BUBR1 phosphorylation is regulated during mitotic checkpoint activation

Cell Growth and Differentiation

Volumn 10, Issue 11, 1999, Pages 769-775

  Li, Wenqing ^a   Lan, Zhengdao ^a   Wu, Huiyun ^a   Wu, Shechao ^a   Meadows, Juliana ^a   Chen, Jie ^a   Zhu, Veronica ^a   Dai, Wei ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOCODAZOLE; PHOSPHATASE; PROTEIN KINASE;

ARTICLE; AUTOPHOSPHORYLATION; CELL ACTIVATION; CELL CYCLE; CONTROLLED STUDY; ENZYME ACTIVATION; EUKARYOTIC CELL; GENE DISRUPTION; HUMAN; HUMAN CELL; MITOSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

CELL CYCLE PROTEINS; DNA, COMPLEMENTARY; G1 PHASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; MITOSIS; PHOSPHORYLATION; PROTEIN KINASES; RNA, MESSENGER; TRANSFECTION;

EUKARYOTA;

EID: 0032694402     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Elledge, S. J. Cell cycle checkpoints: preventing an identity crisis. Science (Washington DC), 274: 1664-1672, 1996.
2. Paulovich, A. G., Toczyski, P. P., and Hartwell, L. H. When checkpoints fail. Cell, 88: 315-321, 1997.
3. Hoyt, M. A., Totis, L., and Roberts, B. T. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell, 66: 507-517, 1991.
4. Li, R., and Murray A. W. Feedback control of mitosis in budding yeast. Cell, 66: 519-531, 1991.
5. Weiss, E., and Winey, M. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J. Cell Biol., 132: 111-123, 1996.
6. Jin, D. Y., Spencer, F., and Jeang, K-T. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell, 93: 81-91, 1998.
7. Li, Y., and Benezra, R. Identification of a human mitotic checkpoint gene: hsMAD2. Science (Washington DC), 274: 246-248, 1996.
8. Taylor, S. S., and McKeon, F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell, 89: 727-735, 1997.
9. Cahill, D. P., Lengauer, C., Yu, J., Riggins, G. J., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W., and Vogelstein, B. Mutations of mitotic checkpoint genes in human cancers. Nature (Lond.), 392: 300-303, 1998.
10. Li, Y., Gorbea, C., Mahaffey, D., Rachsteiner, M., and Benezra, R. MAD2 associates with the cyclosome/anaphase promoting complex and inhibits its activity. Proc. Natl. Acad. Sci. USA, 94: 12431-12436, 1997.
11. Gorbsky, G. J., Chen, R-H., and Murray, A. W. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase. J. Cell Biol., 141: 1193-1205, 1998.
12. Ouyang, B., Lan, Z., Meadows, J., Pan, H., Fukasawa, K., Li, W., and Dai, W. Human Bub1: a putative mitotic checkpoint kinase closely linked to cell proliferation. Cell Growth Differ., 9: 877-885, 1998.
13. Lengauer, C., Kinzler, K. W., and Vogelstein, B. Genetic instabilities in human cancers. Nature (Lond.), 396: 642-649, 1999.
14. Chan, G. K. T., Scharr, B. T., and Yen, T. J. Characterization of the kinetochore binding domain of CENP-E reveals interaction with the kinetochore proteins CEPN-F and hBUBR1. J. Cell Biol., 143: 49-63, 1998.
15. Taylor, S., Ha, E., and McKeon, F. The human homologue of BUB3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. J. Cell Biol., 142: 1-11, 1998.
16. Davenport, J. W., Femandes, E. R., Harris, L. D., Neale, G. A., and Gooha, R. The mouse mitotic checkpoint gene BUB1B, a novel BUB1 family member, is expressed in a cell cycle-dependent manner. Genomics, 55: 113-117, 1999.
17. Donadelli, R., Benatti, L., Remussi, A., Morigi, M., Gullans, S. R., Benigni, A., Remuzzi, G., and Noris, M. Identification of novel gene SSK1 in human endothelial cells exposed to shear stress. Biochem. Biophys. Res. Commun., 246: 881-887, 1998.
18. Davenport, J. W., Femandes, E. R., Harris, L. D., Neale, G. A. M., and Goorha, R. The mouse mitotic checkpoint gene Bub1b, a novel BUB1 family member, is expressed in a cell cycle-dependent manner. Genomics, 55: 113-117, 1999.
19. Ouyang, B., Pan, H., Lu, L., Stambrook, P., and Dai, W. Human Prk is a conserved protein Ser/Thr kinase involved in regulating M phase functions. J. Biol. Chem., 272: 28646-28651, 1997.
20. Chan, G. K., Jablonski, S. A., Sudakin, V., Hittle, J. C., and Yen, T. J. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. J. Cell Biol., 146: 941-954, 1999.
21. Weinstein, J. Cell cycle-regulated expression, phosphorylation, and degradation of p55CDC. J. Biol. Chem., 272: 28501-28511, 1997.
22. Jablonski, S. A., Chan, G. K. T., Cooke, C. A., Earnshaw, W. C., and Yen, T. J. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. Chromosoma, 107: 386-396, 1998.
23. Wells, W. A. The spindle assembly checkpoint: aiming for a perfect mitosis, every time. Trends Cell Biol., 6: 228-234, 1996.
24. Farr, K., and Hoyt, M. A. Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint. Mol. Cell. Biol., 18: 2738-2747, 1998.
25. Takenaka, K., Moriguchi, T., and Nishida, E. Activation of the protein kinase p38 in the mitotic checkpoint and mitotic arrest. Science (Washington DC), 280: 599-602, 1998.
26. Hwang, L. H., Lau, L. F., Smith, D. L., Mistrot, C. A., Hardwick, K. G., Hwang, E. S., Amon, A., and Murray, A. W. Budding yeast Cdc20: a target of the mitotic checkpoint. Science (Washington DC), 279: 1041-1044, 1998.
27. Weinstein, J., Jacobsen, F. W., Hsu-Chen, J., Wu, T., and Baum, L. G. A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle protein Cdc20 and Cdc4. Mol. Cell. Biol., 14: 3350-3363, 1994.
28. Sherr, C. J. Cancer cell cycle. Science (Washington DC), 274: 1672-1677, 1996.
29. Xu, Y., Ashley, T., Brainerd, E. E., Bronson, R. T., Meyn, M. S., and Baltimore, D. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev., 10: 2411-2422, 1996.
30. Mahlamaki, E. H., Hoglund, M., Gorunova, L., Karhu, R., Dawiskiba, S., Andren-Sandberg, A., Kallioniemi, O. P., and Johansson, B. Comparative genomic hybridization reveals frequent gains of 20q, 8q, 111q, 12p and 17q, and losses of 18q, 19p, and 15q in pancreatic cancer. Genes Chromosomes Cancer, 20: 389-391, 1997.
31. Balsara, B. R., Bell, D. W., Sonoda, G., Rienzo, A. D., Manoir, S. D., Jhanwar, S. C., and Testa, J. R. Comparative genomic hybridization and loss of heterozygosity analyses identify a common region of deletion at 15q11.1-15 in human malignant mesothelioma. Cancer Res., 59: 450-454, 1999.