BubR1 is essential for kinetochore localization of other spindle checkpoint proteins and its phosphorylation requires Mad1

Journal of Cell Biology

Volumn 158, Issue 3, 2002, Pages 487-496

  Chen, Rey Huei ^a  

^a Department of Population Medicine and Diagnostic Sciences   (United States)

Author keywords

Bub1; BubR1; Mad1; Spindle checkpoint; Xenopus

Indexed keywords

BUB1 RELATED PROTEIN; BUB3 PROTEIN; CELL CYCLE PROTEIN 20; PROTEIN; PROTEIN BUB1; PROTEIN CENPE; PROTEIN MAD1; PROTEIN MAD2; UNCLASSIFIED DRUG;

ANAPHASE; ANIMAL CELL; ARTICLE; CENTROMERE; CONTROLLED STUDY; ENZYME ACTIVITY; MITOSIS INHIBITION; MITOSIS SPINDLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; XENOPUS;

ANIMALS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELLS, CULTURED; CHROMOSOMAL PROTEINS, NON-HISTONE; EUKARYOTIC CELLS; FEMALE; FUNGAL PROTEINS; GENES, CDC; KINETOCHORES; MITOTIC SPINDLE APPARATUS; MOLECULAR WEIGHT; NUCLEAR PROTEINS; OOCYTES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; XENOPUS LAEVIS;

ANIMALIA;

EID: 0036322225     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200204048     Document Type: Article

References (34)

1. Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint
2. The spindle checkpoint
3. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
4. Mutations of mitotic checkpoint genes in human cancers
5. Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
6. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
7. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
8. Spindle checkpoint protein Xmadl recruits Xmad2 to unattached kinetochores
9. The spindle checkpoint requires Mad1-bound and Mad1-free Mad2
10. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
11. Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint
12. Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores
13. Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
14. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption
15. MAD3 encodes a novel component of the spindle checkpoint that interacts with Bub3p, Cdc20p, and Mad2p
16. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells
17. Budding yeast Cdc20: A target of the spindle checkpoint
18. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis
19. Fission yeast Slp1: An effector of the Mad2-dependent spindle checkpoint
20. Mitotic forces control a cell cycle checkpoint
21. Identification of a human mitotic checkpoint gene: HsMAD2
22. Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner
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24. Cell cycle extracts
25. The anaphase-promoting complex: New subunits and regulators
26. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
27. Waiting for anaphase: Mad2 and the spindle assembly checkpoint
28. Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity
29. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
30. Mad2-independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1
31. The human homologue of bub3 is required for kinetochore localization of bub1 and a Mad3/Bub1-related protein kinase
32. Localization of mad2 to kinetochores depends on microtubule attachment, not tension
33. The S. cerevisiae SPB duplication gene MPS1 is part of a mitotic checkpoint
34. Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: Model for spindle checkpoint regulation