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Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 18, 2000, Pages 2083-2086

Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT

(6) Sagnou, Marina J a Howard, Philip W a Gregson, Stephen J a Eno Amooquaye, Ebun b Burke, Philip J b Thurston, David E a

a UNIVERSITY OF PORTSMOUTH (United Kingdom)

b CHARING CROSS HOSPITAL (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; ANTINEOPLASTIC ANTIBIOTIC; DSB 120; NITROREDUCTASE; PRODRUG; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; TOMAYMYCIN; UNCLASSIFIED DRUG;

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVATION; DRUG DESIGN; DRUG SYNTHESIS; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL;

ANTIBIOTICS, ANTINEOPLASTIC; BENZODIAZEPINES; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; NAD; NITROREDUCTASES; PRODRUGS; PYRROLES; TUMOR CELLS, CULTURED;

EID: 0033822932 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(00)00404-2 Document Type: Article

Times cited : (29)

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