Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells

Gene Therapy

Volumn 5, Issue 3, 1998, Pages 419-426

  Balzarini, J ^a   Degreve, B ^a   Andrei, G ^a   Neyts, J ^a   Sandvold, M ^a   Myhren, F ^a   De Clercq, E ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Ganciclovir elaidic ester; Gene therapy; HSV 1 thymidine kinase

Indexed keywords

ELAIDIC ACID; ESTER; GANCICLOVIR; PRODRUG; THYMIDINE KINASE;

ARTICLE; BIOSYNTHESIS; BREAST CARCINOMA; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSTASIS; GENE THERAPY; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; LIPOPHILICITY; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL CULTURE; VIRUS REPLICATION;

DNA VIRUSES; HERPES; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2;

EID: 0031907361     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300586     Document Type: Article

References (25)