-
1
-
-
0342697534
-
The development of anticancer drugs
-
Jarman, M. The development of anticancer drugs. Chem. Br. 1989, 25, 51-54.
-
(1989)
Chem. Br.
, vol.25
, pp. 51-54
-
-
Jarman, M.1
-
2
-
-
0029183844
-
Advances in cancer gene theraphy
-
Zhang, W. W.; Fujiwara, T.; Grimm, E. A.; Roth, J. A. Advances in cancer gene theraphy. Adv. Pharmacol. (San Diego) 1995, 6, 289-341.
-
(1995)
Adv. Pharmacol. (San Diego)
, vol.6
, pp. 289-341
-
-
Zhang, W.W.1
Fujiwara, T.2
Grimm, E.A.3
Roth, J.A.4
-
3
-
-
0029609610
-
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954
-
Bridgewater, G.; Springer, C. J.; Knox, R.; Minton, N.; Michael, P.; Collins, M. Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954. Eur. J. Cancer 1995, 31A, 2362-2370.
-
(1995)
Eur. J. Cancer
, vol.31 A
, pp. 2362-2370
-
-
Bridgewater, G.1
Springer, C.J.2
Knox, R.3
Minton, N.4
Michael, P.5
Collins, M.6
-
4
-
-
0025858452
-
Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: An innovative approach for cancer therapy
-
Huber, B. A.; Richards, C. A.; Krenitsky, T. A. Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: An innovative approach for cancer therapy. Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 8039-8043.
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 8039-8043
-
-
Huber, B.A.1
Richards, C.A.2
Krenitsky, T.A.3
-
5
-
-
0031983448
-
Gene-directed enzyme prodrug therapy
-
Niculescu-Duvaz, I.; Spooner, R. A.; Marais, R.; Springer, C. J. S. Gene-directed enzyme prodrug therapy. Bioconjugate Chem. 1998, 9, 4-22.
-
(1998)
Bioconjugate Chem.
, vol.9
, pp. 4-22
-
-
Niculescu-Duvaz, I.1
Spooner, R.A.2
Marais, R.3
Springer, C.J.S.4
-
6
-
-
0019453510
-
A novel connector linkage applicable in prodrug design
-
Carl, P. L.; Chakravarty, P. K.; Katzenellenbogen, J. A. A novel connector linkage applicable in prodrug design. J. Med. Chem. 1981, 24, 479-480.
-
(1981)
J. Med. Chem.
, vol.24
, pp. 479-480
-
-
Carl, P.L.1
Chakravarty, P.K.2
Katzenellenbogen, J.A.3
-
7
-
-
0000231181
-
1,4 and 1,6 eliminations from hydroxy- and amino-substituted benzyl systems: Chemical and biochemical applications
-
Wakselman, M. 1,4 and 1,6 eliminations from hydroxy- and amino-substituted benzyl systems: chemical and biochemical applications. N. J. Chim. 1983, 7, 439-447.
-
(1983)
N. J. Chim.
, vol.7
, pp. 439-447
-
-
Wakselman, M.1
-
8
-
-
0030950486
-
Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (ADEPT): A phenol nitrogen mustard carbamate
-
Schmidt, F.; Florent, J.-C.; Monneret, C.; Straub, R.; Czech, J.; Gerken, M.; Bosslet, K. Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (ADEPT): a phenol nitrogen mustard carbamate. Bioorg. Med. Chem. Lett. 1997, 7, 1071-1076.
-
(1997)
Bioorg. Med. Chem. Lett.
, vol.7
, pp. 1071-1076
-
-
Schmidt, F.1
Florent, J.-C.2
Monneret, C.3
Straub, R.4
Czech, J.5
Gerken, M.6
Bosslet, K.7
-
9
-
-
0030907756
-
Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy
-
Friedlos, F.; Denny, W. A.; Palmer, B. D.; Springer, C. J. S. Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy. J. Med. Chem. 1997, 40, 1270-1275.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 1270-1275
-
-
Friedlos, F.1
Denny, W.A.2
Palmer, B.D.3
Springer, C.J.S.4
-
10
-
-
0021871027
-
Purification and properties of carboxypeptidase G2 Pseudonomas sp strain RS-16
-
Sherwood, R. F.; Melton, R. G.; Alwan, S. M.; Hughes, P. Purification and properties of carboxypeptidase G2 Pseudonomas sp strain RS-16. Eur. J. Biochem. 1985, 24, 447-453.
-
(1985)
Eur. J. Biochem.
, vol.24
, pp. 447-453
-
-
Sherwood, R.F.1
Melton, R.G.2
Alwan, S.M.3
Hughes, P.4
-
11
-
-
0025189891
-
Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2
-
Springer, C. J.; Antoniw, P.; Bagshawe, K. D.; Searle, F.; Bisset, G. M. F.; Jarman, M. Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2. J. Med. Chem. 1990, 33, 677-681.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 677-681
-
-
Springer, C.J.1
Antoniw, P.2
Bagshawe, K.D.3
Searle, F.4
Bisset, G.M.F.5
Jarman, M.6
-
12
-
-
0028122014
-
Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluoro benzoic acids for antibody-directed enzyme prodrug therapy
-
Springer, C. J.; Niculescu-Duvaz, I.; Pedley, R. B. Novel prodrugs of alkylating agents derived from 2-fluoro- and 3-fluoro benzoic acids for antibody-directed enzyme prodrug therapy. J. Med. Chem. 1994, 37, 2361-2370.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 2361-2370
-
-
Springer, C.J.1
Niculescu-Duvaz, I.2
Pedley, R.B.3
-
13
-
-
0029621825
-
Optimization of alkylating prodrugs derived from phenol and aniline mustards: A new clinical candidate prodrug (ZD2767) for ADEPT
-
Springer, C. J.; Dowell, R. L.; Burke, P. J.; Hadley, E.; Davies, D. H.; Blakey, D. C.; Melton, R. G.; Niculescu-Duvaz, I. Optimization of alkylating prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for ADEPT. J. Med. Chem. 1995, 38, 5051-5065.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 5051-5065
-
-
Springer, C.J.1
Dowell, R.L.2
Burke, P.J.3
Hadley, E.4
Davies, D.H.5
Blakey, D.C.6
Melton, R.G.7
Niculescu-Duvaz, I.8
-
14
-
-
13344276593
-
New mustards prodrugs for antibody-directed enzyme prodrug therapy: Alternative for the amide link
-
Dowell, R.; Springer, C. J.; Davies, D. H.; Hadley, E. M.; Burke, P. J.; Boyle, F. T.; Melton, R. G.; Connors, T. A.; Blakey, D. C.; Mauger, A. B. New mustards prodrugs for antibody-directed enzyme prodrug therapy: alternative for the amide link. J. Med. Chem. 1996, 39, 1100-1105.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1100-1105
-
-
Dowell, R.1
Springer, C.J.2
Davies, D.H.3
Hadley, E.M.4
Burke, P.J.5
Boyle, F.T.6
Melton, R.G.7
Connors, T.A.8
Blakey, D.C.9
Mauger, A.B.10
-
15
-
-
0031437780
-
A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy
-
Marais, R.; Spooner, R. A.; Stribbling, S. M.; Light, Y.; Martin, J.; Springer, C. J. S. A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy. Nature Biotechnol. 1997, 15, 1373-1377.
-
(1997)
Nature Biotechnol.
, vol.15
, pp. 1373-1377
-
-
Marais, R.1
Spooner, R.A.2
Stribbling, S.M.3
Light, Y.4
Martin, J.5
Springer, C.J.S.6
-
17
-
-
29644432244
-
Protection of hydroxyl groups as tert-butyltrimethylsilyl derivatives
-
Corey, E. J.; Venkateswarlu, A. Protection of hydroxyl groups as tert-butyltrimethylsilyl derivatives. J. Am. Chem. Soc. 1972, 94, 6190-6191.
-
(1972)
J. Am. Chem. Soc.
, vol.94
, pp. 6190-6191
-
-
Corey, E.J.1
Venkateswarlu, A.2
-
18
-
-
0001642223
-
The preparation and the utility of tert-butyldiphenylsilyl ethers
-
Hanessian, S.; Lavallee, P. The preparation and the utility of tert-butyldiphenylsilyl ethers. Can. J. Chem. 1975, 53, 2975-2977.
-
(1975)
Can. J. Chem.
, vol.53
, pp. 2975-2977
-
-
Hanessian, S.1
Lavallee, P.2
-
19
-
-
0000640459
-
Synthetic applications of 2-chloro-1,3-dithiane. 2. Reaction with carbon nucleophiles
-
Kruse, C. G.; Wijsman, A.; van der Gen, A. Synthetic applications of 2-chloro-1,3-dithiane. 2. Reaction with carbon nucleophiles. J. Org. Chem. 1979, 44, 1847-1851.
-
(1979)
J. Org. Chem.
, vol.44
, pp. 1847-1851
-
-
Kruse, C.G.1
Wijsman, A.2
Van Der Gen, A.3
-
20
-
-
0025897111
-
Cephalosporin nitrogen mustard carbamate prodrugs for "ADEPT"
-
Alexander, R. P.; Beeley, N. R. A.; O'Driscoll, M.; O'Neil, F. P.; Millican, T. A.; Pratt, A. J.; Willenbrock, F. W. Cephalosporin nitrogen mustard carbamate prodrugs for "ADEPT". Tetrahedron Lett. 1991, 32, 3269-3272.
-
(1991)
Tetrahedron Lett.
, vol.32
, pp. 3269-3272
-
-
Alexander, R.P.1
Beeley, N.R.A.2
O'Driscoll, M.3
O'Neil, F.P.4
Millican, T.A.5
Pratt, A.J.6
Willenbrock, F.W.7
-
21
-
-
0030805612
-
Efficient mitomycin C coupling with stable p-nitro-benzyl carbonates using N-hydroxybenzotriazole as a catalytic additive
-
Dubowchik, G. M.; Dalton King, H.; Pham-Kaplita, K. Efficient mitomycin C coupling with stable p-nitro-benzyl carbonates using N-hydroxybenzotriazole as a catalytic additive. Tetrahedron Lett. 1997, 38, 5261-5264.
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 5261-5264
-
-
Dubowchik, G.M.1
Dalton King, H.2
Pham-Kaplita, K.3
-
22
-
-
20644470650
-
-
Penem derivatives. EP 0 236 880 A2, 1987
-
Perrone, E.; Alpegiani, M.; Bedeschi, A.; Zarini, F.; Della Bruna, C.; Franceschi, G. Penem derivatives. EP 0 236 880 A2, 1987.
-
-
-
Perrone, E.1
Alpegiani, M.2
Bedeschi, A.3
Zarini, F.4
Della Bruna, C.5
Franceschi, G.6
-
24
-
-
0001064674
-
A regioselective and stereospecific route to enol carbonates and carbamates: Closer look at a "naked anion"
-
Olofson, R. A.; Cuomo, J. A regioselective and stereospecific route to enol carbonates and carbamates: closer look at a "naked anion". Tetrahedron Lett. 1980, 21, 819-822.
-
(1980)
Tetrahedron Lett.
, vol.21
, pp. 819-822
-
-
Olofson, R.A.1
Cuomo, J.2
-
25
-
-
0016976705
-
4,6-Diphenylthieno[3,4-d][1,3]dioxol-2-one 5,5-dioxide, a novel activating agent for peptide synthesis
-
Hollitzer, O.; Seewald, A.; Steglich, W. 4,6-Diphenylthieno[3,4-d][1,3]dioxol-2-one 5,5-dioxide, a novel activating agent for peptide synthesis. Angew. Chem., Int. Ed. Engl. 1976, 5, 444-445.
-
(1976)
Angew. Chem., Int. Ed. Engl.
, vol.5
, pp. 444-445
-
-
Hollitzer, O.1
Seewald, A.2
Steglich, W.3
-
26
-
-
0043219593
-
Eine einfache Synthese von Harnstoffe, Urethanen und Isocyanaten
-
Schmidt, H.; Hollitzer, O.; Seewald, A.; Steglich, W. Eine einfache Synthese von Harnstoffe, Urethanen und Isocyanaten. Chem. Ber. 1979, 112, 727-733.
-
(1979)
Chem. Ber.
, vol.112
, pp. 727-733
-
-
Schmidt, H.1
Hollitzer, O.2
Seewald, A.3
Steglich, W.4
-
27
-
-
0025021102
-
Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines
-
Palmer, B. D.; Wilson, W. R.; Pullen, S. M.; Denny, W. A. Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines. J. Med. Chem. 1990, 33, 112-121.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 112-121
-
-
Palmer, B.D.1
Wilson, W.R.2
Pullen, S.M.3
Denny, W.A.4
-
28
-
-
0021054335
-
Molecular cloning of the Pseudomonas carboxypeptidase G2 gene and its expression in Escherichia coli and Pseudomonas putida
-
Minton, N. P.; Atkinson, T.; Sherwood, R. F. Molecular cloning of the Pseudomonas carboxypeptidase G2 gene and its expression in Escherichia coli and Pseudomonas putida. J. Bacteriol. 1983, 156, 1222-1227.
-
(1983)
J. Bacteriol.
, vol.156
, pp. 1222-1227
-
-
Minton, N.P.1
Atkinson, T.2
Sherwood, R.F.3
-
29
-
-
0029815716
-
Gene-directed enzyme prodrug therapy with a mustard prodrug/ carboxypeptidase G2 combination
-
Marais, R.; Spooner, R. A.; Light, Y.; Martin, J.; Springer, C. J. Gene-directed enzyme prodrug therapy with a mustard prodrug/ carboxypeptidase G2 combination. Cancer Res. 1996, 56, 4735-4742.
-
(1996)
Cancer Res.
, vol.56
, pp. 4735-4742
-
-
Marais, R.1
Spooner, R.A.2
Light, Y.3
Martin, J.4
Springer, C.J.5
|