메뉴 건너뛰기




Volumn 15, Issue 2, 2000, Pages 177-184

Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: Comparison of ganciclovir, penciclovir and aciclovir

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; CLASTOGEN; DNA; GANCICLOVIR; PENCICLOVIR; PURINE NUCLEOSIDE DERIVATIVE; THYMIDINE KINASE;

EID: 0034060815     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/15.2.177     Document Type: Article
Times cited : (29)

References (35)
  • 1
    • 0343984200 scopus 로고
    • The fate of chromosomal aberrations in a proliferating cell system
    • Beek, B., Klein, G. and Obe, G. (1980) The fate of chromosomal aberrations in a proliferating cell system. Biol. Zentralbl., 99, 73-84.
    • (1980) Biol. Zentralbl. , vol.99 , pp. 73-84
    • Beek, B.1    Klein, G.2    Obe, G.3
  • 2
    • 0021807545 scopus 로고
    • Metabolic activation of the nucleoside analog 9-[2-hydroxy-1-(hydroxymethyl)ethoxy|methyl] guanine in human diploid fibroblasts infected with human cytomegalovirus
    • Biron, K.K., Stanat, S.C., Sorrell, J.B., Fyfe, J.A., Keller, P.M., Lambe, C.U. and Nelson, D.J. (1985) Metabolic activation of the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy|methyl] guanine in human diploid fibroblasts infected with human cytomegalovirus. Proc. Natl Acad. Sci. USA. 82, 2473-2477.
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 2473-2477
    • Biron, K.K.1    Stanat, S.C.2    Sorrell, J.B.3    Fyfe, J.A.4    Keller, P.M.5    Lambe, C.U.6    Nelson, D.J.7
  • 3
    • 0002827405 scopus 로고
    • Molecular aspects of anti-herpesvirus drugs
    • Coen, D.M. (1992) Molecular aspects of anti-herpesvirus drugs. Virology, 3, 3-12.
    • (1992) Virology , vol.3 , pp. 3-12
    • Coen, D.M.1
  • 4
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
    • Culver, K.W., Ram, Z., Wallbridge, S., Ishii, H., Oldtield, E.H. and Blaese, R.M. (1992) In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science, 256, 1550-1552.
    • (1992) Science , vol.256 , pp. 1550-1552
    • Culver, K.W.1    Ram, Z.2    Wallbridge, S.3    Ishii, H.4    Oldtield, E.H.5    Blaese, R.M.6
  • 5
    • 0028111530 scopus 로고
    • A history of antiherpes research
    • Darby, G. (1994) A history of antiherpes research. Antiviral Chem. Chemother., 5 (suppl. 1), 3-9.
    • (1994) Antiviral Chem. Chemother. , vol.5 , Issue.SUPPL. 1 , pp. 3-9
    • Darby, G.1
  • 6
    • 0029003515 scopus 로고
    • In search of the perfect antiviral
    • Darby, G. (1995) In search of the perfect antiviral. Antiviral Chem. Chemother., 6 (suppl. 1), 54-63.
    • (1995) Antiviral Chem. Chemother. , vol.6 , Issue.SUPPL. 1 , pp. 54-63
    • Darby, G.1
  • 7
    • 0028364918 scopus 로고
    • Antiviral activity spectrum and target of action of different classes of nucleoside analogues
    • De Clercq, E. (1994) Antiviral activity spectrum and target of action of different classes of nucleoside analogues. Nucleosides Nucleotides, 13, 1271-1295.
    • (1994) Nucleosides Nucleotides , vol.13 , pp. 1271-1295
    • De Clercq, E.1
  • 8
    • 0029553879 scopus 로고
    • Trends in the development of new antiviral agents for the chemotherapy of infections caused by herpesviruses and retroviruses
    • De Clercq, E. (1995) Trends in the development of new antiviral agents for the chemotherapy of infections caused by herpesviruses and retroviruses. Rev. Med. Virol., 5, 149-164.
    • (1995) Rev. Med. Virol. , vol.5 , pp. 149-164
    • De Clercq, E.1
  • 10
    • 0026493737 scopus 로고
    • Penciclovir: Mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus (HSV-1), HSV-2 and varicella zoster virus
    • Earnshaw, D.L., Bacon, T.H. and Darlison, S.J. (1992) Penciclovir: mode of antiviral action of penciclovir in MRC-5 cells infected with herpes simplex virus (HSV-1), HSV-2 and varicella zoster virus. Antimicrob. Agents Chemother., 36, 2747-2757.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 2747-2757
    • Earnshaw, D.L.1    Bacon, T.H.2    Darlison, S.J.3
  • 12
    • 0030969636 scopus 로고    scopus 로고
    • Solution structure of a DNA decamer containing the antiviral drug ganciclovir: Combined use of NMR, restrained molecular dynamics and full relaxation matrix refinement
    • Foti, M., Marshalko, S.J., Schuster, E., Kumar, S., Beardsley, G.P. and Schweitzer, B.I. (1997) Solution structure of a DNA decamer containing the antiviral drug ganciclovir: combined use of NMR, restrained molecular dynamics and full relaxation matrix refinement. Biochemistry, 36, 5336-5345.
    • (1997) Biochemistry , vol.36 , pp. 5336-5345
    • Foti, M.1    Marshalko, S.J.2    Schuster, E.3    Kumar, S.4    Beardsley, G.P.5    Schweitzer, B.I.6
  • 13
    • 0028947749 scopus 로고
    • The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: Implications for methylation-associated processes
    • Haaf, T. (1995) The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated processes. Pharmacol. Ther., 65, 19-46.
    • (1995) Pharmacol. Ther. , vol.65 , pp. 19-46
    • Haaf, T.1
  • 14
    • 0032148384 scopus 로고    scopus 로고
    • 2-M arrest and cytoskeletal reorganization induced by cytotoxic nucleoside analogues
    • 2-M arrest and cytoskeletal reorganization induced by cytotoxic nucleoside analogues. Cancer Res., 58, 3855-3865.
    • (1998) Cancer Res. , vol.58 , pp. 3855-3865
    • Halloran, P.J.1    Fenton, R.G.2
  • 15
    • 0029997766 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells
    • Hamel, W., Magnelli, L., Chiarugi, V.P. and Israel, M.A. (1996) Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res., 56, 2697-2702.
    • (1996) Cancer Res. , vol.56 , pp. 2697-2702
    • Hamel, W.1    Magnelli, L.2    Chiarugi, V.P.3    Israel, M.A.4
  • 17
    • 0030861825 scopus 로고    scopus 로고
    • Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells
    • Ianzini, F. and Mackey, M.A. (1997) Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells. Int. J. Radiat. Biol., 73, 409-421.
    • (1997) Int. J. Radiat. Biol. , vol.73 , pp. 409-421
    • Ianzini, F.1    Mackey, M.A.2
  • 18
    • 0032480042 scopus 로고    scopus 로고
    • Critical steps in alkylation-induced aberration formation
    • Kaina, B. (1998) Critical steps in alkylation-induced aberration formation. Mutat. Res., 404, 119-124.
    • (1998) Mutat. Res. , vol.404 , pp. 119-124
    • Kaina, B.1
  • 19
    • 0023787230 scopus 로고
    • Nuclear fragmentation and premature chromosome condensation induced by heat shock in S-phase Chinese hamster ovary cells
    • Mackey, M.A., Morgan, W.F. and Dewey, W.C. (1988) Nuclear fragmentation and premature chromosome condensation induced by heat shock in S-phase Chinese hamster ovary cells. Cancer Res., 48, 6478-6483.
    • (1988) Cancer Res. , vol.48 , pp. 6478-6483
    • Mackey, M.A.1    Morgan, W.F.2    Dewey, W.C.3
  • 20
    • 0029145834 scopus 로고
    • Chiral chemical synthesis of DNA containing (S)-9-(1,3-dihydroxy-2-propoxymethyl) guanine (DHPG) and effects on thermal stability, duplex structure and thermodynamics of duplex formation
    • Marshalko, S.J., Schweitzer, B.I. and Beardsley, G.P. (1995) Chiral chemical synthesis of DNA containing (S)-9-(1,3-dihydroxy-2-propoxymethyl) guanine (DHPG) and effects on thermal stability, duplex structure and thermodynamics of duplex formation. Biochemistry, 34, 9235-9248.
    • (1995) Biochemistry , vol.34 , pp. 9235-9248
    • Marshalko, S.J.1    Schweitzer, B.I.2    Beardsley, G.P.3
  • 21
    • 0029996360 scopus 로고    scopus 로고
    • Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins
    • Mesnil, M., Piccoli, C., Tiraby, G., Willecke, K. and Yamasaki, H. (1996) Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc. Natl Acad. Sci. USA, 93, 1831-1835.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 1831-1835
    • Mesnil, M.1    Piccoli, C.2    Tiraby, G.3    Willecke, K.4    Yamasaki, H.5
  • 22
    • 0022485359 scopus 로고
    • Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for prospective cancer control strategy
    • Moolten, F.L. (1986) Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for prospective cancer control strategy. Cancer Res., 46, 5276-5281.
    • (1986) Cancer Res. , vol.46 , pp. 5276-5281
    • Moolten, F.L.1
  • 23
    • 0027548077 scopus 로고
    • Gene therapy of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir
    • Oldfield, E.H., Ram., Z., Culver, K.W., Blaese, R.M., De Vroom, H.L. and Anderson, W.F. (1993) Gene therapy of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum. Gene Ther., 4, 39-69.
    • (1993) Hum. Gene Ther. , vol.4 , pp. 39-69
    • Oldfield, E.H.1    Culver, K.W.2    Blaese, R.M.3    De Vroom, H.L.4    Anderson, W.F.5
  • 24
    • 0032169967 scopus 로고    scopus 로고
    • Superior cytotoxicity with ganciclovir compared to acyclovir and arat in HSV-TK-expressing cells: A novel paradigm for cell killing
    • Rubsam, L.Z., Davidson, B.L. and Shewach, D.S. (1998) Superior cytotoxicity with ganciclovir compared to acyclovir and araT in HSV-TK-expressing cells: a novel paradigm for cell killing. Cancer Res., 58, 3873-3882.
    • (1998) Cancer Res. , vol.58 , pp. 3873-3882
    • Rubsam, L.Z.1    Davidson, B.L.2    Shewach, D.S.3
  • 26
    • 0029083564 scopus 로고
    • Fragile site at Xq21 in chinese hamster and its implications for the in vitro chromosomal aberration test
    • Slijepcevic, P. and Natarajan, A.T. (1995) Fragile site at Xq21 in Chinese hamster and its implications for the in vitro chromosomal aberration test. Mutagenesis. 10, 353-355.
    • (1995) Mutagenesis. , vol.10 , pp. 353-355
    • Slijepcevic, P.1    Natarajan, A.T.2
  • 27
    • 0021860994 scopus 로고
    • Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)guanine and acyclovir in herpes simplex virus-infected and uninfected cells
    • Smee, D.F., Boehme, R., Chernow, M., Binko, B.P. and Matthews, T.R. (1985) Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)guanine and acyclovir in herpes simplex virus-infected and uninfected cells. Biochem. Pharmacol., 34, 1049-1056.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 1049-1056
    • Smee, D.F.1    Boehme, R.2    Chernow, M.3    Binko, B.P.4    Matthews, T.R.5
  • 28
    • 0016158843 scopus 로고
    • The phenomenon of premature chromosome condensation: Its relevance to basic and applied research
    • Sperling, K. and Rao, P.N. (1974) The phenomenon of premature chromosome condensation: its relevance to basic and applied research. Humangenetik, 23, 235-258.
    • (1974) Humangenetik , vol.23 , pp. 235-258
    • Sperling, K.1    Rao, P.N.2
  • 29
    • 0023183303 scopus 로고
    • Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information
    • St Clair, M.H., Lambe, C.U. and Furman, P.A. (1987) Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information. Antimicrob. Agents Chemother., 31, 844-849.
    • (1987) Antimicrob. Agents Chemother. , vol.31 , pp. 844-849
    • St Clair, M.H.1    Lambe, C.U.2    Furman, P.A.3
  • 30
    • 0017733050 scopus 로고
    • Differential giemsa staining of sister chromatids after extraction with acids
    • Takayama, S. and Sakanishi, S. (1977) Differential Giemsa staining of sister chromatids after extraction with acids. Chromosoma, 64, 109-116.
    • (1977) Chromosoma , vol.64 , pp. 109-116
    • Takayama, S.1    Sakanishi, S.2
  • 31
    • 0029884088 scopus 로고    scopus 로고
    • Cytogenetic genotoxicity of antiherpes virostatics in Chinese hamster V79-E cells, I. Purine nucleoside analogues
    • Thust, R., Schacke, M. and Wutzler, P. (1996) Cytogenetic genotoxicity of antiherpes virostatics in Chinese hamster V79-E cells, I. Purine nucleoside analogues. Antiviral Res., 31. 105-113.
    • (1996) Antiviral Res. , vol.31 , pp. 105-113
    • Thust, R.1    Schacke, M.2    Wutzler, P.3
  • 32
    • 0033974798 scopus 로고    scopus 로고
    • Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in CHO cells transfected with the thymidine kinase gene of HSV-1: Implications for gene therapeutic approaches
    • Thust, R., Tomicic, M., Klöcking, R., Voutilainen, N., Wutzler, P. and Kaina, B. (2000) Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in CHO cells transfected with the thymidine kinase gene of HSV-1: implications for gene therapeutic approaches. Cancer Gene Ther., 7, 107-117.
    • (2000) Cancer Gene Ther. , vol.7 , pp. 107-117
    • Thust, R.1    Tomicic, M.2    Klöcking, R.3    Voutilainen, N.4    Wutzler, P.5    Kaina, B.6
  • 33
  • 34
    • 0024595771 scopus 로고
    • Mode of action of 9-(4-hydroxymethylbut-1-yl)guanine (BRL 39123) against herpes simplex virus in MRC-5 cells
    • Vere Hodge, R.A. and Perkins, R.M. (1989) Mode of action of 9-(4-hydroxymethylbut-1-yl)guanine (BRL 39123) against herpes simplex virus in MRC-5 cells. Antimicrob. Agents Chemother., 33, 223-229.
    • (1989) Antimicrob. Agents Chemother. , vol.33 , pp. 223-229
    • Vere Hodge, R.A.1    Perkins, R.M.2
  • 35
    • 0029892826 scopus 로고    scopus 로고
    • Segregation of DNA polynucleotide strands into sister chromatids and the use of endoreduplicated cells to track sister chromatid exchanges induced by crosslinks, alkylations, or x-ray damage
    • Wolff, S. and Afzal, V. (1996) Segregation of DNA polynucleotide strands into sister chromatids and the use of endoreduplicated cells to track sister chromatid exchanges induced by crosslinks, alkylations, or x-ray damage. Proc. Natl Acad. Sci. USA, 93, 5765-5769.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 5765-5769
    • Wolff, S.1    Afzal, V.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.