Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine

Biochemistry

Volumn 39, Issue 31, 2000, Pages 9597-9603

  Prota, A ^a   Vogt, J ^b   Pilger, B ^a,c   Perozzo, R ^a,d   Wurth, C ^a   Marquez, V E ^e   Russ, P ^e   Schulz, G E ^b   Folkers, G ^a   Scapozza, L ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF FREIBURG   (Germany)

^c HARVARD MEDICAL SCHOOL   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' EXOMETHANOCARBATHYMIDINE; ANTIVIRUS AGENT; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG PROTEIN BINDING; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; HERPES SIMPLEX VIRUS 1; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; BICYCLO COMPOUNDS; BINDING, COMPETITIVE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HERPESVIRUS 1, HUMAN; HUMANS; KINETICS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PHOSPHORYLATION; PROTEIN CONFORMATION; THYMIDINE; THYMIDINE KINASE; TYROSINE;

FELIS CATUS; HERPES; HUMAN HERPESVIRUS 1;

EID: 0034622629     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi000668q     Document Type: Article

References (61)