Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes

Human Gene Therapy

Volumn 8, Issue 15, 1997, Pages 1825-1835

  Denning, C ^a   Pitts, J D ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; FLUOROURIDINE; GANCICLOVIR; PRODRUG; THYMIDINE KINASE; THYMIDINE PHOSPHORYLASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER; CANCER CELL; CANCER CELL CULTURE; CELL COMMUNICATION; CELL DEATH; CONTROLLED STUDY; DRUG CYTOTOXICITY; GENE THERAPY; GENE TRANSFER; HERPES SIMPLEX VIRUS; MOUSE; NONHUMAN; SUICIDE GENE;

ANIMALIA; HERPES; RODENTIA; SIMPLEXVIRUS;

EID: 0030724139     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.15-1825     Document Type: Article

References (4)

1. ABRAHAM, D., MUIR, H., WINCHESTER, B., and OLSEN, I. (1988). Lyphocytes transfer only the lysosomal form of α-D-mannosidase during cell-to-cell contact. Exp. Cell Res. 175, 158-168.
2. BARBA, D., HARDIN, J., SADELAIN, M., and GAGE, F.H. (1994). Development of antitumour immunity following thymidine kinase mediated killing of experimental brain tumours. Proc. Natl. Acad. Sci. USA 91, 4348-4352.
3. BI, W.L., PARYSEK, L.M., WARNICK, R., and STAMBROOK, P.J. (1993). In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV-TK retroviral gene therapy. Hum. Gene Ther. 4, 725-731.
4. BRIDGEWATER, J.A., SPRINGER, C.J., KNOX, RJ., MINTON, N.P., MICHAEL, N.P., and COLLINS, M.K. (1995). Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954. Eur. J. Cancer 31A, 2362-2370.