Significance of MAD2 expression to mitotic checkpoint control in ovarian cancer cells

Cancer Research

Volumn 62, Issue 6, 2002, Pages 1662-1668

  Wang, Xianghong ^a   Jin, Dong Yan ^a   Ng, Raymond W M ^a   Feng, Huichen ^a   Wong, Yong C ^a   Cheung, Annie L M ^a   Tsao, Sai W ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; BRCA1 PROTEIN; BRCA2 PROTEIN; DNA; NOCODAZOLE; PONASTERONE A; PROTEIN MAD2;

ARTICLE; CANCER CELL; CELL CYCLE; CHROMOSOME; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOSIS; OVARY CANCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CALCIUM-BINDING PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; FEMALE; HUMANS; MITOSIS; OVARIAN NEOPLASMS; PLASMIDS; REPRESSOR PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037085936     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Genetic instabilities in human cancers
2. The spindle assembly checkpoint
3. Mitotic checkpoints: From yeast to cancer
4. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
5. Feedback control of mitosis in budding yeast
6. Identification of a human mitotic checkpoint gene: hsMAD2
7. Kinetochore localization of murine Buhl is required for normal mitotic timing and checkpoint response to spindle damage
8. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
9. Mitotic checkpoint locus MADIL1 maps to human chromosome 7p22 and mouse chromosome 5
10. The spindle checkpoint
11. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
12. Spindle checkpoint protein bubl is required for kinetochore localization of mad1, mad2, bub3, and cenp-e, independently of its kinase activity
13. Cell division gatekeepers identified
14. A checkpoint on the road to cancer
15. Waiting for anaphase: Mad2 and the spindle assembly checkpoint
16. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase
17. The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins
18. MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p
19. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
20. Budding yeast Cdc20: A target of the spindle checkpoint
21. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events
22. Fission yeast Stp1: An effector of the Mad2-dependent spindle checkpoint
23. Mad2 transiently associates with an APC/p55Cdc complex during mitosis
24. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
25. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
26. Mutations of mitotic checkpoint genes in human cancers
27. Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers
28. Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells
29. Molecular analyses of the mitotic checkpoint components hsMAD2, hBUB1 and hBUB3 in human cancer
30. Expression and mutational analyses of the human MAD2L1 gene in breast cancer cells
31. Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers
32. Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers
33. Genetic analysis of benign, low-grade, and high-grade ovarian tumors
34. Comparative genomic hybridization detects frequent overrepresentation of chromosomal material from 3q26, 8q24, and 20q13 in human ovarian carcinomas
35. Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer
36. Whole genome amplification and high-throughput allelotyping identified five distinct deletion regions on chromosomes 5 and 6 in microdissected early-stage ovarian tumors
37. Altered expression of BRCAI, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines
38. The outcome of heregulin-induced activation of ovarian cancer cells depends on the relative levels of HER-2 and HER-3 expression
39. Ecdysone-inducible gene expression in mammalian cells and transgenic mice
40. Comparative genomic hybridization detects genetic imbalances in primary ovarian carcinomas as correlated with grade of differentiation
41. When checkpoints fail
42. Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage
43. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
44. Dioxin suppresses the checkpoint protein, MAD2, by an aryl hydrocarbon receptor-independent pathway