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Volumn 57, Issue 19, 1997, Pages 4205-4209

Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE DEAMINASE; FLUCYTOSINE; VIRUS VECTOR;

EID: 0030768615     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (91)

References (59)
  • 2
    • 0019410935 scopus 로고
    • Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads) + 5-FU, and high dose radiation + 5-FU
    • Phila.
    • The Gastrointestinal Tumor Study Group. Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads) + 5-FU, and high dose radiation + 5-FU. Cancer (Phila.), 48: 1705-1710, 1981.
    • (1981) Cancer , vol.48 , pp. 1705-1710
  • 3
    • 0021792174 scopus 로고
    • Prolongation of the disease-free interval in surgically treated rectal carcinoma
    • The Gastrointestinal Tumor Study Group. Prolongation of the disease-free interval in surgically treated rectal carcinoma. N. Engl. J. Med., 312: 1465-1472, 1985.
    • (1985) N. Engl. J. Med. , vol.312 , pp. 1465-1472
  • 5
    • 0014691062 scopus 로고
    • Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer
    • Moertel, C. G., Childs, D. S., Jr., Reitemeier, R. J., Colby, M. Y., Jr., and Holbrook, M. A. Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet, 2: 865-867, 1969.
    • (1969) Lancet , vol.2 , pp. 865-867
    • Moertel, C.G.1    Childs Jr., D.S.2    Reitemeier, R.J.3    Colby Jr., M.Y.4    Holbrook, M.A.5
  • 10
    • 0025858452 scopus 로고
    • Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: An innovative approach for cancer therapy
    • Huber, B. E., Richards, C. A., and Krenitsky, T. A. Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy. Proc. Natl. Acad. Sci. USA, 88: 8039-8043, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8039-8043
    • Huber, B.E.1    Richards, C.A.2    Krenitsky, T.A.3
  • 11
  • 12
    • 0026599586 scopus 로고
    • Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: A negative selection system
    • Mullen, C. A., Kilstrup, M., and Blaese, R. M. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc. Natl. Acad. Sci. USA, 89: 33-37, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 33-37
    • Mullen, C.A.1    Kilstrup, M.2    Blaese, R.M.3
  • 13
    • 0027496518 scopus 로고
    • In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase
    • Huber, B. E., Austin, E. A., Good, S. S., Knick, V. C., Tibbels, S., and Richards, C. A. In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res., 53: 4619-4626, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 4619-4626
    • Huber, B.E.1    Austin, E.A.2    Good, S.S.3    Knick, V.C.4    Tibbels, S.5    Richards, C.A.6
  • 14
    • 0028108469 scopus 로고
    • Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
    • Huber, B. E., Austin, E. A., Richards, C. A., Davis, S. T., and Good, S. S. Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc. Natl. Acad. Sci. USA, 91: 8302-8306, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8302-8306
    • Huber, B.E.1    Austin, E.A.2    Richards, C.A.3    Davis, S.T.4    Good, S.S.5
  • 15
    • 0028795075 scopus 로고
    • In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine
    • Hirschowitz, E. A., Ohwada, A., Pascal, W. R., Russi, T. J., and Crystal, R. G. In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine. Hum. Gene Ther., 6: 1055-1063, 1995.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 1055-1063
    • Hirschowitz, E.A.1    Ohwada, A.2    Pascal, W.R.3    Russi, T.J.4    Crystal, R.G.5
  • 16
    • 0029743164 scopus 로고    scopus 로고
    • Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver
    • Ohwada, A., Hirschowitz, E. A., and Crystal, R. G. Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver. Hum. Gene Ther., 7: 1567-1576, 1996.
    • (1996) Hum. Gene Ther. , vol.7 , pp. 1567-1576
    • Ohwada, A.1    Hirschowitz, E.A.2    Crystal, R.G.3
  • 17
    • 0031087212 scopus 로고    scopus 로고
    • Enzyme/prodrug gene therapy approach for breast cancer using a recombinant adenovirus expressing Escherichia coli cytosine deaminase
    • Li, Z., Shanmugam, N., Katayose, D., Huber, B., Srivastava, S., Cowan, K., and Seth, P. Enzyme/prodrug gene therapy approach for breast cancer using a recombinant adenovirus expressing Escherichia coli cytosine deaminase. Cancer Gene Ther., 4: 113-117, 1997.
    • (1997) Cancer Gene Ther. , vol.4 , pp. 113-117
    • Li, Z.1    Shanmugam, N.2    Katayose, D.3    Huber, B.4    Srivastava, S.5    Cowan, K.6    Seth, P.7
  • 18
    • 0027548077 scopus 로고
    • Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir
    • Oldfield, E. H., Ram, Z., Culver, K. W., Blaese, R. M., DeVroom, H. L., and Anderson, W. F. Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum. Gene Ther., 4: 39-69, 1993.
    • (1993) Hum. Gene Ther. , vol.4 , pp. 39-69
    • Oldfield, E.H.1    Ram, Z.2    Culver, K.W.3    Blaese, R.M.4    DeVroom, H.L.5    Anderson, W.F.6
  • 19
    • 0028032719 scopus 로고
    • Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene
    • Kim, J. H., Kim, S. H., Brown, S. L., and Freytag, S. O. Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene. Cancer Res., 54: 6053-6056, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 6053-6056
    • Kim, J.H.1    Kim, S.H.2    Brown, S.L.3    Freytag, S.O.4
  • 21
    • 0029018605 scopus 로고
    • Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human α-fetoprotein gene promoter
    • Ido, A., Nakata, K., Kato, Y., Nakao, K., Murata, K., Fujita, M., Ishii, N., Tamaoki, T., Shiku, H., and Nagataki, S. Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human α-fetoprotein gene promoter. Cancer Res., 55: 3105-3109, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 3105-3109
    • Ido, A.1    Nakata, K.2    Kato, Y.3    Nakao, K.4    Murata, K.5    Fujita, M.6    Ishii, N.7    Tamaoki, T.8    Shiku, H.9    Nagataki, S.10
  • 22
  • 23
    • 0029048478 scopus 로고
    • Genetic delivery of enzymes for cancer therapy
    • Deonarain, M. P., Spooner, R. A., and Epenetos, A. A. Genetic delivery of enzymes for cancer therapy. Gene Ther., 2: 235-244, 1995.
    • (1995) Gene Ther. , vol.2 , pp. 235-244
    • Deonarain, M.P.1    Spooner, R.A.2    Epenetos, A.A.3
  • 24
    • 0028297316 scopus 로고
    • Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor
    • Mullen, C. A., Coale, M. M., Lowe, R., and Blaese, R. M. Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor. Cancer Res., 54: 1503-1506, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 1503-1506
    • Mullen, C.A.1    Coale, M.M.2    Lowe, R.3    Blaese, R.M.4
  • 25
    • 0028989592 scopus 로고
    • 5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory
    • Consalvo, M., Mullen, C. A., Modesti, A., Musiani, P., Allione, A., Cavallo, F., Giovarelli, M., and Forni, G. 5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory. J. Immunol., 154: 5302-5312, 1995.
    • (1995) J. Immunol. , vol.154 , pp. 5302-5312
    • Consalvo, M.1    Mullen, C.A.2    Modesti, A.3    Musiani, P.4    Allione, A.5    Cavallo, F.6    Giovarelli, M.7    Forni, G.8
  • 26
    • 0031008801 scopus 로고    scopus 로고
    • Targeted gene therapy for cancer: Herpes simplex virus thymidine kinase gene-mediated cell killing leads to anti-tumour immunity that can be augmented by co-expression of cytokines in the tumour cells
    • Vile, R. G., Diaz, R. M., Castleden, S., and Chong, H. Targeted gene therapy for cancer: herpes simplex virus thymidine kinase gene-mediated cell killing leads to anti-tumour immunity that can be augmented by co-expression of cytokines in the tumour cells. Biochem. Soc. Trans., 25: 717-722, 1997.
    • (1997) Biochem. Soc. Trans. , vol.25 , pp. 717-722
    • Vile, R.G.1    Diaz, R.M.2    Castleden, S.3    Chong, H.4
  • 27
    • 0011724482 scopus 로고
    • Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients
    • Weichselbaum, R. R., Dahlberg, W., Beckett, M., Karrison, T., Miller, D., Clark, J., and Ervin, T. J. Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients. Proc. Natl. Acad. Sci. USA, 83: 2684-2688, 1986.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 2684-2688
    • Weichselbaum, R.R.1    Dahlberg, W.2    Beckett, M.3    Karrison, T.4    Miller, D.5    Clark, J.6    Ervin, T.J.7
  • 28
    • 0027054126 scopus 로고
    • The interaction of 5-fluorouracil, hydroxyurea, and radiation in two human head and neck cancer cell lines
    • Vokes, E. E., Beckett, M., Karrison, T., and Weichselbaum, R. R. The interaction of 5-fluorouracil, hydroxyurea, and radiation in two human head and neck cancer cell lines. Oncology, 49: 454-460, 1992.
    • (1992) Oncology , vol.49 , pp. 454-460
    • Vokes, E.E.1    Beckett, M.2    Karrison, T.3    Weichselbaum, R.R.4
  • 29
    • 0022511464 scopus 로고
    • Combined use of drugs and radiation in the treatment of liver metastases
    • Byfield, J. E. Combined use of drugs and radiation in the treatment of liver metastases. Recent Results Cancer Res., 100: 298-306, 1986.
    • (1986) Recent Results Cancer Res. , vol.100 , pp. 298-306
    • Byfield, J.E.1
  • 30
    • 0020393438 scopus 로고
    • Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or ftorafur and X rays
    • Byfield, J. E., Calabro-Jones, P., Klisak, I., and Kulhanian, F. Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or ftorafur and X rays. Int. J. Radiat. Oncol. Biol. Phys., 8: 1923-1933, 1982.
    • (1982) Int. J. Radiat. Oncol. Biol. Phys. , vol.8 , pp. 1923-1933
    • Byfield, J.E.1    Calabro-Jones, P.2    Klisak, I.3    Kulhanian, F.4
  • 31
    • 0024381604 scopus 로고
    • 5-Fluorouracil radiation sensitization: A brief review
    • Byfield, J. E. 5-Fluorouracil radiation sensitization: a brief review. Invest. New Drugs, 7: 111-116, 1989.
    • (1989) Invest. New Drugs , vol.7 , pp. 111-116
    • Byfield, J.E.1
  • 32
    • 0026028777 scopus 로고
    • 5-Fluorouracil modulation of radiosensitivity in cultured human carcinoma cells
    • Smalley, S. R., Kimler, B. F., and Evans, R. G. 5-Fluorouracil modulation of radiosensitivity in cultured human carcinoma cells. Int. J. Radiat. Oncol. Biol. Phys., 20: 207-211, 1991.
    • (1991) Int. J. Radiat. Oncol. Biol. Phys. , vol.20 , pp. 207-211
    • Smalley, S.R.1    Kimler, B.F.2    Evans, R.G.3
  • 33
    • 0026756073 scopus 로고
    • Heterogeneity of 5-fluorouracil radiosensitivity modulation in cultured mammalian cell lines
    • Smalley, S. R., Kimler, B. F., Evans, R. G., and Dalziel, W. C. Heterogeneity of 5-fluorouracil radiosensitivity modulation in cultured mammalian cell lines. Int. J. Radiat. Oncol. Biol. Phys., 24: 519-525, 1992.
    • (1992) Int. J. Radiat. Oncol. Biol. Phys. , vol.24 , pp. 519-525
    • Smalley, S.R.1    Kimler, B.F.2    Evans, R.G.3    Dalziel, W.C.4
  • 34
    • 0022970363 scopus 로고
    • Experimental studies on interactions of radiation and cancer chemotherapeutic drugs in normal tissues and a solid tumor
    • Von Der Masse, H. Experimental studies on interactions of radiation and cancer chemotherapeutic drugs in normal tissues and a solid tumor. Radiother. Oncol., 7: 47-68, 1986.
    • (1986) Radiother. Oncol. , vol.7 , pp. 47-68
    • Von Der Masse, H.1
  • 35
    • 0025651424 scopus 로고
    • Fluorodeoxyuridine-induced radiosensitization and inhibition of DNA double strand break repair in human colon cancer cells
    • Bruso, C. E., Shewach, D. S., and Lawrence, T. S. Fluorodeoxyuridine-induced radiosensitization and inhibition of DNA double strand break repair in human colon cancer cells. Int. J. Radiat. Oncol. Biol. Phys., 19: 1411-1417, 1990.
    • (1990) Int. J. Radiat. Oncol. Biol. Phys. , vol.19 , pp. 1411-1417
    • Bruso, C.E.1    Shewach, D.S.2    Lawrence, T.S.3
  • 36
    • 1842361165 scopus 로고
    • Rahway, NJ: Merck and Co., Inc.
    • Windholz, M. (ed.). The Merck Index, Vol. 9, p. 534. Rahway, NJ: Merck and Co., Inc., 1976.
    • (1976) The Merck Index , vol.9 , pp. 534
    • Windholz, M.1
  • 37
    • 0028335819 scopus 로고
    • Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine
    • Wallace, P. M., MacMaster, J. F., Smith, V. F., Kerr, D. E., Senter, P. D., and Cosand, W. L. Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine. Cancer Res., 54: 2719-2723, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 2719-2723
    • Wallace, P.M.1    MacMaster, J.F.2    Smith, V.F.3    Kerr, D.E.4    Senter, P.D.5    Cosand, W.L.6
  • 38
    • 0028800141 scopus 로고
    • Enzyme/prodrug gene therapy: Comparison of cytosine deaminase/5- fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line
    • Trinh, Q. T., Austin, E. A., Murray, D. M., Knick, V. C., and Huber, B. E. Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line. Cancer Res., 55: 4808-4812, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 4808-4812
    • Trinh, Q.T.1    Austin, E.A.2    Murray, D.M.3    Knick, V.C.4    Huber, B.E.5
  • 39
    • 0027268254 scopus 로고
    • Transport of 5-fluorouracil and uracil into human erythrocytes
    • Domin, B. A., Mahony, W. B., and Zimmerman, T. P. Transport of 5-fluorouracil and uracil into human erythrocytes. Biochem. Pharmacol., 46: 503-510, 1993.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 503-510
    • Domin, B.A.1    Mahony, W.B.2    Zimmerman, T.P.3
  • 40
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
    • Washington DC
    • Culver, K. W., Ram, Z., Wallbridge, S., Ishii, H., Oldfield, E. H., and Blaese, R. M. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science (Washington DC), 256: 1550-1552, 1992.
    • (1992) Science , vol.256 , pp. 1550-1552
    • Culver, K.W.1    Ram, Z.2    Wallbridge, S.3    Ishii, H.4    Oldfield, E.H.5    Blaese, R.M.6
  • 41
    • 0027255414 scopus 로고
    • Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA
    • Vile, R. G., and Hart, I. R. Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA. Cancer Res., 53: 3860-3864, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 3860-3864
    • Vile, R.G.1    Hart, I.R.2
  • 42
    • 0028071271 scopus 로고
    • The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats
    • Ram, Z., Wallbridge, S., Shawker, T., Culver, K. W., Blaese, R. M., and Oldfield, E. H. The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats. J. Neurosurg., 81: 256-260, 1994.
    • (1994) J. Neurosurg. , vol.81 , pp. 256-260
    • Ram, Z.1    Wallbridge, S.2    Shawker, T.3    Culver, K.W.4    Blaese, R.M.5    Oldfield, E.H.6
  • 43
    • 0026445469 scopus 로고
    • Gene therapy of malignant brain tumors: A rat glioma line bearing the herpes simplex virus type 1-thymidine kinase gene and wild type retrovirus kills other tumor cells
    • Takamiya, Y., Short, M. P., Ezzeddine, Z. D., Moolten, F. L., Breakefield, X. O., and Martuza, R. L. Gene therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type 1-thymidine kinase gene and wild type retrovirus kills other tumor cells. J. Neurosci. Res., 33: 493-503, 1992.
    • (1992) J. Neurosci. Res. , vol.33 , pp. 493-503
    • Takamiya, Y.1    Short, M.P.2    Ezzeddine, Z.D.3    Moolten, F.L.4    Breakefield, X.O.5    Martuza, R.L.6
  • 44
    • 0028127077 scopus 로고
    • Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir
    • Manome, Y., Abe, M., Hagen, M. F., Fine, H. A., and Kufe, D. W. Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir. Cancer Res 54: 5408-5413, 1994.
    • (1994) Cancer Res , vol.54 , pp. 5408-5413
    • Manome, Y.1    Abe, M.2    Hagen, M.F.3    Fine, H.A.4    Kufe, D.W.5
  • 45
    • 0027787053 scopus 로고
    • In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy
    • Bi, W. L., Parysek, L. M., Warnick, R., and Stambrook, P. J. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy. Hum. Gene Ther., 4: 725-731, 1993.
    • (1993) Hum. Gene Ther. , vol.4 , pp. 725-731
    • Bi, W.L.1    Parysek, L.M.2    Warnick, R.3    Stambrook, P.J.4
  • 47
    • 0029161615 scopus 로고
    • The. "bystander effect": Association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice
    • Colombo, B. M., Benedetti, S., Ottolenghi, S., Mora, M., Pollo, B., Poli, G., and Finocchiaro, G. The. "bystander effect": association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice. Hum. Gene Ther., 6: 763-772, 1995.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 763-772
    • Colombo, B.M.1    Benedetti, S.2    Ottolenghi, S.3    Mora, M.4    Pollo, B.5    Poli, G.6    Finocchiaro, G.7
  • 48
    • 0029996360 scopus 로고    scopus 로고
    • Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins
    • Mesnil, M., Piccoli, C., Tiraby, G., Willecke, K., and Yamasaki, H. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc. Natl. Acad. Sci. USA, 93: 1831-1835, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1831-1835
    • Mesnil, M.1    Piccoli, C.2    Tiraby, G.3    Willecke, K.4    Yamasaki, H.5
  • 52
    • 0028075655 scopus 로고
    • Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component
    • Vile, R. G., Nelson, J. A., Castleden, S., Chong, H., and Hart, I. R. Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res., 54: 6228-6234, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 6228-6234
    • Vile, R.G.1    Nelson, J.A.2    Castleden, S.3    Chong, H.4    Hart, I.R.5
  • 53
    • 0030917683 scopus 로고    scopus 로고
    • Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression
    • Vile, R. G., Castleden, S., Marshall, J., Camplejohn, R., Upton, C., and Chong, H. Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression. Int. J. Cancer, 71: 267-274, 1997.
    • (1997) Int. J. Cancer , vol.71 , pp. 267-274
    • Vile, R.G.1    Castleden, S.2    Marshall, J.3    Camplejohn, R.4    Upton, C.5    Chong, H.6
  • 54
    • 0030052050 scopus 로고    scopus 로고
    • Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene
    • Khil, M. S., Kim, J. H., Mullen, C. A., Kim, S. H., and Freytag, S. O. Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene. Clin. Cancer Res., 2: 53-57, 1996.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 53-57
    • Khil, M.S.1    Kim, J.H.2    Mullen, C.A.3    Kim, S.H.4    Freytag, S.O.5
  • 55
    • 0028805459 scopus 로고
    • Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents
    • Kim, J. H., Kim, S. H., Kolozsvary, A., Brown, S. L., Kim, O. B., and Freytag, S. O. Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents. Int. J. Radiat. Oncol. Biol. Phys., 33: 861-868, 1995.
    • (1995) Int. J. Radiat. Oncol. Biol. Phys. , vol.33 , pp. 861-868
    • Kim, J.H.1    Kim, S.H.2    Kolozsvary, A.3    Brown, S.L.4    Kim, O.B.5    Freytag, S.O.6
  • 56
    • 0030906438 scopus 로고    scopus 로고
    • Preferential radiosensitization of 9L glioma cells transduced with HSV-tk gene by acyclovir
    • Kim, S. H., Kim, J. H., Kolozsvary, A., Brown, S. L., and Freytag, S. O. Preferential radiosensitization of 9L glioma cells transduced with HSV-tk gene by acyclovir. J. Neuro-Oncol., 33: 189-194, 1997.
    • (1997) J. Neuro-Oncol. , vol.33 , pp. 189-194
    • Kim, S.H.1    Kim, J.H.2    Kolozsvary, A.3    Brown, S.L.4    Freytag, S.O.5
  • 57
    • 0031024794 scopus 로고    scopus 로고
    • Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity
    • Rogulski, K. R., Kim, J. H., Kim, S. H., and Freytag, S. O. Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity. Hum. Gene Ther., 8: 73-85, 1997.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 73-85
    • Rogulski, K.R.1    Kim, J.H.2    Kim, S.H.3    Freytag, S.O.4
  • 58
    • 0017332164 scopus 로고
    • 5-Fluorocytosine: A brief review
    • Phila.
    • Ashe, W. D., Jr., and Van Reken, D. E. 5-Fluorocytosine: a brief review. Clin. Pediatr. (Phila.), 16: 364-366, 1977.
    • (1977) Clin. Pediatr. , vol.16 , pp. 364-366
    • Ashe Jr., W.D.1    Van Reken, D.E.2
  • 59
    • 0002190941 scopus 로고
    • Fluorocytosine
    • D. C. E. Spellar (ed.), Chichester, United Kingdom: John Wiley
    • Scholer, H. J., Fluorocytosine, In: D. C. E. Spellar (ed.), Antifungal Chemotherapy, pp. 36-106. Chichester, United Kingdom: John Wiley, 1980.
    • (1980) Antifungal Chemotherapy , pp. 36-106
    • Scholer, H.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.