Regional 'pro-drug' gene therapy: Intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma

Gene Therapy

Volumn 5, Issue 4, 1998, Pages 507-513

  Topf, N ^a   Worgall, S ^a   Hackett, N R ^a   Crystal, R G ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

5 Fluorocytosine; Adenovirus; Colon carcinoma; Gene therapy; Prodrug

Indexed keywords

CYTOSINE DEAMINASE; FLUOROURACIL; PRODRUG; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOMA CELL; COLON CARCINOMA; ESCHERICHIA COLI; GENE THERAPY; GENE TRANSFER; LIVER CELL; LIVER METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOVIRIDAE; ANIMALIA; ESCHERICHIA COLI;

EID: 0031941292     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300611     Document Type: Article

References (32)

1. Cohen AM, Minsky BD, Schilsky RL. Cancer of the colon. In: DeVita VTJ, Hellman S, Rosenberg SA (eds) Cancer: Principles and Practice of Oncology. Lippincott-Raven: Philadelphia, 1997, pp 1144-1197
2. Vaughn DJ, Haller DG. Nonsurgical management of recurrent colorectal cancer. Cancer 1993; 71: 4278-4292.
3. Kemeny NE Regional chemotherapy of colorectal cancer. Eur J Cancer 1995; 31A: 1271-1276.
4. Vauthey JN et al. Arterial therapy of hepatic colorectal metastases. Br J Surg 1996; 83: 447-455.
5. Mullen CA, Kilstrup M, Blaese RM. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc Natl Acad Sci USA 1992; 89: 33-37.
6. Huber BE et al. In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res 1993, 53: 4619-4626.
7. Moolten FL. Drug sensitivity ('suicide') genes for selective cancer chemotherapy. Cancer Gene Ther 1994; 1: 279-287.
8. Huber BE et al. Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc Nat! Acad Sci USA 1994; 91: 8302-8306.
9. Mullen CA, Coale MM, Lowe R, Blaese RM. Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild-type tumor. Cancer Res 1994; 54: 1503-1506.
10. Hirschowitz EA et al. In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine. Hum Gene Ther 1995; 6: 1055-1063.
11. Ohwada A, Hirschowitz EA, Crystal RG. Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver. Hum Gene Ther 1996; 7: 1567-1576.
12. Herz J, Gerard RD. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci USA 1993; 90: 2812-2816.
13. Huard J et al. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants. Gene Therapy 1995; 2: 107-115.
14. Worgall S, Wolff G, Falck-Pedersen E, Crystal RG. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Hum Gene Ther 1997; 8: 37-44.
15. Pinedo HM, Peters GF. Fluorouracil: biochemistry and pharmacology. J Clin Oncol 1988; 6: 1653-1664.
16. Haberkorn U et al. Monitoring gene therapy with cytosine deaminase: in vitro studies using tritiated-5-fluorocytosine. J Nucleic Med 1996; 37: 87-94.
17. Trinh QT et al. Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line. Cancer Res 1995; 55: 4808-4812.
18. Ackerman NB. The blood supply of experimental liver metastases i.v. changes in vascularity with increasing tumor growth. Surgery 1974; 75: 589-596.
19. Breedis C, Young G. The blood supply of neoplasms in the liver. Am J Pathol 1954; 30: 969-985.
20. Tanaka H et al. Intra-arterial administration of the angiogenesis inhibitor tnp-470 blocks liver metastasis in a rabbit model. Br J Cancer 1995; 72: 650-653.
21. Terayarna N, Terada T, Nakanurna Y. A morphometric and immunohistochemical study on angiogenesis of human metastatic carcinomas of the liver. Hepatology 1996; 24: 816-819.
22. Northover JM, Terblanche J. A new look at the arterial supply of the bile duct in man and its surgical implications. Br J Surg 1979; 66: 379-384.
23. Mack CA et al. Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype. Hum Gene Ther 1997; 8: 99-109.
24. Hersh J, Crystal RG, Bewig B. Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector. Gene Therapy 1995; 2: 124-131.
25. Rosenfeld MA et al. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 1992; 68: 143-155.
26. Rosenfeld MA et al. Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo. Science 1991; 252: 431-434.
27. Jaffe HA et al. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat Genet 1992; 1: 372-378.
28. Seglen PO. Hepatocyte suspensions and cultures as tools in experimental carcinogenesis. J Toxicol Environ Health 1979; 5: 551-560.
29. Senter PD et al. Expression of DNA sequences encoding a thermally stable cytosine deaminase from saccharomyces. Washington, USA. United States Patent No. 5,338,678. 1997.
30. Wallace PM et al. Intratumoral generation of 5-flourouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine. Cancer Res 1994; 54: 2719-2723.
31. Alley MC et al. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 1988; 48: 589-601.
32. Mastrangeli A et al. Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer. J Clin Invest 1993; 91: 225-234.