Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

Journal of Cell Biology

Volumn 146, Issue 5, 1999, Pages 941-954

  Chan, G K T ^a   Jablonski, S A ^a   Sudakin, V ^a   Hittle, J C ^a   Yen, T J ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

Anaphase promoting complex; CENP E; HBUBR1; Kinetochore; Mitotic checkpoint

Indexed keywords

NOCODAZOLE; PROTEIN KINASE;

ANAPHASE; ARTICLE; CELL CYCLE; CENTROMERE; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANAPHASE; APOPTOSIS; CELL CYCLE PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOMES, HUMAN; ENZYME ACTIVATION; GENE EXPRESSION; HELA CELLS; HUMANS; K562 CELLS; KINETOCHORES; LIGASES; METAPHASE; MITOSIS; MITOTIC SPINDLE APPARATUS; NOCODAZOLE; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN KINASES; SEQUENCE DELETION; UBIQUITIN-PROTEIN LIGASE COMPLEXES; UBIQUITIN-PROTEIN LIGASES;

EID: 0032846338     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.146.5.941     Document Type: Article

References (45)

1. Basu, J., E. Logarinho, S. Herrmann, H. Bousbaa, Z. Li, G.K. Chan, T.J. Yen, C.E. Sunkel, and M.L. Goldberg. 1998. Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Buh1 but not Zw10 or Rod. Chromosoma. 107:376-385.
2. Cahill, D.P., C. Lengauer, J. Yu, G.J. Riggins, J.K. Willson, S.D. Markowitz, K.W. Kinzler, and B. Vogelstein. 1998. Mutations of mitotic checkpoint genes in human cancers. Nature. 392:300-303.
3. Chan, G.K.T., B.T. Schaar, and T.J. Yen. 1998. Characterization of the kinetochore-binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. J. Cell Biol. 143:49-63.
4. Chen, R.H., J.C. Waters, E.D. Salmon, and A.W. Murray. 1996. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science. 274:242-246.
5. Chen, R.H., A. Shevchenko, M. Mann, and A.W. Murray. 1998. Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores. J. Cell Biol. 143:283-295.
6. Dawson, I.A., S. Roth, and S. Artavanis-Tsakonas. 1995. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J. Cell Biol. 129:725-737.
7. Fang, G., H. Yu, and M.W. Kirschner. 1998. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev. 12:1871-1883.
8. Gately, D.P., J.C. Hittle, G.K.T. Chan, and T.J. Yen. 1998. Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity. Mol. Biol. Cell. 9:2361-2374.
9. Gorbsky, G.J., R.H. Chen, and A.W. Murray. 1998. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase. J. Cell Biol. 141:1193-1205.
10. Hanks, S.K., and A.M. Quinn. 1991. Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol. 200:38-62.
11. Hardwick, K.G., and A.W. Murray. 1995. Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131:709-720.
12. Hershko, A., and A. Ciechanover. 1998. The ubiquilin system. Annu. Rev. Biochem. 67:425-479.
13. Hoyt, M.A., L. Totis, and B.T. Roberts. 1991. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell. 66:507-517.
14. Hunter, T. 1987. A thousand and one protein kinases. Cell. 50:823-829.
15. Hwang, L.H., L.F. Lau, D.L. Smith, C.A. Mistrot, K.G. Hardwick, E.S. Hwang, A. Amon. and A.W. Murray. 1998. Budding yeast Cdc20: a target of the spindle checkpoint. Science. 279:1041-1044.
16. Inoue, S., and E.D. Salmon. 1995. Force generation by microtubule assembly/ disassembly in mitosis and related movements. Mol. Biol. Cell. 6:1619-1640.
17. Jablonski, S.A., G.K.T. Chan, C.A. Cooke, W.C. Earnshaw, and T.J. Yen. 1998. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. Chromasoma. 107:386-396.
18. Jin, D.Y., F. Spencer, and K.T. Jeang. 1998. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell. 93:81-91.
19. Kallio, M., J. Weinstein, J.R. Daum, D.J. Burke, and G.J. Gorbsky. 1998. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J. Cell Biol. 141:1393-1406.
20. Kim, S.H., D.P. Lin, S. Matsumoto, A. Kitazono, and T. Matsumoto. 1998. Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint. Science. 279:1045-1047.
21. King, R.W., R.J. Deshaies, J.M. Peters, and M.W. Kirschner. 1996. How proteolysis drives the cell cycle. Science. 274:1652-1659.
22. Li, R., and A.W. Murray. 1991. Feedback control of mitosis in budding yeast. Cell. 66:519-531.
23. Li, X., and R.B. Nicklas. 1995. Mitotic forces control a cell-cycle checkpoint. Nature. 373:630-632.
24. Li, Y., and R. Benezra. 1996. Identification of a human mitotic checkpoint gene: hsMAD2. Science. 274:246-248.
25. Li, Y., C. Gorbea, D. Mahaffey, M. Rechsteiner, and R. Benezra. 1997. MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity. Proc. Natl. Acad. Sci. USA. 94:12431-12436.
26. Nicklas, R.B. 1997. How cells get the right chromosomes. Science. 275:632-637.
27. Rattner, J.B., J. Lew, and J.H. Wang. 1990. p.34cdc2 kinase is localized to distinct domains within the mitotic apparatus. Cell Motil. Cytoskeleton. 17:227-235.
28. Rieder, C.L., and E.D. Salmon. 1998. The vertebrate cell kinetochore and its roles during mitosis. Trends Cell Biol. 8:310-318.
29. Rieder, C.L., A. Schultz, R. Cole, and G. Sluder. 1994. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle. J. Cell Biol. 127:1301-1310.
30. Rieder, C.L., R.W. Cole, A. Khodjakov, and G. Sluder. 1995. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J. Cell Biol. 130:941-948.
31. Roberts, B.T., K.A. Farr, and M.A. Hoyt. 1994. The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol. Cell. Biol. 14: 8282-8291.
32. Schaar, B.T., G.K.T. Chan, P. Maddox, E.D. Salmon, and T.J. Yen. 1997. CENP-E function at kinetochores is essential for chromosome alignment. J. Cell Biol. 139:1373-1382.
33. Shapiro, P.S., E. Vaisberg, A.J. Hunt, N.S. Tolwinski, A.M. Whalen, J.R. McIntosh, and N.G. Ahn. 1998. Activation of the MKK/ERK pathway during somalic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen. J. Cell Biol. 142:1533-1545.
34. Sudakin, V., D. Ganoth, A. Dahan, H. Heller, J. Hershko, F.C. Luca, J.V. Ruderman, and A. Hershko. 1995. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell. 6:185-197.
35. Taylor, S.S., and F. McKeon. 1997. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell. 89:727-735.
36. Taylor, S.S., E. Ha, and F. McKeon. 1998. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. J. Cell Biol. 142:1-11.
37. Tugendreich, S., J. Tomkiel, W. Earnshaw, and P. Hieter. 1995. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Cell. 81:261-268.
38. Visintin, R., S. Prinz, and A. Amon. 1997. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science. 278:460-463.
39. Waters, J.C., R.H. Chen, A.W. Murray, and E.D. Salmon. 1998. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J. Cell Biol. 141:1181-1191.
40. Weinstein, J. 1997. Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc. A mammalian homolog of CDC20/Fizzy/slp1. J. Biol. Chem. 272:28501-28511.
41. Weiss, E., and M. Winey. 1996. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J. Cell Biol. 132:111-123.
42. Wood, K.W., R. Sakowicz, L.S. Goldstein, and D.W. Cleveland. 1997. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Cell. 91:357-366.
43. Yen, T.J., and B.T. Schaar. 1996. Kinetochore function: molecular motors, switches and gates. Curr. Opin. Cell Biol. 8:381-388.
44. Yu, H., J.M. Peters, R.W. King, A.M. Page, P. Hieter, and M.W. Kirschner. 1998. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science. 279:1219-1222.
45. Zecevic, M., A.D. Catling, S.T. Eblen, L. Renzi, J.C. Hittle, T.J. Yen, G.J. Gorbsky, and M.J. Weber. 1998. Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E. J. Cell Biol. 142:1547-1558.