Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers

Japanese Journal of Cancer Research

Volumn 90, Issue 8, 1999, Pages 837-840

  Imai, Yasuo ^a   Shiratori, Yasushi ^a   Kato, Naoya ^a   Inoue, Tohru ^b   Omata, Masao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO KOSEI NENKIN HOSPITAL   (Japan)

Author keywords

Digestive tract cancers; hBUB1; hsMAD2; Mitotic checkpoint

Indexed keywords

ADULT; AGED; ANEUPLOIDY; ARTICLE; CARCINOGENESIS; CHROMOSOME; CLINICAL ARTICLE; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; FEMALE; GENE MUTATION; GENETIC CODE; GENETIC CONSERVATION; GENETIC STABILITY; HUMAN; HUMAN TISSUE; MALE; MISSENSE MUTATION; MITOSIS; MITOSIS SPINDLE; PRIORITY JOURNAL; RECTUM CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; YEAST;

EID: 0032850288     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1999.tb00824.x     Document Type: Article

References (16)

1. Lengauer, C., Kinzler, K. W. and Vogelstein, B. Genetic instability in human cancers. Nature, 396, 643-649 (1998).
2. Aaltonen, L. A., Peltomaaki, P., Leach, F. S., Sistonen, P., Pylkkanen, L., Meckline, J.-P., Jarvinen, H., Powell, S. M., Jen, J., Hamilton, S. R., Petersen, G. M., Kinzler, K. W., Vogelstein, B. and de la Chapelle, A. Clues to the pathogenesis of familial colorectal cancer. Science, 260, 812-816 (1993).
3. Shibata, D., Peinado, M. A., Ionov, Y., Malkhosyan, S. and Perucho, M. Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nat. Genet., 6, 273-281 (1994).
4. Kouri, M., Laasonen, A., Mecklin, J. P., Jarvinen, H., Franssila, K. and Pyrhonen, S. Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flowcytometry. Cancer, 65, 1825-1829 (1990).
5. Frei, J. V. Hereditary nonpolyposis colorectal cancer (Lynch syndrome II). Diploid malignancies with prolonged survival. Cancer, 69, 1108-1111 (1992).
6. Orr-Weaver, T. L. and Weinberg, R. A. A checkpoint on the road to cancer. Nature, 392, 223-224 (1998).
7. Hoyt, M. A., Totis, L. and Roberts, B. T. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell, 66, 507-517 (1991).
8. Li, R. and Murray, A. Feedback control of mitosis in budding yeast. Cell, 66, 519-531 (1991).
9. Li, Y. and Benezra, R. Identification of a human mitotic checkpoint gene: hsMAD2. Science, 274, 246-248 (1996).
10. Cahill, D. P., Lengauer, C., Yu, J., Riggins, G. J., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W. and Vogelstein, B. Mutations of mitotic checkpoint genes in human cancers. Nature, 392, 300-303 (1998).
11. Japanese Society for Cancer of the Colon and Rectum. "General Rules for Clinical and Pathological Studies on Cancer of the Colon, Rectum and Anus," 6th Ed. (1998). Kanehara Co., Tokyo.
12. Japanese Research Society for Gastric Cancer. "The General Rules for the Gastric Cancer Study," 12th Ed. (1993). Kanehara Co., Tokyo.
13. Japanese Society for Esophageal Diseases. "Guidelines for the Clinical and Pathologic Studies on Carcinoma of the Esophageal Diseases," 9th Ed. (1999). Kanehara Co., Tokyo.
14. Roberts, B. T., Farr, K. A. and Hoyt, M. A. The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase. Mol. Cell. Biol., 14, 8282-8291 (1994).
15. Taylor, S. S. and McKeon, F. Kinetochore localization of murine BUB1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell, 89, 727-735 (1997).
16. Cahill, D. P., da Costa, L. T., Carson-Walter, E. B., Kinzler, K. W., Vogelstein, B. and Lengauer, C. Characterization of hMAD2B and other mitotic spindle checkpoint genes. Genomics, 58, 181-187 (1999).