Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities

Biochemistry

Volumn 39, Issue 14, 2000, Pages 4105-4111

  Hinds, Trenton A ^a   Compadre, Cesar ^b   Hurlburt, Barry K ^a   Drake, Richard R ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; GLUTAMINE; PYRIMIDINE; THYMIDINE KINASE;

ARTICLE; CELL KILLING; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENETIC CONSERVATION; HERPES SIMPLEX VIRUS 1; HYDROGEN BOND; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; TARGET CELL; VIRUS MUTATION;

GANCICLOVIR; HERPESVIRUS 1, HUMAN; MUTATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THYMIDINE KINASE;

HERPES; HERPESVIRIDAE; HUMAN HERPESVIRUS 1; MAMMALIA;

EID: 0034636067     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992453q     Document Type: Article

References (35)

1. Whitley, R. J. (1985) in The Herpesviruses (Roizman, B., and Lopez, C., Eds.) Vol. 4, pp 339-369, Plenum Press, New York.
2. Machida, H. (1986) Antimicrob. Agents Chemother. 29, 524-526.
3. Freeman, S. M., Whartenby, K. A., Freeman, J. L., Abboud, C. N., and Marrogi, A. J. (1996). Sem. Oncol. 23, 31-45.
4. Tiberghien, P. (1994) J. Leukocyte Biol. 56, 203-209.
5. Elion, G. B., Furman, P. A., Fyfe, J. A., deMiranda, P., Beaucham, P. L., and Schaefer, H. J. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 5716-5720.
6. Kit, S., Leung, W. C., Trkula, D., and Jorgensen, G. (1974) Int. J. Cancer 13, 203-218.
7. Chen, M. S., and Prusoff, W. H. (1978) J. Biol. Chem. 253, 1325-1327.
8. Chen, M. S., Walker, J., and Prusoff, W. H. (1979) J. Biol. Chem. 254, 10747-10753.
9. Mao, F., Rechtin, T. M., Jones, R., Cantu, A., Anderson, S., Radominska, A., Moyer, M. P., and Drake, R. R. (1995) J. Biol. Chem. 270, 13660-13664.
10. Rechtin, T. M., Black, M. E., and Drake, R. R. (1996) Anal. Biochem. 237, 135-140.
11. Maga, G., Focher, F., Wright, G. E., Capobianco, M., Garbesi, A., Bendiscioli, A., and Spadari, S. (1994) Biochem. J. 302, 279-282.
12. Rechtin, T., Black, M., Mao, F., Lewis, M., and Drake, R. (1995) J. Biol. Chem. 270, 7055-7060.
13. Brown, D. G., Visse, R. Sandhu, G., Davies, A., Rizkallah, P. J., Melitz, C., Summers, W. C., and Sanderson, M. R. (1995) Nat. Struct. Biol. 2, 876-881.
14. Wild, K., Bohner, T., Folkers, G., and Schulz, G. (1997) Protein Sci. 6, 2097-2100.
15. Champness, J. N., Bennettt, M. S., Wien, F., Visse, R., Summers, W. C., Herdewijn. P., de Dlercq, E., Ostrowski, T., Jarveet, R. L., and Sanderson, M. R. (1998) Proteins: Struct., Funct., Genet. 82, 350-361.
16. Bennettt, M. S., Wien, F., Champness, J. N., Batuwangala, T., Rutherford, T., Summers, W. C., Sun, H., Wright, G., and Sanderson, M. R. (1999) FEBS Lett. 443, 121-125.
17. Kussmann-Gerber, S., Kuonen, O., Folkers, G., Pilger, B. D., and Scapozza, L. (1998) Eur. J. Biochem. 255, 472-481.
18. Vieira, J., and Messing, J. (1987) Methods Enzymol. 153, 3-11.
19. Sayers, J. R., Krekel, C., and Eckstein, F. (1992) BioTechniques 13, 592-596.
20. Studier, F. W., Rosenberg, A. H., Dunn, J. J., and Dubendorff, J. W. (1990) Methods Enzymol. 185, 60-89.
21. Drake, R. R., McMasters, R., Krisa, S., Hume, S. D., Rechtin, T. M., Saylors, R. L., Chiang, Y., Govindarajan, R., and Munshi, N. C. (1997) Antiviral Res. 35, 177-185.
22. Pastuszak, I., Drake, R. R., and Elbein, A. D. (1996) J. Biol. Chem. 271, 20776-20782.
23. Radominska, A., and Drake, R. R. (1993) Methods Enzymol. 230, 330-339.
24. McMasters, R., Jones, K. E., Saylors, R. L., Hendrix, E. M., Moyer, M. P., and Drake, R. R. (1998) Hum. Gene Ther. 9, 2253-2261.
25. Alley, M. C., Scudiero, D. A., Monks, A., Hursey, M. L., Czerwinski, M. J., Fine, D. L., Abbott, B. J., Mayo, J. G., Shoemaker, R. H., and Boyd, M. R. (1988) Cancer Res. 48, 589-601.
26. Drake, R. R., Wilbert, T. N., Hinds, T. A., and Gilbert, K. (1999) J. Biol. Chem. 274, 37186-37192.
27. Dube, D. K., Parker, J. D., French, D. C., Cahill, D. S., Dube, S., Horwitz, M. S. Z., Munir, K. M., and Loeb, L. A. (1991) Biochemistry 30, 11760-11767.
28. Black, M. E., and Loeb, L. A. (1993) Biochemistry 32, 11618-11626.
29. Black, M. E., Newcomb, T. G., Wilson, H. P., and Loeb, L. A. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 3525-3529.
30. Chen, C.-Y., Chang, Y.-N., Ryan, P., Linscott, M., McGarrity, G. J., and Chiang, Y. L. (1995) Hum. Gene Ther. 6, 1467-1476.
31. Ishii-Morita, H., Agbaria, R., Mullen, C. A., Hirano, H., Koeplin, D. A., Ram, Z., Oldfiield, E. H., Johns, D. G., and Blaese, R. M. (1997) Gene Ther. 4, 244-251.
32. Kim, Y.-G, Bi, W., Feliciana, E. S., Drake. R. R., and Stambrook, P. J. (2000) Cancer Gene Ther. (in press).
33. Boucher, P. D., Ruch, R. J., and Shewach, D. S. (1998) Hum. Gene Ther. 9, 801-814.
34. Munshi, N. C., Govindarajan, R., Drake, R., Ding, L. M., Iyer, R., Saylors, R., Kornbluth, J., Marcus, S., Chiang, Y., Ennist, D., Kwak, L., Reynolds, C., Tricot, G., and Barlogie, B. (1997) Blood 89, 1334-1340.
35. Bonini, C., Ferrari, G., Verzeletti, S., Servida, P., Zappone, E., Ruggieri, L., Ponzoni, M., Rossini, S., Mavilio, F., Traversari, C., and Bordignon, C. (1997) Science 276, 1719-1724.