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Volumn 34, Issue 3, 2003, Pages 155-165

The spindle checkpoint: From normal cell division to tumorigenesis

Author keywords

Aneuploidy; Cancer; Checkpoint; Mitosis

Indexed keywords

ANEUPLOIDY; CARCINOGENESIS; CELL DIVISION; CENTROMERE; CHROMOSOME SEGREGATION; GENE MUTATION; HUMAN; METAPHASE; MICROTUBULE; MITOSIS; NEOPLASM; REGULATORY MECHANISM; REVIEW; SPINDLE CELL; TUMOR CELL; TUMOR CELL LINE;

EID: 0037824791     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0188-4409(03)00024-9     Document Type: Review
Times cited : (16)

References (116)
  • 1
    • 0024425887 scopus 로고
    • Checkpoint controls that ensure the order of cell cycle events
    • Hartwell L.H., Weinert T.A. Checkpoint controls that ensure the order of cell cycle events. Science. 246:1989;629-634.
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 2
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers J.H.J. Genome maintenance mechanisms for preventing cancer. Nature. 411:2001;366-374.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.J.1
  • 3
    • 0035916365 scopus 로고    scopus 로고
    • Replication checkpoint: Preventing mitotic catastrophe
    • Canman C.E. Replication checkpoint: preventing mitotic catastrophe. Curr Biol. 11:2001;R121-R124.
    • (2001) Curr Biol , vol.11
    • Canman, C.E.1
  • 6
    • 0035188129 scopus 로고    scopus 로고
    • Managing the centrosome numbers game: From chaos to stability in cancer cell division
    • Brinkley B.R. Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol. 11:2001;18-21.
    • (2001) Trends Cell Biol , vol.11 , pp. 18-21
    • Brinkley, B.R.1
  • 7
    • 0027942033 scopus 로고
    • Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle
    • Rieder C.L., Schultz A., Cole R., Sluder G. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J Cell Biol. 127:1994;1301-1310.
    • (1994) J Cell Biol , vol.127 , pp. 1301-1310
    • Rieder, C.L.1    Schultz, A.2    Cole, R.3    Sluder, G.4
  • 8
    • 0029912971 scopus 로고    scopus 로고
    • Aberrantly segregating centromeres activate the spindle assembly checkpoint in budding yeast
    • Wells W.A., Murray A.W. Aberrantly segregating centromeres activate the spindle assembly checkpoint in budding yeast. J Cell Biol. 133:1996;75-84.
    • (1996) J Cell Biol , vol.133 , pp. 75-84
    • Wells, W.A.1    Murray, A.W.2
  • 9
    • 0028872743 scopus 로고
    • Mitotic forces control a cell-cycle checkpoint
    • Li X., Nicklas R.B. Mitotic forces control a cell-cycle checkpoint. Nature. 373:1995;630-632.
    • (1995) Nature , vol.373 , pp. 630-632
    • Li, X.1    Nicklas, R.B.2
  • 10
    • 0029160299 scopus 로고
    • The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
    • Rieder C.L., Cole R.W., Khodjakov A., Sluder G. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J Cell Biol. 130:1995;941-948.
    • (1995) J Cell Biol , vol.130 , pp. 941-948
    • Rieder, C.L.1    Cole, R.W.2    Khodjakov, A.3    Sluder, G.4
  • 11
    • 0033677801 scopus 로고    scopus 로고
    • Tension on chromosomes increases the number of kinetochore microtubules but only within limits
    • King J.M., Nicklas R.B. Tension on chromosomes increases the number of kinetochore microtubules but only within limits. J Cell Sci. 113:2000;3815-3823.
    • (2000) J Cell Sci , vol.113 , pp. 3815-3823
    • King, J.M.1    Nicklas, R.B.2
  • 12
    • 0027303640 scopus 로고
    • Differential expression of a phosphoepitope at kinetochores of moving chromosomes
    • Gorbsky G.J., Ricketts W.A. Differential expression of a phosphoepitope at kinetochores of moving chromosomes. J Cell Biol. 1993;1311-1321.
    • (1993) J Cell Biol , pp. 1311-1321
    • Gorbsky, G.J.1    Ricketts, W.A.2
  • 13
    • 0029146196 scopus 로고
    • Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint
    • Nicklas R.B., Ward S.C., Gorbsky G.J. Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint. J Cell Biol. 130:1995;929-939.
    • (1995) J Cell Biol , vol.130 , pp. 929-939
    • Nicklas, R.B.1    Ward, S.C.2    Gorbsky, G.J.3
  • 14
    • 0029069368 scopus 로고
    • Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase
    • Campbell M.S., Gorbsky G.J. Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase. J Cell Biol. 129:1995;1195-1204.
    • (1995) J Cell Biol , vol.129 , pp. 1195-1204
    • Campbell, M.S.1    Gorbsky, G.J.2
  • 15
    • 14444267778 scopus 로고    scopus 로고
    • How cells get the right chromosomes
    • Nicklas R.B. How cells get the right chromosomes. Science. 275:1997;632-637.
    • (1997) Science , vol.275 , pp. 632-637
    • Nicklas, R.B.1
  • 16
    • 0025941405 scopus 로고
    • S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
    • Hoyt M.A., Totis L., Roberts B.T. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell. 66:1991;507-517.
    • (1991) Cell , vol.66 , pp. 507-517
    • Hoyt, M.A.1    Totis, L.2    Roberts, B.T.3
  • 17
    • 0026009964 scopus 로고
    • Feedback control of mitosis in budding yeast
    • Li R., Murray A.W. Feedback control of mitosis in budding yeast. Cell. 66:1991;519-531.
    • (1991) Cell , vol.66 , pp. 519-531
    • Li, R.1    Murray, A.W.2
  • 18
    • 0030066347 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint
    • Weiss E., Winey M. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J Cell Biol. 132:1996;111-123.
    • (1996) J Cell Biol , vol.132 , pp. 111-123
    • Weiss, E.1    Winey, M.2
  • 19
    • 0032514260 scopus 로고    scopus 로고
    • The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
    • Taylor S.S., Ha E., McKeon F. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. J Cell Biol. 142:1998;1-11.
    • (1998) J Cell Biol , vol.142 , pp. 1-11
    • Taylor, S.S.1    Ha, E.2    McKeon, F.3
  • 20
    • 0032846338 scopus 로고    scopus 로고
    • Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
    • Chan G.K., Jablonski S.A., Sudakin V., Hittle J.C., Yen T.J. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. J Cell Biol. 146:1999;941-954.
    • (1999) J Cell Biol , vol.146 , pp. 941-954
    • Chan, G.K.1    Jablonski, S.A.2    Sudakin, V.3    Hittle, J.C.4    Yen, T.J.5
  • 21
    • 0033620688 scopus 로고    scopus 로고
    • Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2
    • Fraschini R., Formenti E., Lucchini G., Piatti S. Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2. J Cell Biol. 145:1999;979-991.
    • (1999) J Cell Biol , vol.145 , pp. 979-991
    • Fraschini, R.1    Formenti, E.2    Lucchini, G.3    Piatti, S.4
  • 22
    • 0034253537 scopus 로고    scopus 로고
    • Anaphase spindle position is monitored by the BUB2 checkpoint
    • Bloecher A., Venturi G.M., Tatchell K. Anaphase spindle position is monitored by the BUB2 checkpoint. Nat Cell Biol. 2:2000;556-558.
    • (2000) Nat Cell Biol , vol.2 , pp. 556-558
    • Bloecher, A.1    Venturi, G.M.2    Tatchell, K.3
  • 23
    • 0029845891 scopus 로고    scopus 로고
    • Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
    • Chen R.H., Waters J.C., Salmon E.D., Murray A.W. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science. 274:1996;242-246.
    • (1996) Science , vol.274 , pp. 242-246
    • Chen, R.H.1    Waters, J.C.2    Salmon, E.D.3    Murray, A.W.4
  • 24
    • 10244251532 scopus 로고    scopus 로고
    • Identification of a human mitotic checkpoint gene: HsMAD2
    • Li Y., Benezra R. Identification of a human mitotic checkpoint gene: hsMAD2. Science. 274:1996;246-248.
    • (1996) Science , vol.274 , pp. 246-248
    • Li, Y.1    Benezra, R.2
  • 25
    • 0032101607 scopus 로고    scopus 로고
    • Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase
    • Gorbsky G.J., Chen R.H., Murray A.W. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase. J Cell Biol. 141:1998;1193-1205.
    • (1998) J Cell Biol , vol.141 , pp. 1193-1205
    • Gorbsky, G.J.1    Chen, R.H.2    Murray, A.W.3
  • 26
    • 0034625268 scopus 로고    scopus 로고
    • Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
    • Dobles M., Liberal V., Scott M.L., Benezra R., Sorger P.K. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell. 101:2000;635-645.
    • (2000) Cell , vol.101 , pp. 635-645
    • Dobles, M.1    Liberal, V.2    Scott, M.L.3    Benezra, R.4    Sorger, P.K.5
  • 27
    • 0032547733 scopus 로고    scopus 로고
    • Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
    • Chen R.H., Shevchenko A., Mann M., Murray A.W. Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores. J Cell Biol. 143:1998;283-295.
    • (1998) J Cell Biol , vol.143 , pp. 283-295
    • Chen, R.H.1    Shevchenko, A.2    Mann, M.3    Murray, A.W.4
  • 28
    • 0036161468 scopus 로고    scopus 로고
    • The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20
    • Luo X., Tang Z., Rizo J., Yu H. The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell. 9:2002;59-71.
    • (2002) Mol Cell , vol.9 , pp. 59-71
    • Luo, X.1    Tang, Z.2    Rizo, J.3    Yu, H.4
  • 29
    • 0028842802 scopus 로고
    • Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
    • Hardwick K.G., Murray A.W. Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J Cell Biol. 131:1995;709-720.
    • (1995) J Cell Biol , vol.131 , pp. 709-720
    • Hardwick, K.G.1    Murray, A.W.2
  • 30
    • 0029791321 scopus 로고    scopus 로고
    • Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption
    • Hardwick K.G., Weiss E., Luca F.C., Winey M., Murray A.W. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science. 273:1996;953-956.
    • (1996) Science , vol.273 , pp. 953-956
    • Hardwick, K.G.1    Weiss, E.2    Luca, F.C.3    Winey, M.4    Murray, A.W.5
  • 31
    • 0032776301 scopus 로고    scopus 로고
    • The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins
    • Chen R.H., Brady D.M., Smith D., Murray A.W., Hardwick K.G. The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins. Mol Biol Cell. 10:1999;2607-2618.
    • (1999) Mol Biol Cell , vol.10 , pp. 2607-2618
    • Chen, R.H.1    Brady, D.M.2    Smith, D.3    Murray, A.W.4    Hardwick, K.G.5
  • 33
    • 0037007206 scopus 로고    scopus 로고
    • Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication
    • Stucke V.M., Sillje H.H., Arnaud L., Nigg E.A. Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication. EMBO J. 21:2002;1723-1732.
    • (2002) EMBO J , vol.21 , pp. 1723-1732
    • Stucke, V.M.1    Sillje, H.H.2    Arnaud, L.3    Nigg, E.A.4
  • 34
    • 0030687987 scopus 로고    scopus 로고
    • Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
    • Taylor S.S., McKeon F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell. 89:1997;727-735.
    • (1997) Cell , vol.89 , pp. 727-735
    • Taylor, S.S.1    McKeon, F.2
  • 36
    • 0035844878 scopus 로고    scopus 로고
    • Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity
    • Sharp-Baker H., Chen R.H. Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity. J Cell Biol. 153:2001;1239-1250.
    • (2001) J Cell Biol , vol.153 , pp. 1239-1250
    • Sharp-Baker, H.1    Chen, R.H.2
  • 37
    • 0032576574 scopus 로고    scopus 로고
    • Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis
    • Bernard P., Hardwick K., Javerzat J.P. Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis. J Cell Biol. 143:1998;1775-1787.
    • (1998) J Cell Biol , vol.143 , pp. 1775-1787
    • Bernard, P.1    Hardwick, K.2    Javerzat, J.P.3
  • 38
    • 0033549477 scopus 로고    scopus 로고
    • Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
    • Basu J., Bousbaa H., Logarinho E., Li Z., Williams B.C., Lopes C., Sunkel C.E., Goldberg M.L. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. J Cell Biol. 146:1999;13-28.
    • (1999) J Cell Biol , vol.146 , pp. 13-28
    • Basu, J.1    Bousbaa, H.2    Logarinho, E.3    Li, Z.4    Williams, B.C.5    Lopes, C.6    Sunkel, C.E.7    Goldberg, M.L.8
  • 39
    • 0035694452 scopus 로고    scopus 로고
    • Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells
    • Taylor S.S., Hussein D., Wang Y., Elderkin S., Morrow C.J. Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. J Cell Sci. 114:2001;4385-4395.
    • (2001) J Cell Sci , vol.114 , pp. 4385-4395
    • Taylor, S.S.1    Hussein, D.2    Wang, Y.3    Elderkin, S.4    Morrow, C.J.5
  • 40
    • 0028089758 scopus 로고
    • The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase
    • Roberts B.T., Farr K.A., Hoyt M.A. The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol Cell Biol. 14:1994;8282-8291.
    • (1994) Mol Cell Biol , vol.14 , pp. 8282-8291
    • Roberts, B.T.1    Farr, K.A.2    Hoyt, M.A.3
  • 41
    • 0034214405 scopus 로고    scopus 로고
    • Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function
    • Brady D.M., Hardwick K.G. Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function. Curr Biol. 10:2000;675-678.
    • (2000) Curr Biol , vol.10 , pp. 675-678
    • Brady, D.M.1    Hardwick, K.G.2
  • 42
  • 43
    • 0031893014 scopus 로고    scopus 로고
    • Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint
    • Farr K.A., Hoyt M.A. Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint. Mol Cell Biol. 18:1998;2738-2747.
    • (1998) Mol Cell Biol , vol.18 , pp. 2738-2747
    • Farr, K.A.1    Hoyt, M.A.2
  • 45
    • 0034665634 scopus 로고    scopus 로고
    • Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis
    • Kalitsis P., Earle E., Fowler K.J., Choo K.H. Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis. Genes Dev. 14:2000;2277-2282.
    • (2000) Genes Dev , vol.14 , pp. 2277-2282
    • Kalitsis, P.1    Earle, E.2    Fowler, K.J.3    Choo, K.H.4
  • 46
    • 0034611013 scopus 로고    scopus 로고
    • MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p
    • Hardwick K.G., Johnston R.C., Smith D.L., Murray A.W. MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p. J Cell Biol. 148:2000;871-882.
    • (2000) J Cell Biol , vol.148 , pp. 871-882
    • Hardwick, K.G.1    Johnston, R.C.2    Smith, D.L.3    Murray, A.W.4
  • 47
    • 0036210713 scopus 로고    scopus 로고
    • Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner
    • Millband D.N., Hardwick K.G. Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner. Mol Cell Biol. 22:2002;2728-2742.
    • (2002) Mol Cell Biol , vol.22 , pp. 2728-2742
    • Millband, D.N.1    Hardwick, K.G.2
  • 48
    • 0036322225 scopus 로고    scopus 로고
    • BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1
    • Chen R.H. BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1. J Cell Biol. 158:2002;487-496.
    • (2002) J Cell Biol , vol.158 , pp. 487-496
    • Chen, R.H.1
  • 50
    • 0032487444 scopus 로고    scopus 로고
    • Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
    • Chan G.K., Schaar B.T., Yen T.J. Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. J Cell Biol. 143:1998;49-63.
    • (1998) J Cell Biol , vol.143 , pp. 49-63
    • Chan, G.K.1    Schaar, B.T.2    Yen, T.J.3
  • 51
    • 0032415592 scopus 로고    scopus 로고
    • The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis
    • Jablonski S.A., Chan G.K., Cooke C.A., Earnshaw W.C., Yen T.J. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. Chromosoma. 107:1998;386-396.
    • (1998) Chromosoma , vol.107 , pp. 386-396
    • Jablonski, S.A.1    Chan, G.K.2    Cooke, C.A.3    Earnshaw, W.C.4    Yen, T.J.5
  • 52
    • 0001665802 scopus 로고    scopus 로고
    • CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint
    • Yao X., Abrieu A., Zheng Y., Sullivan K.F., Cleveland D.W. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat Cell Biol. 2:2000;484-491.
    • (2000) Nat Cell Biol , vol.2 , pp. 484-491
    • Yao, X.1    Abrieu, A.2    Zheng, Y.3    Sullivan, K.F.4    Cleveland, D.W.5
  • 53
    • 0034664766 scopus 로고    scopus 로고
    • CENP-E as an essential component of the mitotic checkpoint in vitro
    • Abrieu A., Kahana J.A., Wood K.W., Cleveland D.W. CENP-E as an essential component of the mitotic checkpoint in vitro. Cell. 102:2000;817-826.
    • (2000) Cell , vol.102 , pp. 817-826
    • Abrieu, A.1    Kahana, J.A.2    Wood, K.W.3    Cleveland, D.W.4
  • 55
    • 0036789555 scopus 로고    scopus 로고
    • The spindle checkpoint: Structural insights into dynamic signalling
    • Musacchio A., Hardwick K.G. The spindle checkpoint: structural insights into dynamic signalling. Nat Rev Mol Cell Biol. 3:2002;731-741.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 731-741
    • Musacchio, A.1    Hardwick, K.G.2
  • 56
    • 0035999976 scopus 로고    scopus 로고
    • Spindle checkpoint requires Mad1-bound and Mad1-free Mad2
    • Chung E., Chen R.H. Spindle checkpoint requires Mad1-bound and Mad1-free Mad2. Mol Biol Cell. 13:2002;1501-1511.
    • (2002) Mol Biol Cell , vol.13 , pp. 1501-1511
    • Chung, E.1    Chen, R.H.2
  • 57
    • 0032101688 scopus 로고    scopus 로고
    • Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
    • Waters J.C., Chen R.H., Murray A.W., Salmon E.D. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J Cell Biol. 141:1998;1181-1191.
    • (1998) J Cell Biol , vol.141 , pp. 1181-1191
    • Waters, J.C.1    Chen, R.H.2    Murray, A.W.3    Salmon, E.D.4
  • 58
    • 0035836655 scopus 로고    scopus 로고
    • Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints
    • Skoufias D.A., Andreassen P.R., Lacroix F.B., Wilson L., Margolis R.L. Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. Proc Natl Acad Sci USA. 98:2001;4492-4497.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 4492-4497
    • Skoufias, D.A.1    Andreassen, P.R.2    Lacroix, F.B.3    Wilson, L.4    Margolis, R.L.5
  • 59
    • 0037053409 scopus 로고    scopus 로고
    • Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint
    • Zhou J., Panda D., Landen J.W., Wilson L., Joshi H.C. Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint. J Biol Chem. 277:2002;17200-17208.
    • (2002) J Biol Chem , vol.277 , pp. 17200-17208
    • Zhou, J.1    Panda, D.2    Landen, J.W.3    Wilson, L.4    Joshi, H.C.5
  • 60
    • 0034647893 scopus 로고    scopus 로고
    • Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis
    • Shonn M.A., McCarroll R., Murray A.W. Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis. Science. 289:2000;300-303.
    • (2000) Science , vol.289 , pp. 300-303
    • Shonn, M.A.1    McCarroll, R.2    Murray, A.W.3
  • 61
    • 0035908913 scopus 로고    scopus 로고
    • Lack of tension at kinetochores activates the spindle checkpoint in budding yeast
    • Stern B.M., Murray A.W. Lack of tension at kinetochores activates the spindle checkpoint in budding yeast. Curr Biol. 11:2001;1462-1467.
    • (2001) Curr Biol , vol.11 , pp. 1462-1467
    • Stern, B.M.1    Murray, A.W.2
  • 62
    • 0034717297 scopus 로고    scopus 로고
    • Splitting the chromosome: Cutting the ties that bind sister chromatids
    • Nasmyth K., Peters J.M., Uhlmann F. Splitting the chromosome: cutting the ties that bind sister chromatids. Science. 288:2000;1379-1385.
    • (2000) Science , vol.288 , pp. 1379-1385
    • Nasmyth, K.1    Peters, J.M.2    Uhlmann, F.3
  • 63
    • 0033567387 scopus 로고    scopus 로고
    • Whose end is destruction: Cell division and the anaphase-promoting complex
    • Zachariae W., Nasmyth K. Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13:1999;2039-2058.
    • (1999) Genes Dev , vol.13 , pp. 2039-2058
    • Zachariae, W.1    Nasmyth, K.2
  • 64
    • 0033147334 scopus 로고    scopus 로고
    • Regulation of the APC and the exit from mitosis
    • Morgan D.O. Regulation of the APC and the exit from mitosis. Nat Cell Biol. 1:1999;E47-E53.
    • (1999) Nat Cell Biol , vol.1
    • Morgan, D.O.1
  • 65
    • 0036284778 scopus 로고    scopus 로고
    • The anaphase-promoting complex: Proteolysis in mitosis and beyond
    • Peters J.M. The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol Cell. 9:2002;931-943.
    • (2002) Mol Cell , vol.9 , pp. 931-943
    • Peters, J.M.1
  • 66
    • 0030794972 scopus 로고    scopus 로고
    • The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex
    • He X., Patterson T.E., Sazer S. The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. Proc Natl Acad Sci USA. 94:1997;7965-7970.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7965-7970
    • He, X.1    Patterson, T.E.2    Sazer, S.3
  • 67
    • 0030730855 scopus 로고    scopus 로고
    • MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity
    • Li Y., Gorbea C., Mahaffey D., Rechsteiner M., Benezra R. MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity. Proc Natl Acad Sci USA. 94:1997;12431-12436.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12431-12436
    • Li, Y.1    Gorbea, C.2    Mahaffey, D.3    Rechsteiner, M.4    Benezra, R.5
  • 69
    • 0000273639 scopus 로고    scopus 로고
    • Fission yeast Slp1: An effector of the Mad2-dependent spindle checkpoint
    • Kim S.H., Lin D.P., Matsumoto S., Kitazono A., Matsumoto T. Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint. Science. 279:1998;1045-1047.
    • (1998) Science , vol.279 , pp. 1045-1047
    • Kim, S.H.1    Lin, D.P.2    Matsumoto, S.3    Kitazono, A.4    Matsumoto, T.5
  • 70
    • 0032526415 scopus 로고    scopus 로고
    • Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events
    • Kallio M., Weinstein J., Daum J.R., Burke D.J., Gorbsky G.J. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J Cell Biol. 141:1998;1393-1406.
    • (1998) J Cell Biol , vol.141 , pp. 1393-1406
    • Kallio, M.1    Weinstein, J.2    Daum, J.R.3    Burke, D.J.4    Gorbsky, G.J.5
  • 71
    • 0032525783 scopus 로고    scopus 로고
    • The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
    • Fang G., Yu H., Kirschner M.W. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev. 12:1998;1871-1883.
    • (1998) Genes Dev , vol.12 , pp. 1871-1883
    • Fang, G.1    Yu, H.2    Kirschner, M.W.3
  • 72
    • 0032530832 scopus 로고    scopus 로고
    • Mad2 transiently associates with an APC/p55Cdc complex during mitosis
    • Wassmann K., Benezra R. Mad2 transiently associates with an APC/p55Cdc complex during mitosis. Proc Natl Acad Sci USA. 95:1998;11193-11198.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11193-11198
    • Wassmann, K.1    Benezra, R.2
  • 73
    • 0037009056 scopus 로고    scopus 로고
    • Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells
    • Kallio M.J., Beardmore V.A., Weinstein J., Gorbsky G.J. Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. J Cell Biol. 158:2002;841-847.
    • (2002) J Cell Biol , vol.158 , pp. 841-847
    • Kallio, M.J.1    Beardmore, V.A.2    Weinstein, J.3    Gorbsky, G.J.4
  • 74
    • 0034683744 scopus 로고    scopus 로고
    • Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells
    • Howell B.J., Hoffman D.B., Fang G., Murray A.W., Salmon E.D. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells. J Cell Biol. 150:2000;1233-1250.
    • (2000) J Cell Biol , vol.150 , pp. 1233-1250
    • Howell, B.J.1    Hoffman, D.B.2    Fang, G.3    Murray, A.W.4    Salmon, E.D.5
  • 75
    • 0035802122 scopus 로고    scopus 로고
    • Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
    • Sudakin V., Chan G.K., Yen T.J. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. J Cell Biol. 154:2001;925-936.
    • (2001) J Cell Biol , vol.154 , pp. 925-936
    • Sudakin, V.1    Chan, G.K.2    Yen, T.J.3
  • 76
    • 0035435063 scopus 로고    scopus 로고
    • Mad2-independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1
    • Tang Z., Bharadwaj R., Li B., Yu H. Mad2-independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1. Dev Cell. 1:2001;227-237.
    • (2001) Dev Cell , vol.1 , pp. 227-237
    • Tang, Z.1    Bharadwaj, R.2    Li, B.3    Yu, H.4
  • 77
    • 0035803404 scopus 로고    scopus 로고
    • Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores
    • Fraschini R., Beretta A., Sironi L., Musacchio A., Lucchini G., Piatti S. Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores. EMBO J. 20:2001;6648-6659.
    • (2001) EMBO J , vol.20 , pp. 6648-6659
    • Fraschini, R.1    Beretta, A.2    Sironi, L.3    Musacchio, A.4    Lucchini, G.5    Piatti, S.6
  • 78
    • 0030995427 scopus 로고    scopus 로고
    • Mitosis in vertebrate somatic cells with two spindles: Implications for the metaphase/anaphase transition checkpoint and cleavage
    • Rieder C.L., Khodjakov A., Paliulis L.V., Fortier T.M., Cole R.W., Sluder G. Mitosis in vertebrate somatic cells with two spindles: implications for the metaphase/anaphase transition checkpoint and cleavage. Proc Natl Acad Sci USA. 94:1997;5107-5112.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5107-5112
    • Rieder, C.L.1    Khodjakov, A.2    Paliulis, L.V.3    Fortier, T.M.4    Cole, R.W.5    Sluder, G.6
  • 79
    • 0030451851 scopus 로고    scopus 로고
    • Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state
    • Andreassen P.R., Martineau S.N., Margolis R.L. Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state. Mutat Res. 372:1996;181-194.
    • (1996) Mutat Res , vol.372 , pp. 181-194
    • Andreassen, P.R.1    Martineau, S.N.2    Margolis, R.L.3
  • 80
    • 0030920846 scopus 로고    scopus 로고
    • Disregulation of mitotic checkpoints and regulatory proteins following acute expression of SV40 large T antigen in diploid human cells
    • Chang T.H., Ray F.A., Thompson D.A., Schlegel R. Disregulation of mitotic checkpoints and regulatory proteins following acute expression of SV40 large T antigen in diploid human cells. Oncogene. 14:1997;2383-2393.
    • (1997) Oncogene , vol.14 , pp. 2383-2393
    • Chang, T.H.1    Ray, F.A.2    Thompson, D.A.3    Schlegel, R.4
  • 81
    • 0031930282 scopus 로고    scopus 로고
    • Human papillomavirus oncoproteins E6 and E7 independently abrogate the mitotic spindle checkpoint
    • Thomas J.T., Laimins L.A. Human papillomavirus oncoproteins E6 and E7 independently abrogate the mitotic spindle checkpoint. J Virol. 72:1998;1131-1137.
    • (1998) J Virol , vol.72 , pp. 1131-1137
    • Thomas, J.T.1    Laimins, L.A.2
  • 82
    • 0032478547 scopus 로고    scopus 로고
    • Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
    • Jin D.Y., Spencer F., Jeang K.T. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell. 93:1998;81-91.
    • (1998) Cell , vol.93 , pp. 81-91
    • Jin, D.Y.1    Spencer, F.2    Jeang, K.T.3
  • 83
    • 0037085278 scopus 로고    scopus 로고
    • Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors
    • Kasai T., Iwanaga Y., Iha H., Jeang K.T. Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors. J Biol Chem. 277:2002;5187-5193.
    • (2002) J Biol Chem , vol.277 , pp. 5187-5193
    • Kasai, T.1    Iwanaga, Y.2    Iha, H.3    Jeang, K.T.4
  • 84
    • 0033604452 scopus 로고    scopus 로고
    • Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers
    • Nomoto S., Haruki N., Takahashi T., Masuda A., Koshikawa T., Fujii Y., Osada H. Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers. Oncogene. 18:1999;7180-7183.
    • (1999) Oncogene , vol.18 , pp. 7180-7183
    • Nomoto, S.1    Haruki, N.2    Takahashi, T.3    Masuda, A.4    Koshikawa, T.5    Fujii, Y.6    Osada, H.7
  • 85
    • 0034308209 scopus 로고    scopus 로고
    • Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma
    • Ohshima K., Haraoka S., Yoshioka S., Hamasaki M., Fujiki T., Suzumiya J., Kawasaki C., Kanda M., Kikuchi M. Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma. Cancer Lett. 158:2000;141-150.
    • (2000) Cancer Lett , vol.158 , pp. 141-150
    • Ohshima, K.1    Haraoka, S.2    Yoshioka, S.3    Hamasaki, M.4    Fujiki, T.5    Suzumiya, J.6    Kawasaki, C.7    Kanda, M.8    Kikuchi, M.9
  • 86
    • 0037063174 scopus 로고    scopus 로고
    • HBUB1 defects in leukemia and lymphoma cells
    • Ru H.Y., Chen R.L., Lu W.C., Chen J.H. hBUB1 defects in leukemia and lymphoma cells. Oncogene. 21:2002;4673-4679.
    • (2002) Oncogene , vol.21 , pp. 4673-4679
    • Ru, H.Y.1    Chen, R.L.2    Lu, W.C.3    Chen, J.H.4
  • 89
    • 0032959720 scopus 로고    scopus 로고
    • Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines
    • Yamaguchi K., Okami K., Hibi K., Wehage S.L., Jen J., Sidransky D. Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines. Cancer Lett. 139:1999;183-187.
    • (1999) Cancer Lett , vol.139 , pp. 183-187
    • Yamaguchi, K.1    Okami, K.2    Hibi, K.3    Wehage, S.L.4    Jen, J.5    Sidransky, D.6
  • 90
    • 0033614936 scopus 로고    scopus 로고
    • Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers
    • Takahashi T., Haruki N., Nomoto S., Masuda A., Saji S., Osada H. Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers. Oncogene. 18:1999;4295-4300.
    • (1999) Oncogene , vol.18 , pp. 4295-4300
    • Takahashi, T.1    Haruki, N.2    Nomoto, S.3    Masuda, A.4    Saji, S.5    Osada, H.6
  • 91
    • 0034037094 scopus 로고    scopus 로고
    • Differential spindle assembly checkpoint response in human lung adenocarcinoma cells
    • Weitzel D.H., Vandre D.D. Differential spindle assembly checkpoint response in human lung adenocarcinoma cells. Cell Tissue Res. 300:2000;57-65.
    • (2000) Cell Tissue Res , vol.300 , pp. 57-65
    • Weitzel, D.H.1    Vandre, D.D.2
  • 96
    • 0032850288 scopus 로고    scopus 로고
    • Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rarein sporadic digestive tract cancers
    • Imai Y., Shiratori Y., Kato N., Inoue T., Omata M. Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rarein sporadic digestive tract cancers. Jpn J Cancer Res. 90:1999;837-840.
    • (1999) Jpn J Cancer Res , vol.90 , pp. 837-840
    • Imai, Y.1    Shiratori, Y.2    Kato, N.3    Inoue, T.4    Omata, M.5
  • 97
    • 0034193627 scopus 로고    scopus 로고
    • Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines
    • Myrie K.A., Percy M.J., Azim J.N., Neeley C.K., Petty E.M. Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines. Cancer Lett. 152:2000;193-199.
    • (2000) Cancer Lett , vol.152 , pp. 193-199
    • Myrie, K.A.1    Percy, M.J.2    Azim, J.N.3    Neeley, C.K.4    Petty, E.M.5
  • 99
    • 0035228338 scopus 로고    scopus 로고
    • Mutation analysis of hBUB1, human mitotic checkpoint gene in multiple carcinomas
    • Mimori K., Inoue H., Alder H., Ueo H., Tanaka Y., Mori M. Mutation analysis of hBUB1, human mitotic checkpoint gene in multiple carcinomas. Oncol Rep. 8:2001;39-42.
    • (2001) Oncol Rep , vol.8 , pp. 39-42
    • Mimori, K.1    Inoue, H.2    Alder, H.3    Ueo, H.4    Tanaka, Y.5    Mori, M.6
  • 101
    • 0035031228 scopus 로고    scopus 로고
    • Mitotic checkpoint genes hBUB1, hBUB1B, hBUB3 and TTK in human bladder cancer, screening for mutations and loss of heterozygosity
    • Olesen S.H., Thykjaer T., Orntoft T.F. Mitotic checkpoint genes hBUB1, hBUB1B, hBUB3 and TTK in human bladder cancer, screening for mutations and loss of heterozygosity. Carcinogenesis. 22:2001;813-815.
    • (2001) Carcinogenesis , vol.22 , pp. 813-815
    • Olesen, S.H.1    Thykjaer, T.2    Orntoft, T.F.3
  • 102
    • 0035919860 scopus 로고    scopus 로고
    • Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer
    • Hernando E., Orlow I., Liberal V., Nohales G., Benezra R., Cordon-Cardo C. Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer. Int J Cancer. 95:2001;223-227.
    • (2001) Int J Cancer , vol.95 , pp. 223-227
    • Hernando, E.1    Orlow, I.2    Liberal, V.3    Nohales, G.4    Benezra, R.5    Cordon-Cardo, C.6
  • 105
    • 0036223590 scopus 로고    scopus 로고
    • Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: Evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1
    • Ouyang B., Knauf J.A., Ain K., Nacev B., Fagin J.A. Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1. Clin Endocrinol (Oxf). 56:2002;341-350.
    • (2002) Clin Endocrinol (Oxf) , vol.56 , pp. 341-350
    • Ouyang, B.1    Knauf, J.A.2    Ain, K.3    Nacev, B.4    Fagin, J.A.5
  • 107
    • 0036969268 scopus 로고    scopus 로고
    • Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer
    • Yoon D.S., Wersto R.P., Zhou W., Chrest F.J., Garrett E.S., Kwon T.K., Gabrielson E. Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer. Am J Pathol. 161:2002;391-397.
    • (2002) Am J Pathol , vol.161 , pp. 391-397
    • Yoon, D.S.1    Wersto, R.P.2    Zhou, W.3    Chrest, F.J.4    Garrett, E.S.5    Kwon, T.K.6    Gabrielson, E.7
  • 108
    • 0034518709 scopus 로고    scopus 로고
    • Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells
    • Wang X., Jin D.Y., Wong Y.C., Cheung A.L., Chun A.C., Lo A.K., Liu Y., Tsao S.W. Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells. Carcinogenesis. 21:2000;2293-2297.
    • (2000) Carcinogenesis , vol.21 , pp. 2293-2297
    • Wang, X.1    Jin, D.Y.2    Wong, Y.C.3    Cheung, A.L.4    Chun, A.C.5    Lo, A.K.6    Liu, Y.7    Tsao, S.W.8
  • 110
    • 0037085936 scopus 로고    scopus 로고
    • Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells
    • Wang X., Jin D.Y., Ng R.W., Feng H., Wong Y.C., Cheung A.L., Tsao S.W. Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells. Cancer Res. 62:2002;1662-1668.
    • (2002) Cancer Res , vol.62 , pp. 1662-1668
    • Wang, X.1    Jin, D.Y.2    Ng, R.W.3    Feng, H.4    Wong, Y.C.5    Cheung, A.L.6    Tsao, S.W.7
  • 111
    • 0036141441 scopus 로고    scopus 로고
    • Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival
    • Shichiri M., Yoshinaga K., Hisatomi H., Sugihara K., Hirata Y. Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. Cancer Res. 62:2002;13-17.
    • (2002) Cancer Res , vol.62 , pp. 13-17
    • Shichiri, M.1    Yoshinaga, K.2    Hisatomi, H.3    Sugihara, K.4    Hirata, Y.5
  • 114
  • 116
    • 0035176077 scopus 로고    scopus 로고
    • Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation
    • Zumbrunn J., Kinoshita K., Hyman A.A., Nathke I.S. Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. Curr Biol. 11:2001;44-49.
    • (2001) Curr Biol , vol.11 , pp. 44-49
    • Zumbrunn, J.1    Kinoshita, K.2    Hyman, A.A.3    Nathke, I.S.4


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