CENP-E as an essential component of the mitotic checkpoint in vitro

Cell

Volumn 102, Issue 6, 2000, Pages 817-826

  Abrieu, Ariane ^a   Kahana, Jason A ^a   Wood, Kenneth W ^a   Cleveland, Don W ^a,b  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CENTROMERE PROTEIN E; MICROTUBULE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CENTROMERE; CONTROLLED STUDY; IN VITRO STUDY; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALIA; VERTEBRATA;

EID: 0034664766     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)00070-2     Document Type: Article

References (42)

1. The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A
2. Mutations of mitotic checkpoint genes in human cancers
3. Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1
4. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
5. Characterization of spindle assembly checkpoint in Xenopus egg extracts
6. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
7. Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
8. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
9. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p
10. Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase
11. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae
12. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
13. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
14. Budding yeast Cdc20: A target of the spindle checkpoint
15. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis
16. Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events
17. Fission yeast Sip1: An effector of the Mad2-dependent spindle checkpoint
18. Feedback control of mitosis in budding yeast
19. Identification of a human mitotic checkpoint gene: hsMAD2
20. MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity
21. Retention of the BUB3 checkpoint protein on lagging chromosomes
22. A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts
23. Cell cycle extracts
24. Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint
25. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
26. CENP-E function at kinetochores is essential for chromosome alignment
27. Activation of the MKK/ERK pathway during somatic cell mitosis: Direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen
28. Kinetochore localization of mutine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
29. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
30. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
31. A role for mitogen-activated protein kinase in the spindle assembly checkpoint in XTC cells
32. Mad2 transiently associates with an APC/p55Cdc complex during mitosis
33. Localization of Med2 to kinetochores depends on microtubule attachment, not tension
34. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint
35. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment
36. The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules
37. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint
38. CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase
39. The maize homologue of the cell cycle checkpoint protein MAD2 reveals kinetochore substructure and contrasting mitotic and meiotic localization patterns
40. Active MAP kinase in mitosis: Localization at kinetochores and association with the motor protein CENP-E
41. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis