Oxic and anoxic enhancement of radiation-mediated toxicity by horseradish peroxidase/indole-3-acetic acid gene therapy

International Journal of Radiation Biology

Volumn 78, Issue 3, 2002, Pages 173-181

  Greco, O ^a   Tozer, G M ^a   Dachs, G U ^a  

^a Gray Cancer Institute   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; HORSERADISH PEROXIDASE; INDOLEACETIC ACID; PRODRUG;

ANOXIA; ARTICLE; BLADDER CARCINOMA; CANCER RADIOTHERAPY; CELL HYPOXIA; CLONOGENIC ASSAY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IONIZING RADIATION; NASOPHARYNX CARCINOMA; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; RADIOSENSITIVITY; SOLID TUMOR;

CELL HYPOXIA; CELL SURVIVAL; GENE THERAPY; HORSERADISH PEROXIDASE; HUMANS; INDOLEACETIC ACIDS; NEOPLASMS; OXYGEN; RADIOTHERAPY, ADJUVANT; TRANSFECTION; TUMOR CELLS, CULTURED;

ARMORACIA RUSTICANA;

EID: 0036191855     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553000110097983     Document Type: Article

References (53)

1. Modulation of c-myc activity and apoptosis in vivo
2. Nonprotein thiols and the radiation response of A549 human lung carcinoma cells
3. The role of thiols in cellular response to radiation and drugs
4. The effect of L-buthionine sulfoximine on the aerobic radiation response of A549 human lung carcinoma cells
5. Adenoviral transduction of a cytosine deaminase/thymidine kinase fusion gene into prostate carcinoma cells enhances prodrug and radiation sensitivity
6. Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome
7. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
8. Approaches to enhance cancer radiotherapy employing gene transfer methods
9. Radiosensitization of hypoxic tumor cells by depletion of intracellular glutathione
10. Free-radical intermediates and stable products in the oxidation of indole-3-acetic acid
11. Development and progress on a phase II study evaluating HSVtk + valacyclovir gene therapy in combination with radiotherapy for prostate cancer
12. Glutathione depletion, radiosensitization, and misodinazole potentiation in hypoxic Chinese hamster ovary cells by buthionine sulfoximine
13. Transport into and out the Golgi complex studied by transfecting cells with cDNAs encoding horseradish peroxidase
14. Gene delivery to hypoxic cells in vitro
15. Targeting gene expression to hypoxic tumor cells
16. Survival curves of glutathione synthetase deficient human fibroblasts: Correlation between radiosensitivity in hypoxia and glutathione synthetase activity
17. Towards targeted 'oxidation therapy' of cancer: Peroxidase-catalyzed cytotoxicity of indole-3-acetic acids
18. Peroxidase-catalyzed effects of indole-3-acetic acid and analogues on lipid membranes, DNA, and mammalian cells in vitro
19. Oxidative activation of indole-3-acetic acids to cytotoxic species - A potential new role for plant auxins in cancer therapy
20. 5-Fluoroindole-3-acetic acid: A prodrug activated by a peroxidase with potential use in targeted cancer therapy
21. Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for local recurrence of prostate cancer after definitive radiation-therapy
22. Oxygenation predicts radiation response and survival in patients with cervix cancer
23. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
24. Gene-directed enzyme/prodrug therapy of cancer: Historical appraisal and future prospectives
25. Development of a novel enzyme/prodrug combination for gene therapy of cancer: Horseradish peroxidase/indole-3-acetic acid
26. Can gene therapy overcome the problem of hypoxia in radiotherapy?
27. Horseradish peroxidase-mediated gene therapy: Choice of prodrugs in oxic and anoxic tumour conditions
28. Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts
29. Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector
30. Hypoxic cervical cancers with low apoptotic index are highly aggressive
31. Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene
32. Selective enhancement by an antiviral agent if the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene
33. Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents
34. 2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix
35. The potential therapeutic gain of radiation-associated gene therapy with the suicide gene cytosine deaminase
36. Radiosensitivity of mammalian cell lines engineered to overexpress cytosolic glutathione peroxidase
37. Hypoglycemic action of indole-3-acetic acid by mouth in patients with diabetes mellitus
38. Cellular glutathione depletion by diethyl maleate or buthionine sulfoximine: No effect of glutathione depletion on the oxygen enhancement ratio
39. Hypoxia in human soft tissue sarcomas is associated with poor survival
40. Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo
41. Effect of indole acetic acid on oxygen metabolism in cultured rat neutrophil
42. Peroxidase activity may play a role in the cytotoxic effect of indole acetic acid
43. The role of the bystander effect in suicide gene therapy
44. Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy
45. The 'X model': A modified version of the competition theory
46. Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models
47. Radiosensitization of mouse skin by oxygen and depletion of glutathione
48. Combined radiotherapy and chemotherapy: Clinical application and evaluation
49. Tumor hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
50. Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant herpes simplex virus-thymidine kinase in combination with aciclovir
51. Depletion of intracellular GSH and NPSH by buthionine sulfoximine and diethyl maleate: Factors that influence enhancement of aerobic radiation response
52. Cells at intermediate oxygen levels can be more important than the 'hypoxic fraction' in determining tumor response to fractionated radiotherapy