Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides?

Journal of Medicinal Chemistry

Volumn 39, Issue 19, 1996, Pages 3739-3747

  Marquez, Victor E ^a   Siddiqui, Maqbool A ^a   Ezzitouni, Abdallah ^a   Russ, Pamela ^a   Wang, Jianying ^b   Wagner, Richard W ^b   Matteucci, Mark D ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GILEAD SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; HETERODUPLEX; NUCLEOSIDE; NUCLEOSIDE DERIVATIVE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; RIBONUCLEASE H;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; FIBROBLAST; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; NONHUMAN; PREPUCE; VIRUS PLAQUE;

ACYCLOVIR; ANTISENSE ELEMENTS (GENETICS); ANTIVIRAL AGENTS; BASE SEQUENCE; CYTOPATHOGENIC EFFECT, VIRAL; DRUG STABILITY; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HUMANS; HYDROGEN BONDING; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; NUCLEOSIDES; OLIGONUCLEOTIDES; PLAQUE ASSAY; RIBONUCLEASE H, CALF THYMUS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0029815436     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960306+     Document Type: Article

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