hulme A, Dexter MT, et al. Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954. Cancer Gene Ther. 2000;7(5):721-731.
    • (2000) Cancer Gene Ther , vol.7 , Issue.5 , pp. 721-731
    • Djeha, A.H.1    Hulme, A.2    Dexter, M.T.3
  • 126
    • 0033981131 scopus 로고    scopus 로고
    • The nitroreductase/CB1954 combination in Epstein-Barr virus-positive B-cell lines: Induction of bystander killing in vitro and in vivo
    • Westphal EM, Ge J, Catchpole JR, Ford M, Kenney SC. The nitroreductase/CB1954 combination in Epstein-Barr virus-positive B-cell lines: induction of bystander killing in vitro and in vivo. Cancer Gene Ther. 2000;7(1):97-106.
    • (2000) Cancer Gene Ther , vol.7 , Issue.1 , pp. 97-106
    • Westphal, E.M.1    Ge, J.2    Catchpole, J.R.3    Ford, M.4    Kenney, S.C.5
  • 127
    • 0036159410 scopus 로고    scopus 로고
    • Inhibition of myc-dependent breast tumor formation in transgenic mice
    • Cui W, Gusterson BA, Clark AJ. Inhibition of myc-dependent breast tumor formation in transgenic mice. Breast Cancer Res Treat. 2002;71(1):9-20.
    • (2002) Breast Cancer Res Treat , vol.71 , Issue.1 , pp. 9-20
    • Cui, W.1    Gusterson, B.A.2    Clark, A.J.3
  • 128
    • 0034814342 scopus 로고    scopus 로고
    • Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: A phase I and pharmacokinetic study of its prodrug, CB1954
    • Chung-Faye G, Palmer D, Anderson D, et al. Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954. Clin Cancer Res. 2001;7(9):2662-2668.
    • (2001) Clin Cancer Res , vol.7 , Issue.9 , pp. 2662-2668
    • Chung-Faye, G.1    Palmer, D.2    Anderson, D.3
  • 129
    • 0029147264 scopus 로고
    • Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase
    • Anlezark GM, Melton RG, Sherwood RF, et al. Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase. Biochem Pharmacol. 1995;50(5):609-618.
    • (1995) Biochem Pharmacol , vol.50 , Issue.5 , pp. 609-618
    • Anlezark, G.M.1    Melton, R.G.2    Sherwood, R.F.3
  • 130
    • 0028916689 scopus 로고
    • Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide
    • Palmer BD, van Zijl P, Denny WA, Wilson WR. Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide. J Med Chem. 1995;38(7):1229-1241.
    • (1995) J Med Chem , vol.38 , Issue.7 , pp. 1229-1241
    • Palmer, B.D.1    Van Zijl, P.2    Denny, W.A.3    Wilson, W.R.4
  • 132
    • 0026665360 scopus 로고
    • Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells
    • Palmer BD, Wilson WR, Cliffe S, Denny WA. Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells. J Med Chem. 1992;35(17):3214-3222.
    • (1992) J Med Chem , vol.35 , Issue.17 , pp. 3214-3222
    • Palmer, B.D.1    Wilson, W.R.2    Cliffe, S.3    Denny, W.A.4
  • 133
    • 0028246907 scopus 로고
    • Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide
    • Palmer BD, Wilson WR, Atwell GJ, Schultz D, Xu XZ, Denny WA. Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide. J Med Chem. 1994;37(14):2175-2184.
    • (1994) J Med Chem , vol.37 , Issue.14 , pp. 2175-2184
    • Palmer, B.D.1    Wilson, W.R.2    Atwell, G.J.3    Schultz, D.4    Xu, X.Z.5    Denny, W.A.6
  • 134
    • 0029856403 scopus 로고    scopus 로고
    • Synthesis and evaluation of 4-substituted analogues of 5-[N,N-bis (2-chloroethyl)amino]-2-nitrobenzamide as bioreductively activated prodrugs using an Escherichia coli nitroreductase
    • Atwell GJ, Boyd M, Palmer BD, et al. Synthesis and evaluation of 4-substituted analogues of 5-[N,N-bis (2-chloroethyl)amino]-2-nitrobenzamide as bioreductively activated prodrugs using an Escherichia coli nitroreductase. Anticancer Drug Des. 1996;11(7):553-567.
    • (1996) Anticancer Drug Des , vol.11 , Issue.7 , pp. 553-567
    • Atwell, G.J.1    Boyd, M.2    Palmer, B.D.3
  • 135
    • 0030907756 scopus 로고    scopus 로고
    • Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy
    • Friedlos F, Denny WA, Palmer BD, Springer CJ. Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy. J Med Chem. 1997;40(8):1270-1275.
    • (1997) J Med Chem , vol.40 , Issue.8 , pp. 1270-1275
    • Friedlos, F.1    Denny, W.A.2    Palmer, B.D.3    Springer, C.J.4
  • 136
    • 0022272179 scopus 로고
    • Some reactions and properties of nitro radical-anions important in biology and medicine
    • Wardman P. Some reactions and properties of nitro radical-anions important in biology and medicine. Environ Health Perspect. 1985;64:309-320.
    • (1985) Environ Health Perspect , vol.64 , pp. 309-320
    • Wardman, P.1
  • 137
    • 0028090161 scopus 로고
    • Self-immolative prodrugs: Candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme
    • Mauger AB, Burke PJ, Somani HH, Friedlos F, Knox RJ. Self-immolative prodrugs: candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme. J Med Chem. 1994;37(21):3452-3458.
    • (1994) J Med Chem , vol.37 , Issue.21 , pp. 3452-3458
    • Mauger, A.B.1    Burke, P.J.2    Somani, H.H.3    Friedlos, F.4    Knox, R.J.5
  • 139
    • 0035415493 scopus 로고    scopus 로고
    • Prodrug strategies in cancer therapy
    • Denny WA. Prodrug strategies in cancer therapy. Eur J Med Chem. 2001;36(7-8):577-595.
    • (2001) Eur J Med Chem , vol.36 , Issue.7-8 , pp. 577-595
    • Denny, W.A.1
  • 141
    • 0343471489 scopus 로고    scopus 로고
    • Synthesis of an aminopropyl analog of the experimental anticancer drug tallimustine, and activation of its 4-nitrobenzylcarbamoyl prodrug by nitroreductase and NADH
    • Lee M, Simpson JE, Woo S, et al. Synthesis of an aminopropyl analog of the experimental anticancer drug tallimustine, and activation of its 4-nitrobenzylcarbamoyl prodrug by nitroreductase and NADH. Bioorg Med Chem Lett. 1997;7:1065-1070.
    • (1997) Bioorg Med Chem Lett , vol.7 , pp. 1065-1070
    • Lee, M.1    Simpson, J.E.2    Woo, S.3
  • 142
    • 0033590267 scopus 로고    scopus 로고
    • Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT)
    • Hay MP, Wilson WR, Denny WA. Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT). Bioorg Med Chem Lett. 1999;9(24):3417-3422.
    • (1999) Bioorg Med Chem Lett , vol.9 , Issue.24 , pp. 3417-3422
    • Hay, M.P.1    Wilson, W.R.2    Denny, W.A.3
  • 143
    • 0033516908 scopus 로고    scopus 로고
    • A 2-nitroimidazole carbamate prodrug of 5-amimo-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1, 2-dihydro-3H-benz[E]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT
    • Hay MP, Sykes BM, Denny WA, Wilson WR. A 2-nitroimidazole carbamate prodrug of 5-amimo-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1, 2-dihydro-3H-benz[E]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT. Bioorg Med Chem Lett. 1999;9(15):2237-2242.
    • (1999) Bioorg Med Chem Lett , vol.9 , Issue.15 , pp. 2237-2242
    • Hay, M.P.1    Sykes, B.M.2    Denny, W.A.3    Wilson, W.R.4
  • 144
    • 0030458785 scopus 로고    scopus 로고
    • Investigation of alternative prodrugs for use with E. coli nitroreductase in "suicide gene" approaches to cancer therapy
    • Bailey SM, Knox RJ, Hobbs SM, et al. Investigation of alternative prodrugs for use with E. coli nitroreductase in "suicide gene" approaches to cancer therapy. Gene Ther. 1996;3(12):1143-1150.
    • (1996) Gene Ther , vol.3 , Issue.12 , pp. 1143-1150
    • Bailey, S.M.1    Knox, R.J.2    Hobbs, S.M.3
  • 145
    • 0036015564 scopus 로고    scopus 로고
    • Indole-3-acetic acids and horseradish peroxidase: A new prodrug/enzyme combination for targeted cancer therapy
    • Wardman P. Indole-3-acetic acids and horseradish peroxidase: a new prodrug/enzyme combination for targeted cancer therapy. Curr Pharm Des. 2002;8(15):1363-1374.
    • (2002) Curr Pharm Des , vol.8 , Issue.15 , pp. 1363-1374
    • Wardman, P.1
  • 146
    • 0033664464 scopus 로고    scopus 로고
    • Development of a novel enzyme/prodrug combination for gene therapy of cancer: Horseradish peroxidase/indole-3-acetic acid
    • Greco O, Folkes LK, Wardman P, Tozer GM, Dachs GU. Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid. Cancer Gene Ther. 2000;7(11):1414-1420.
    • (2000) Cancer Gene Ther , vol.7 , Issue.11 , pp. 1414-1420
    • Greco, O.1    Folkes, L.K.2    Wardman, P.3    Tozer, G.M.4    Dachs, G.U.5
  • 147
    • 0036191855 scopus 로고    scopus 로고
    • Oxic and anoxic enhancement of radiation-mediated toxicity by horseradish peroxidase/indole-3-acetic acid gene therapy
    • Greco O, Tozer GM, Dachs GU. Oxic and anoxic enhancement of radiation-mediated toxicity by horseradish peroxidase/indole-3-acetic acid gene therapy. Int J Radiat Biol. 2002;78(3):173-181.
    • (2002) Int J Radiat Biol , vol.78 , Issue.3 , pp. 173-181
    • Greco, O.1    Tozer, G.M.2    Dachs, G.U.3
  • 148
    • 0037081743 scopus 로고    scopus 로고
    • 5-Fluoroindole-3-acetic acid: A prodrug activated by a peroxidase with potential for use in targeted cancer therapy
    • Folkes LK, Greco O, Dachs GU, Stratford MR, Wardman P. 5-fluoroindole-3-acetic acid: a prodrug activated by a peroxidase with potential for use in targeted cancer therapy. Biochem Pharmacol. 2002;63(2):265-272.
    • (2002) Biochem Pharmacol , vol.63 , Issue.2 , pp. 265-272
    • Folkes, L.K.1    Greco, O.2    Dachs, G.U.3    Stratford, M.R.4    Wardman, P.5
  • 149
    • 0030137379 scopus 로고    scopus 로고
    • Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine
    • Tamiya T, Ono Y, Wei MX, Mroz PJ, Moolten FL, Chiocca EA. Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine. Cancer Gene Ther. 1996;3(3):155-162.
    • (1996) Cancer Gene Ther , vol.3 , Issue.3 , pp. 155-162
    • Tamiya, T.1    Ono, Y.2    Wei, M.X.3    Mroz, P.J.4    Moolten, F.L.5    Chiocca, E.A.6
  • 150
    • 0031581178 scopus 로고    scopus 로고
    • Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy
    • Ono Y, Ikeda K, Wei MX, Harsh GR 4th, Tamiya T, Chiocca EA. Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy. Hum Gene Ther. 1997;8(17):2043-2055.
    • (1997) Hum Gene Ther , vol.8 , Issue.17 , pp. 2043-2055
    • Ono, Y.1    Ikeda, K.2    Wei, M.X.3    Harsh G.R. IV4    Tamiya, T.5    Chiocca, E.A.6
  • 151
    • 0033223554 scopus 로고    scopus 로고
    • Cationic polymeric gene delivery of beta-glucuronidase for doxorubicin prodrug therapy
    • Fonseca MJ, Storm G, Hennink WE, Gerritsen WR, Haisma HJ. Cationic polymeric gene delivery of beta-glucuronidase for doxorubicin prodrug therapy. J Gene Med. 1999;1(6):407-414.
    • (1999) J Gene Med , vol.1 , Issue.6 , pp. 407-414
    • Fonseca, M.J.1    Storm, G.2    Hennink, W.E.3    Gerritsen, W.R.4    Haisma, H.J.5
  • 152
    • 0033993506 scopus 로고    scopus 로고
    • Secreted human beta-glucuronidase: A novel tool for gene-directed enzyme prodrug therapy
    • Weyel D, Sedlacek HH, Muller R, Brusselbach S. Secreted human beta-glucuronidase: a novel tool for gene-directed enzyme prodrug therapy. Gene Ther. 2000;7(3):224-231.
    • (2000) Gene Ther , vol.7 , Issue.3 , pp. 224-231
    • Weyel, D.1    Sedlacek, H.H.2    Muller, R.3    Brusselbach, S.4
  • 153
    • 0034947012 scopus 로고    scopus 로고
    • Cell surface display of a lysosomal enzyme for extracellular gene-directed enzyme prodrug therapy
    • Heine D, Muller R, Brusselbach S. Cell surface display of a lysosomal enzyme for extracellular gene-directed enzyme prodrug therapy. Gene Ther. 2001;8(13):1005-1010.
    • (2001) Gene Ther , vol.8 , Issue.13 , pp. 1005-1010
    • Heine, D.1    Muller, R.2    Brusselbach, S.3
  • 154
    • 0033495663 scopus 로고    scopus 로고
    • Intensely cytotoxic anthracycline prodrugs: Galactosides
    • Bakina E, Farquhar D. Intensely cytotoxic anthracycline prodrugs: galactosides. Anticancer Drug Des. 1999;14(6):507-515.
    • (1999) Anticancer Drug Des , vol.14 , Issue.6 , pp. 507-515
    • Bakina, E.1    Farquhar, D.2
  • 155
    • 0031457848 scopus 로고    scopus 로고
    • Intensely cytotoxic anthracycline prodrugs: Glucuronides
    • Bakina E, Wu Z, Rosenblum M, Farquhar D. Intensely cytotoxic anthracycline prodrugs: glucuronides. J Med Chem. 1997;40(25):4013-4018.
    • (1997) J Med Chem , vol.40 , Issue.25 , pp. 4013-4018
    • Bakina, E.1    Wu, Z.2    Rosenblum, M.3    Farquhar, D.4
  • 156
    • 0032797555 scopus 로고    scopus 로고
    • Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase
    • Evrard A, Cuq P, Ciccolini J, Vian L, Cano JP. Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase. Br J Cancer. 1999;80(11):1726-1733.
    • (1999) Br J Cancer , vol.80 , Issue.11 , pp. 1726-1733
    • Evrard, A.1    Cuq, P.2    Ciccolini, J.3    Vian, L.4    Cano, J.P.5
  • 157
    • 0031056806 scopus 로고    scopus 로고
    • Enhancement of drug sensitivity and a bystander effect in PC-9 cells transfected with a platelet-derived endothelial cell growth factor thymidine phosphorylase cDNA
    • Kato Y, Matsukawa S, Muraoka R, Tanigawa N. Enhancement of drug sensitivity and a bystander effect in PC-9 cells transfected with a platelet-derived endothelial cell growth factor thymidine phosphorylase cDNA. Br J Cancer. 1997;75(4):506-511.
    • (1997) Br J Cancer , vol.75 , Issue.4 , pp. 506-511
    • Kato, Y.1    Matsukawa, S.2    Muraoka, R.3    Tanigawa, N.4
  • 158
    • 0029100420 scopus 로고
    • Increased sensitivity to the prodrug 5′-deoxy-5-fluorouridine and modulation of 5-fluoro-2′-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase
    • Patterson AV, Zhang H, Moghaddam A, et al. Increased sensitivity to the prodrug 5′-deoxy-5-fluorouridine and modulation of 5-fluoro-2′-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase. Br J Cancer. 1995;72(3):669-675.
    • (1995) Br J Cancer , vol.72 , Issue.3 , pp. 669-675
    • Patterson, A.V.1    Zhang, H.2    Moghaddam, A.3
  • 159
    • 0342399315 scopus 로고
    • High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine
    • Hoffman RM, Erbe RW. High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine. Proc Natl Acad Sci USA. 1976;73(5):1523-1527.
    • (1976) Proc Natl Acad Sci USA , vol.73 , Issue.5 , pp. 1523-1527
    • Hoffman, R.M.1    Erbe, R.W.2
  • 160
    • 0035884607 scopus 로고    scopus 로고
    • Methioninase cancer gene therapy with selenomethionine as suicide prodrug substrate
    • Miki K, Xu M, Gupta A, et al. Methioninase cancer gene therapy with selenomethionine as suicide prodrug substrate. Cancer Res. 2001;61(18):6805-6510.
    • (2001) Cancer Res , vol.61 , Issue.18 , pp. 6805-6510
    • Miki, K.1    Xu, M.2    Gupta, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.