Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells

Journal of Cell Science

Volumn 114, Issue 24, 2001, Pages 4385-4395

  Taylor, Stephen S ^a   Hussein, Deema ^a   Wang, Yunmei ^a   Elderkin, Sarah ^a   Morrow, Christopher J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Bub1; Mitosis; Spindle checkpoint

Indexed keywords

NOCODAZOLE; PACLITAXEL; PROTEIN KINASE; TOXIN;

ANAPHASE; ANIMAL CELL; ARTICLE; CELL CYCLE; CENTROMERE; CHROMOSOMAL LOCALIZATION; CHROMOSOME; CONTROLLED STUDY; DOWNSTREAM PROCESSING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; METAPHASE CHROMOSOME; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TENSION; YEAST;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; CELL CYCLE PROTEINS; CELL LINE; CRICETINAE; G1 PHASE; HELA CELLS; HUMANS; KINETOCHORES; MACROMOLECULAR SUBSTANCES; METAPHASE; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; NOCODAZOLE; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; STAINING AND LABELING; TUMOR CELLS, CULTURED;

ANIMALIA; SACCHAROMYCETALES;

EID: 0035694452     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. The spindle checkpoint
2. Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod
3. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
4. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
5. Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function
6. Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase
7. Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-E and hBUBR1
8. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
9. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
10. Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
11. Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase
12. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
13. Differential expression of a phosphoepitope at the kinetochores of moving chromosomes
14. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase
15. MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p
16. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
17. Budding yeast Cdc20: A target of the spindle checkpoint
18. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis
19. Mechanism of inhibition of cell proliferation by Vinca alkaloids
20. Fission yeast Slpl: An effector of the Mad2-dependent spindle checkpoint
21. Feedback control of mitosis in budding yeast
22. Mitotic forces control a cell-cycle checkpoint
23. Identification of a human mitotic checkpoint gene: hsMAD2
24. Separating sister chromatids
25. Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint
26. How cells get the right chromosomes
27. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle
28. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
29. The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase
30. CENP-E function at kinetochores is essential for chromosome alignment
31. Bub1 is activated by the protein kinase p90(Rsk) during Xenopus oocyte maturation
32. Waiting for anaphase: Mad2 and the spindle assembly checkpoint
33. Spindle checkpoint protein bub1 is required for kinetochore localization of mad1, mad2, bub3, and cenp-e, independently of its kinase activity
34. Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints
35. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
36. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
37. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
38. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment
39. Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies
40. The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules
41. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint
42. Ultraviolet-microbeam irradiation of newt-cell cytoplasm: Spindle destruction, false anaphase, and delay of true anaphase