Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity

Journal of Cell Biology

Volumn 153, Issue 6, 2001, Pages 1239-1249

  Sharp Baker, Hilary ^a   Chen, Rey Huei ^a  

^a Department of Population Medicine and Diagnostic Sciences   (United States)

Author keywords

Bub1; Kinetochore; Mad1; Spindle checkpoint; Xenopus

Indexed keywords

BUB3 PROTEIN; CELL PROTEIN; PHOSPHOTRANSFERASE; PROTEIN BUB1; PROTEIN MAD1; PROTEIN MAD2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CENTROMERE; CONTROLLED STUDY; INTERPHASE; MITOSIS; MITOSIS SPINDLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; XENOPUS;

ANIMALS; CELL CYCLE PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; KINETOCHORES; MITOTIC SPINDLE APPARATUS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEIN KINASES; PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; XENOPUS; XENOPUS PROTEINS;

ANIMALIA;

EID: 0035844878     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.6.1239     Document Type: Article

References (48)

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4. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
5. Complex formation between Mad1p. Bub1p and Bub3p is crucial for spindle checkpoint function
6. Mutations of mitotic checkpoint genes in human cancers
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8. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
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14. Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint
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39. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
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