In vivo sensitization of ovarian tumors to chemotherapy by expression of E. coli purine nucleoside phosphorylase in a small fraction of cells

Gene Therapy

Volumn 7, Issue 20, 2000, Pages 1738-1743

  Gadi, V K ^a   Alexander, S D ^a   Kudlow, J E ^b   Allan, P ^c   Parker, W B ^c   Sorscher, E J ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

Bystander killing; E coli PNP; MeP dR; Ovarian cancer

Indexed keywords

6 METHYLPURINE; ANTINEOPLASTIC AGENT; PURINE NUCLEOSIDE PHOSPHORYLASE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIZATION; ENZYME ACTIVITY; ESCHERICHIA COLI; EXPRESSION VECTOR; FEMALE; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVARY TUMOR; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIMIAN VIRUS 40; SUICIDE GENE; TUMOR CELL; TUMOR GROWTH; TUMOR VOLUME;

ANIMALIA; ESCHERICHIA COLI; NEGIBACTERIA; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

EID: 0033759371     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301286     Document Type: Article

References (26)

1. Tumor cell bystander killing in colonic carcinoma utilizing the E. coli Deo D gene and generation of toxic purines
2. Bystander killing of melanoma cells using the human tyrosinase promoter to express the Escherichia coli purine nucleoside phosphorylase gene
3. Converting cancer genes into killer genes
4. In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase
5. Cell to cell contact is not required for bystander cell killing by Escherichia coli purine nucleoside phosphorylase
6. Metabolism and metabolic action of 6-methylpurine and 2-fluoroadenine in human cells
7. Relative efficiency of tumor cell killing in vitro by two enzyme-prodrug systems delivered by identical adenovirus vectors
8. In vivo gene therapy for prostate cancer: Preclinical evaluation of two different enzyme-directed pro-drug therapy systems delivered by identical adenovirus vectors
9. Thymidine kinase-deleted vaccinia virus expressing purine nucleoside phosphorylase as a vector for tumor-directed gene therapy
10. Purine nucleoside phosphorylase from Escherichia coli and Salmonella typhimurium. Purification and some properties
11. The crystal structure of Escherichia coli purine nucleoside phosphorylase: A comparison with the human enzyme reveals a conserved topology
12. Foamy virus vectors for suicide gene therapy
13. Gene-directed enzyme prodrug therapy
14. Comparison of the effects of three different toxin genes and their levels of expression on cell growth and bystander effect in lung adenocarcinoma
15. The thymidine kinase/ganciclovir-mediated 'suicide' effect is variable in different tumor cells
16. Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo
17. Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro
18. The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro
19. Bystander tumoricidal effect gap junctional communication in lung cancer cell lines
20. The 'bystander effect': Tumor regression when a fraction of the tumor mass is genetically modified
21. Partial regression, yet incomplete eradication of mammary tumors in transgenic mice by retrovirally mediated HSVtk transfer in vivo
22. Assessment of bystander effect potency produced by intratumoral implantation of HSVtk-expressing cells using surrogate marker secretion to monitor tumor growth kinetics
23. Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component
24. Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma
25. Gene therapy of rat 91 gliosarcoma tumors by transduction with selectable genes does not require drug selection
26. Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase