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Volumn 12, Issue 12, 1998, Pages 1871-1883

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

Author keywords

Anaphase initiation; Anaphase promoting complex; CDC20; CDH1; MAD2; Spindle assembly checkpoint

Indexed keywords

ANAPHASE; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DIVISION; CONTROLLED STUDY; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; XENOPUS;

EID: 0032525783     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.12.1871     Document Type: Article
Times cited : (503)

References (48)
  • 1
    • 0031011234 scopus 로고    scopus 로고
    • Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast
    • Amon, A. 1997. Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast. EMBO J. 16: 2693-2702.
    • (1997) EMBO J. , vol.16 , pp. 2693-2702
    • Amon, A.1
  • 2
    • 0028240049 scopus 로고
    • Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle
    • Amon, A., S. Irniger, and K. Nasmyth. 1994. Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. Cell 77: 1037-1050.
    • (1994) Cell , vol.77 , pp. 1037-1050
    • Amon, A.1    Irniger, S.2    Nasmyth, K.3
  • 3
    • 0029789637 scopus 로고    scopus 로고
    • The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase
    • Brandeis, M. and T. Hunt. 1996. The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase. EMBO J. 15: 5280-5289.
    • (1996) EMBO J. , vol.15 , pp. 5280-5289
    • Brandeis, M.1    Hunt, T.2
  • 4
    • 0029845891 scopus 로고    scopus 로고
    • Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
    • Chen, R.H., J.C. Waters, E.D. Salmon, and A.W. Murray. 1996. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science 274: 242-246.
    • (1996) Science , vol.274 , pp. 242-246
    • Chen, R.H.1    Waters, J.C.2    Salmon, E.D.3    Murray, A.W.4
  • 5
    • 0028881986 scopus 로고
    • Regulation of the appearance of division asynchrony and microtubule-dependent chromosome cycles in Xenopus laevis embryos
    • Clute, P. and Y. Masui. 1995. Regulation of the appearance of division asynchrony and microtubule-dependent chromosome cycles in Xenopus laevis embryos. Dev. Biol. 171: 273-285.
    • (1995) Dev. Biol. , vol.171 , pp. 273-285
    • Clute, P.1    Masui, Y.2
  • 6
    • 0031149419 scopus 로고    scopus 로고
    • Microtubule dependence of chromosome cycles in Xenopus laevis blastomeres under the influence of a DNA synthesis inhibitor, aphidicolin
    • _. 1997. Microtubule dependence of chromosome cycles in Xenopus laevis blastomeres under the influence of a DNA synthesis inhibitor, aphidicolin. Dev. Biol. 185: 1-13.
    • (1997) Dev. Biol. , vol.185 , pp. 1-13
  • 7
    • 0030448251 scopus 로고    scopus 로고
    • Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pdslp
    • Cohen-Fix, O., J.-M. Peters, M.W. Kirschner, and D. Koshland. 1996. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pdslp. Genes & Dev. 10: 3081-3093.
    • (1996) Genes & Dev. , vol.10 , pp. 3081-3093
    • Cohen-Fix, O.1    Peters, J.-M.2    Kirschner, M.W.3    Koshland, D.4
  • 8
    • 0028958186 scopus 로고
    • The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins a and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae
    • Dawson, I.A., S. Roth, and T.S. Artavanis. 1995. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J. Cell Biol. 129: 725-737.
    • (1995) J. Cell Biol. , vol.129 , pp. 725-737
    • Dawson, I.A.1    Roth, S.2    Artavanis, T.S.3
  • 9
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints - Preventing an identity crisis
    • Elledge, S.J. 1996. Cell cycle checkpoints - preventing an identity crisis. Science 274: 1664-1672.
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 10
    • 0030013594 scopus 로고    scopus 로고
    • Cut2 proteolysis required for sister-chromatid separation in fission yeast
    • Funabiki, H., H. Yamano, K. Kumada, K. Nagao, T. Hunt, and M. Yanagida. 1996. Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature 381: 438-441.
    • (1996) Nature , vol.381 , pp. 438-441
    • Funabiki, H.1    Yamano, H.2    Kumada, K.3    Nagao, K.4    Hunt, T.5    Yanagida, M.6
  • 11
    • 0026089183 scopus 로고
    • Cyclin is degraded by the ubiquitin pathway
    • Glotzer, M., A.W. Murray, and M.W. Kirschner. 1991. Cyclin is degraded by the ubiquitin pathway. Nature 349: 132-138.
    • (1991) Nature , vol.349 , pp. 132-138
    • Glotzer, M.1    Murray, A.W.2    Kirschner, M.W.3
  • 12
    • 0028842802 scopus 로고
    • Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
    • Hardwick, K.G. and A.W. Murray. 1995. Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131: 709-720.
    • (1995) J. Cell Biol. , vol.131 , pp. 709-720
    • Hardwick, K.G.1    Murray, A.W.2
  • 13
    • 0029791321 scopus 로고    scopus 로고
    • Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption
    • Hardwick, K.G., E. Weiss, F.C. Luca, M. Winey, and A.W. Murray. 1996. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science 273: 953-956.
    • (1996) Science , vol.273 , pp. 953-956
    • Hardwick, K.G.1    Weiss, E.2    Luca, F.C.3    Winey, M.4    Murray, A.W.5
  • 14
    • 0003448569 scopus 로고
    • Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
    • Harlow, E. and D. Lane. 1988. Antibodies: A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
    • (1988) Antibodies: A Laboratory Manual
    • Harlow, E.1    Lane, D.2
  • 15
    • 0030794972 scopus 로고    scopus 로고
    • The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex
    • He, X., T.E. Patterson, and S. Sazer. 1997. The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. Proc. Natl. Acad. Sci. 94: 7965-7970.
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 7965-7970
    • He, X.1    Patterson, T.E.2    Sazer, S.3
  • 16
    • 0027319328 scopus 로고
    • Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor
    • Holloway, S.L., M. Glotzer, R.W. King, and A.W. Murray. 1993. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell 73: 1393-1402.
    • (1993) Cell , vol.73 , pp. 1393-1402
    • Holloway, S.L.1    Glotzer, M.2    King, R.W.3    Murray, A.W.4
  • 17
    • 0025941405 scopus 로고
    • S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
    • Hoyt, M.A., L. Totis, and B.T. Roberts. 1991. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 66: 507-517.
    • (1991) Cell , vol.66 , pp. 507-517
    • Hoyt, M.A.1    Totis, L.2    Roberts, B.T.3
  • 19
    • 0029033504 scopus 로고
    • Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast
    • Irniger, S., S. Piatti, C. Michaelis, and K. Nasmyth. 1995. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell 81: 269-277.
    • (1995) Cell , vol.81 , pp. 269-277
    • Irniger, S.1    Piatti, S.2    Michaelis, C.3    Nasmyth, K.4
  • 20
    • 0032478547 scopus 로고    scopus 로고
    • Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
    • Jin, D.Y., Spencer, F., and K.T. Jeang. 1998. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93: 81-91.
    • (1998) Cell , vol.93 , pp. 81-91
    • Jin, D.Y.1    Spencer, F.2    Jeang, K.T.3
  • 21
    • 2642684539 scopus 로고    scopus 로고
    • A subunit of the anaphase-promoting complex is a centromere-associated protein in mammalian cells
    • Jorgensen, P.M., E. Brundell, M. Starborg, and C. Höög. 1998. A subunit of the anaphase-promoting complex is a centromere-associated protein in mammalian cells. Mol Cell. Biol 18: 468-476.
    • (1998) Mol Cell. Biol , vol.18 , pp. 468-476
    • Jorgensen, P.M.1    Brundell, E.2    Starborg, M.3    Höög, C.4
  • 22
    • 0000273639 scopus 로고    scopus 로고
    • Fission yeast Slp1: An effector of the Mad2-dependent spindle checkpoint
    • Kim, S.H., D.P. Lin, S. Matsumoto, A. Kitazono, and T. Matsumoto. 1998. Fission yeast Slp1: An effector of the Mad2-dependent spindle checkpoint. Science 279: 1045-1047.
    • (1998) Science , vol.279 , pp. 1045-1047
    • Kim, S.H.1    Lin, D.P.2    Matsumoto, S.3    Kitazono, A.4    Matsumoto, T.5
  • 23
    • 0029004815 scopus 로고
    • A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
    • King, R.W., J.M. Peters, S. Tugendreich, M. Rolfe, P. Hieter, and M.W. Kirschner. 1995. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81: 279-288.
    • (1995) Cell , vol.81 , pp. 279-288
    • King, R.W.1    Peters, J.M.2    Tugendreich, S.3    Rolfe, M.4    Hieter, P.5    Kirschner, M.W.6
  • 24
    • 0029787091 scopus 로고    scopus 로고
    • Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates
    • King, R.W., M. Glotzer, and M.W. Kirschner. 1996. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Mol. Biol. Cell 7: 1343-1357.
    • (1996) Mol. Biol. Cell , vol.7 , pp. 1343-1357
    • King, R.W.1    Glotzer, M.2    Kirschner, M.W.3
  • 25
    • 0029075883 scopus 로고
    • Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase
    • Lahav-Baratz, S., V. Sudakin, J.V. Ruderman, and A. Hershko. 1995. Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. Proc. Natl. Acad. Sci. 92: 9303-9307.
    • (1995) Proc. Natl. Acad. Sci. , vol.92 , pp. 9303-9307
    • Lahav-Baratz, S.1    Sudakin, V.2    Ruderman, J.V.3    Hershko, A.4
  • 26
    • 0026009964 scopus 로고
    • Feedback control of mitosis in budding yeast
    • Li, R. and A.W. Murray. 1991. Feedback control of mitosis in budding yeast. Cell 66: 519-531.
    • (1991) Cell , vol.66 , pp. 519-531
    • Li, R.1    Murray, A.W.2
  • 27
    • 10244251532 scopus 로고    scopus 로고
    • Identification of a human mitotic checkpoint gene: HsMAD2
    • Li, Y. and R. Benezra. 1996. Identification of a human mitotic checkpoint gene: hsMAD2. Science 274: 246-248.
    • (1996) Science , vol.274 , pp. 246-248
    • Li, Y.1    Benezra, R.2
  • 28
    • 0030730855 scopus 로고    scopus 로고
    • MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity
    • Li, Y., C. Gorbea, D. Mahaffey, M. Rechsteiner, and R. Benezra. 1997. MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity. Proc. Natl. Acad. Sci. 94: 12431-12436.
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 12431-12436
    • Li, Y.1    Gorbea, C.2    Mahaffey, D.3    Rechsteiner, M.4    Benezra, R.5
  • 29
    • 0031038678 scopus 로고    scopus 로고
    • A fission yeast homolog of CDC20/ p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2
    • Matsumoto, T. 1997. A fission yeast homolog of CDC20/ p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2. Mol Cell. Biol. 17: 742-750.
    • (1997) Mol Cell. Biol. , vol.17 , pp. 742-750
    • Matsumoto, T.1
  • 30
    • 0028134981 scopus 로고
    • A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts
    • Minshull, J., H. Sun, N.K. Tonks, and A.W. Murray. 1994. A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts. Cell 79: 475-486.
    • (1994) Cell , vol.79 , pp. 475-486
    • Minshull, J.1    Sun, H.2    Tonks, N.K.3    Murray, A.W.4
  • 31
  • 32
    • 0028962292 scopus 로고
    • The genetics of cell cycle checkpoints
    • _. 1995. The genetics of cell cycle checkpoints. Curr. Opin. Genet. Dev. 5: 5-11.
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 5-11
  • 33
    • 14444267778 scopus 로고    scopus 로고
    • How cells get the right chromosomes
    • Nicklas, R.B. 1997. How cells get the right chromosomes. Science 275: 632-637.
    • (1997) Science , vol.275 , pp. 632-637
    • Nicklas, R.B.1
  • 34
    • 0025240329 scopus 로고
    • Radiolabeling of proteins
    • Parker, C.W. 1990. Radiolabeling of proteins. Methods Enzymol. 182: 721-737.
    • (1990) Methods Enzymol. , vol.182 , pp. 721-737
    • Parker, C.W.1
  • 35
    • 0029909251 scopus 로고    scopus 로고
    • Identification of BIME as a subunit of the anaphase-promoting complex
    • Peters, J.-M., R.W. King, C. Höög, and M.W. Kirschner. 1996. Identification of BIME as a subunit of the anaphase-promoting complex. Science 274: 1199-1201.
    • (1996) Science , vol.274 , pp. 1199-1201
    • Peters, J.-M.1    King, R.W.2    Höög, C.3    Kirschner, M.W.4
  • 37
    • 0030738748 scopus 로고    scopus 로고
    • Yeast Hct1 is a regulator of Clb2 cyclin proteolysis
    • Schwab, M., A.S. Lutum, and W. Seufert. 1997. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell 90: 683-693.
    • (1997) Cell , vol.90 , pp. 683-693
    • Schwab, M.1    Lutum, A.S.2    Seufert, W.3
  • 38
    • 0030835478 scopus 로고    scopus 로고
    • Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles
    • Sigrist, S.J. and C.F. Lehner. 1997. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell 90: 671-681.
    • (1997) Cell , vol.90 , pp. 671-681
    • Sigrist, S.J.1    Lehner, C.F.2
  • 39
    • 0029025606 scopus 로고
    • The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis
    • Sudakin, V., D. Ganoth, A. Dahan, H. Heller, J. Hershko, F.C. Luca, J.V. Ruderman, and A. Hershko. 1995. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6: 185-198.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 185-198
    • Sudakin, V.1    Ganoth, D.2    Dahan, A.3    Heller, H.4    Hershko, J.5    Luca, F.C.6    Ruderman, J.V.7    Hershko, A.8
  • 40
    • 0030687987 scopus 로고    scopus 로고
    • Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
    • Taylor, S.S. and F. McKeon. 1997. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 89: 727-735.
    • (1997) Cell , vol.89 , pp. 727-735
    • Taylor, S.S.1    McKeon, F.2
  • 41
    • 0029028237 scopus 로고
    • The CDC27HS protein co-localizes with the CDC16HS protein to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transtion
    • Tugendreich, S., J. Tomkiel, W. Earnshaw, and P. Hieter. 1995. The CDC27HS protein co-localizes with the CDC16HS protein to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transtion. Cell 81: 261-268.
    • (1995) Cell , vol.81 , pp. 261-268
    • Tugendreich, S.1    Tomkiel, J.2    Earnshaw, W.3    Hieter, P.4
  • 42
    • 0030693087 scopus 로고    scopus 로고
    • CDC20 and CDH1 - A family of substrate-specific activators of APC-dependent proteolysis
    • Visintin, R., S. Prinz, and A. Amon. 1997. CDC20 and CDH1 - a family of substrate-specific activators of APC-dependent proteolysis. Science 278: 460-463.
    • (1997) Science , vol.278 , pp. 460-463
    • Visintin, R.1    Prinz, S.2    Amon, A.3
  • 43
    • 0031046069 scopus 로고    scopus 로고
    • Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae
    • Wang, Y. and D.J. Burke. 1997. Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Mol. Cell. Biol. 17: 620-626.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 620-626
    • Wang, Y.1    Burke, D.J.2
  • 44
    • 0030679670 scopus 로고    scopus 로고
    • Cell cycle-regulated expression, phosphorylation, and degradation of p55CDC. A mammalian homolog of CDC20/Fizzy/slp1
    • Weinstein, J. 1997. Cell cycle-regulated expression, phosphorylation, and degradation of p55CDC. A mammalian homolog of CDC20/Fizzy/slp1. J. Biol. Chem. 272: 28501-28511.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28501-28511
    • Weinstein, J.1
  • 45
    • 0028256410 scopus 로고
    • A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4
    • Weinstein, J., F.W. Jacobsen, C.J. Hsu, T. Wu, and L.G. Baum. 1994. A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4. Mol. Cell. Biol. 14: 3350-3363.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3350-3363
    • Weinstein, J.1    Jacobsen, F.W.2    Hsu, C.J.3    Wu, T.4    Baum, L.G.5
  • 46
    • 0030725561 scopus 로고    scopus 로고
    • A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes
    • Yamaguchi, S., H. Murakami, and H. Okayama. 1997. A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes. Mol. Biol. Cell 8: 2475-2486.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 2475-2486
    • Yamaguchi, S.1    Murakami, H.2    Okayama, H.3
  • 47
    • 0029997447 scopus 로고    scopus 로고
    • Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae
    • Yamamoto, A., V. Guacci, and D. Koshland. 1996a. Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae. J. Cell Biol 133: 85-97.
    • (1996) J. Cell Biol , vol.133 , pp. 85-97
    • Yamamoto, A.1    Guacci, V.2    Koshland, D.3
  • 48
    • 0029960782 scopus 로고    scopus 로고
    • Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s)
    • _. 1996b. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s). J. Cell Biol. 133: 99-110.
    • (1996) J. Cell Biol. , vol.133 , pp. 99-110


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