Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer

Journal of Urology

Volumn 163, Issue 6, 2000, Pages 1747-1750

  Shalev, Moshe ^a   Kadmon, Dov ^a   Teh, Bin S ^a   Butler, Edward B ^a   Aguilar Cordova, Estuardo ^a   Thompson, Timothy C ^a   Herman, James R ^a   Adler, Howard L ^a   Scardino, Peter T ^a   Miles, Brian J ^a  

^a TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

Adenoviridae; Ganciclovir; Gene therapy; Prostate; Prostatic neoplasms

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE; VALACICLOVIR;

ADENOVIRUS; ARTICLE; CLINICAL PROTOCOL; FEVER; GENE THERAPY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; SUICIDE GENE; THROMBOCYTOPENIA; TREATMENT OUTCOME;

EID: 0034041950     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)67534-9     Document Type: Article

References (23)

1. Bacchietti, S. and Graham, F.: Inhibition of cell proliferation by an adenovirus vector expressing the human wild type p53 protein. Int J Oncol, 3: 781, 1993
2. Wills, K. N., Maneval, D. C., Menzel, P. et al: Development and characterization of recombinant adenovirus encoding human p53 for gene therapy of cancer. Hum Gene Ther, 5: 1079, 1994
3. Zhang, W-W., Fang, X., Mazur, W. et al: High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther, 1: 5, 1994
4. Ko, S-C., Gotoh, A., Thalmann, G. N. et al: Molecular therapy with recombinant p53 adenovirus in an androgen-independent, metastatic human prostate cancer model. Hum Gene Ther, 7: 1683, 1996
5. Vieweg, J., Rosenthal, F. M., Bannerji, R. et al: Immunotherapy of prostate cancer in the Dunning rat model: use of cytokine gene modified tumor vaccines. Cancer Res, 54: 1760, 1994
6. Moolten, F. L.: Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res, 46: 5276, 1986
7. Moolten, F. L. and Wells, J. M.: Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J Natl Cancer Inst, 82: 297, 1990
8. Borrelli, E., Heyman, R., Hsi, M. et al: Targeting of an inducible toxic phenotype in animal cells. Proc Natl Acad Sci USA, 85: 7572, 1988
9. Culver, K. W., Ram, Z., Wallbridge, S. et al: In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science, 256: 1550, 1992
10. Caruso, M., Panis, Y., Gagandeep, S. et al: Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc Natl Acad Sci USA, 90: 7024, 1993
11. Freeman, S. M., Abboud, C. N., Whartenby, K. A. et al: The "by-stander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res., 53: 5274, 1993
12. Chen, S.-H., Shine, H. D., Goodman, J. C. et al: Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Nat Acad Sci USA, 91: 3054, 1994
13. O'Malley, B. W., Jr., Chen, S.H., Schwartz, M. R. et al: Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model. Cancer Res, 55: 1080, 1995
14. Mulligan, R. C.: The basic science of gene therapy. Science, 260: 926, 1993
15. Eastham, J. A., Chen, S.-H., Sehgal, I. et al: Prostate cancer gene therapy: herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models. Hum Gene Ther, 7: 515, 1996
16. Hall, S. J., Mutchnik, S. E., Chen, S.-H. et al: Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer. Int J Cancer, 70: 183,1997
17. Singhal, S. and Kaiser, L. R.: Cancer chemotherapy using suicide genes. Surg Oncol Clin North Am, 7: 505, 1998
18. Simons, W. J. and Marshall, F. F.: The future of gene therapy in the treatment of urologic malignancies. Urol Clin North Am, 25: 23, 1998
19. Herman, J. R., Adler, H. L., Aguilar-Cordova, E. et al: In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial. Hum Gene Ther, 10: 1239, 1999
20. Kattan, M. W., Eastham, J. A., Stapleton, A. M. et al: A preoperative nomogram for disease recurrence following radical prostatectomy for prostate cancer. J Natl Cancer Inst, 90: 766, 1998
21. Mufson, M. A. and Belshe, R. B.: A review of adenoviruses in the etiology of acute hemorrhagic cystitis. J Urol, 115: 191, 1976
22. Rodríguez, L. V. and Terris, M. K.: Risks and complications of transrectal ultrasound guided prostate needle biopsy: a prospective study and review of the literature. J Urol, 160: 2115, 1998
23. Physicians' Desk Reference 1998, 52nd ed. New York: Medical Economics Co., p. 2452, 1997