Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores

Journal of Cell Biology

Volumn 143, Issue 2, 1998, Pages 283-295

  Chen, Rey Huei ^a   Shevchenko, Andrej ^c   Mann, Matthias ^c,d   Murray, Andrew W ^b  

^a Cornell University ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Checkpoint; Kinetochore; Mitosis; Xenopus; Xmad1

Indexed keywords

ARTICLE; CENTROMERE; CHROMOSOME ANALYSIS; MASS SPECTROMETRY; MICROTUBULE; MITOSIS; MOLECULAR CLONING; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ANIMALS; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; KINETOCHORES; METAPHASE; MICROSCOPY, FLUORESCENCE; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD2 PROTEIN; TRANS-ACTIVATORS; XENOPUS LAEVIS; XENOPUS PROTEINS;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0032547733     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.143.2.283     Document Type: Article

References (52)

1. Cahill, D.P., C. Lengauer, J. Yu, G.J. Riggins, J.K. Willson, S.D. Markowitz, K.W. Kinzler, and B. Vogelstein. 1998. Mutations of mitotic checkpoint genes in human cancers. Nature. 392:300-303.
2. Ohen, R.-H., and A.W. Murray. 1997. Characterization of spindle assembly checkpoint in Xenopus egg extracts. Methods Enzymol. 283:572-584.
3. Chen, R.-H., C. Sarnecki, and J. Blenis. 1992. Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol. Cell. Biol. 12:915-927.
4. Chen, R.-H., J.C. Waters, E.D. Salmon, and A.W. Murray. 1996. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science. 274:242-246.
5. Cohen-Fix, O., and D. Koshland. 1997. The metaphase-to-anaphase transition: avoiding a mid-life crisis. Curr. Opin. Cell Biol. 9:800-806.
6. Cohen-Fix, O., J.M. Peters, M.W. Kirschner, and D. Koshland. 1996. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 10:3081-3093.
7. Dawson, I.A., S. Roth, and S. Artavanis-Tsakonas. 1995. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J. Cell Biol. 129:725-737.
8. Fang, G., H. Yu, and M.W. Kirschner. 1998. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev. 12:1871-1883.
9. Farr, K.A., and M.A. Hoyt. 1998. Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint. Mol. Cell. Biol. 18:2738-2747.
10. Funabiki, H., H. Yamano, K. Kumada, K. Nagao, T. Hunt, and M. Yangida. 1996. Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature. 381:438-441.
11. Glotzer, M., A.W. Murray, and M.W. Kirschner. 1991. Cyclin is degraded by the ubiquitin pathway. Nature. 349:132-138.
12. Gorbsky, G.J., R.H. Chen, and A.W. Murray. 1998. Microinjection of antibody to mad2 protein into mammalian cells in mitosis induces premature anaphase. J. Cell Biol. 141:1193-1205.
13. Hardwick, K., and A.W. Murray. 1995. Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131:709-720.
14. Hardwick, K.G. 1998. The spindle checkpoint. Trends Genet. 14:1-4.
15. Hardwick, K.G., E. Weiss, F.C. Luca, M. Winey, and A.W. Murray. 1996. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science. 273:953-956.
16. Harlow, E., and D. Lane. 1988. Antibodies. A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. 309-310.
17. He, X., T.E. Patterson, and S. Sazer. 1997. The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. Proc. Natl. Acad. Sci. USA. 94:7965-7970.
18. He, X., M.H. Jones, M. Winey, and S. Sazer. 1998. mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe. J. Cell Sci. 111:1635-1647.
19. Hershko, A. 1997. Roles of ubiquitin-mediated proteolysis in cell cycle control. Curr. Opin. Cell Biol. 9:788-799.
20. Hershko, A., D. Ganoth, J. Pehrson, R.E. Palazzo, and L.H. Cohen. 1991. Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts. J. Biol. Chem. 266:16376-16379.
21. Holloway, S.L., M. Glotzer, R.W. King, and A.W. Murray. 1993. Anaphase is initiated by proteolysis rather than by the inactivation of MPF. Cell. 73: 1393-1402.
22. Hoyt, M.A., L. Trotis, and B.T. Roberts. 1991. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell. 66:507-517.
23. Hwang, L.H., L.F. Lau, D.L. Smith, C.A. Mistrot, K.G. Hardwick, E.S. Hwang, A. Amon, and A.W. Murray. 1998. Budding yeast Cdc20: a target of the spindle checkpoint. Science. 279:1041-1044.
24. Irniger, S., S. Piatti, C. Michaelis, and K. Nasmyth. 1995. Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell. 77:1037-1050.
25. Jin, D.Y., F. Spencer, and K.T. Jeang. 1998. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell. 93:81-91.
26. Kallio, M., J. Weinstein, J.R. Daum, D.J. Burke, and G.J. Gorbsky. 1998. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J. Cell Biol. 141:1393-1406.
27. Kim, S.H., D.P. Lin, S. Matsumoto, A. Kitazono, and T. Matsumoto. 1998. Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint. Science. 279:1045-1047.
28. King, R.W., J.M. Peters, S. Tugendreich, M. Rolfe, P. Hieter, and M.W. Kirschner. 1995. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell. 81:279-288.
29. Li, R., and A.W. Murray. 1991. Feedback control of mitosis in budding yeast. Cell. 66:519-531.
30. Li, X., and R.B. Nicklas. 1995. Mitotic forces control a cell cycle checkpoint. Nature. 373:630-632.
31. Li, Y., and R. Benezra. 1996. Identification of a human mitotic checkpoint gene: hsMAD2. Science. 274:246-248.
32. Li, Y., C. Gorbea, D. Mahaffey, M. Rechsteiner, and R. Benezra. 1997. MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity. Proc. Natl. Acad. Sci. USA. 94:12431-12436.
33. Minshull, J., H. Sun, N.K. Tonks, and A.W. Murray. 1994. MAP-kinase dependent mitotic feedback arrest in Xenopus egg extracts. Cell. 79:475-486.
34. Murone, M., and V. Simanis. 1996. The fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. EMBO (Eur. Mol. Biol. Organ.) J. 15:6605-6616.
35. Murray, A.W. 1991. Cell cycle extracts. Methods Cell Biol. 36:573-597.
36. Rieder, C.L., R.W. Cole, A. Khodjakov, and G. Sluder. 1995. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores. J. Cell Biol. 130:941-948.
37. Roberts, R.T., K.A. Farr, and M.A. Hoyt. 1994. The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol. Cell Biol. 14: 8282-8291.
38. Sagata, N., N. Watanabe, G.F. Vande Woude, and Y. Ikawa. 1989. The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs. Nature. 342:512-518.
39. Sambrook, J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning, A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
40. Schwab, M., A.S. Lutum, and W. Seufert. 1997. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis. Cell. 90:683-693.
41. Shamu, C.E., and A.W. Murray. 1992. Sister chromatid separation in frog egg extracts requires DNA topoisomerase II activity during anaphase. J. Cell Biol. 117:921-934.
42. Shevchenko, A., M. Wilm, O. Vorm, and M. Mann. 1996. Mass spectrometric sequencing of proteins from silver stained polyacrylamide gels. Anal. Chem. 68:850-858.
43. Shevchenko, A., I. Chernushevich, W. Ens, K.G. Standing, B. Thomson, M. Wilm, and M. Mann. 1997. Rapid 'de novo' peptide sequencing by a combination of nanoelectrospray, isotopic labeling and a quadrupole/time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom. 11:1015-1024.
44. Sudakin, V., D. Ganoth, A. Dahan, H. Heller, J. Hersko, F. Luca, J.V. Ruderman, and A. Hershko. 1995. The cyclosome, a large complex containing cyclin-selective ubiquitination ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell. 6:185-198.
45. Surana, U., A. Amon, C. Dowzer, J. McGrew, B. Byers, and K. Nasmyth. 1993. Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO (Eur. Mol. Biol. Organ.) J. 12:1969-1978.
46. Takenaka, K., Y. Gotoh, and E. Nishida. 1997. MAP kinase is required for the spindle assembly checkpoint but is dispensable for the normal M phase entry and exit in Xenopus egg cell cycle extracts. J. Cell Biol. 136:1091-1097.
47. Taylor, S.S., and F. McKeon. 1997. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell. 89:727-735.
48. Taylor, S.S., E. Ha, and F. McKeon. 1998. The human homologue of Bub3 is required for kinetochore localization of bub1 and a Mad3/Bub1-related protein kinase. J. Cell Biol. 142:1-11.
49. Visintin, R., S. Prinz, and A. Amon. 1997. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science. 278:460-463.
50. Waters, J.C., R.H. Chen, A.W. Murray, and E.D. Salmon. 1998. Localization of mad2 to kinetochores depends on microtubule attachment, not tension. J. Cell Biol. 141:1181-1191.
51. Weiss, E., and M. Winey. 1996. The S. cerevisiae SPB duplication gene MPS1 is part of a mitotic checkpoint. J. Cell Biol. 132:111-123.
52. Wilm, M., and M. Mann. 1996. Analytical properties of the nano electrospray ion source. Anal. Chem. 66:1-8.