Spindle checkpoint requires Mad1-bound and Mad1-free Mad2

Molecular Biology of the Cell

Volumn 13, Issue 5, 2002, Pages 1501-1511

  Chung, Eunah ^a   Chen, Rey Huei ^a  

^a Cornell University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; PROTEIN MAD1; PROTEIN MAD2; CALCIUM BINDING PROTEIN; CARRIER PROTEIN; CELL CYCLE PROTEIN; FUNGAL PROTEIN; MAD1L1 PROTEIN, HUMAN; MAD1L1 PROTEIN, MOUSE; NUCLEAR PROTEIN; PHOSPHOPROTEIN; PROTEIN; REPRESSOR PROTEIN;

ANAPHASE; ARTICLE; BINDING SITE; CENTROMERE; CHROMOSOME; COMPLEX FORMATION; DISSOCIATION; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; XENOPUS; ANIMAL; DOMINANT GENE; GENETICS; IMMUNOBLOTTING; METABOLISM; MUTATION; OOCYTE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMAL; CALCIUM-BINDING PROTEINS; CHROMOSOMES; FUNGAL PROTEINS; GENES, DOMINANT; IMMUNOBLOTTING; KINETOCHORES; MITOTIC SPINDLE APPARATUS; MUTATION; OVUM; PHOSPHOPROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEINS; REPRESSOR PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; XENOPUS; ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; NUCLEAR PROTEINS;

EID: 0035999976     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.02-01-0003     Document Type: Article

References (37)

1. Mpsl is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint
2. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
3. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
4. The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins
5. Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
6. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
7. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
8. The spindle checkpoint: Two transitions, two pathways
9. Protein dynamics at the kinetochore: Cell cycle regulation of the metaphase to anaphase transition
10. Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
11. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption
12. The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex
13. A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro
14. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells
15. Exit from mitosis: Spindle pole power
16. Budding yeast Cdc20: A target of the spindle checkpoint
17. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis
18. Human T cell leukemia virus type I oncoprotein Tax targets the human mitotic checkpoint protein MAD1
19. Fission yeast Slp1: An effector of the Mad2-dependent spindle checkpoint
20. Identification of a human mitotic checkpoint gene: hsMAD2
21. Mitotic forces control a cell cycle checkpoint
22. Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts
23. MAP-kinase dependent mitotic feedback arrest in Xenopus egg extracts
24. Cell Cycle Extracts
25. The anaphase-promoting complex: New subunits and regulators
26. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
27. Waiting for anaphase: Mad2 and the spindle assembly checkpoint
28. Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity
29. Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint
30. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
31. Cdc20 by the mitotic checkpoint protein BubR1
32. The human homologue of bub3 is required for kinetochore localization of bub1 and a Mad3/Bub1-related protein kinase
33. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
34. CDC20 and CDHI: A family of substrate-specific activators of APC-dependent proteolysis
35. Localization of mad2 to kinetochores depends on microtubule attachment, not tension
36. The S. cerevisiae SPB duplication gene MPS1 is part of a mitotic checkpoint
37. Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: Model for spindle checkpoint regulation