Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells

Carcinogenesis

Volumn 21, Issue 12, 2000, Pages 2293-2297

  Wang, Xianghong ^a   Jin, Dong Yan ^a   Wong, Y C ^a   Cheung, Annie L M ^a   Chun, Abel C S ^a   Lo, Angela K F ^a   Liu, Yu ^a   Tsao, Sai Wah ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMITOTIC AGENT; CELL CYCLE PROTEIN; CELL NUCLEUS DNA; PROTEIN MAD2;

ARTICLE; ASIA; CANCER INCIDENCE; CARCINOMA CELL; CELL CYCLE PARAMETERS; CELL NUCLEUS; CHROMOSOME ABERRATION; CONTROL SYSTEM; CONTROLLED STUDY; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MITOSIS INDEX; MITOSIS INHIBITION; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING;

EID: 0034518709     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.12.2293     Document Type: Article

References (28)

1. Epstein-Barr virus infection and the pathogenesis of nasopharyngeal carcinoma: Viral gene expression, tumour cell phenotype, and the role of the lymphoid stroma
2. Nasopharyngeal carcinoma research in Hong Kong in the past decade
3. Absence of p53 gene mutations in primary nasopharyngeal carcinomas
4. Nasopharyngeal carcinoma shows no detectable retinoblastoma susceptibility gene alterations
5. Cytogenetics of undifferentiated nasopharyngeal carcinoma xenografts from southern Chinese
6. Establishment of a cell line (NPC/HK1) from a differentiated squamous carcinoma of nasopharynx
7. Detection of recurrent chromosomal gains and losses in primary nasopharyngeal carcinoma by comparative genomic hybridisation
8. Genetic instabilities in human cancers
9. Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery
10. Mutations of mitotic checkpoint genes in human cancers
11. CDC, in human lung cancers
12. Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers
13. Identification of a human mitotic checkpoint gene: HsMAD2
14. Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells
15. Cisplatin-induced p53-independent growth arrest and cell death in cancer cells
16. Telomerase activation in nasopharyngeal carcinomas
17. Establishment of an epithelial cell line (CNE-2) from an NPC patient with poorly differentiated squamous cell carcinoma
18. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
19. Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5
20. A checkpoint on the road to cancer
21. Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis
22. Cell division gatekeeper identified
23. 2/M boundary without apoptosis, or unrestricted proliferation
24. Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines
25. Cytogenetic studies on an epithelial-cell line derived from poorly differentiated nasopharyngeal carcinoma
26. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
27. Waf1/Cip1/sid1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells
28. Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation