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Volumn 14, Issue 6, 1999, Pages 517-538

Prodrugs for antibody- and gene-directed enzyme prodrug therapies (ADEPT and GDEPT)

Author keywords

ADEPT; Bystander effect; Enzyme; GDEPT; Gene therapy; Prodrug; Viral vectors

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ALKYLATING AGENT; ANTHRACYCLINE ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; CARBOXYPEPTIDASE G2; CHLORMETHINE; ENZYME; NITROREDUCTASE; PRODRUG; TUMOR ANTIGEN;

EID: 0033502650     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (51)

References (94)
  • 2
    • 0026745562 scopus 로고
    • The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954). 1. Purification and properties of nitroreductase enzyme from E. coli, a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT)
    • Anlezark G. M., Melton R.G., Sherwood R.F., Coles B., Friedlos F., Knox R.J. (1992) The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954). 1. Purification and properties of nitroreductase enzyme from E. coli, a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT). Biochemical Pharmacology, 44, 2289.
    • (1992) Biochemical Pharmacology , vol.44 , pp. 2289
    • Anlezark, G.M.1    Melton, R.G.2    Sherwood, R.F.3    Coles, B.4    Friedlos, F.5    Knox, R.J.6
  • 6
    • 0024722750 scopus 로고
    • Toward generating cytotoxic agents at cancer sites
    • Bagshawe K.D. (1989) Toward generating cytotoxic agents at cancer sites. British Journal of Cancer, 60, 275.
    • (1989) British Journal of Cancer , vol.60 , pp. 275
    • Bagshawe, K.D.1
  • 9
    • 0028592664 scopus 로고
    • Antibody-Directed Enzyme Prodrug Therapy (ADEPT): A review of some theoretical, experimental and clinical aspects
    • Bagshawe K.D., Sharma S.K., Springer C.J., Rogers G.T. (1994) Antibody-Directed Enzyme Prodrug Therapy (ADEPT): a review of some theoretical, experimental and clinical aspects. Analytical Oncology, 5, 879.
    • (1994) Analytical Oncology , vol.5 , pp. 879
    • Bagshawe, K.D.1    Sharma, S.K.2    Springer, C.J.3    Rogers, G.T.4
  • 13
    • 0026034848 scopus 로고
    • The differences in kinetics of rat and human DT-diaphorase result in a differential sensitivity of cells lines to CB 1954 5-(aziridin-1-yl)-2,4-dinitrobenzamide
    • Boland M.P., Knox R.J., Roberts J.J. (1991) The differences in kinetics of rat and human DT-diaphorase result in a differential sensitivity of cells lines to CB 1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide. Biochemical Pharmacology, 41, 867.
    • (1991) Biochemical Pharmacology , vol.41 , pp. 867
    • Boland, M.P.1    Knox, R.J.2    Roberts, J.J.3
  • 14
    • 0028348376 scopus 로고
    • Tumor-selective prodrug activation by fusion protein-mediated catalysis
    • Bosslet K., Czech J., Hoffmann D. (1994) Tumor-selective prodrug activation by fusion protein-mediated catalysis. Cancer Research, 54, 2151.
    • (1994) Cancer Research , vol.54 , pp. 2151
    • Bosslet, K.1    Czech, J.2    Hoffmann, D.3
  • 15
    • 0029609610 scopus 로고
    • Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB 1954
    • Bridgewater G., Springer C.J., Knox R., Minton N., Michael P., Collins M. (1995) Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB 1954. European Journal of Cancer, 31A, 2362.
    • (1995) European Journal of Cancer , vol.31 A , pp. 2362
    • Bridgewater, G.1    Springer, C.J.2    Knox, R.3    Minton, N.4    Michael, P.5    Collins, M.6
  • 16
    • 0014446677 scopus 로고
    • Potential anticancer agents. 5. Nitrogen mustards related to 3[N,N-bis(2-chloroethyl)amino]-4-methyl benzoic acid
    • Cambanis A., Dobre V., Niculescu-Duvaz I. (1969) Potential anticancer agents. 5. Nitrogen mustards related to 3[N,N-bis(2-chloroethyl)amino]-4-methyl benzoic acid. Journal of Medicinal Chemistry, 12, 161.
    • (1969) Journal of Medicinal Chemistry , vol.12 , pp. 161
    • Cambanis, A.1    Dobre, V.2    Niculescu-Duvaz, I.3
  • 19
    • 0031956262 scopus 로고    scopus 로고
    • The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme-prodrug therapies
    • Denny W.A., Wilson W.R. (1998) The design of selectively-activated anti-cancer prodrugs for use in antibody-directed and gene-directed enzyme-prodrug therapies. Journal of Pharmaceutical Pharmacology, 50, 387.
    • (1998) Journal of Pharmaceutical Pharmacology , vol.50 , pp. 387
    • Denny, W.A.1    Wilson, W.R.2
  • 20
    • 0028154911 scopus 로고
    • Targeting enzymes for cancer therapy: Old enzymes in new roles
    • Deonarain M.P., Epenetos A.A. (1994) Targeting enzymes for cancer therapy: old enzymes in new roles. British Journal of Cancer, 70, 786.
    • (1994) British Journal of Cancer , vol.70 , pp. 786
    • Deonarain, M.P.1    Epenetos, A.A.2
  • 21
    • 0023183283 scopus 로고
    • Mild palladium(0)-catalyzed deprotection of allylesters. An useful application in the synthesis of carbapenem and other β-lactam derivatives
    • Deziel R. (1987) Mild palladium(0)-catalyzed deprotection of allylesters. An useful application in the synthesis of carbapenem and other β-lactam derivatives. Tetrahedron Letters, 28, 4371.
    • (1987) Tetrahedron Letters , vol.28 , pp. 4371
    • Deziel, R.1
  • 24
    • 0343867891 scopus 로고    scopus 로고
    • Improving enzymes for cancer gene therapy
    • Encell L.P., Loeb L.A. (1998) Improving enzymes for cancer gene therapy. Tumor Targeting, 3, 191.
    • (1998) Tumor Targeting , vol.3 , pp. 191
    • Encell, L.P.1    Loeb, L.A.2
  • 26
    • 0026713627 scopus 로고
    • Metabolism of NAD(P)H by blood components. Relevance to bioreductively activated prodrugs in a targeted enzyme therapy system
    • Friedlos F., Knox R.J. (1992) Metabolism of NAD(P)H by blood components. Relevance to bioreductively activated prodrugs in a targeted enzyme therapy system. Biochemical Pharmacology, 44, 631.
    • (1992) Biochemical Pharmacology , vol.44 , pp. 631
    • Friedlos, F.1    Knox, R.J.2
  • 27
    • 0026773434 scopus 로고
    • Identification of novel reduced pyridinium derivatives as synthetic cofactors for the enzyme DT diaphorase NAD(P)H dehydrogenase (quinone), EC 1.6.99.2
    • Friedlos F., Jarman M., Davies L.C., Boland M.P., Knox R.J. (1992a) Identification of novel reduced pyridinium derivatives as synthetic cofactors for the enzyme DT diaphorase NAD(P)H dehydrogenase (quinone), EC 1.6.99.2. Biochemical Pharmacology, 44, 25.
    • (1992) Biochemical Pharmacology , vol.44 , pp. 25
    • Friedlos, F.1    Jarman, M.2    Davies, L.C.3    Boland, M.P.4    Knox, R.J.5
  • 28
    • 0026490035 scopus 로고
    • Potentiation of CB 1954 cytotoxicity by reduced pyrimidine nucleotides in human tumour cells by stimulation of DT diaphorase activity
    • Friedlos F., Biggs P.J., Abrahamson J.A., Knox R.J. (1992b) Potentiation of CB 1954 cytotoxicity by reduced pyrimidine nucleotides in human tumour cells by stimulation of DT diaphorase activity. Biochemical Pharmacology, 44, 1739.
    • (1992) Biochemical Pharmacology , vol.44 , pp. 1739
    • Friedlos, F.1    Biggs, P.J.2    Abrahamson, J.A.3    Knox, R.J.4
  • 29
    • 0030907756 scopus 로고    scopus 로고
    • Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy
    • Friedlos F., Denny W.A., Palmer B.D., Springer C.J.S. (1997) Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy. Journal of Medicinal Chemistry, 40, 1270.
    • (1997) Journal of Medicinal Chemistry , vol.40 , pp. 1270
    • Friedlos, F.1    Denny, W.A.2    Palmer, B.D.3    Springer, C.J.S.4
  • 30
    • 0031974255 scopus 로고    scopus 로고
    • Gene-directed enzyme prodrug therapy: Quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cell expressing bacterial nitroreductase
    • Friedlos F., Court S., Ford M., Denny W.A., Springer C.J. (1998) Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cell expressing bacterial nitroreductase. Gene Therapy, IB, 105.
    • (1998) Gene Therapy , vol.IB , pp. 105
    • Friedlos, F.1    Court, S.2    Ford, M.3    Denny, W.A.4    Springer, C.J.5
  • 34
    • 0001445293 scopus 로고
    • Quantitative structure - activity relationships studies on anticancer agents
    • Gupta S.P. (1994) Quantitative structure - activity relationships studies on anticancer agents. Chemical Reviews, 94, 1507.
    • (1994) Chemical Reviews , vol.94 , pp. 1507
    • Gupta, S.P.1
  • 35
    • 0026802983 scopus 로고
    • A monoclonal antibody-β-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for the specific treatment of cancer
    • Haisma H.J., Boven E., van Muijen M., de Jong J., van der Vygh W.J.F., Pinedo H.M. (1992) A monoclonal antibody-β-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for the specific treatment of cancer. British Journal of Cancer, 66, 474.
    • (1992) British Journal of Cancer , vol.66 , pp. 474
    • Haisma, H.J.1    Boven, E.2    Van Muijen, M.3    De Jong, J.4    Van Der Vygh, W.J.F.5    Pinedo, H.M.6
  • 36
    • 0028718114 scopus 로고
    • Comparison of two anthracycline-based produgs for activation by a monoclonal antibody-β-glucuronidase conjugate in specific treatment of cancer
    • Haisma H.J., Van Muijen M., Pinedo H.M., Boven E. (1994) Comparison of two anthracycline-based produgs for activation by a monoclonal antibody-β-glucuronidase conjugate in specific treatment of cancer. Cell Biophysics, 24/25, 185.
    • (1994) Cell Biophysics , vol.24-25 , pp. 185
    • Haisma, H.J.1    Van Muijen, M.2    Pinedo, H.M.3    Boven, E.4
  • 38
    • 0029803995 scopus 로고    scopus 로고
    • Antibody-directed enzyme-prodrug therapy (ADEPT)
    • Hay M.P., Denny W.A. (1996) Antibody-directed enzyme-prodrug therapy (ADEPT). Drugs of the Future, 21, 917.
    • (1996) Drugs of the Future , vol.21 , pp. 917
    • Hay, M.P.1    Denny, W.A.2
  • 39
    • 0001358368 scopus 로고    scopus 로고
    • Deprotection of allyl groups with sulfinic acids and palladium catalyst
    • Honda M., Morita H., Nagakura I. (1997) Deprotection of allyl groups with sulfinic acids and palladium catalyst. Journal of Organic Chemistry, 62, 8932.
    • (1997) Journal of Organic Chemistry , vol.62 , pp. 8932
    • Honda, M.1    Morita, H.2    Nagakura, I.3
  • 40
    • 0029637158 scopus 로고
    • VDEPT. An enzyme/prodrug gene therapy approach for the treatment of metastatic colorectal cancer
    • Huber B.E., Richards C.A., Austin E.A. (1995) VDEPT. An enzyme/prodrug gene therapy approach for the treatment of metastatic colorectal cancer. Advanced Drug Delivery Reviews, 17, 279.
    • (1995) Advanced Drug Delivery Reviews , vol.17 , pp. 279
    • Huber, B.E.1    Richards, C.A.2    Austin, E.A.3
  • 41
    • 38249007327 scopus 로고
    • Synthesis of tetrafluorinated analogue of the quinazolin antifolate 2-desamino-2-methyl-N(10)-propargyl-5,8-dideazafolic acid
    • Jarman M., Bisset G.M.F., Thornton J.T. (1993) Synthesis of tetrafluorinated analogue of the quinazolin antifolate 2-desamino-2-methyl-N(10)-propargyl-5,8-dideazafolic acid. Journal of Fluorine Chemistry, 60, 31.
    • (1993) Journal of Fluorine Chemistry , vol.60 , pp. 31
    • Jarman, M.1    Bisset, G.M.F.2    Thornton, J.T.3
  • 42
    • 0000814098 scopus 로고
    • Synthesis of a cephalosporin - doxorubicin antitumor prodrug: A substrate for an antibody-targeted enzyme
    • Jungheim L.N., Shepherd T.A., Kling J.K. (1993) Synthesis of a cephalosporin - doxorubicin antitumor prodrug: a substrate for an antibody-targeted enzyme. Heterocycles, 35, 339.
    • (1993) Heterocycles , vol.35 , pp. 339
    • Jungheim, L.N.1    Shepherd, T.A.2    Kling, J.K.3
  • 43
    • 0345678344 scopus 로고
    • Design of antitumor prodrugs: Substrates for antibody targeted enzymes
    • Jungheim L.N., Shepherd T.T. (1994) Design of antitumor prodrugs: substrates for antibody targeted enzymes. Chemical Reviews, 94, 1553.
    • (1994) Chemical Reviews , vol.94 , pp. 1553
    • Jungheim, L.N.1    Shepherd, T.T.2
  • 44
    • 0011366429 scopus 로고
    • The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)
    • Knox R.J., Boland M.P., Friedlos F., Coles B., Southan C., Roberts J.J. (1988) The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2). Biochemical Pharmacology, 44, 2297.
    • (1988) Biochemical Pharmacology , vol.44 , pp. 2297
    • Knox, R.J.1    Boland, M.P.2    Friedlos, F.3    Coles, B.4    Southan, C.5    Roberts, J.J.6
  • 45
    • 0026075733 scopus 로고
    • Bioactivation of CB 1954: Reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA - DNA interstrand crosslinking species
    • Knox R.J., Friedlos F., Marchbank T., Roberts J.J. (1991) Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA - DNA interstrand crosslinking species. Biochemical Pharmacology, 42, 1691.
    • (1991) Biochemical Pharmacology , vol.42 , pp. 1691
    • Knox, R.J.1    Friedlos, F.2    Marchbank, T.3    Roberts, J.J.4
  • 46
    • 0026677838 scopus 로고
    • The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954). II. A comparison of an Escherichia coli nitroreductase and Walker DT-diaphorase
    • Knox R.J., Friedlos F., Sherwood R.F., Melton R.G., Anlezark G.M. (1992) The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954). II. A comparison of an Escherichia coli nitroreductase and Walker DT-diaphorase. Biochemical Pharmacology, 44, 2297.
    • (1992) Biochemical Pharmacology , vol.44 , pp. 2297
    • Knox, R.J.1    Friedlos, F.2    Sherwood, R.F.3    Melton, R.G.4    Anlezark, G.M.5
  • 47
    • 0029009389 scopus 로고
    • Virtual cofactors for an E. coli nitroreductase enzyme: Relevance to reductively activated prodrugs in antibody-directed enzyme prodrug therapy (ADEPT)
    • Knox R.J., Friedlos F., Jarman M., Davies L.C., Goddard P., Anlezark G.M., Melton R.G., Sherwood R.F. (1995) Virtual cofactors for an E. coli nitroreductase enzyme: relevance to reductively activated prodrugs in antibody-directed enzyme prodrug therapy (ADEPT). Biochemical Pharmacology, 49, 1641.
    • (1995) Biochemical Pharmacology , vol.49 , pp. 1641
    • Knox, R.J.1    Friedlos, F.2    Jarman, M.3    Davies, L.C.4    Goddard, P.5    Anlezark, G.M.6    Melton, R.G.7    Sherwood, R.F.8
  • 48
    • 0000819461 scopus 로고    scopus 로고
    • Synthesis of self-immolative glucuronide spacers based on aminomethylcarbamates. Application to 5-fluorouracil prodrugs for antibody-directed enzyme prodrug therapy
    • Madec-Lougerstay R., Florent J.C., Monneret C. (1999) Synthesis of self-immolative glucuronide spacers based on aminomethylcarbamates. Application to 5-fluorouracil prodrugs for antibody-directed enzyme prodrug therapy. Journal of Chemical Society, Perkin Transactions 1, 1369.
    • (1999) Journal of Chemical Society, Perkin Transactions , vol.1 , pp. 1369
    • Madec-Lougerstay, R.1    Florent, J.C.2    Monneret, C.3
  • 49
    • 0029815716 scopus 로고    scopus 로고
    • Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination
    • Marais R., Spooner R.A., Light Y., Martin J., Springer C.J. (1996) Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination. Cancer Research, 56, 4735.
    • (1996) Cancer Research , vol.56 , pp. 4735
    • Marais, R.1    Spooner, R.A.2    Light, Y.3    Martin, J.4    Springer, C.J.5
  • 51
    • 33845280830 scopus 로고
    • Structural basis of the action of thermolysin and related zinc peptidases
    • Matthews B.W. (1988) Structural basis of the action of thermolysin and related zinc peptidases. Accounts of Chemical Research, 21, 333.
    • (1988) Accounts of Chemical Research , vol.21 , pp. 333
    • Matthews, B.W.1
  • 52
    • 0025194134 scopus 로고
    • The potential of carboxypeptidase G2: Antibody conjugates as anti-tumor agents. 2. In vivo localising and clearance properties in a choriocarcinoma model
    • Melton R.G., Searle F., Sherwood R.F., Bagshawe K.D., Boden J.A. (1990) The potential of carboxypeptidase G2: antibody conjugates as anti-tumor agents. 2. In vivo localising and clearance properties in a choriocarcinoma model. British Journal of Cancer, 61, 420.
    • (1990) British Journal of Cancer , vol.61 , pp. 420
    • Melton, R.G.1    Searle, F.2    Sherwood, R.F.3    Bagshawe, K.D.4    Boden, J.A.5
  • 54
    • 0021689684 scopus 로고
    • The complete nucleotide sequence of the Pseudomonas gene coding for carboxypeptidase G2
    • Minton N.P., Atkinson T., Bruton C.J., Sherwood R.F. (1984) The complete nucleotide sequence of the Pseudomonas gene coding for carboxypeptidase G2. Gene, 31, 31.
    • (1984) Gene , vol.31 , pp. 31
    • Minton, N.P.1    Atkinson, T.2    Bruton, C.J.3    Sherwood, R.F.4
  • 56
    • 0344004064 scopus 로고
    • Adamantanyloxycarbonyl: A novel protecting group for phenols carrying strongly electron-withdrawing substituents
    • Niculescu-Duvaz I., Springer C.J. (1994) Adamantanyloxycarbonyl: a novel protecting group for phenols carrying strongly electron-withdrawing substituents. Journal of Chemical Research, 242.
    • (1994) Journal of Chemical Research , pp. 242
    • Niculescu-Duvaz, I.1    Springer, C.J.2
  • 57
    • 0028972656 scopus 로고
    • Antibody-directed enzyme prodrug therapy (ADEPT): A targeting strategy in chemotherapy
    • Niculescu-Duvaz I., Springer C.J. (1995) Antibody-directed enzyme prodrug therapy (ADEPT): a targeting strategy in chemotherapy. Current Medicinal Chemistry, 2, 687.
    • (1995) Current Medicinal Chemistry , vol.2 , pp. 687
    • Niculescu-Duvaz, I.1    Springer, C.J.2
  • 60
    • 0019178186 scopus 로고
    • Potential anticancer agents. 20. Quantitative structure -activity relationships (QSAR) in the field of nitrogen mustards
    • Niculescu-Duvaz I., Craescu T., Stihi G., Simon G. (1980) Potential anticancer agents. 20. Quantitative structure -activity relationships (QSAR) in the field of nitrogen mustards. Neoplasma, 27, 271.
    • (1980) Neoplasma , vol.27 , pp. 271
    • Niculescu-Duvaz, I.1    Craescu, T.2    Stihi, G.3    Simon, G.4
  • 66
    • 0028246907 scopus 로고
    • Hypoxia selective antitumor agents. 9. Structure - activity relationships for hypoxia-selective cytotoxicity of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide
    • Palmer B.D., Wilson W.R., Atwell G.J., Schultz D., Xu X.D., Denny W.A. (1994) Hypoxia selective antitumor agents. 9. Structure - activity relationships for hypoxia-selective cytotoxicity of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide. Journal of Medicinal Chemistry, 37, 2175.
    • (1994) Journal of Medicinal Chemistry , vol.37 , pp. 2175
    • Palmer, B.D.1    Wilson, W.R.2    Atwell, G.J.3    Schultz, D.4    Xu, X.D.5    Denny, W.A.6
  • 68
    • 0022978891 scopus 로고
    • CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells
    • Roberts J.J., Friedlos F., Knox R.J. (1986) CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells. Biochemistry and Biophysics Research Communications, 140, 1073.
    • (1986) Biochemistry and Biophysics Research Communications , vol.140 , pp. 1073
    • Roberts, J.J.1    Friedlos, F.2    Knox, R.J.3
  • 70
    • 0017808095 scopus 로고
    • Methotrexate analogues. 10. Direct coupling of methotrexate and diethyl-L-glutamate in the presence of peptide bond-forming reagents
    • Rosowski A., Yu C.S. (1978) Methotrexate analogues. 10. Direct coupling of methotrexate and diethyl-L-glutamate in the presence of peptide bond-forming reagents. Journal of Medicinal Chemistry, 21, 170.
    • (1978) Journal of Medicinal Chemistry , vol.21 , pp. 170
    • Rosowski, A.1    Yu, C.S.2
  • 71
    • 0019839154 scopus 로고
    • Methotrexate analogues. 14. Synthesis of new γ-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents
    • Rosowsky A., Forsh R., Uren J., Wick M. (1981) Methotrexate analogues. 14. Synthesis of new γ-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents. Journal of Medicinal Chemistry, 24, 1450.
    • (1981) Journal of Medicinal Chemistry , vol.24 , pp. 1450
    • Rosowsky, A.1    Forsh, R.2    Uren, J.3    Wick, M.4
  • 72
    • 0031569353 scopus 로고    scopus 로고
    • Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy
    • Roswell S., Pauptit R.A., Tucker A.D., Melton R.G., Blow D.M., Brick P. (1997) Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy. Structure, 5.
    • (1997) Structure , vol.5
    • Roswell, S.1    Pauptit, R.A.2    Tucker, A.D.3    Melton, R.G.4    Blow, D.M.5    Brick, P.6
  • 79
    • 0029145803 scopus 로고
    • Antibody-directed enzyme prodrug therapy (ADEPT) with mustard prodrugs
    • Springer C.J., Niculescu-Duvaz I. (1995) Antibody-directed enzyme prodrug therapy (ADEPT) with mustard prodrugs. Anti-Cancer Drug Design, 10, 361-372.
    • (1995) Anti-cancer Drug Design , vol.10 , pp. 361-372
    • Springer, C.J.1    Niculescu-Duvaz, I.2
  • 82
    • 0026335039 scopus 로고
    • Comparison of half-lives and cytotoxicity of N-mesyloxyethyl- and N-chloroethyl-4-amino benzoyl compounds, products of prodrugs in antibody-directed enzyme prodrug therapy (ADEPT)
    • Springer C.J., Antoniw P., Bagshawe K.D., Wilman D.E.V. (1991) Comparison of half-lives and cytotoxicity of N-mesyloxyethyl- and N-chloroethyl-4-amino benzoyl compounds, products of prodrugs in antibody-directed enzyme prodrug therapy (ADEPT). Anti-Cancer Drug Design, 6, 467.
    • (1991) Anti-cancer Drug Design , vol.6 , pp. 467
    • Springer, C.J.1    Antoniw, P.2    Bagshawe, K.D.3    Wilman, D.E.V.4
  • 84
    • 0027538972 scopus 로고
    • Identification of prodrug, active drug and metabonates in an ADEPT clinical study
    • Springer C.J., Poon G. K., Sharma S.K., Bagshawe K.D. (1993) Identification of prodrug, active drug and metabonates in an ADEPT clinical study. Cell Biophysics, 22, 1.
    • (1993) Cell Biophysics , vol.22 , pp. 1
    • Springer, C.J.1    Poon, G.K.2    Sharma, S.K.3    Bagshawe, K.D.4
  • 85
    • 0028122014 scopus 로고
    • Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluoro benzoic acids for antibody-directed enzyme prodrug therapy
    • Springer C.J., Niculescu-Duvaz I., Pedley R.B. (1994) Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluoro benzoic acids for antibody-directed enzyme prodrug therapy. Journal of Medicinal Chemistry, 37, 2361.
    • (1994) Journal of Medicinal Chemistry , vol.37 , pp. 2361
    • Springer, C.J.1    Niculescu-Duvaz, I.2    Pedley, R.B.3
  • 90
    • 0023932510 scopus 로고
    • Development of alkylating agent resistant human tumor cell lines
    • Teicher B.A., Frei E. III (1988) Development of alkylating agent resistant human tumor cell lines. Cancer Chemotherapy and Pharmacology, 21, 292.
    • (1988) Cancer Chemotherapy and Pharmacology , vol.21 , pp. 292
    • Teicher, B.A.1    Frei E. III2
  • 91
    • 0028939031 scopus 로고
    • Cephalosporin derivatives of doxorubicin as prodrugs for activation by monoclonal antibody-β-lactamase conjugates
    • Vrudhula N.H., Svensson H. P., Senter P.D. (1995) Cephalosporin derivatives of doxorubicin as prodrugs for activation by monoclonal antibody-β-lactamase conjugates. Journal of Medicinal Chemistry, 38, 1380.
    • (1995) Journal of Medicinal Chemistry , vol.38 , pp. 1380
    • Vrudhula, N.H.1    Svensson, H.P.2    Senter, P.D.3
  • 92
    • 0000231181 scopus 로고
    • 1,4 and 1,6 eliminations from hydroxy- and amino-substituted benzyl systems: Chemical and biochemical applications
    • Wakselman M. (1983) 1,4 and 1,6 eliminations from hydroxy- and amino-substituted benzyl systems: chemical and biochemical applications. Nouveau Journal de Chimie, 7, 439.
    • (1983) Nouveau Journal de Chimie , vol.7 , pp. 439
    • Wakselman, M.1
  • 93
    • 0343867881 scopus 로고
    • NMR and the determination of nitrogen mustards stability
    • Wilman D.E.V., Boritzki T.J., Denny W.A. (1994) NMR and the determination of nitrogen mustards stability. British Journal of Cancer, 69 (Suppl. xxi), 56.
    • (1994) British Journal of Cancer , vol.69 , Issue.SUPPL. XXI , pp. 56
    • Wilman, D.E.V.1    Boritzki, T.J.2    Denny, W.A.3


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