Gene-directed enzyme prodrug therapy: Quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase

Gene Therapy

Volumn 5, Issue 1, 1998, Pages 105-112

  Friedlos, F ^a   Court, S ^b   Ford, M ^b   Denny, W A ^c   Springer, C ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Bystander effect; CB1954; Gene therapy; Nitroreductase

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; BACTERIAL ENZYME; DNA; NITROREDUCTASE; PRODRUG; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL STRAIN V 79; COLON CARCINOMA; CONTROLLED STUDY; DNA CROSS LINKING; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME KINETICS; ESCHERICHIA COLI; GENE THERAPY; GENE TRANSFER; HUMAN; HUMAN CELL; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; SUICIDE GENE;

ANIMALIA; BACTERIA (MICROORGANISMS); CRICETINAE; CRICETULUS GRISEUS; ESCHERICHIA; ESCHERICHIA COLI B; ILEX COOKII;

EID: 0031974255     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300569     Document Type: Article

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