The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins

Molecular Biology of the Cell

Volumn 10, Issue 8, 1999, Pages 2607-2618

  Chen, Rey Huei ^a,b   Brady, D Michelle ^c   Smith, Dana ^a   Murray, Andrew W ^a   Hardwick, Kevin G ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Cornell University ^*  (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN DERIVATIVE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CYCLE; CONTROLLED STUDY; GENE DISRUPTION; GENE ISOLATION; MITOSIS SPINDLE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; YEAST;

ANIMALIA; FUNGI; SACCHAROMYCETALES;

EID: 0032776301     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.10.8.2607     Document Type: Article

References (41)

1. Aravind, L., and Koonin, E.V. (1998). The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair. Trends Biochem Sci. 23, 284-286.
2. Cahill, D.P., Lengauer, C., Yu, J., Riggins, G.J., Willson, J.K., Markowitz, S.D., Kinzler, K.W., and Vogelstein, B. (1998). Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300-303.
3. Chan, G.K., Schaar, B.T., and Yen, T.J. (1998). Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. J Cell Biol. 143, 49-63.
4. Chen, R.-H., Juo, P.-C., Curran, T., and Blenis, J. (1996). Phosphorylation of c-Fos at the C-terminus enhances its transforming activity. Oncogene 12, 1493-1502.
5. Chen, R.-H., Shevchenko, A., Mann, M., and Murray, A.W. (1998). Spindle checkpoint protein xmad1 recruits xmad2 to unattached kinetochores. J. Cell Biol. 143, 283-295.
6. Chen, R.-H., Waters, J.C., Salmon, E.D., and Murray, A.W. (1996). Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science 274, 242-246.
7. Cohen-Fix, O., Peters, J.M., Kirschner, M.W., and Koshland, D. (1996). Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes & Dev. 20, 3081-3093.
8. Elledge, S.J. (1996). Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672.
9. Fang, G., Yu, H., and Kirschner, M.W. (1998). The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes & Dev. 12, 1871-1883.
10. Fang, G., Yu, H., and Kirschner, M.W. (1998). Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol. Cell 2, 163-171.
11. Farr, K.A., and Hoyt, M.A. (1998). Bublp kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint. Mol. Cell. Biol. 18, 2738-2747.
12. Gorbsky, G.J., Chen, R.H., and Murray, A.W. (1998). Microinjection of antibody to mad2 protein into mammalian cells in mitosis induces premature anaphase. J. Cell Biol. 141, 1193-1205.
13. Guthrie, C., and Fink, G.R. (1991). Guide to Yeast Genetics and Molecular Biology, vol. 194, San Diego: Academic Press.
14. Hardwick, K., and Murray, A.W. (1995). Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131, 709-720.
15. Hardwick, K.G. (1998). The spindle checkpoint. Trends Genet. 14, 1-4.
16. Hardwick, K.G., Weiss, E., Luca, F.C., Winey, M., and Murray, A.W. (1996). Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science 273, 953-956.
17. Harlow, E., and Lane, D. (1988). Antibodies. A Laboratory Manual, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
18. Hartwell, L.H., and Kastan, M.B. (1994). Cell cycle control and cancer. Science 266, 1821-1828.
19. Hartwell, L.H., and Weinert, T.A. (1989). Checkpoints: controls that ensure the order of cell cycle events. Science 246, 629-634.
20. Hoyt, M.A., Trotis, L., and Roberts, B.T. (1991). S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66, 507-517.
21. Hwang, L.H., Lau, L.F., Smith, D.L., Mistrot, C.A., Hardwick, K.G., Hwang, E.S., Amon, A., and Murray, A.W. (1998). Budding yeast Cdc20: a target of the spindle checkpoint. Science 279, 1041-1044.
22. Jin, D.Y., Spencer, F., and Jeang, K.T. (1998). Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93, 81-91.
23. Juang, Y.L., Huang, J., Peters, J.M., McLaughlin, M.E., Tai, C.Y., and Pellman, D. (1997). APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science 275, 1311-1314.
24. Kim, S.H., Lin, D.P., Matsumoto, S., Kitazono, A., and Matsumoto, T. (1998). Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint. Science 279, 1045-1047.
25. King, R.W., Peters, J.M., Tugendreich, S., Rolfe, M., Hieter, P., and Kirschner, M.W. (1995). A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81, 279-288.
26. Li, R., Chen, R-H., and Murray, A.W. (1994). Feedback control of mitosis in budding yeast (correction). Cell 79, 388.
27. Li, R., Havel, C., Watson, J.A., and Murray, A.W. (1993). The mitotic feedback control gene MAD2 encodes the a subunit of a prenyl transferase. Nature 336, 82-84.
28. Li, R., and Murray, A.W. (1991). Feedback control of mitosis in budding yeast. Cell 66, 519-531.
29. Li, Y., and Benezra, R. (1996). Identification of a human mitotic checkpoint gene: hsMAD2. Science 274, 246-248.
30. Maniatis, T., Fritsch, E.F., and Sambrook, J. (1982). Molecular Cloning: a Laboratory Manual, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
31. Roberts, R.T., Farr, K.A., and Hoyt, M.A. (1994). The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol. Cell. Biol. 14, 8282-8291.
32. Rudner, A.D., and Murray, A.W. (1996). The spindle assembly checkpoint. Curr. Opin. Cell Biol. 8, 773-780.
33. Sikorski, R.S., and Hieter, P. (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 222, 19-27.
34. Sudakin, V., Ganoth, D., Dahan, A., Heller, H., Hersko, J., Luca, F., Ruderman, J.V., and Hershko, A. (1995). The cyclosome, a large complex containing cyclin-selective ubiquitination ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185-198.
35. Surana, U., Amon, A., Dowzer, C., McGrew, J., Byers, B., and Nasmyth, K. (1993). Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J. 12, 1969-1978.
36. Takebe, Y., Seiki, M., Fujisawa, J., Hoy, P., Yokota, K., Arai, K., Yoshida, M., and Arai, N. (1988). SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 8, 466-472.
37. Taylor, S.S., Ha, E., and McKeon, F. (1998). The human homologue of bub3 is required for kinetochore localization of bub1 and a Mad3/Bub1-related protein kinase. J. Cell Biol. 142, 1-11.
38. Taylor, S.S., and McKeon, F. (1997). Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 89, 727-735.
39. Waters, J.C., Chen, R.H., Murray, A.W., and Salmon, E.D. (1998). Localization of mad2 to kinetochores depends on microtubule attachment, not tension. J. Cell Biol. 141, 1181-1191.
40. Weiss, E., and Winey, M. (1996). The S. cerevisiae SPB duplication gene MPS1 is part of a mitotic checkpoint. J. Cell Biol. 132, 111-123.
41. Zachariae, W., and Nasmyth, K. (1996). TPR proteins required for anaphase progression mediate ubiquitination of mitotic B type cyclins in yeast. Mol. Biol. Cell 7, 791-801.