Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts

Cancer Research

Volumn 60, Issue 23, 2000, Pages 6649-6655

  Kievit, E ^a   Nyati, M K ^a   Ng, E ^a   Stegman, L D ^a   Parsels, J ^a   Ross, B D ^a   Rehemtulla, A ^a   Lawrence, T S ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE DEAMINASE; FLUCYTOSINE; FLUOROURACIL; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; FEMALE; GENE THERAPY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RADIOSENSITIZATION; TUMOR VOLUME; TUMOR XENOGRAFT; YEAST;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BACTERIA; BIOTRANSFORMATION; CYTOSINE DEAMINASE; FEMALE; FLUCYTOSINE; FLUOROURACIL; GENE THERAPY; HT29 CELLS; HUMANS; MICE; MICE, NUDE; NUCLEOSIDE DEAMINASES; PRODRUGS; RADIATION-SENSITIZING AGENTS; SACCHAROMYCES CEREVISIAE; TRANSDUCTION, GENETIC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0034547928     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. The choice of prodrugs for gene directed enzyme prodrug therapy of cancer
2. Genetic delivery of enzymes for cancer therapy
3. Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-fluorocytosine
4. Gap junction function and cancer
5. Gap junctional communication and neoplastic transformation
6. Dependence of 5-fluorouracil-mediated radiosensitization on DNA-directed effects
7. Comparison of the effects of three different toxin genes and their levels of expression on cell growth and bystander effect in lung adenocarcinoma
8. Enzyme/prodrug gene therapy: Comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/gancliclovir enzyme/prodrug systems in a human colorectal carcinoma cell line
9. Purification and some properties of cytosine deaminase from Salmonella typhimurium
10. Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts
11. Cloning, overexpression, and purification of cytosine deaminase from Saccaromyces cerevisiae
12. The effect of single versus double-strand substitution on halogenated pyrimidine-induced radiosensitization and DNA strand breakage in human tumor cells
13. Reduction of doxorubicin cytotoxicity by ouabain: Correlation with topoisomerase-induced DNA strand breakage in human and hamster cells
14. Mean inactivation dose: A useful concept for intercomparison of human cell survival curves
15. Enhancement of hyperthermia effect in vivo by amiloride and DIDS
16. The potential superiority of bromodeoxyuridine to iododeoxyuridine as a radiation sensitizer in the treatment of colorectal cancer
17. Effect of irradiation on bromodeoxyuridine incorporation in human colon cancer xenografts
18. Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene
19. Selective in vivo radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells transduced with the E. Coli cytosine deaminase (CD) gene
20. Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy
21. Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts
22. Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo