In vivo gene therapy for prostate cancer: Preclinical evaluation of two different enzyme-directed prodrug therapy systems delivered by identical adenovirus vectors

Human Gene Therapy

Volumn 9, Issue 11, 1998, Pages 1617-1626

  Martiniello Wilks, Rosetta ^a,b   Garcia Aragon, Juanita ^a,b,c   Daja, Mirella M ^a,b   Russell, Peter ^d   Both, Gerald W ^e   Molloy, Peter L ^e   Lockett, Linda J ^e   Russell, Pamela J ^a,b  

^a PRINCE OF WALES HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^d ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^e CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

6 METHYL 9 (2 DEOXY BETA D ERYTHRO PENTOFURANOSYL) PURINE; DEOXYADENOSINE DERIVATIVE; DNA; GANCICLOVIR; PRODRUG; PROSTATE SPECIFIC ANTIGEN; PURINE NUCLEOSIDE PHOSPHORYLASE; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DNA REPLICATION; EXPRESSION VECTOR; GENE THERAPY; HERPES SIMPLEX VIRUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROSTATE CANCER; SURVIVAL;

ADENOVIRIDAE; ANIMALIA; HERPES; HUMAN ADENOVIRUS; MUS MUSCULUS; SIMPLEXVIRUS;

EID: 0032551657     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.11-1617     Document Type: Article

References (12)

1. ANDERSON, W.F. (1994). Gene therapy for cancer. 5, 1-2.
2. ANDERSON-MCKAY, J.E., BOTH, G.W., and SIMPSON, G.W. (1996). Regio- and stereoselective synthesis of 6-methyl-9-(2-deoxy-β-D-erythro-pentofuranosyl) purine. Nucleotides Nucleosides 15, 1307-1313.
3. BERGES, R.R., VUKANOVIC, J., EPSTEIN, J.I., CARMICHAEL, M., CISEK, L., JOHNSON, D.E., VELTRI, R.W., WALSH, P.C., and ISAACS, J.T. (1995). Implication of cell kinetic changes during progression of human prostatic cancer. Clin. Cancer Res. 1, 473-480.
4. BONNEKOH, B., GREENHALGH, D.A., BUNDMAN, D.S., ECKHARDT, J.N., LONGLEY, M.A., CHEN, S.H., WOO, S.L.C., and ROOP, D.R. (1995). Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo. J. Invest. Dermatol. 104, 313-317.
5. BORING, C.C., SQUIRES, T.S., TONG, T., and MONTGOMERY, S. (1994). Cancer statistics 1994. CA Cancer J. Clin. 44, 7-26.
6. BROOKES, D.E., CAMPBELL-ZANDVLEIT, D., WATT, F., RUSSELL, P.J., and MOLLOY, P.L. (1998). Relative activity and specificity of promoters from prostate-expressed genes. Prostate 35, 18-26.
7. CHEN, Y.C., HUAN, E.S., LIN, J.C., MAR, E.C., PAGANO, J.S., DUTSCHMAN, G.E., and GRILL, S.P. (1983). Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy) methyl]-guanine against herpes viruses in vitro and its mode of action against herpes simplex virus type 1. Proc. Natl. Acad. Sci. U.S.A. 80, 2767-2770.
8. HUGHES. B.W., WELLS, A.H., BEBOK, Z., GADI, V.K., GARVER, R.I., JR., PARKER, B., and SORSCHER, E.J. (1995). Bystander killing of melanoma cells using the human tyrosinase promoter to express the Escherichia coli purine nucleoside phosphorylase gene. Cancer Res. 55, 3339-3345.
9. JENSEN, K.F., and NYGAARD, P. (1975). Purine nucleoside phosphorylase from Escherichia coli and Salmonella typhimurium. Purification and some properties. Eur. J. Biochem. 51, 253-265.
10. KAIGHN, M.E., NARAYAN, K.S., OHNUKI, Y., LECHNER, J.F., and JONES, L.W. (1979). Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest Urol. 17, 16-23.
11. KASPER, S., RENNIE, P.S., BRUCHOVSKY, N., SHEPPARD, P.C., CHEN, H., LIN, L., SHIU, R.P.C., SNOEK, R., and MATUSFK, R.J. (1994). Cooperative binding of androgen receptors to two DNA sequences is required for androgen induction of the probasin gene. J. Biol. Chem. 269, 3173-3179.
12. ZINCKE, H., OESTERLING, J.E., BLUTE, M.L., BERGSTRALH, E.H., MEYERS, R.P., and BARRETT, D.M. (1994). Long-term (15 years) results after radical prostatectomy for clinically localized (stage T2c of lower) prostate cancer. J Urol. 152, 1850-1857.