The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

Journal of Cell Biology

Volumn 142, Issue 1, 1998, Pages 1-11

  Taylor, Stephen S ^a   Ha, Edward ^a   McKeon, Frank ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Anaphase; Cell cycle; Checkpoint; hBub3; Mitosis

Indexed keywords

PROTEIN KINASE;

ANAPHASE; ANIMAL CELL; ARTICLE; CELL CYCLE; CELLULAR DISTRIBUTION; CENTROMERE; FEEDBACK SYSTEM; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL CYCLE PROTEINS; CELL LINE; CONSERVED SEQUENCE; CRICETINAE; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; HUMANS; KINETOCHORES; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN KINASES; PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SMAD3 PROTEIN; TRANS-ACTIVATORS;

EID: 0032514260     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.142.1.1     Document Type: Article

References (50)

1. Adams, M.D., A.R. Kerlavage, R.D. Fleischmann, R.A. Fuldner, C.J. Bull. N.H. Lee, E.F. Kirkness, K.G. Weinstock, J.D. Gocayne, O. White, et al. 1995. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Nature. 377(Suppl.): 3-174.
2. Altschul, S.F., W. Gish, W. Miller, E.W. Myers, and D.J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
3. Bharathi, A., A. Ghosh, W.A. Whalen, J.H. Yoon, R. Pu, M. Dasso, and R. Dhar. 1997. The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rael gene involved in nuclear export of Poly(A)+ RNA. Gene. 198:251-258.
4. Brown, J.A., A. Bharathi, A. Ghosh, W. Whalen, E. Fitzgerald, and R. Dhar. 1995. A mutation in the Schizosaccharomyces pombe rael gene causes defects in poly(A)+ RNA export and in the cytoskeleton. J. Biol. Chem. 270: 7411-7419.
5. Cahill, D.P., C. Lengauer, J. Yu, G.J. Riggins, J.K. Willson, S.D. Markowitz, K.W. Kinzler, and B. Vogelstein. 1998. Mutations of mitotic checkpoint genes in human cancers. Nature. 392:300-303.
6. Callan, H.G., and P.A. Jacobs. 1957. The meiolic process in Mantis Religiosa L. males. J. Genet. 55:200-217.
7. Campbell, M.S., and G.J. Gorbsky. 1995. Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase. J. Cell Biol. 129:1195-1204.
8. Chen, R.-H., J.C. Waters, E.D. Salmon, and A.W. Murray. 1996. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science. 274:242-246.
9. Cohen-Fix, O., J.M. Peters, M.W. Kirschner, and D. Koshland. 1996. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 10:3081-3093.
10. Dalrymple, M.A., S. Petersen-Bjorn, J.D. Friesen, and J.D. Beggs. 1989. The product of the PRP4 gene of S. cerevisiae shows homology to beta subunits of G proteins. Cell. 58:811-812.
11. Farr, K.A., and M.A. Hoyt. 1998. Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint. Mol. Cell. Biol. 18:2738-2747.
12. Funabiki, H., H. Yamano, K. Kumada, K. Nagao, T. Hunt, and M. Yanagida. 1996. Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature. 381:438-441.
13. Gorbsky, G.J., and W.A. Ricketts. 1993. Differential expression of a phosphoepitope at the kinetochores of moving chromosomes. J. Cell Biol. 122:1311-1321.
14. Hanks, S.K., and T. Hunter. 1995. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB (Fed. Am. Soc. Exp. Biol.) J. 9:576-596.
15. Hardwick, K.G., and A.W. Murray. 1995. Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131:709-720.
16. Hardwick, K.G., E. Weiss, F.C. Luca, M. Winey, and A.W. Murray. 1996. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science. 273:953-956.
17. Harwell, L.H., and T.A. Weinert. 1989. Checkpoints: controls that ensure the order of cell cycle events. Science. 246:629-634.
18. He, X., T.E. Patterson, and S. Sazer. 1997. The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. Proc. Natl. Acad. Sci. USA. 94:7965-7970.
19. Heald, R., M. McLoughlin, and F. McKeon. 1993. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell. 74:463-474.
20. Hoyt, M.A., L. Totis, and B.T. Roberts. 1991. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell. 66:507-517.
21. Hwang, L.H., L.F. Lau, D.L. Smith, C.A. Mistrot, K.G. Hardwick, E.S. Hwang, A. Amon, and A.W. Murray. 1998. Budding yeast cdc20: a target of the spindle checkpoint. Science. 279:1041-1044.
22. Irniger, S., S. Piatti, C. Michaelis, and K. Nasmyth. 1995. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell. 81:269-278.
23. Juang, Y.L., J. Huang, J.M. Peters, M.E. McLaughlin, C.Y. Tai, and D. Pellman. 1997. APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science. 275:1311-1314.
24. Kim, S.H., D.P. Lin, S. Matsumoto, A. Kitazono, and T. Matsumoto. 1998. Fission yeast slp1: an effector of the Mad2-dependent spindle checkpoint. Science. 279:1045-1047.
25. King, R.W., J.M. Peters, S. Tugendreich, M. Rolfe, P. Hieter, and M.W. Kirschner. 1995. A 20S complex containing CDC27 and CDC26 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell. 81:279-288.
26. Li, R., and A.W. Murray. 1991. Feedback control of mitosis in budding yeast. Cell. 66:519-531.
27. Li, X., and R.B. Nicklas. 1995. Mitotic forces control a cell-cycle checkpoint. Nature. 373:630-632.
28. Li, X., and R.B. Nicklas. 1997. Tension-sensitive kinetochore phosphorylation and the chromosome distribution checkpoint in praying mantid spermatocytes. J. Cell Sci. 110:537-545.
29. Li, Y., and R. Benezra. 1996. Identification of a human mitotic checkpoint gene: hsMAD2. Science. 274:246-248.
30. Li, Y., C. Gorbea, D. Mahaffey, M. Rechsteiner, and R. Benezra. 1997. MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity. Proc. Natl. Acad. Sci. USA. 94:12431-12436.
31. Murphy, R., J.L. Watkins, and S.R. Wente. 1996. GLE2, a Sacchoromyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and function. Mol. Biol. Cell. 7:1921-1937.
32. Neer, E.J., C.J. Schmidt, R. Nambudripad, and T.F. Smith. 1994. The ancient regulatory-protein family of WD-repeat proteins. Nature. 371:297-300.
33. Nicklas, R.B. 1997. How cells get the right chromosomes. Science. 275:632-637.
34. Nicklas, R.B., and C.A. Koch. 1969. Chromosome manipulation III: induced reorientation and the experimental control of segregation in meiosis. J. Cell Biol. 43:40-50.
35. Nicklas, R.B., S.C. Ward, and G.J. Gorbsky. 1995. Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint. J. Cell Biol. 130:929-939.
36. Pangilinan, F., and F. Spencer. 1996. Abnormal kinetochore structure activates the spindle assembly checkpoint in budding yeast. Mol. Cell. Biol. 7:1195-1208.
37. Rieder, C.L., A. Schultz, R. Cole, and G. Sluder. 1994. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J. Cell Biol. 127:1301-1310.
38. Rieder, C.L., R.W. Cole, A. Khodjakov, and G. Sluder. 1995. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J. Cell Biol. 130:941-948.
39. Roberts, B.T., K.A. Farr, and M.A. Hoyt. 1994. The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol. Cell. Biol. 14: 8282-8291.
40. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. 545 pp.
41. Sudakin, V., D. Ganoth, A. Dahan, H. Heller, J. Hersko, F. Luca, J.V. Ruderman, and A. Hershko. 1995. The cyclosome, a large complex containing cyclin-selective ubiquitination ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell. 6:185-198.
42. Taylor, S.S., and F. McKeon. 1997. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell. 89:727-735.
43. Tugendreich, S., J. Tomkiel, W. Earnshaw, and P. Hieter. 1995. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Cell. 81:261-268.
44. Visintin, R., S. Prinz, and A. Amon. 1997. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science. 278:460-463.
45. Wang, Y., and D.J. Burke. 1995. Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 15:6838-6844.
46. Weiss, E., and M. Winey. 1996. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J. Cell Biol. 132:111-123.
47. Wells, W.A.E., and A.W. Murray. 1996. Aberrantly segregating centromeres activate the spindle assembly checkpoint in budding yeast. J. Cell Biol. 133:75-84.
48. Yoon, J.H., W.A. Whalen, A. Bharathi, R. Shen, and R. Dhar. 1997. Npp106p, a Schizosaccharomyces pombe nucleoporin similar to Saccharomyces cerevisiae Nic96p, functionally interacts with Rae1p in mRNA export. Mol. Cell. Biol. 17:7047-7060.
49. Zirkle, R.E. 1970a. Ultraviolet-microbeam irradiation of newt-cell cytoplasm: spindle destruction, false anaphase and delay of true anaphase. Radiat. Res. 41:516-537.
50. Zirkle, R.E. 1970b. Involvement of the prometaphase kinetochore in prevention of precocious anaphase. J. Cell Biol. 47:235a.