Improved radiosensitization of rat glioma cells with adenovirus- expressed mutant herpes simplex virus-thymidine kinase in combination with acyclovir

Cancer Gene Therapy

Volumn 7, Issue 6, 2000, Pages 879-884

  Valerie, Kristoffer ^a,b   Brust, David ^a   Farnsworth, Julie ^a   Amir, Cyrus ^a,b   Taher, Mohiuddin M ^a   Hershey, Chad ^a   Feden, Jeffrey ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cancer gene therapy; Fischer 344 rat; RT2 glioma cells; Suicide gene

Indexed keywords

ACICLOVIR; THYMIDINE KINASE; VIRUS ENZYME; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE THERAPY; GLIOMA; IN VIVO STUDY; MULTIMODALITY CANCER THERAPY; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIZATION; RAT; SUICIDE GENE;

ADENOVIRIDAE; ANIMALIA; HERPES; SIMPLEXVIRUS;

EID: 0033935125     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700185     Document Type: Article

References (21)

1. Perez-Cruet MJ, Trask TW, Chen SH, et al. Adenovirus-mediated gene therapy of experimental gliomas. J Neurosci Res. 1994;39:506-511.
2. Chen SH, Shine HD, Goodman JC, Grossman RG, Woo SL. Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA. 1994;91:3054-3057.
3. Shewach DS, Zerbe LK, Hughes TL, Roessler BJ, Breakefield XO, Davidson BL. Enhanced cytotoxicity of antiviral drugs mediated by adenovirus-directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells. Cancer Gene Ther. 1994;1:107-112.
4. Brust D, Feden J, Farnsworth J, et al. Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow-rate controlled positive pressure infusion. Cancer Gene Ther. 2000;7:778-788.
5. Kim JH, Kim SH, Kolozsvary A, Brown SL, Kim OB, Freytag SO. Selective enhancement of radiation response of herpes simplex virus thymidine kinase-transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents. Int J Radial Oncol Biol Phys. 1995;33:861-868.
6. Kim SH, Kim JH, Kolozsvary A, Brown SL, Freytag SO. Preferential radiosensitization of 9L glioma cells transduced with HSV-tk gene by acyclovir. J Neurooncol. 1997; 33:189-194.
7. Black ME, Newcomb TG, Wilson HM, Loeb LA. Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy. Proc Nad Acad Sci USA. 1996;93:3525-3529.
8. Wilfong RF, Bigner DD, Self DJ, Wechsler W. Brain tumor types induced by the Schmidt-Ruppin strain of Rous sarcoma virus in inbred Fischer rats. Acta Neuropathol. 1973;25:196-206.
9. Mahaley MS Jr, Gentry RE, Bigner DD. Immunobiology of primary intracranial tumors. J Neurosurg. 1977;47:35-43.
10. Contessa JN, Reardon DB, Todd D, et al. The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells. Clin Cancer Res. 1999;5:405-411.
11. Chartier C, Degryse E, Gantzer M, Dieterle A, Pavirani A, Mehtali M. Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J Virol. 1996;70:4805-4810.
12. Valerie K, Singhal A. Host-cell reactivation of reporter genes introduced into cells by adenovirus as a convenient way to measure cellular DNA repair. Mutat Res. 1995;336: 91-100.
13. Taher MM, Baumgardner T, Sent P, Valerie P. Genetic evidence that stress-activated p38 MAP kinase is necessary but not sufficient for UV activation of HIV gene expression. Biochemistry. 1999;38:13055-13062.
14. Balzarini J, Bohman C, De Clercq E. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2. J Biol Chem. 1993;268:6332-6337.
15. Field AK, Davies ME, DeWitt C, et al. 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication. Proc Natl Acad Sci USA. 1983;80:4139-4143.
16. Colombo BM, Benedetti S, Ottolenghi S, et al. The "bystander effect": association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice. Hum Gene Ther. 1995;6:763-772.
17. Hamel W, Magnelli L, Chiarugi VP, Israel MA. Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res. 1996;56:2697-2702.
18. Kim JH, Kim SH, Brown SL, Freytag SO. Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene. Cancer Res. 1994;54:6053-6056.
19. Eck SL, Alavi JB, Alavi A, et al. Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial. Hum Gene Ther. 1996;7: 1465-1482.
20. Brewster ME, Raghavan K, Pop E, Bodor N. Enhanced delivery of ganciclovir to the brain through the use of redox targeting. Antimicrob Agents Chemother. 1994;38: 817-823.
21. Wagstaff AJ, Faulds D, Goa KL. acyclovir: a reappraisal of its antiviral activity, pharmacokinetic properties, and therapeutic efficacy. Drugs. 1994;47:153-205.